A new structural theme in C2-symmetric HIV-1 protease inhibitors: ortho-Substituted P1/P1′ side chains

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 15, 2006, Pages 5303-5315

  Wannberg, Johan ^a   Sabnis, Yogesh A ^a   Vrang, Lotta ^b   Samuelsson, Bertil ^b   Karlén, Anders ^a   Hallberg, Anders ^a   Larhed, Mats ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b MEDIVIR AB   (Sweden)

Author keywords

3D QSAR CoMFA; Catalysis; Docking studies; High speed synthesis; HIV 1 protease inhibitors; Microwave; Palladium

Indexed keywords

PALLADIUM; PROTEINASE INHIBITOR;

ARTICLE; BINDING AFFINITY; BINDING SITE; CATALYSIS; CHEMICAL BOND; CHEMICAL STRUCTURE; CONFORMATIONAL TRANSITION; HUMAN IMMUNODEFICIENCY VIRUS 1; MATHEMATICAL COMPUTING; NONHUMAN;

AMIDES; CATALYSIS; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; HIV PROTEASE; HIV PROTEASE INHIBITORS; MICROWAVES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PALLADIUM; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; STEREOISOMERISM;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 33745179573     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.03.045     Document Type: Article

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