Trisubstituted imidazoles as mycobacterium tuberculosis glutamine synthetase inhibitors

Journal of Medicinal Chemistry

Volumn 55, Issue 6, 2012, Pages 2894-2898

  Gising, Johan ^a   Nilsson, Mikael T ^a   Odell, Luke R ^a   Yahiaoui, Samir ^a   Lindh, Martin ^a   Iyer, Harini ^b   Sinha, Achyut M ^b   Srinivasa, Bachally R ^b   Larhed, Mats ^a   Mowbray, Sherry L ^a   Karlén, Anders ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b ASTRAZENECA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2 TERT BUTYL 4,5 DIARYLIMIDAZOLE; ADENOSINE TRIPHOSPHATE; GLUTAMATE AMMONIA LIGASE; IMIDAZOLE; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; IC 50; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; TUBERCULOSIS; X RAY CRYSTALLOGRAPHY;

ADENOSINE TRIPHOSPHATE; ANTITUBERCULAR AGENTS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; GLUTAMATE-AMMONIA LIGASE; IMIDAZOLES; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MYCOBACTERIUM TUBERCULOSIS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84858730203     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm201212h     Document Type: Article

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