메뉴 건너뛰기




Volumn 44, Issue 1, 2012, Pages 51-60

Bromopyruvate mediates autophagy and cardiolipin degradation to monolyso-cardiolipin in GL15 glioblastoma cells

Author keywords

Autophagy; Bromopyruvate; Cardiolipin; Cytochrome c; Glioblastoma cells; Lyso cardiolipin

Indexed keywords

ACRIDINE; ANTIGLYCOLYTIC AGENT; AUTOPHAGY PROTEIN 5; BIOLOGICAL MARKER; BLOCKING AGENT; BROMOPYRUVIC ACID; CARDIOLIPIN; CYTOCHROME C; MONOLYSOCARDIOLIPIN; PHOSPHOLIPID; PROTEIN KINASE B; PYRUVIC ACID; UNCLASSIFIED DRUG;

EID: 84858709386     PISSN: 0145479X     EISSN: 15736881     Source Type: Journal    
DOI: 10.1007/s10863-012-9411-x     Document Type: Article
Times cited : (18)

References (49)
  • 1
    • 34347238938 scopus 로고    scopus 로고
    • Evidence that curcumin suppresses the growth of malignant gliomas in vitro and in vivo through induction of autophagy: Role of akt and extracellular signal-regulated kinase signaling pathways
    • DOI 10.1124/mol.106.033167
    • Aoki H, Takada Y, Kondo S, Sawaya R, Aggarwal BB, Kondo Y (2007) Evidence that curcumin suppresses the growth of malignant gliomas in vitro and in vivo through induction of autophagy: role of Akt and extracellular signal-regulated kinase signaling pathways. Mol Pharmacol 72:29-39 (Pubitemid 46998522)
    • (2007) Molecular Pharmacology , vol.72 , Issue.1 , pp. 29-39
    • Aoki, H.1    Takada, Y.2    Kondo, S.3    Sawaya, R.4    Aggarwal, B.B.5    Kondo, Y.6
  • 2
    • 70449246528 scopus 로고
    • Phosphorus assay in column chromatography
    • Bartlett GR (1959) Phosphorus assay in column chromatography. J Biol Chem 234:466-468
    • (1959) J Biol Chem , vol.234 , pp. 466-468
    • Bartlett, G.R.1
  • 3
    • 33845261493 scopus 로고
    • A rapid method of total lipid extraction and purification
    • Bligh EG, Dyer WJ (1959) A rapid method of total lipid extraction and purification. Can J Biochem Physiol 37:911-917
    • (1959) Can J Biochem Physiol , vol.37 , pp. 911-917
    • Bligh, E.G.1    Dyer, W.J.2
  • 5
    • 42449148424 scopus 로고    scopus 로고
    • Loss of cardiolipin in palmitate-treated GL15 glioblastoma cells favors cytochrome c release from mitochondria leading to apoptosis
    • DOI 10.1111/j.1471-4159.2007.05209.x
    • Buratta M, Castigli E, Sciaccaluga M, Pellegrino RM, Spinozzi F, Roberti R, Corazzi L (2008) Loss of cardiolipin in palmitate-treated GL15 glioblastoma cells favors cytochrome c release from mitochondria leading to apoptosis. J Neurochem 105:1019-1031 (Pubitemid 351562743)
    • (2008) Journal of Neurochemistry , vol.105 , Issue.3 , pp. 1019-1031
    • Buratta, M.1    Castigli, E.2    Sciaccaluga, M.3    Pellegrino, R.M.4    Spinozzi, F.5    Roberti, R.6    Corazzi, L.7
  • 6
    • 0019815655 scopus 로고
    • Energy metabolism of tumor cells. Requirement for a form of hexokinase with a propensity for mitochondrial binding
    • Bustamante E, Morris HP, Pedersen PL (1981) Energy metabolism of tumor cells. Requirement for a form of hexokinase with a propensity for mitochondrial binding. J Biol Chem 256:8699-8704 (Pubitemid 12254812)
    • (1981) Journal of Biological Chemistry , vol.256 , Issue.16 , pp. 8699-8704
    • Bustamante, E.1    Morris, H.P.2    Pedersen, P.L.3
  • 9
    • 33744471979 scopus 로고    scopus 로고
    • GL15 and U251 glioblastoma-derived human cell lines are peculiarly susceptible to induction of mitotic death by very low concentrations of okadaic acid
    • Castigli E, Sciaccaluga M, Schiavoni G, Brozzi F, Fabiani R, Gorello P, Gianfranceschi GL (2006) GL15 and U251 glioblastoma-derived human cell lines are peculiarly susceptible to induction of mitotic death by very low concentrations of okadaic acid. Oncol Rep 15:463-470
    • (2006) Oncol Rep , vol.15 , pp. 463-470
    • Castigli, E.1    Sciaccaluga, M.2    Schiavoni, G.3    Brozzi, F.4    Fabiani, R.5    Gorello, P.6    Gianfranceschi, G.L.7
  • 10
    • 38349043984 scopus 로고    scopus 로고
    • Mitochondrial electron-transport-chain inhibitors of complexes I and II induce autophagic cell death mediated by reactive oxygen species
    • Chen Y, McMillan-Ward E, Kong J, Israels SJ, Gibson SB (2007) Mitochondrial electron-transport-chain inhibitors of complexes I and II induce autophagic cell death mediated by reactive oxygen species. J Cell Sci 120:4155-4166
    • (2007) J Cell Sci , vol.120 , pp. 4155-4166
    • Chen, Y.1    McMillan-Ward, E.2    Kong, J.3    Israels, S.J.4    Gibson, S.B.5
  • 11
    • 72949115495 scopus 로고    scopus 로고
    • Alpha-eleostearic acid induces autophagy-dependent cell death through targeting AKT/mTOR and ERK1/2 signal together with the generation of reactive oxygen species
    • Eom JM, Seo MJ, Baek JY, Chu H, Han SH, Min TS, Cho CS, Yun CH (2010) Alpha-eleostearic acid induces autophagy-dependent cell death through targeting AKT/mTOR and ERK1/2 signal together with the generation of reactive oxygen species. Biochem Biophys Res Commun 391:903-908
    • (2010) Biochem Biophys Res Commun , vol.391 , pp. 903-908
    • Eom, J.M.1    Seo, M.J.2    Baek, J.Y.3    Chu, H.4    Han, S.H.5    Min, T.S.6    Cho, C.S.7    Yun, C.H.8
  • 12
    • 80755153627 scopus 로고    scopus 로고
    • De novo synthesis of phospholipids is coupled with autophagosome formation
    • Girardi JP, Pereira L, Bakovic M (2011) De novo synthesis of phospholipids is coupled with autophagosome formation. Medical Hypotheses 77:1083-1087
    • (2011) Medical Hypotheses , vol.77 , pp. 1083-1087
    • Girardi, J.P.1    Pereira, L.2    Bakovic, M.3
  • 14
    • 33744828248 scopus 로고    scopus 로고
    • Glucose withdrawal induces oxidative stress followed by apoptosis in glioblastoma cells but not in normal human astrocytes
    • DOI 10.1158/1541-7786.MCR-05-0061
    • Jelluma N, Yang X, Stokoe D, Evan GI, Dansen TB, Haas-Kogan DA (2006) Glucose withdrawal induces oxidative stress followed by apoptosis in glioblastoma cells but not in normal human astrocytes. Mol Cancer Res 4:319-330 (Pubitemid 43837333)
    • (2006) Molecular Cancer Research , vol.4 , Issue.5 , pp. 319-330
    • Jelluma, N.1    Yang, X.2    Stokoe, D.3    Evan, G.I.4    Dansen, T.B.5    Haas-Kogan, D.A.6
  • 17
    • 0242467470 scopus 로고    scopus 로고
    • Migrating glioma cells activate the PI3-K pathway and display decreased susceptibility to apoptosis
    • DOI 10.1242/jcs.00712
    • Joy AM, Beaudry CE, Tran NL, Ponce FA, Holz DR, Demuth T, Berens ME (2003) Migrating glioma cells activate the PI3-K pathway and display decreased susceptibility to apoptosis. J Cell Sci 116:4409-4417 (Pubitemid 37369596)
    • (2003) Journal of Cell Science , vol.116 , Issue.21 , pp. 4409-4417
    • Joy, A.M.1    Beaudry, C.E.2    Tran, N.L.3    Ponce, F.A.4    Holz, D.R.5    Demuth, T.6    Berens, M.E.7
  • 18
    • 60849101819 scopus 로고    scopus 로고
    • Role of reactive oxygen species-mediated mitochondrial dysregulation in 3-bromopyruvate induced cell death in hepatoma cells
    • Kim JS, Ahn KJ, Kim JA, Kim HM, Lee JD, Lee JM, Kim SJ, Park JH (2008) Role of reactive oxygen species-mediated mitochondrial dysregulation in 3-bromopyruvate induced cell death in hepatoma cells. J Bioenerg Biomembr 40:607-618
    • (2008) J Bioenerg Biomembr , vol.40 , pp. 607-618
    • Kim, J.S.1    Ahn, K.J.2    Kim, J.A.3    Kim, H.M.4    Lee, J.D.5    Lee, J.M.6    Kim, S.J.7    Park, J.H.8
  • 19
    • 0037146679 scopus 로고    scopus 로고
    • Loss of cardiolipin and mitochondria during programmed neuronal death: Evidence of a role for lipid peroxidation and autophagy
    • DOI 10.1016/S0306-4522(02)00512-2, PII S0306452202005122
    • Kirkland RA, Adibhatla RM, Hatcher JF, Franklin JL (2002) Loss of cardiolipin and mitochondria during programmed neuronal death: evidence of a role for lipid peroxidation and autophagy. Neuroscience 115:587-602 (Pubitemid 35284774)
    • (2002) Neuroscience , vol.115 , Issue.2 , pp. 587-602
    • Kirkland, R.A.1    Adibhatla, R.M.2    Hatcher, J.F.3    Franklin, J.L.4
  • 21
    • 0035829074 scopus 로고    scopus 로고
    • Glucose catabolism in the rabbit VX2 tumor model for liver cancer: Characterization and targeting hexokinase
    • DOI 10.1016/S0304-3835(01)00667-X, PII S030438350100667X
    • Ko YH, Pedersen PL, Geschwind JF (2001) Glucose catabolism in the rabbit VX2 tumor model for liver cancer: characterization and targeting hexokinase. Cancer Lett 173:83-91 (Pubitemid 32907513)
    • (2001) Cancer Letters , vol.173 , Issue.1 , pp. 83-91
    • Ko, Y.H.1    Pedersen, P.L.2    Geschwind, J.F.3
  • 23
    • 25444440875 scopus 로고    scopus 로고
    • The role of autophagy in cancer development and response to therapy
    • DOI 10.1038/nrc1692, PII N1692
    • Kondo Y, Kanzawa T, Sawaya R, Kondo S (2005) The role of autophagy in cancer development and response to therapy. Nat Rev Cancer 5:726-734 (Pubitemid 41486365)
    • (2005) Nature Reviews Cancer , vol.5 , Issue.9 , pp. 726-734
    • Kondo, Y.1    Kanzawa, T.2    Sawaya, R.3    Kondo, S.4
  • 24
    • 77954341696 scopus 로고    scopus 로고
    • Survival signaling and apoptosis resistance in glioblastomas: Opportunities for targeted therapeutics
    • Krakstad C, Chekenya M (2010) Survival signaling and apoptosis resistance in glioblastomas: opportunities for targeted therapeutics. Molecular Cancer 9:135-148
    • (2010) Molecular Cancer , vol.9 , pp. 135-148
    • Krakstad, C.1    Chekenya, M.2
  • 25
    • 33747198528 scopus 로고    scopus 로고
    • Autophagy, the Trojan horse to combat glioblastomas
    • Lefranc F, Kiss R (2006) Autophagy, the Trojan horse to combat glioblastomas. Neurosurg Focus 20:E7
    • (2006) Neurosurg Focus , vol.20
    • Lefranc, F.1    Kiss, R.2
  • 26
    • 38049027838 scopus 로고    scopus 로고
    • Proautophagic drugs: A novel means to combat apoptosis-resistant cancers, with a special emphasis on glioblastomas
    • Lefranc F, Facchini V, Kiss R (2007) Proautophagic drugs: a novel means to combat apoptosis-resistant cancers, with a special emphasis on glioblastomas. Oncologist 12:1395-1403
    • (2007) Oncologist , vol.12 , pp. 1395-1403
    • Lefranc, F.1    Facchini, V.2    Kiss, R.3
  • 27
    • 78649711427 scopus 로고    scopus 로고
    • The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes
    • Levine AJ, Puzio-Kuter AM (2010) The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes. Science 330:1340-1344
    • (2010) Science , vol.330 , pp. 1340-1344
    • Levine, A.J.1    Puzio-Kuter, A.M.2
  • 29
    • 77955013562 scopus 로고    scopus 로고
    • Cytochrome c redox state influences the binding and release of cytochrome c in model membranes and in brain mitochondria
    • Macchioni L, Corazzi T, Davidescu M, Francescangeli E, Roberti R, Corazzi L (2010) Cytochrome c redox state influences the binding and release of cytochrome c in model membranes and in brain mitochondria. Mol Cell Biochem 341:149-157
    • (2010) Mol Cell Biochem , vol.341 , pp. 149-157
    • Macchioni, L.1    Corazzi, T.2    Davidescu, M.3    Francescangeli, E.4    Roberti, R.5    Corazzi, L.6
  • 32
    • 33746924468 scopus 로고    scopus 로고
    • Hexokinase II: Cancer's double-edged sword acting as both facilitator and gatekeeper of malignancy when bound to mitochondria
    • DOI 10.1038/sj.onc.1209603, PII 1209603
    • Mathupala SP, Ko YH, Pedersen PL (2006) Hexokinase II: cancer's double-edged sword acting as both facilitator and gatekeeper of malignancy when bound to mitochondria. Oncogene 25:4777-4786 (Pubitemid 44187625)
    • (2006) Oncogene , vol.25 , Issue.34 , pp. 4777-4786
    • Mathupala, S.P.1    Ko, Y.H.2    Pedersen, P.L.3
  • 33
    • 0014119257 scopus 로고
    • Bromopyruvate inactivation of 2-keto-3-deoxy-6- Phpsphogluconic aldolase. I. Kinetic evidence for active site specificity
    • Meloche HP (1967) Bromopyruvate inactivation of 2-keto-3-deoxy-6- phpsphogluconic aldolase. I. Kinetic evidence for active site specificity. Biochemistry 6:2273-2280
    • (1967) Biochemistry , vol.6 , pp. 2273-2280
    • Meloche, H.P.1
  • 34
    • 0015501409 scopus 로고
    • The substrate analog, bromopyruvate, as both a substrate and alkylating agent for 2-keto-3-deoxy-6-phpsphogluconic aldolase. Kinetic and stereochemical study
    • Meloche HP, Luczak MA, Wurster JM (1972) The substrate analog, bromopyruvate, as both a substrate and alkylating agent for 2-keto-3-deoxy-6- phpsphogluconic aldolase. Kinetic and stereochemical study. J Biol Chem 247:4186-4191
    • (1972) J Biol Chem , vol.247 , pp. 4186-4191
    • Meloche, H.P.1    Luczak, M.A.2    Wurster, J.M.3
  • 35
    • 52449119836 scopus 로고    scopus 로고
    • Regulation of hexokinase binding to VDAC
    • Pastorino JG, Hoek JB (2008) Regulation of hexokinase binding to VDAC. J Bioenerg Biomembr 40:171-182
    • (2008) J Bioenerg Biomembr , vol.40 , pp. 171-182
    • Pastorino, J.G.1    Hoek, J.B.2
  • 36
    • 28544436922 scopus 로고    scopus 로고
    • Activation of glycogen synthase kinase 3beta disrupts the binding of hexokinase II to mitochondria by phosphorylating voltage-dependent anion channel and potentiates chemotherapy-induced cytotoxicity
    • DOI 10.1158/0008-5472.CAN-05-1925
    • Pastorino JG, Hoek JB, Shulga N (2005) Activation of glycogen synthase kinase 3beta disrupts the binding of hexokinase II to mitochondria by phosphorylating voltage-dependent anion channel and potentiates chemotherapy-induced cytoxicity. Cancer Res 65:10545-10554 (Pubitemid 41743749)
    • (2005) Cancer Research , vol.65 , Issue.22 , pp. 10545-10554
    • Pastorino, J.G.1    Hoek, J.B.2    Shulga, N.3
  • 37
    • 0017841405 scopus 로고
    • Tumor mitochondria and the bioenergetics of cancer cells
    • Pedersen PL (1978) Tumor mitochondria and the bioenergetics of cancer cells. Progr in Exp Tumor Res 22:190-274
    • (1978) Progr in Exp Tumor Res , vol.22 , pp. 190-274
    • Pedersen, P.L.1
  • 38
    • 35448964610 scopus 로고    scopus 로고
    • Warburg, me and hexokinase 2: Multiple discoveries of key molecular events underlying one of cancers' most common phenotypes, the "Warburg effect", i.e., elevated glycolysis in the presence of oxygen
    • Pedersen PL (2007)Warburg, me and hexokinase 2: multiple discoveries of key molecular events underlying one of cancers' most common phenotypes, the "Warburg effect", i.e., elevated glycolysis in the presence of oxygen. J Bioenerg Biomembr 39:211-222
    • (2007) J Bioenerg Biomembr , vol.39 , pp. 211-222
    • Pedersen, P.L.1
  • 39
    • 52449089360 scopus 로고    scopus 로고
    • Voltage dependent anion channels (VDACs): A brief introduction with a focus on the outer mitochondrial compartment's roles together with hexokinase-2 in the "Warburg effect" in cancer
    • Pedersen PL (2008) Voltage dependent anion channels (VDACs): a brief introduction with a focus on the outer mitochondrial compartment's roles together with hexokinase-2 in the "Warburg effect" in cancer. J Bioenerg Biomembr 40:123-126
    • (2008) J Bioenerg Biomembr , vol.40 , pp. 123-126
    • Pedersen, P.L.1
  • 41
    • 77952745676 scopus 로고    scopus 로고
    • 3-Bromopyruvate induces necrotic cell death in sensitive melanoma cell lines
    • Qin J-Z, Xin H, Nickoloff BJ (2010) 3-Bromopyruvate induces necrotic cell death in sensitive melanoma cell lines. Biochem Biophys Res Commun 396:495-500
    • (2010) Biochem Biophys Res Commun , vol.396 , pp. 495-500
    • Qin, J.-Z.1    Xin, H.2    Nickoloff, B.J.3
  • 43
    • 1842740658 scopus 로고    scopus 로고
    • Cardiolipin and its metabolites move from mitochondria to other cellular membranes during death receptor-mediated apoptosis
    • DOI 10.1038/sj.cdd.4401457
    • Sorice M, Circella A, Cristea IM, Garofalo T, Di Renzo L, Alessandri C, Valesini G, Degli Esposti M (2004) Cardiolipin and its metabolites move from mitochondria to other cellular membranes during death receptor-mediated apoptosis. Cell Death Differ 11:1133-1145 (Pubitemid 39341639)
    • (2004) Cell Death and Differentiation , vol.11 , Issue.10 , pp. 1133-1145
    • Sorice, M.1    Circella, A.2    Cristea, I.M.3    Garofalo, T.4    Di, R.L.5    Alessandri, C.6    Valesini, G.7    Degli, E.M.8
  • 44
    • 54749108383 scopus 로고    scopus 로고
    • Matrix-assisted laser desorption/ionization time-of-flight mass spectrometric analysis of cellular glycerophospholipids enabled by multiplexed solvent dependent analyte-matrix interactions
    • Sun G, Yang K, Zhao Z, Guan S, Han X, Gross RW (2008) Matrix-assisted laser desorption/ionization time-of-flight mass spectrometric analysis of cellular glycerophospholipids enabled by multiplexed solvent dependent analyte-matrix interactions. Anal Chem 80:7576-7585
    • (2008) Anal Chem , vol.80 , pp. 7576-7585
    • Sun, G.1    Yang, K.2    Zhao, Z.3    Guan, S.4    Han, X.5    Gross, R.W.6
  • 46
    • 69249153394 scopus 로고    scopus 로고
    • A non-canonical MEK/ERK signaling pathway regulates autophagy via regulating Beclin 1
    • Wang J, Whiteman MW, Lian H, Wang G, Singh A, Huang D, Denmark T (2009) A non-canonical MEK/ERK signaling pathway regulates autophagy via regulating Beclin 1. J Biol Chem 284:21412-21424
    • (2009) J Biol Chem , vol.284 , pp. 21412-21424
    • Wang, J.1    Whiteman, M.W.2    Lian, H.3    Wang, G.4    Singh, A.5    Huang, D.6    Denmark, T.7
  • 47
    • 12544256565 scopus 로고    scopus 로고
    • Inhibition of glycolysis in cancer cells: A novel strategy to overcome drug resistance associated with mitochondrial respiratory defect and hypoxia
    • Xu R-H, Pelicano H, Zhou Y, Carew JS, Feng L, Bhalla KN, Keating MJ, Huang P (2005) Inhibition of glycolysis in cancer cells: a novel strategy to overcome drug resistance associated with mitochondrial respiratory defect and hypoxia. Cancer Res 65:613-621
    • (2005) Cancer Res , vol.65 , pp. 613-621
    • Xu, R.-H.1    Pelicano, H.2    Zhou, Y.3    Carew, J.S.4    Feng, L.5    Bhalla, K.N.6    Keating, M.J.7    Huang, P.8
  • 49
    • 0037113864 scopus 로고    scopus 로고
    • Gluing the respiratory chain together: Cardiolipin is required for supercomplex formation in the inner mitochondrial membrane
    • DOI 10.1074/jbc.C200551200
    • Zhang M, Mileykovskaya E, Dowhan W (2002) Gluing the respiratory chain together. Cardiolipin is required for supercomplex formation in the inner mitochondrial membrane. J Biol Chem 277:43553-43556 (Pubitemid 36157767)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.46 , pp. 43553-43556
    • Zhang, M.1    Mileykovskaya, E.2    Dowhan, W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.