메뉴 건너뛰기




Volumn 3, Issue 1, 2012, Pages 30-38

Genetic variation in MME in relation to neprilysin protein and enzyme activity, Aβ levels, and Alzheimer's disease risk

Author keywords

amyloid; Alzheimer disease; Association; Gene; MME; Neprilysin; Polymorphism

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-42]; MEMBRANE METALLOENDOPEPTIDASE;

EID: 84858711606     PISSN: None     EISSN: 19481756     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (25)

References (51)
  • 2
    • 0036794008 scopus 로고    scopus 로고
    • Declining expression of neprilysin in Alzheimer disease vasculature: Possible involvement in cerebral amyloid angiopathy
    • Carpentier M, Robitaille Y, DesGroseillers L, Boileau G and Marcinkiewicz M. Declining expression of neprilysin in Alzheimer disease vasculature: possible involvement in cerebral amyloid angiopathy. J Neuropathol Exp Neurol 2002; 61: 849-856.
    • (2002) J Neuropathol Exp Neurol , vol.61 , pp. 849-856
    • Carpentier, M.1    Robitaille, Y.2    Desgroseillers, L.3    Boileau, G.4    Marcinkiewicz, M.5
  • 3
    • 33749475139 scopus 로고    scopus 로고
    • Decreased expression and activity of neprilysin in Alzheimer disease are associated with cerebral amyloid angiopathy
    • Miners JS, Van Helmond Z, Chalmers K, Wilcock G, Love S and Kehoe PG. Decreased expression and activity of neprilysin in Alzheimer disease are associated with cerebral amyloid angiopathy. J Neuropathol Exp Neurol 2006; 65: 1012-1021.
    • (2006) J Neuropathol Exp Neurol , vol.65 , pp. 1012-1021
    • Miners, J.S.1    van Helmond, Z.2    Chalmers, K.3    Wilcock, G.4    Love, S.5    Kehoe, P.G.6
  • 7
    • 33750047859 scopus 로고    scopus 로고
    • Regulation of steady-state beta -amyloid levels in the brain by neprilysin and endothelin-converting enzyme, but not angiotensin-converting enzyme
    • Eckman EA, Adams SK, Troendle FJ, Stodola BA, Kahn MA, Fauq AH, Xiao HD, Bernstein KE and Eckman CB. Regulation of steady-state beta -amyloid levels in the brain by neprilysin and endothelin-converting enzyme, but not angiotensin-converting enzyme. J Biol Chem 2006; 281: 30471-30478.
    • (2006) J Biol Chem , vol.281 , pp. 30471-30478
    • Eckman, E.A.1    Adams, S.K.2    Troendle, F.J.3    Stodola, B.A.4    Kahn, M.A.5    Fauq, A.H.6    Xiao, H.D.7    Bernstein, K.E.8    Eckman, C.B.9
  • 8
    • 33947245344 scopus 로고    scopus 로고
    • Effects of prolonged angiotensin-converting enzyme inhibitor treatment on amyloid beta-protein metabolism in mouse models of Alzheimer disease
    • Hemming ML, Selkoe DJ and Farris W. Effects of prolonged angiotensin-converting enzyme inhibitor treatment on amyloid beta-protein metabolism in mouse models of Alzheimer disease. Neurobiol Dis 2007; 26: 273-281.
    • (2007) Neurobiol Dis , vol.26 , pp. 273-281
    • Hemming, M.L.1    Selkoe, D.J.2    Farris, W.3
  • 12
    • 27344441173 scopus 로고    scopus 로고
    • Metabolism of amyloid-beta peptide and Alzheimer's disease
    • Iwata N, Higuchi M and Saido TC. Metabolism of amyloid-beta peptide and Alzheimer's disease. Pharmacol Ther 2005; 108: 129-148.
    • (2005) Pharmacol Ther , vol.108 , pp. 129-148
    • Iwata, N.1    Higuchi, M.2    Saido, T.C.3
  • 13
    • 77953933868 scopus 로고    scopus 로고
    • Evaluation of neprilysin sequence variation in relation to CSF beta-Amyloid levels and Alzheimer disease risk
    • Blomqvist ME, McCarthy S, Blennow K, Andersson B and Prince JA. Evaluation of neprilysin sequence variation in relation to CSF beta-Amyloid levels and Alzheimer disease risk. Int J Mol Epidemiol Genet 2010; 1: 47-52.
    • (2010) Int J Mol Epidemiol Genet , vol.1 , pp. 47-52
    • Blomqvist, M.E.1    McCarthy, S.2    Blennow, K.3    Andersson, B.4    Prince, J.A.5
  • 14
    • 65649132717 scopus 로고    scopus 로고
    • Lack of association of neprilysin gene polymorphisms with Alzheimer's disease in a southern Chinese community
    • Fu Y, Li AF, Shi JJ, Tang MN, Guo YB and Zhao ZH. Lack of association of neprilysin gene polymorphisms with Alzheimer's disease in a southern Chinese community. Int Psychogeriatr 2009; 21: 354-358.
    • (2009) Int Psychogeriatr , vol.21 , pp. 354-358
    • Fu, Y.1    Li, A.F.2    Shi, J.J.3    Tang, M.N.4    Guo, Y.B.5    Zhao, Z.H.6
  • 17
    • 0037421496 scopus 로고    scopus 로고
    • No association between polymorphisms in the neprilysin promoter region and Swedish Alzheimer's disease patients
    • Lilius L, Forsell C, Axelman K, Winblad B, Graff C and Tjernberg L. No association between polymorphisms in the neprilysin promoter region and Swedish Alzheimer's disease patients. Neurosci Lett 2003; 337: 111-113.
    • (2003) Neurosci Lett , vol.337 , pp. 111-113
    • Lilius, L.1    Forsell, C.2    Axelman, K.3    Winblad, B.4    Graff, C.5    Tjernberg, L.6
  • 22
    • 0035209377 scopus 로고    scopus 로고
    • Lack of association of neprilysin polymorphism with Alzheimer's disease and Alzheimer's disease-type neuropathological changes
    • Sodeyama N, Mizusawa H, Yamada M, Itoh Y, Otomo E and Matsushita M. Lack of association of neprilysin polymorphism with Alzheimer's disease and Alzheimer's disease-type neuropathological changes. J Neurol Neurosurg Psychiatry 2001; 71: 817-818.
    • (2001) J Neurol Neurosurg Psychiatry , vol.71 , pp. 817-818
    • Sodeyama, N.1    Mizusawa, H.2    Yamada, M.3    Itoh, Y.4    Otomo, E.5    Matsushita, M.6
  • 24
    • 35448964218 scopus 로고    scopus 로고
    • Association between neprilysin polymorphisms and sporadic Alzheimer's disease
    • Wood LS, Pickering EH, McHale D and Dechairo BM. Association between neprilysin polymorphisms and sporadic Alzheimer's disease. Neurosci Lett 2007; 427: 103-106.
    • (2007) Neurosci Lett , vol.427 , pp. 103-106
    • Wood, L.S.1    Pickering, E.H.2    McHale, D.3    Dechairo, B.M.4
  • 25
    • 57649171529 scopus 로고    scopus 로고
    • Characterisation of two antibodies to oligomeric Abeta and their use in ELISAs on human brain tissue homogenates
    • van Helmond Z, Heesom K and Love S. Characterisation of two antibodies to oligomeric Abeta and their use in ELISAs on human brain tissue homogenates. J Neurosci Methods 2009; 176: 206-212.
    • (2009) J Neurosci Methods , vol.176 , pp. 206-212
    • van Helmond, Z.1    Heesom, K.2    Love, S.3
  • 26
    • 75949101330 scopus 로고    scopus 로고
    • Oligomeric Abeta in Alzheimer's Disease: Relationship to Plaque and Tangle Pathology, APOE Genotype and Cerebral Amyloid Angiopathy
    • van Helmond Z, Miners JS, Kehoe PG and Love S. Oligomeric Abeta in Alzheimer's Disease: Relationship to Plaque and Tangle Pathology, APOE Genotype and Cerebral Amyloid Angiopathy. Brain Pathol 2010; 20: 468-480.
    • (2010) Brain Pathol , vol.20 , pp. 468-480
    • van Helmond, Z.1    Miners, J.S.2    Kehoe, P.G.3    Love, S.4
  • 27
    • 0025908356 scopus 로고
    • The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease
    • Mirra SS, Heyman A, McKeel D, Sumi SM, Crain BJ, Brownlee LM, Vogel FS, Hughes JP, van Belle G and Berg L. The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease. Neurology 1991; 41: 479-486.
    • (1991) Neurology , vol.41 , pp. 479-486
    • Mirra, S.S.1    Heyman, A.2    McKeel, D.3    Sumi, S.M.4    Crain, B.J.5    Brownlee, L.M.6    Vogel, F.S.7    Hughes, J.P.8    van Belle, G.9    Berg, L.10
  • 28
    • 0021271971 scopus 로고
    • Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
    • McKhann G, Drachman D, Folstein M, Katzman R, Price D and Stadlan EM. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 1984; 34: 939-944.
    • (1984) Neurology , vol.34 , pp. 939-944
    • McKhann, G.1    Drachman, D.2    Folstein, M.3    Katzman, R.4    Price, D.5    Stadlan, E.M.6
  • 29
    • 0025801744 scopus 로고
    • Apolipoprotein E Genotyping By One-stage PCR
    • Wenham PR, Price WH and Blandell G. Apolipoprotein E genotyping by one-stage PCR. Lancet 1991; 337: 1158-1159.
    • (1991) Lancet , vol.337 , pp. 1158-1159
    • Wenham, P.R.1    Price, W.H.2    Blandell, G.3
  • 30
    • 69449102820 scopus 로고    scopus 로고
    • Neprilysin and insulin-degrading enzyme levels are increased in Alzheimer disease in relation to disease severity
    • Miners JS, Baig S, Tayler H, Kehoe PG and Love S. Neprilysin and insulin-degrading enzyme levels are increased in Alzheimer disease in relation to disease severity. J Neuropathol Exp Neurol 2009; 68: 902-914.
    • (2009) J Neuropathol Exp Neurol , vol.68 , pp. 902-914
    • Miners, J.S.1    Baig, S.2    Tayler, H.3    Kehoe, P.G.4    Love, S.5
  • 31
    • 37049011221 scopus 로고    scopus 로고
    • Immunocapture-based fluorometric assay for the measurement of neprilysinspecific enzyme activity in brain tissue homogenates and cerebrospinal fluid
    • Miners JS, Verbeek MM, Rikkert MO, Kehoe PG and Love S. Immunocapture-based fluorometric assay for the measurement of neprilysinspecific enzyme activity in brain tissue homogenates and cerebrospinal fluid. J Neurosci Methods 2008; 167: 229-236.
    • (2008) J Neurosci Methods , vol.167 , pp. 229-236
    • Miners, J.S.1    Verbeek, M.M.2    Rikkert, M.O.3    Kehoe, P.G.4    Love, S.5
  • 32
    • 13444269543 scopus 로고    scopus 로고
    • Haploview: Analysis and visualization of LD and haplotype maps
    • Barrett JC, Fry B, Maller J and Daly MJ. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2005; 21: 263-265.
    • (2005) Bioinformatics , vol.21 , pp. 263-265
    • Barrett, J.C.1    Fry, B.2    Maller, J.3    Daly, M.J.4
  • 33
    • 0016319012 scopus 로고
    • Estimation of linkage disequilibrium in randomly mating populations
    • Hill WG. Estimation of linkage disequilibrium in randomly mating populations. Heredity 1974; 33: 229-239.
    • (1974) Heredity , vol.33 , pp. 229-239
    • Hill, W.G.1
  • 34
    • 77953193048 scopus 로고    scopus 로고
    • Changes with Age in the Activities of betasecretase and the Abeta-degrading Enzymes Neprilysin, Insulin-degrading Enzyme and Angiotensin-converting Enzyme
    • Miners JS, van Helmond Z, Kehoe PG and Love S. Changes with Age in the Activities of betasecretase and the Abeta-degrading Enzymes Neprilysin, Insulin-degrading Enzyme and Angiotensin-converting Enzyme. Brain Pathol 2010; 20: 794-802.
    • (2010) Brain Pathol , vol.20 , pp. 794-802
    • Miners, J.S.1    van Helmond, Z.2    Kehoe, P.G.3    Love, S.4
  • 35
    • 84858731535 scopus 로고    scopus 로고
    • Downregulation of neprilysin in Alzheimer's disease is associated with cerebral amyloid angiopathy and APOE ε4
    • submitted
    • Miners JS, van Helmond ZK, Chalmers K, Wilcock GK, Love S and Kehoe PG. Downregulation of neprilysin in Alzheimer's disease is associated with cerebral amyloid angiopathy and APOE ε4. JNEN 2006; submitted.
    • (2006) JNEN
    • Miners, J.S.1    van Helmond, Z.K.2    Chalmers, K.3    Wilcock, G.K.4    Love, S.5    Kehoe, P.G.6
  • 36
    • 77953185697 scopus 로고    scopus 로고
    • Higher Soluble Amyloid beta Concentration in Frontal Cortex of Young Adults than in Normal Elderly or Alzheimer's Disease
    • van Helmond Z, Miners JS, Kehoe PG and Love S. Higher Soluble Amyloid beta Concentration in Frontal Cortex of Young Adults than in Normal Elderly or Alzheimer's Disease. Brain Pathol 2010; 20: 787-793.
    • (2010) Brain Pathol , vol.20 , pp. 787-793
    • van Helmond, Z.1    Miners, J.S.2    Kehoe, P.G.3    Love, S.4
  • 42
    • 70450045976 scopus 로고    scopus 로고
    • Angiotensins in Alzheimer's disease friend or foe?
    • Kehoe PG, Miners S and Love S. Angiotensins in Alzheimer's disease friend or foe? Trends Neurosci 2009; 32: 619-628.
    • (2009) Trends Neurosci , vol.32 , pp. 619-628
    • Kehoe, P.G.1    Miners, S.2    Love, S.3
  • 43
    • 40149093247 scopus 로고    scopus 로고
    • Angiotensin-converting enzyme (ACE) levels and activity in Alzheimer's disease, and relationship of perivascular ACE-1 to cerebral amyloid angiopathy
    • Miners JS, Ashby E, Van Helmond Z, Chalmers KA, Palmer LE, Love S and Kehoe PG. Angiotensin-converting enzyme (ACE) levels and activity in Alzheimer's disease, and relationship of perivascular ACE-1 to cerebral amyloid angiopathy. Neuropathol Appl Neurobiol 2008; 34: 181-193.
    • (2008) Neuropathol Appl Neurobiol , vol.34 , pp. 181-193
    • Miners, J.S.1    Ashby, E.2    van Helmond, Z.3    Chalmers, K.A.4    Palmer, L.E.5    Love, S.6    Kehoe, P.G.7
  • 46
    • 42749087642 scopus 로고    scopus 로고
    • Erikson C and Janciauskiene S. rCBF pathology in Alzheimer's disease is associated with slow processing speed
    • Warkentin S, Erikson C and Janciauskiene S. rCBF pathology in Alzheimer's disease is associated with slow processing speed. Neuropsychologia 2008; 46: 1193-1200.
    • (2008) Neuropsychologia , vol.46 , pp. 1193-1200
    • Warkentin, S.1
  • 50
    • 79952928727 scopus 로고    scopus 로고
    • Angiotensins and Alzheimer's disease: A bench to bedside overview
    • Kehoe PG. Angiotensins and Alzheimer's disease: a bench to bedside overview. Alzheimers Res Ther 2009; 1: 3.
    • (2009) Alzheimers Res Ther , vol.1 , pp. 3
    • Kehoe, P.G.1
  • 51
    • 0025165779 scopus 로고
    • An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels
    • Rigat B, Hubert C, Alhenc-Gelas F, Cambien F, Corvol P and Soubrier F. An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. J Clin Invest 1990; 86: 1343-1346.
    • (1990) J Clin Invest , vol.86 , pp. 1343-1346
    • Rigat, B.1    Hubert, C.2    Alhenc-Gelas, F.3    Cambien, F.4    Corvol, P.5    Soubrier, F.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.