Novel, druglike 1,7-disubstituted 2,3,4,5-tetrahydro-1H-benzo[b]azepine- based selective inhibitors of human neuronal nitric oxide synthase (nNOS)

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 7, 2012, Pages 2510-2513

  Annedi, Subhash C ^a   Ramnauth, Jailall ^a   Cossette, Michele ^a   Maddaford, Shawn P ^a   Dove, Peter ^a   Rakhit, Suman ^a   Andrews, John S ^a   Porreca, Frank ^b  

^a NeurAxon Inc   (Canada)

^b UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

Author keywords

2,3,4,5 Tetrahydro 1H benzo b azepine derivatives; Neuropathic pain; Nitric oxide; Nitric oxide synthase; Selective neuronal nitric oxide synthase inhibitors

Indexed keywords

ANALGESIC AGENT; BENZAZEPINE DERIVATIVE; NEURONAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; POTASSIUM CHANNEL HERG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; ASSAY; CONTROLLED STUDY; DRUG POTENCY; DRUG SAFETY; ENZYME INHIBITION; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; HYPERALGESIA; IN VITRO STUDY; IN VIVO STUDY; NERVE LIGATION; NEUROPATHIC PAIN; NONHUMAN; RAT; SPINAL NERVE; STRUCTURE ACTIVITY RELATION;

ANALGESICS; ANIMALS; BENZAZEPINES; ENZYME INHIBITORS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; MICE; NEURALGIA; NITRIC OXIDE SYNTHASE TYPE I; NITRIC OXIDE SYNTHASE TYPE II; NITRIC OXIDE SYNTHASE TYPE III; RECOMBINANT PROTEINS; SPINAL NERVES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84858702117     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.02.004     Document Type: Article

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