3-aminopiperidine-based peptide analogues as the first selective noncovalent inhibitors of the bacterial cysteine protease IdeS

Journal of Medicinal Chemistry

Volumn 55, Issue 6, 2012, Pages 2549-2560

  Berggren, Kristina ^a,c   Vindebro, Reine ^b   Bergström, Claes ^a   Spoerry, Christian ^b   Persson, Helena ^b   Fex, Tomas ^c   Kihlberg, Jan ^c   Von Pawel Rammingen, Ulrich ^b   Luthman, Kristina ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b UMEÅ UNIVERSITY   (Sweden)

^c ASTRAZENECA R AND D   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

2 (PIPERIDIN 3 YLAMINO)ACETAMIDE; BACTERIAL ENZYME; CYSTEINE PROTEINASE; CYSTEINE PROTEINASE INHIBITOR; ETHYL 2 (BENZYLOXYCARBONYL)(1 TERT BUTOXYCARBONYL LEUCINYL PIPERIDIN 3 YL)AMINO] ACETATE; ETHYL 2 [(1 TERT BUTOXYCARBONYL PIPERIDIN 3 YL) AMINO]ACETATE; ETHYL 2 [(1 TERT BUTOXYCARBONYLPIPERIDIN 3 YL)AMINO]ACETATE; ETHYL 2 [(BENZYLOXYCARBONYL) (1 TERT BUTOXYCARBONYL PIPERIDIN 3 YL)AMINO]ACETATE; ETHYL 2 [(BENZYLOXYCARBONYL)(1 TERT BUTOXYCARBONYL LEUCINYL PIPERIDIN 3 YL)AMINO]ACETATE; GLYCINE; IMMUNOGLOBULIN G; PAPAIN; PIPERIDINE DERIVATIVE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; CONTROLLED STUDY; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; HINGE REGION; HUMAN; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN CLEAVAGE; SPECTROSCOPY; STREPTOCOCCUS PYOGENES; SURFACE PLASMON RESONANCE;

AMINO ACID SEQUENCE; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; CYSTEINE PROTEINASE INHIBITORS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENZYME ASSAYS; EXOTOXINS; IMMUNOGLOBULIN G; MOLECULAR SEQUENCE DATA; PAPAIN; PEPTIDOMIMETICS; PIPERIDINES; STEREOISOMERISM; STREPTOCOCCUS PYOGENES; STRUCTURE-ACTIVITY RELATIONSHIP; SURFACE PLASMON RESONANCE;

EID: 84858733285     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm201517a     Document Type: Article

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