메뉴 건너뛰기




Volumn 165, Issue 1, 2012, Pages 53-58

A spheroid-based biosensor for the label-free detection of drug-induced field potential alterations

Author keywords

BioMEMS; Biosensor; Drug discovery; Microelectrode array; Spheroid; Tissue engineering

Indexed keywords

ACTION POTENTIALS; CARDIAC CELL; CARDIAC DRUGS; CELLULAR INTERACTION; CELLULAR NETWORK; CELLULAR RESPONSE; DRUG DISCOVERY; EXPERIMENTAL CONDITIONS; FIELD POTENTIAL; IN-VITRO; IN-VIVO; LABEL-FREE DETECTION; MICROELECTRODE ARRAY; MONOLAYER CELL CULTURE; MULTI-CHANNEL RECORDING; PHYSIOLOGICAL PARAMETERS; PRIMARY CELLS; SPHEROID; THREE-DIMENSIONAL PATTERNS;

EID: 84858699363     PISSN: 09254005     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.snb.2012.02.011     Document Type: Article
Times cited : (24)

References (55)
  • 1
    • 0042045214 scopus 로고    scopus 로고
    • Whole cell biosensors
    • PII S0925400596019065
    • L. Bousse Whole cell biosensors Sens. Actuators B: Chem. 34 1996 270 275 (Pubitemid 126379872)
    • (1996) Sensors and Actuators, B: Chemical , vol.34 , Issue.1-3 , pp. 270-275
    • Bousse, L.1
  • 2
    • 0026517792 scopus 로고
    • Chicken retinospheroids as developmental and pharmacological in vitro models: Acetylcholinesterase is regulated by its own and by butyrylcholinesterase activity
    • P.G. Layer, T. Weikert, and E. Willbold Chicken retinospheroids as developmental and pharmacological in vitro models: acetylcholinesterase is regulated by its own and by butyrylcholinesterase activity Cell Tissue Res. 268 1992 409 418
    • (1992) Cell Tissue Res. , vol.268 , pp. 409-418
    • Layer, P.G.1    Weikert, T.2    Willbold, E.3
  • 3
    • 0034861754 scopus 로고    scopus 로고
    • Characterization of acute neurotoxic effects of trimethylolpropane phosphate via neuronal network biosensors
    • DOI 10.1016/S0956-5663(01)00165-8, PII S0956566301001658
    • E.W. Keefer, A. Gramowski, D.A. Stenger, J.J. Pancrazio, and G.W. Gross Characterization of acute neurotoxic effects of trimethylolpropane phosphate via neuronal network biosensors Biosens. Bioelectron. 16 2001 513 525 (Pubitemid 32816918)
    • (2001) Biosensors and Bioelectronics , vol.16 , Issue.7-8 , pp. 513-525
    • Keefer, E.W.1    Gramowski, A.2    Stenger, D.A.3    Pancrazio, J.J.4    Gross, G.W.5
  • 6
    • 14644398533 scopus 로고    scopus 로고
    • In vitro cortical neuronal networks as a new high-sensitive system for biosensing applications
    • DOI 10.1016/j.bios.2004.09.012, PII S0956566304004233
    • S. Martinoia, L. Bonzano, M. Chiappalone, M. Tedesco, M. Marcoli, and G. Maura In vitro cortical neuronal networks as a new high-sensitive system for biosensing applications Biosens. Bioelectron. 20 2005 2071 2078 (Pubitemid 40320474)
    • (2005) Biosensors and Bioelectronics , vol.20 , pp. 2071-2078
    • Martinoia, S.1    Bonzano, L.2    Chiappalone, M.3    Tedesco, M.4    Marcoli, M.5    Maura, G.6
  • 7
    • 42149193214 scopus 로고    scopus 로고
    • High-throughput electrophysiology: An emerging paradigm for ion-channel screening and physiology
    • J. Dunlop, M. Bowlby, R. Peri, D. Vasilyev, and R. Arias High-throughput electrophysiology: an emerging paradigm for ion-channel screening and physiology Nat. Rev. Drug Discov. 7 2008 358 368
    • (2008) Nat. Rev. Drug Discov. , vol.7 , pp. 358-368
    • Dunlop, J.1    Bowlby, M.2    Peri, R.3    Vasilyev, D.4    Arias, R.5
  • 8
    • 0031021775 scopus 로고    scopus 로고
    • Involvement of the calcium inward current in cardiac impulse propagation: Induction of unidirectional conduction block by nifedipine and reversal by bay K 8644
    • S. Rohr, and J.P. Kucera Involvement of the calcium inward current in cardiac impulse propagation: induction of unidirectional conduction block by nifedipine and reversal by Bay K 8644 Biophys. J. 72 1997 754 766 (Pubitemid 27044881)
    • (1997) Biophysical Journal , vol.72 , Issue.2 , pp. 754-766
    • Rohr, S.1    Kucera, J.P.2
  • 9
    • 84892816079 scopus 로고    scopus 로고
    • Heart on chip - Extracellular multielectrode recordings from cardiac myocytes in vitro
    • S. Dhein, Springer Berlin
    • U. Egert, and T. Meyer Heart on chip - extracellular multielectrode recordings from cardiac myocytes in vitro S. Dhein, Practical Methods in Cardiovascular Research 2005 Springer Berlin 432 453
    • (2005) Practical Methods in Cardiovascular Research , pp. 432-453
    • Egert, U.1    Meyer, T.2
  • 10
    • 77949923815 scopus 로고    scopus 로고
    • Human and murine embryonic stem cell-derived cardiomyocytes serve together as a valuable model for drug safety screening
    • H. Liang, M. Matzkies, H. Schunkert, M. Tang, H. Bonnemeier, J. Hescheler, and M. Reppel Human and murine embryonic stem cell-derived cardiomyocytes serve together as a valuable model for drug safety screening Cell. Physiol. Biochem. 25 2010 459 466
    • (2010) Cell. Physiol. Biochem. , vol.25 , pp. 459-466
    • Liang, H.1    Matzkies, M.2    Schunkert, H.3    Tang, M.4    Bonnemeier, H.5    Hescheler, J.6    Reppel, M.7
  • 11
    • 0344492207 scopus 로고    scopus 로고
    • Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: Evidence for a provisional safety margin in drug development
    • DOI 10.1016/S0008-6363(02)00846-5
    • W.S. Redfern, L. Carlsson, A.S. Davis, W.G. Lynch, I. MacKenzie, S. Palethorpe, P.K. Siegl, I. Strang, A.T. Sullivan, R. Wallis, A.J. Camm, and T.G. Hammond Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development Cardiovasc. Res. 58 2003 32 45 (Pubitemid 36351620)
    • (2003) Cardiovascular Research , vol.58 , Issue.1 , pp. 32-45
    • Redfern, W.S.1    Carlsson, L.2    Davis, A.S.3    Lynch, W.G.4    MacKenzie, I.5    Palethorpe, S.6    Siegl, P.K.S.7    Strang, I.8    Sullivan, A.T.9    Wallis, R.10    Camm, A.J.11    Hammond, T.G.12
  • 12
    • 4544254897 scopus 로고    scopus 로고
    • Micro-electrode arrays in cardiac safety pharmacology: A novel tool to study QT interval prolongation
    • DOI 10.2165/00002018-200427110-00002
    • T. Meyer, K.H. Boven, E. Guenther, and M. Fejtl Micro-electrode arrays in cardiac safety pharmacology: a novel tool to study QT interval prolongation Drug Saf. 27 2004 763 772 (Pubitemid 39243560)
    • (2004) Drug Safety , vol.27 , Issue.11 , pp. 763-772
    • Meyer, T.1    Boven, K.-H.2    Gunther, E.3    Fejtl, M.4
  • 14
    • 1942529811 scopus 로고    scopus 로고
    • Automated electrophysiology: High throughput of art
    • X. Wang, and M. Li Automated electrophysiology: high throughput of art Assay Drug Dev. Technol. 1 2003 695 708
    • (2003) Assay Drug Dev. Technol. , vol.1 , pp. 695-708
    • Wang, X.1    Li, M.2
  • 15
    • 0025138578 scopus 로고
    • An extracellular microelectrode array for monitoring electrogenic cells in culture
    • DOI 10.1016/0956-5663(90)80011-2
    • P. Connolly, P. Clark, A.S. Curtis, J.A. Dow, and C.D. Wilkinson An extracellular microelectrode array for monitoring electrogenic cells in culture Biosens. Bioelectron. 5 1990 223 234 (Pubitemid 20071564)
    • (1990) Biosensors and Bioelectronics , vol.5 , Issue.3 , pp. 223-234
    • Connolly, P.1    Clark, P.2    Curtis, A.S.G.3    Dow, J.A.T.4    Wilkinson, C.D.W.5
  • 17
    • 33644772060 scopus 로고    scopus 로고
    • Microelectrode array recordings of cardiac action potentials as a high throughput method to evaluate pesticide toxicity
    • DOI 10.1016/j.tiv.2005.08.014, PII S0887233305001712
    • A. Natarajan, P. Molnar, K. Sieverdes, A. Jamshidi, and J.J. Hickman Microelectrode array recordings of cardiac action potentials as a high throughput method to evaluate pesticide toxicity Toxicol. In Vitro 20 2006 375 381 (Pubitemid 43343769)
    • (2006) Toxicology in Vitro , vol.20 , Issue.3 , pp. 375-381
    • Natarajan, A.1    Molnar, P.2    Sieverdes, K.3    Jamshidi, A.4    Hickman, J.J.5
  • 19
    • 34648834682 scopus 로고    scopus 로고
    • The third dimension bridges the gap between cell culture and live tissue
    • DOI 10.1038/nrm2236, PII NRM2236
    • F. Pampaloni, E.G. Reynaud, and E.H.K. Stelzer The third dimension bridges the gap between cell culture and live tissue Nat. Rev. Mol. Cell Biol. 8 2007 839 845 (Pubitemid 47462131)
    • (2007) Nature Reviews Molecular Cell Biology , vol.8 , Issue.10 , pp. 839-845
    • Pampaloni, F.1    Reynaud, E.G.2    Stelzer, E.H.K.3
  • 20
    • 0042358985 scopus 로고    scopus 로고
    • Biology's new dimension
    • DOI 10.1038/424870a
    • A. Abbott Cell culture: biology's new dimension Nature 424 2003 870 872 (Pubitemid 37051657)
    • (2003) Nature , vol.424 , Issue.6951 , pp. 870-872
    • Abbott, A.1
  • 21
    • 58749093939 scopus 로고    scopus 로고
    • Recent advances in three-dimensional multicellular spheroid culture for biomedical research
    • R.Z. Lin, and H.Y. Chang Recent advances in three-dimensional multicellular spheroid culture for biomedical research Biotechnol. J. 3 2008 1172 1184
    • (2008) Biotechnol. J. , vol.3 , pp. 1172-1184
    • Lin, R.Z.1    Chang, H.Y.2
  • 22
    • 0035947405 scopus 로고    scopus 로고
    • From stem cells towards neural layers: A lesson from re-aggregated embryonic retinal cells
    • P.G. Layer, A. Rothermel, and E. Willbold From stem cells towards neural layers: a lesson from re-aggregated embryonic retinal cells Neuroreport 12 2001 A39 A46
    • (2001) Neuroreport , vol.12
    • Layer, P.G.1    Rothermel, A.2    Willbold, E.3
  • 23
    • 0022475251 scopus 로고
    • Electrotonic interactions between aggregates of chick embryo cardiac pacemaker cells
    • R.D. Veenstra, and R.L. DeHaan Electrotonic interactions between aggregates of chick embryo cardiac pacemaker cells Am. J. Physiol. 250 1986 H453 H463
    • (1986) Am. J. Physiol. , vol.250
    • Veenstra, R.D.1    Dehaan, R.L.2
  • 24
    • 0028252569 scopus 로고
    • A review of the effects of three cardioactive agents on the electrical activity from embryonic chick heart cell aggregates: TTX, ACh, and E-4031
    • J.R. Clay, A.S. Kristof, J. Shenasa, R.M. Brochu, and A. Shrier A review of the effects of three cardioactive agents on the electrical activity from embryonic chick heart cell aggregates: TTX, ACh, and E-4031 Prog. Biophys. Mol. Biol. 62 1994 185 202 (Pubitemid 124002414)
    • (1994) Progress in Biophysics and Molecular Biology , vol.62 , Issue.3 , pp. 185-202
    • Clay, J.R.1    Kristof, A.S.2    Shenasa, J.3    Brochu, R.M.4    Shrier, A.5
  • 25
    • 0028131891 scopus 로고
    • Study of the cardiotoxic potential of pharmaceutical compounds in chick myocardial myocyte reaggregate cultures
    • DOI 10.1016/0887-2333(94)90011-6
    • C.W. Seaman, C.D. Toseland, P.A. Maile, I. Francis, and D.J. White Study of the cardiotoxic potential of pharmaceutical compounds in chick myocardial myocyte reaggregate cultures Toxicol. In Vitro 8 1994 543 544 (Pubitemid 24312722)
    • (1994) Toxicology in Vitro , vol.8 , Issue.4 , pp. 543-544
    • Seaman, C.W.1    Toseland, C.D.N.2    Maile, P.A.3    Francis, I.4    White, D.J.5
  • 26
    • 0030512315 scopus 로고    scopus 로고
    • Study of the effects of cardiovascular drugs in heart cell cultures
    • DOI 10.1016/S0887-2333(96)00058-6
    • C.D. Toseland, C.W. Seaman, I. Francis, D.J. White, and L.K. Earl Study of the effects of cardiovascular drugs in heart cell cultures Toxicol. In Vitro 10 1996 765 773 (Pubitemid 27078147)
    • (1996) Toxicology in Vitro , vol.10 , Issue.6 , pp. 765-773
    • Toseland, C.D.N.1    Seaman, C.W.2    Francis, I.3    White, D.J.4    Earl, L.K.5
  • 27
    • 29144530591 scopus 로고    scopus 로고
    • Three-dimensional in vitro reaggregates of embryonic cardiomyocytes: A potential model system for monitoring effects of bioactive agents
    • DOI 10.1177/1087057105280070
    • P. Bartholoma, E. Gorjup, D. Monz, A. Reininger-Mack, H. Thielecke, and A. Robitzki Three-dimensional in vitro reaggregates of embryonic cardiomyocytes: a potential model system for monitoring effects of bioactive agents J. Biomol. Screen. 10 2005 814 822 (Pubitemid 41818157)
    • (2005) Journal of Biomolecular Screening , vol.10 , Issue.8 , pp. 814-822
    • Bartholoma, P.1    Gorjup, E.2    Monz, D.3    Reininger-Mack, A.4    Thielecke, H.5    Robitzki, A.6
  • 29
    • 79956283426 scopus 로고    scopus 로고
    • Electromagnetic exposure of scaffold-free three-dimensional cell culture systems
    • A.W. Daus, M. Goldhammer, P.G. Layer, and C. Thielemann Electromagnetic exposure of scaffold-free three-dimensional cell culture systems Bioelectromagnetics 32 2011 351 359
    • (2011) Bioelectromagnetics , vol.32 , pp. 351-359
    • Daus, A.W.1    Goldhammer, M.2    Layer, P.G.3    Thielemann, C.4
  • 30
    • 84924926133 scopus 로고
    • A series of normal stages in the development of the chick embryo
    • V. Hamburger, and H.L. Hamilton A series of normal stages in the development of the chick embryo J. Morphol. 88 1951 49 92
    • (1951) J. Morphol. , vol.88 , pp. 49-92
    • Hamburger, V.1    Hamilton, H.L.2
  • 31
    • 42949124474 scopus 로고    scopus 로고
    • The application of cell-based label-free technology in drug discovery
    • DOI 10.1002/biot.200800020
    • B. Xi, N. Yu, X. Wang, X. Xu, and Y.A. Abassi The application of cell-based label-free technology in drug discovery Biotechnol. J. 3 2008 484 495 (Pubitemid 351618734)
    • (2008) Biotechnology Journal , vol.3 , Issue.4 , pp. 484-495
    • Xi, B.1    Yu, N.2    Wang, X.3    Xu, X.4    Abassi, Y.A.5
  • 32
    • 0742305697 scopus 로고    scopus 로고
    • Beyond the Petri dish
    • DOI 10.1038/nbt0204-151
    • S. Zhang Beyond the Petri dish Nat. Biotechnol. 22 2004 151 152 (Pubitemid 38160524)
    • (2004) Nature Biotechnology , vol.22 , Issue.2 , pp. 151-152
    • Zhang, S.1
  • 33
    • 77949875030 scopus 로고    scopus 로고
    • Moving into the third dimension
    • G.E. Jones Moving into the third dimension Nat. Rev. Mol. Cell Biol. 11 2010 231
    • (2010) Nat. Rev. Mol. Cell Biol. , vol.11 , pp. 231
    • Jones, G.E.1
  • 34
    • 0027449297 scopus 로고
    • Histogenesis of the avian retina in reaggregation culture: From dissociated cells to laminar neuronal networks
    • P.G. Layer, and E. Willbold Histogenesis of the avian retina in reaggregation culture: from dissociated cells to laminar neuronal networks Int. Rev. Cytol. 146 1993 1 47 (Pubitemid 23286698)
    • (1993) International Review of Cytology , vol.146 , pp. 1-47
    • Layer, P.G.1    Willbold, E.2
  • 35
    • 27944497333 scopus 로고    scopus 로고
    • Tissue cells feel and respond to the stiffness of their substrate
    • DOI 10.1126/science.1116995
    • D.E. Discher, P. Janmey, and Y.L. Wang Tissue cells feel and respond to the stiffness of their substrate Science 310 2005 1139 1143 (Pubitemid 41681732)
    • (2005) Science , vol.310 , Issue.5751 , pp. 1139-1143
    • Discher, D.E.1    Janmey, P.2    Wang, Y.-L.3
  • 37
    • 78449297031 scopus 로고    scopus 로고
    • Stiffness of the substrate influences the phenotype of embryonic chicken cardiac myocytes
    • P. Bajaj, X. Tang, T.A. Saif, and R. Bashir Stiffness of the substrate influences the phenotype of embryonic chicken cardiac myocytes J. Biomed. Mater. Res. A 95 2010 1261 1269
    • (2010) J. Biomed. Mater. Res. A , vol.95 , pp. 1261-1269
    • Bajaj, P.1    Tang, X.2    Saif, T.A.3    Bashir, R.4
  • 39
    • 0015977334 scopus 로고
    • Scanning electron microscopy of cell aggregation: Cardiac and mixed retina-cardiac cell suspensions
    • Y. Shimada, A.A. Moscona, and D.A. Fischman Scanning electron microscopy of cell aggregation: cardiac and mixed retina-cardiac cell suspensions Dev. Biol. 36 1974 428 446
    • (1974) Dev. Biol. , vol.36 , pp. 428-446
    • Shimada, Y.1    Moscona, A.A.2    Fischman, D.A.3
  • 40
    • 0036498496 scopus 로고    scopus 로고
    • Of layers and spheres: The reaggregate approach in tissue engineering
    • DOI 10.1016/S0166-2236(00)02036-1, PII S0166223600020361
    • P.G. Layer, A. Robitzki, A. Rothermel, and E. Willbold Of layers and spheres: the reaggregate approach in tissue engineering Trends Neurosci. 25 2002 131 134 (Pubitemid 34164333)
    • (2002) Trends in Neurosciences , vol.25 , Issue.3 , pp. 131-134
    • Layer, P.G.1    Robitzki, A.2    Rothermel, A.3    Willbold, E.4
  • 42
    • 0036912235 scopus 로고    scopus 로고
    • Adverse effects of beta-agonists
    • M.R. Sears Adverse effects of beta-agonists J. Allergy Clin. Immunol. 110 2002 S322 S328
    • (2002) J. Allergy Clin. Immunol. , vol.110
    • Sears, M.R.1
  • 43
    • 33845502082 scopus 로고    scopus 로고
    • Embryonic stem cells as a novel cell source of cell-based biosensors
    • DOI 10.1016/j.bios.2006.03.006, PII S0956566306000947
    • Q. Liu, H. Huang, H. Cai, Y. Xu, Y. Li, R. Li, and P. Wang Embryonic stem cells as a novel cell source of cell-based biosensors Biosens. Bioelectron. 22 2007 810 815 (Pubitemid 44914046)
    • (2007) Biosensors and Bioelectronics , vol.22 , Issue.6 , pp. 810-815
    • Liu, Q.1    Huang, H.2    Cai, H.3    Xu, Y.4    Li, Y.5    Li, R.6    Wang, P.7
  • 44
    • 39449096154 scopus 로고    scopus 로고
    • 2-adrenoceptor responses in cardiomyocytes derived from human embryonic stem cells: Comparison with failing and non-failing adult human heart
    • DOI 10.1038/sj.bjp.0707619, PII 0707619
    • M. Brito-Martins, S.E. Harding, and N.N. Ali Beta(1)- and beta(2)-adrenoceptor responses in cardiomyocytes derived from human embryonic stem cells: comparison with failing and non-failing adult human heart Br. J. Pharmacol. 153 2008 751 759 (Pubitemid 351271760)
    • (2008) British Journal of Pharmacology , vol.153 , Issue.4 , pp. 751-759
    • Brito-Martins, M.1    Harding, S.E.2    Ali, N.N.3
  • 45
    • 0026337381 scopus 로고
    • Local anesthetics
    • J.A. Yagiela Local anesthetics Anesth. Prog. 38 1991 128 141
    • (1991) Anesth. Prog. , vol.38 , pp. 128-141
    • Yagiela, J.A.1
  • 46
    • 0032890559 scopus 로고    scopus 로고
    • + channels
    • DOI 10.1085/jgp.113.1.7
    • V. Vedantham, and S.C. Cannon The position of the fast-inactivation gate during lidocaine block of voltage-gated Na+ channels J. Gen. Physiol. 113 1999 7 16 (Pubitemid 29051243)
    • (1999) Journal of General Physiology , vol.113 , Issue.1 , pp. 7-16
    • Vedantham, V.1    Cannon, S.C.2
  • 47
    • 3242787268 scopus 로고    scopus 로고
    • Perioperative cardiac arrhythmias
    • DOI 10.1093/bja/aeh166
    • A. Thompson, and J.R. Balser Perioperative cardiac arrhythmias Br. J. Anaesth. 93 2004 86 94 (Pubitemid 38967430)
    • (2004) British Journal of Anaesthesia , vol.93 , Issue.1 , pp. 86-94
    • Thompson, A.1    Balser, J.R.2
  • 49
    • 78851470335 scopus 로고    scopus 로고
    • Effect of 4-aminopyridine on action potential parameters in isolated dog Purkinje fibers
    • G. Thomas, B. Klatt, and A. Blight Effect of 4-aminopyridine on action potential parameters in isolated dog Purkinje fibers Arch. Drug. Inf. 3 2010 19 25
    • (2010) Arch. Drug. Inf. , vol.3 , pp. 19-25
    • Thomas, G.1    Klatt, B.2    Blight, A.3
  • 50
    • 36049018325 scopus 로고    scopus 로고
    • The plateau outward current in canine ventricle, sensitive to 4-aminopyridine, is a constitutive contributor to ventricular repolarization
    • DOI 10.1038/sj.bjp.0707403, PII 0707403
    • A. Sridhar, D.N. da Cunha, V.A. Lacombe, Q. Zhou, J.J. Fox, R.L. Hamlin, and C.A. Carnes The plateau outward current in canine ventricle, sensitive to 4-aminopyridine, is a constitutive contributor to ventricular repolarization Br. J. Pharmacol. 152 2007 870 879 (Pubitemid 350100487)
    • (2007) British Journal of Pharmacology , vol.152 , Issue.6 , pp. 870-879
    • Sridhar, A.1    Da Cunha, D.N.Q.2    Lacombe, V.A.3    Zhou, Q.4    Fox, J.J.5    Hamlin, R.L.6    Carnes, C.A.7
  • 51
    • 0015512432 scopus 로고
    • Development of sensitivity to tetrodotoxin in beating chick embryo hearts, single cells, and aggregates
    • T.F. McDonald, H.G. Sachs, and R.L. DeHaan Development of sensitivity to tetrodotoxin in beating chick embryo hearts, single cells, and aggregates Science 16 1972 1248 1250
    • (1972) Science , vol.16 , pp. 1248-1250
    • McDonald, T.F.1    Sachs, H.G.2    Dehaan, R.L.3
  • 52
    • 0030936450 scopus 로고    scopus 로고
    • Reversion of the malignant phenotype of human breast cells in three- dimensional culture and in vivo by integrin blocking antibodies
    • DOI 10.1083/jcb.137.1.231
    • V.M. Weaver, O.W. Petersen, F. Wang, C.A. Larabell, P. Briand, C. Damsky, and M.J. Bissell Reversion of the malignant phenotype of human breast cells in three-dimensional culture and in vivo by integrin blocking antibodies J. Cell. Biol. 137 1997 231 245 (Pubitemid 27167310)
    • (1997) Journal of Cell Biology , vol.137 , Issue.1 , pp. 231-245
    • Weaver, V.M.1    Petersen, O.W.2    Wang, F.3    Larabell, C.A.4    Briand, P.5    Damsky, C.6    Bissell, M.J.7
  • 53
    • 0344584377 scopus 로고    scopus 로고
    • Cultivation in Rotating Bioreactors Promotes Maintenance of Cardiac Myocyte Electrophysiology and Molecular Properties
    • DOI 10.1089/10763270360728152
    • N. Bursac, M. Papadaki, J.A. White, S.R. Eisenberg, G. Vunjak-Novakovic, and L.E. Freed Cultivation in rotating bioreactors promotes maintenance of cardiac myocyte electrophysiology and molecular properties Tissue Eng. 9 2003 1243 1253 (Pubitemid 37467672)
    • (2003) Tissue Engineering , vol.9 , Issue.6 , pp. 1243-1253
    • Bursac, N.1    Papadaki, M.2    White, J.A.3    Eisenberg, S.R.4    Vunjak-Novakovic, G.5    Freed, L.E.6
  • 54
    • 23744472983 scopus 로고    scopus 로고
    • Gene expression perturbation in vitro - A growing case for three-dimensional (3D) culture systems
    • DOI 10.1016/j.semcancer.2005.06.009, PII S1044579X05000416
    • A. Birgersdotter, R. Sandberg, and I. Ernberg Gene expression perturbation in vitro - a growing case for three-dimensional (3D) culture systems Semin. Cancer Biol. 15 2005 405 412 (Pubitemid 41140308)
    • (2005) Seminars in Cancer Biology , vol.15 , pp. 405-412
    • Birgersdotter, A.1    Sandberg, R.2    Ernberg, I.3
  • 55
    • 33748775190 scopus 로고    scopus 로고
    • Optimization of fibrin scaffolds for differentiation of murine embryonic stem cells into neural lineage cells
    • DOI 10.1016/j.biomaterials.2006.07.036, PII S0142961206006612, Biomaterials and Stem Cells
    • S.M. Willerth, K.J. Arendas, D.I. Gottlieb, and S.E. Sakiyama-Elbert Optimization of fibrin scaffolds for differentiation of murine embryonic stem cells into neural lineage cells Biomaterials 27 2006 5990 6003 (Pubitemid 44414979)
    • (2006) Biomaterials , vol.27 , Issue.36 , pp. 5990-6003
    • Willerth, S.M.1    Arendas, K.J.2    Gottlieb, D.I.3    Sakiyama-Elbert, S.E.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.