Glucose levels regulate the nucleo-mitochondrial distribution of Mig2

Mitochondrion

Volumn 12, Issue 3, 2012, Pages 370-380

  Fernández Cid, Alejandra ^a,b   Riera, Alberto ^a,b   Herrero, Pilar ^a   Moreno, Fernando ^a  

^a UNIVERSITY OF OVIEDO   (Spain)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Glucose repression; Glucose signaling; Mig2; Mitochondrial morphology; Ups1; Yeast

Indexed keywords

GLUCOSE; MIG1 TRANSCRIPTION FACTOR; MIG2 TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ARTICLE; CELL NUCLEUS; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; FUNGAL STRAIN; GENE DELETION; GENE REPRESSION; IMMUNOPRECIPITATION; NONHUMAN; OXIDATIVE STRESS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SACCHAROMYCES CEREVISIAE; WILD TYPE;

CELL NUCLEUS; GENE EXPRESSION REGULATION, FUNGAL; GLUCOSE; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; REPRESSOR PROTEINS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS;

SACCHAROMYCES CEREVISIAE;

EID: 84858722703     PISSN: 15677249     EISSN: 18728278     Source Type: Journal    
DOI: 10.1016/j.mito.2012.02.001     Document Type: Article

References (39)

1. Ahuatzi D., Riera A., Pelaez R., Herrero P., Moreno F. Hxk2 regulates the phosphorylation state of Mig1 and therefore its nucleocytoplasmic distribution. J. Biol. Chem. 2007, 282:4485-4493.
2. Bach D., Pich S., Soriano F.X., Vega N., Baumgartner B., Oriola J., Daugaard J.R., Lloberas J., Camps M., Zierath J.R., Rabasa-Lhoret R., Wallberg-Henriksson H., Laville M., Palacin M., Vidal H., Rivera F., Brand M., Zorzano A. Mitofusin-2 determines mitochondrial network architecture and mitochondrial metabolism. A novel regulatory mechanism altered in obesity. J. Biol. Chem. 2003, 278:17190-17197.
3. Bleazard W., McCaffery J.M., King E.J., Bale S., Mozdy A., Tieu Q., Nunnari J., Shaw J.M. The dynamin-related GTPase Dnm1 regulates mitochondrial fission in yeast. Nat. Cell Biol. 1999, 1:298-304.
4. Brachmann C.B., Davies A., Cost G.J., Caputo E., Li J., Hieter P., Boeke J.D. Designer deletion strains derived from Saccharomyces cerevisiae S288C: a useful set of strains and plasmids for PCR-mediated gene disruption and other applications. Yeast 1998, 14:115-132.
5. Cerveny K.L., Studer S.L., Jensen R.E., Sesaki H. Yeast mitochondrial division and distribution require the cortical num1 protein. Dev. Cell 2007, 12:363-375.
6. Cho D.H., Nakamura T., Lipton S.A. Mitochondrial dynamics in cell death and neurodegeneration. Cell. Mol. Life Sci. 2010, 67:3435-3447.
7. Cohen M.M., Amiott E.A., Day A.R., Leboucher G.P., Pryce E.N., Glickman M.H., McCaffery J.M., Shaw J.M., Weissman A.M. Sequential requirements for the GTPase domain of the mitofusin Fzo1 and the ubiquitin ligase SCFMdm30 in mitochondrial outer membrane fusion. J. Cell Sci. 2011, 124:1403-1410.
8. Daum G., Bohni P.C., Schatz G. Import of proteins into mitochondria. Cytochrome b2 and cytochrome c peroxidase are located in the intermembrane space of yeast mitochondria. J. Biol. Chem. 1982, 257:13028-13033.
9. De Vit M.J., Waddle J.A., Johnston M. Regulated nuclear translocation of the Mig1 glucose repressor. Mol. Biol. Cell 1997, 8:1603-1618.
10. DeVay R.M., Dominguez-Ramirez L., Lackner L.L., Hoppins S., Stahlberg H., Nunnari J. Coassembly of Mgm1 isoforms requires cardiolipin and mediates mitochondrial inner membrane fusion. J. Cell Biol. 2009, 186:793-803.
11. Egner A., Jakobs S., Hell S.W. Fast 100-nm resolution three-dimensional microscope reveals structural plasticity of mitochondria in live yeast. Proc. Natl. Acad. Sci. U. S. A. 2002, 99:3370-3375.
12. Fritz S., Weinbach N., Westermann B. Mdm30 is an F-box protein required for maintenance of fusion-competent mitochondria in yeast. Mol. Biol. Cell 2003, 14:2303-2313.
13. Herlan M., Bornhovd C., Hell K., Neupert W., Reichert A.S. Alternative topogenesis of Mgm1 and mitochondrial morphology depend on ATP and a functional import motor. J. Cell Biol. 2004, 165:167-173.
14. Hermann G.J., Thatcher J.W., Mills J.P., Hales K.G., Fuller M.T., Nunnari J., Shaw J.M. Mitochondrial fusion in yeast requires the transmembrane GTPase Fzo1p. J. Cell Biol. 1998, 143:359-373.
15. Koh J.L., Ding H., Costanzo M., Baryshnikova A., Toufighi K., Bader G.D., Myers C.L., Andrews B.J., Boone C. DRYGIN: a database of quantitative genetic interaction networks in yeast. Nucleic Acids Res. 2010, 38:D502-D507.
16. Kutik S., Rissler M., Guan X.L., Guiard B., Shui G., Gebert N., Heacock P.N., Rehling P., Dowhan W., Wenk M.R., Pfanner N., Wiedemann N. The translocator maintenance protein Tam41 is required for mitochondrial cardiolipin biosynthesis. J. Cell Biol. 2008, 183:1213-1221.
17. Li G., Chen S., Thompson M.N., Greenberg M.L. New insights into the regulation of cardiolipin biosynthesis in yeast: implications for Barth syndrome. Biochim. Biophys. Acta 2007, 1771:432-441.
18. Longtine M.S., McKenzie A., Demarini D.J., Shah N.G., Wach A., Brachat A., Philippsen P., Pringle J.R. Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae. Yeast 1998, 14:953-961.
19. Lutfiyya L.L., Johnston M. Two zinc-finger-containing repressors are responsible for glucose repression of SUC2 expression. Mol. Cell. Biol. 1996, 16:4790-4797.
20. Lutfiyya L.L., Iyer V.R., DeRisi J., DeVit M.J., Brown P.O., Johnston M. Characterization of three related glucose repressors and genes they regulate in Saccharomyces cerevisiae. Genetics 1998, 150:1377-1391.
21. Meeusen S., McCaffery J.M., Nunnari J. Mitochondrial fusion intermediates revealed in vitro. Science 2004, 305:1747-1752.
22. Michaelis C., Ciosk R., Nasmyth K. Cohesins: chromosomal proteins that prevent premature separation of sister chromatids. Cell 1997, 91:35-45.
23. Osman C., Merkwirth C., Langer T. Prohibitins and the functional compartmentalization of mitochondrial membranes. J. Cell Sci. 2009, 122:3823-3830.
24. Otsuga D., Keegan B.R., Brisch E., Thatcher J.W., Hermann G.J., Bleazard W., Shaw J.M. The dynamin-related GTPase, Dnm1p, controls mitochondrial morphology in yeast. J. Cell Biol. 1998, 143:333-349.
25. Pelaez R., Herrero P., Moreno F. Nuclear export of the yeast hexokinase 2 protein requires the Xpo1 (Crm1)-dependent pathway. J. Biol. Chem. 2009, 284:20548-20555.
26. Pich S., Bach D., Briones P., Liesa M., Camps M., Testar X., Palacin M., Zorzano A. The Charcot-Marie-Tooth type 2A gene product, Mfn2, up-regulates fuel oxidation through expression of OXPHOS system. Hum. Mol. Genet. 2005, 14:1405-1415.
27. Randez-Gil F., Herrero P., Sanz P., Prieto J.A., Moreno F. Hexokinase PII has a double cytosolic-nuclear localisation in Saccharomyces cerevisiae. FEBS Lett. 1998, 425:475-478.
28. Rintoul G.L., Reynolds I.J. Mitochondrial trafficking and morphology in neuronal injury. Biochim. Biophys. Acta 2010, 1802:143-150.
29. Scott I., Youle R.J. Mitochondrial fission and fusion. Essays Biochem. 2010, 47:85-98.
30. Sesaki H., Jensen R.E. Division versus fusion: Dnm1p and Fzo1p antagonistically regulate mitochondrial shape. J. Cell Biol. 1999, 147:699-706.
31. Sesaki H., Southard S.M., Yaffe M.P., Jensen R.E. Mgm1p, a dynamin-related GTPase, is essential for fusion of the mitochondrial outer membrane. Mol. Biol. Cell 2003, 14:2342-2356.
32. Sesaki H., Dunn C.D., Iijima M., Shepard K.A., Yaffe M.P., Machamer C.E., Jensen R.E. Ups1p, a conserved intermembrane space protein, regulates mitochondrial shape and alternative topogenesis of Mgm1p. J. Cell Biol. 2006, 173:651-658.
33. Tamura Y., Endo T., Iijima M., Sesaki H. Ups1p and Ups2p antagonistically regulate cardiolipin metabolism in mitochondria. J. Cell Biol. 2009, 185:1029-1045.
34. Wakabayashi J., Zhang Z., Wakabayashi N., Tamura Y., Fukaya M., Kensler T.W., Iijima M., Sesaki H. The dynamin-related GTPase Drp1 is required for embryonic and brain development in mice. J. Cell Biol. 2009, 186:805-816.
35. Wallis J.W., Chrebet G., Brodsky G., Rolfe M., Rothstein R. A hyper-recombination mutation in S. cerevisiae identifies a novel eukaryotic topoisomerase. Cell 1989, 58:409-419.
36. Wong E.D., Wagner J.A., Gorsich S.W., McCaffery J.M., Shaw J.M., Nunnari J. The dynamin-related GTPase, Mgm1p, is an intermembrane space protein required for maintenance of fusion competent mitochondria. J. Cell Biol. 2000, 151:341-352.
37. Zhang M., Mileykovskaya E., Dowhan W. Cardiolipin is essential for organization of complexes III and IV into a supercomplex in intact yeast mitochondria. J. Biol. Chem. 2005, 280:29403-29408.
38. Zick M., Duvezin-Caubet S., Schafer A., Vogel F., Neupert W., Reichert A.S. Distinct roles of the two isoforms of the dynamin-like GTPase Mgm1 in mitochondrial fusion. FEBS Lett. 2009, 583:2237-2243.
39. Zorzano A., Liesa M., Sebastian D., Segales J., Palacin M. Mitochondrial fusion proteins: dual regulators of morphology and metabolism. Semin. Cell Dev. Biol. 2010, 21:566-574.