Synthesis and biological evaluation of reversible inhibitors of IdeS, a bacterial cysteine protease and virulence determinant

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 9, 2009, Pages 3463-3470

  Berggren, Kristina ^a,b   Johansson, Björn ^c   Fex, Tomas ^b   Kihlberg, Jan ^b   Björck, Lars ^c   Luthman, Kristina ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b ASTRAZENECA R AND D   (Sweden)

^c LUND UNIVERSITY   (Sweden)

Author keywords

Cysteine proteases; IdeS; Reversible inhibitors; Streptococcus pyogenes

Indexed keywords

1 AZIDO 2 TOSYLAMINOHEXANE; 1 AZIDO 3 METHYL 2 TOSYLAMINOBUTANE; 1 AZIDO 3 PHENYL 2 TOSYLAMINOPROPANE; 1 AZIDO 6 TERT BUTOXYCARBONYLAMINO 2 TOSYLAMINOTOSYLAMINOHEXANE; 2 TOSYLAMINO 1 HEXANOL; 2 TOSYLAMINOHEXYL 1 TOLUENESULFONATE; 3 METHYL 2 TOSYLAMINO 1 BUTANOL; 3 METHYL 2 TOSYLAMINOBUTYL 1 TOLUENESULFONATE; 3 PHENYL 2 TOSYLAMINO 1 PROPANOL; 3 PHENYL 2 TOSYLAMINO PROPYL 1 TOLUENESULFONATE; 3 TOSYLAMINO 1 HEPTANAL; 3 TOSYLAMINOHEPTANE 1 NITRILE; 4 METHYL 3 TOSYLAMINO 1 PENTANAL; 4 METHYL 3 TOSYLAMINOPENTANE 1 NITRILE; 4 PHENYL 3 TOSYLAMINO 1 BUTANAL; 4 PHENYL 3 TOSYLAMINOBUTANE 1 NITRILE; 6 TERT BUTOXYCARBONYLAMINO 2 TOSYLAMINO 1 HEXANOL; 6 TERT BUTOXYCARBONYLAMINO 2 TOSYLAMINOHEXYL 1 TOLUENESULFONATE; 7 TERT BUTOXYCARBONYLAMINO 3 TOSYLAMINO 1 HEPTANAL; 7 TERT BUTOXYCARBONYLAMINO 3 TOSYLAMINOHEPTANE 1 NITRILE; BACTERIAL ENZYME; CYSTEINE PROTEINASE; ENZYME IDES; ENZYME INHIBITOR; IDES INHIBITOR; METHYL 6 TERT BUTOXYCARBONYLAMINO 2 TOSYLAMINOHEXANOATE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; NONHUMAN; STREPTOCOCCUS PYOGENES; VIRULENCE;

BACTERIAL PROTEINS; BINDING SITES; CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEASES; CYSTEINE PROTEINASE INHIBITORS; KINETICS; PROTEIN BINDING; STREPTOCOCCUS PYOGENES; STRUCTURE-ACTIVITY RELATIONSHIP; TOSYLLYSINE CHLOROMETHYL KETONE; TOSYLPHENYLALANYL CHLOROMETHYL KETONE; VIRULENCE;

BACTERIA (MICROORGANISMS); STREPTOCOCCUS PYOGENES;

EID: 65349158258     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.03.026     Document Type: Article

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