Gender effects in relapsing-remitting multiple sclerosis: Correlation between clinical variables and gene expression molecular pathways

Journal of the Neurological Sciences

Volumn 286, Issue 1-2, 2009, Pages 47-53

  Achiron, A ^a   Gurevich, M ^a  

^a SHEBA MEDICAL CENTER   (Israel)

Author keywords

Apoptosis; EDSS progression; Gender; Gene expression; Inflammation; Multiple sclerosis; Relapsing remitting; Time to second relapse

Indexed keywords

ADOLESCENT; ADULT; APOPTOSIS; ARTICLE; CHILD; COHORT ANALYSIS; DISEASE COURSE; DISEASE DURATION; EXPANDED DISABILITY STATUS SCALE; FEMALE; GENE EXPRESSION; HUMAN; INFLAMMATION; ISRAEL; MAJOR CLINICAL STUDY; MALE; MULTIPLE SCLEROSIS; ONSET AGE; PRIORITY JOURNAL; RELAPSE; REMISSION; RETROSPECTIVE STUDY; SEX DIFFERENCE; SURVIVAL RATE;

ADOLESCENT; ADULT; AGE DISTRIBUTION; AGE FACTORS; AGE OF ONSET; AGED; ANALYSIS OF VARIANCE; CHILD; COHORT STUDIES; DISABILITY EVALUATION; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMANS; MALE; MIDDLE AGED; MULTIPLE SCLEROSIS, RELAPSING-REMITTING; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PRINCIPAL COMPONENT ANALYSIS; RETROSPECTIVE STUDIES; SEX FACTORS; SEX RATIO; YOUNG ADULT;

EID: 70349781720     PISSN: 0022510X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jns.2009.06.038     Document Type: Article

References (25)

1. Schwendimann R.N., and Alekseeva N. Gender issues in multiple sclerosis. In: Minagar A. (Ed). The neurobiology of multiple sclerosis (2007), Academic Press 378-392
2. Amadori A., Zamarchi R., De Silvestro G., Forza G., Cavatton G., Danieli G.A., et al. Genetic control of the CD4/CD8 T-cell ratio in humans. Nat Med 1 (1995) 1279-1283
3. Weinstein Y., Ran S., and Segal S. Sex-associated differences in the regulation of immune responses controlled by the MHC of the mouse. J Immunol 132 (1984) 656-661
4. Burger D., and Dayer J.M. Cytokines, acute-phase proteins, and hormones: IL-1 and TNF-alpha production in contact-mediated activation of monocytes by T lymphocytes. Ann N Y Acad Sci 966 (2002) 464-473
5. Rettew J.A., Huet-Hudson Y.M., and Marriott I. Testosterone reduces macrophage expression in the mouse of Toll-Like Receptor 4, a trigger for inflammation and innate immunity. Biol Reprod 78 (2008) 432-437
6. Temple S.E., Pham K., Glendenning P., Phillips M., and Waterer G.W. Endotoxin induced TNF and IL-10 mRNA production is higher in male than female donors: correlation with elevated expression of TLR4. Cell Immunol 251 (2008) 69-71
7. In: Matthews W.B. (Ed). McAlpine's Multiple Sclerosis (1991), Churchill Livingstone, London
8. Galimberti D., Scalabrini D., Fenoglio C., De Riz M., Comi C., Venturelli E., et al. Gender-specific influence of the chromosome 16 chemokine gene cluster on the susceptibility to Multiple Sclerosis. J Neurol Sci 267 (2008) 86-90
9. Kantarci O.H., Goris A., Hebrink D.D., Heggarty S., Cunningham S., Alloza I., et al. IFNG polymorphisms are associated with gender differences in susceptibility to multiple sclerosis. Genes Immun 6 (2005) 153-161
10. Schrijver H.M., Crusius J.B., García-González M.A., Polman C.H., Peña A.S., Barkhof F., et al. Gender-related association between the TGFB1 + 869 polymorphism and multiple sclerosis. J Interferon Cytokine Res 24 (2004) 536-542
11. Mirowska-Guzel D., Mach A., Gromadzka G., and Czlonkowski A. Czlonkowska A.BDNF A196G and C270T gene polymorphisms and susceptibility to multiple sclerosis in the Polish population. Gender differences. J Neuroimmunol 193 (2008) 170-172
12. Kantarci O.H., Hebrink D.D., Achenbach S.J., Pittock S.J., Altintas A., Schaefer-Klein J.L., et al. Association of APOE polymorphisms with disease severity in MS is limited to women. Neurology 62 (2004) 811-814
13. Graham D.B., Stephenson L.M., Lam S.K., Brim K., Lee H.M., Bautista J., et al. An ITAM-signaling pathway controls cross-presentation of particulate but not soluble antigens in dendritic cells. J Exp Med. 204 (2007) 2889-2897
14. Yasuda Y., Nishijima I., Watanabe S., and Arai K. Thymocyte proliferation and differentiation in human granulocyte-macrophage colony-stimulating factor receptor transgenic mice. J Allergy Clin Immunol 100 (1997) S87-S96
15. Guan Y., Yu S., Zhao Z., Ciric B., Zhang G.X., and Rostami A. Antigen presenting cells treated in vitro by macrophage colony-stimulating factor and autoantigen protect mice from autoimmunity. J Neuroimmunol 192 (2007) 68-78
16. Giannini A.L., Gao Y., and Bijlmakers M.J. T-cell regulator RNF125/TRAC-1 belongs to a novel family of ubiquitin ligases with zinc fingers and a ubiquitin-binding domain. Biochem J 410 (2008) 101-111
17. Tsan M.F., and Gao B. Heat shock protein and innate immunity. Cell Mol Immunol 1 (2004) 274-279
18. Chen G., Cao P., and Goeddel D.V. TNF-induced recruitment and activation of the IKK complex require Cdc37 and Hsp90. Mol Cell 9 (2002) 401-410
19. Sinha S.K., and Chaudhary P.M. Induction of apoptosis by X-linked ectodermal dysplasia receptor via a caspase 8-dependent mechanism. J Biol Chem 279 (2004) 41873-41881
20. Inohara N., Gourley T.S., Carrio R., Muñiz M., Merino J., Garcia I., et al. Diva, a Bcl-2 homologue that binds directly to Apaf-1 and induces BH3-independent cell death. J Biol Chem 273 (1998) 32479-32486
21. Liang Z.Q., Li Y.L., Zhao X.L., Han R., Wang X.X., Wang Y., et al. NF-kappaB contributes to 6-hydroxydopamine-induced apoptosis of nigral dopaminergic neurons through p53. Brain Res 1145 (2007) 190-203
22. Liu Y., and Zheng P. CD24: a genetic checkpoint in T cell homeostasis and autoimmune diseases. Trends Immunol 28 (2007) 315-320
23. Liu J.Q., Carl Jr. J.W., Joshi P.S., RayChaudhury A., Pu X.A., Shi F.D., et al. CD24 on the resident cells of the central nervous system enhances experimental autoimmune encephalomyelitis. J Immunol 178 (2007) 6227-6235
24. Zhou Q., Rammohan K., Lin S., Robinson N., Li O., Liu X., et al. CD24 is a genetic modifier for risk and progression of multiple sclerosis. Proc Natl Acad Sci U S A 100 (2003) 15041-15046
25. Otaegui D., Sáenz A., Camaño P., Blázquez L., Goicoechea M., Ruíz-Martínez J., et al. CD24 V/V is an allele associated with the risk of developing multiple sclerosis in the Spanish population. Mult Scler 12 (2006) 511-514