IdeS: A bacterial proteolytic enzyme with therapeutic potential

PLoS ONE

Volumn 3, Issue 2, 2008, Pages

  Johansson, Björn P ^a   Shannon, Oonagh ^a   Björck, Lars ^a  

^a LUND UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE PROTEINASE; IMMUNOGLOBULIN G ANTIBODY; MEMBRANE ANTIGEN; POLYCLONAL ANTIBODY; PROTEIN IDES; BACTERIAL PROTEIN; IMMUNOGLOBULIN G; MAC 1 LIKE PROTEIN, STREPTOCOCCUS; MAC-1-LIKE PROTEIN, STREPTOCOCCUS;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY SPECIFICITY; ARTICLE; BLEEDING DISORDER; BLOOD FLOW; CONTROLLED STUDY; DISEASE MODEL; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG OVERDOSE; ENZYME INHIBITION; FEMALE; HUMAN; HUMAN CELL; IDIOPATHIC THROMBOCYTOPENIC PURPURA; IN VITRO STUDY; IN VIVO STUDY; LETHAL DOSE; MOUSE; NONHUMAN; PROTEIN DEGRADATION; RABBIT; THROMBOCYTOPENIA; ANIMAL; AUTOIMMUNITY; DRUG EFFECT; ENZYMOLOGY; IMMUNOLOGY; METABOLISM; REMISSION; STREPTOCOCCUS PYOGENES;

ANIMALIA; BACTERIA (MICROORGANISMS); ORYCTOLAGUS CUNICULUS; STREPTOCOCCUS PYOGENES;

ANIMALS; AUTOIMMUNITY; BACTERIAL PROTEINS; CYSTEINE ENDOPEPTIDASES; DISEASE MODELS, ANIMAL; HUMANS; IMMUNOGLOBULIN G; MICE; PURPURA, THROMBOCYTOPENIC, IDIOPATHIC; RABBITS; REMISSION INDUCTION; STREPTOCOCCUS PYOGENES;

EID: 44449121775     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0001692     Document Type: Article

References (20)

1. NIH Autoinumme Disease Coordinating Committee Report (2002) In Bethseda, MD.
2. Bygren P, Freiburghaus C, Lindholm T, Simonsen O, Thysell H, et al. (1985) Goodpasture's syndrome treated with staphylococcal protein A immunoadsorption. Lancet 2: 1295-1296.
3. Palmer A, Gjorstrup P, Severn A, Welsh K, Taube D (1988) Treatment of systemic lupus erythematosus by extracorporeal immunoadsorption. Lancet 2: 272.
4. Palmer A, Taube D, Welsh K, Bewick M, Gjorstrup P, et al. (1989) Removal of anti-HLA antibodies by extracorporeal immunoadsorption to enable renal transplantation. Lancet 1: 10-12.
5. Berta E, Confalonieri P, Simoncini O, Bernardi G, Busnach G, et al. (1994) Removal of antiacetylcholine receptor antibodies by protein-A immununoadsorption in myasthenia gravis. Int J Artif Organs 17: 603-608.
6. Stummvoll GH, Aringer M, Smolen JS, Schmaldienst S, Jimenez-Boj E, et al. (2005) IgG immunoadsorption reduces systemic lupus erythematosus activity and proteinuria: a long term observational study. Ann Rheum Dis 64: 1015-1021.
7. Eming R, Herd M (2006) Immunoadsorption in pemphigus. Autoimmunity 39: 609-616.
8. Collin M, Olsen A (2001) EndoS, a novel secreted protein from Streptococcus pyogenes with endoglycosidase activity on human IgG. Embo J 20: 3046-3055.
9. Nandakumar KS, Collin M, Olsén A, Nimmerjahn F, Blom AM, et al. (2007) Endoglycosidase treatment abrogates IgG arthritogenicity: importance of IgG glycosylation in arthritis. Eur J Immunol 37: 2973-2982.
10. Collin M, Shannon O, Bjorck L, (2007) IgG glycan hydrolysis by a bacterial enzyme as a therapy against autoimmune conditions. Proc Natl Acad Sci U S A Paper in press.
11. von Pawel-Rammingen U, Johansson BP, Bjorck L (2002) IdeS, a novel streptococcal cysteine at proteinase with unique specificity for immunoglobulin G. Embo J 21: 1607-1615.
12. Wenig K, Chatwell L, von Pawel-Rammingen U, Björck L, Huber R, et al. (2004) Structure of the streptococcal endopeptidase IdeS, a cysteine proteinase with strict specificity for IgG. Proc Natl Acad Sci U S A 101: 17371-17376.
13. Nandakumar KS, Johansson BP, Björck L, Holmdahl R (2007) Blocking of experimental arthritis by cleavage of IgG antibodies in vivo. Arthritis Rheum 56: 3253-3260.
14. Lei B, DeLeo FR, Hoe NP, Graham MR, Mackie SM, et al. (2001) Evasion of human innate and acquired immunity by a bacterial homolog of-CD11b that inhibits opsonophagocytosis. Nat Med 7: 1298-1305.
15. Vincents B, von Pawel-Rammingen U, Björck L, Abrahamson M (2004) Enzymatic characterization of the streptococcal endopeptidase, IdeS, reveals that it is a cysteine protease with strict specificity for IgG cleavage due to exosite binding. Biochemistry 43: 15540-15549.
16. Åkesson P, Rasmussen M, Mascini F, von Pawel-Rammingen U, Janulczyk R, et al. (2004) Low antibody levels against cell wall-attached proteins of Streptococcus pyogenes predispose for severe invasive disease. J Infect Dis 189: 797-804.
17. Åkesson P, Moritz L, Truedsson M, Christensson B, von Pawel-Rammingen U (2006) IdeS, a highly specific immunoglobulin G (IgG)-cleaving enzyme from Streptococcus pyogenes, is inhibited by specific IgG antibodies generated during infection. Infect Immun 74: 497-503.
18. Tomer A, Koziol J, McMillan R (2005) Autoimmune thrombocytopenia: flow cytometric determination of platelet-associated autoantibodies against platelet-specific receptors. J Thromb Haemost 3: 74-78.
19. Dominguez V, Govezensky T, Gevorkian G, Larralde C (2003) Low platelet counts alone do not cause bleeding in an experimental immune thrombocytopenic purpura in mice. Haematologica 88: 679-687.
20. Fujimi S, MacConmara MP, Maung AA, Zang Y, Mannick JA, et al. (2006) Platelet depletion in mice increases mortality after thermal injury. Blood 107: 4399-4406.