An inhibitor of exported Mycobacterium tuberculosis glutamine synthetase selectively blocks the growth of pathogenic mycobacteria in axenic culture and in human monocytes: Extracellular proteins as potential novel drug targets

Journal of Experimental Medicine

Volumn 189, Issue 9, 1999, Pages 1425-1435

  Harth, Günter ^a   Horwitz, Marcus A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Drug design; Enzyme inhibitors; Poly L glutamate glutamine; Tuberculosis

Indexed keywords

ALANINE; BACTERIAL ENZYME; ENZYME INHIBITOR; GLUTAMATE AMMONIA LIGASE; GLUTAMINE; METHIONINE SULFOXIMINE; PHOSPHINOTHRICIN; POLYGLUTAMIC ACID;

ARTICLE; BACTERIAL CELL WALL; BACTERIOSTASIS; DRUG DESIGN; DRUG TARGETING; ENZYME INHIBITION; HUMAN; HUMAN CELL; MONOCYTE; MYCOBACTERIUM TERRAE; NONHUMAN; PRIORITY JOURNAL; TUBERCULOSIS;

AMINOBUTYRIC ACIDS; ANIMALS; ANTI-BACTERIAL AGENTS; CELL WALL; DRUG SYNERGISM; ENZYME INHIBITORS; EXTRACELLULAR SPACE; GLUTAMATE-AMMONIA LIGASE; GLUTAMIC ACID; HUMANS; METHIONINE SULFOXIMINE; MONOCYTES; MYCOBACTERIUM TUBERCULOSIS; PEPTIDOGLYCAN; POLYGLUTAMIC ACID; SHEEP;

EID: 0033519232     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.189.9.1425     Document Type: Article

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