A genetically engineered cell-based biosensor for functional classification of agents

Biosensors and Bioelectronics

Volumn 16, Issue 7-8, 2001, Pages 571-577

  Aravanis, Alexander M ^a   DeBusschere, B Derek ^a   Chruscinski, Andrzej J ^b   Gilchrist, Kristin H ^a   Kobilka, Brian K ^b   Kovacs, Gregory T A ^a  

^a Stanford University   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

1 Adrenergic receptor; Cardiac myocyte; Cell based biosensor; Genetically engineered; Microelectrode array; Whole cell biosensor

Indexed keywords

BIOCHEMICAL ENGINEERING; CELLS; CROSSTALK; ELECTRODES; GENETIC ENGINEERING; SPURIOUS SIGNAL NOISE;

CELL-BASED BIOSENSORS (CBB); MULTIELECTRODE ARRAYS;

BIOSENSORS;

BETA 1 ADRENERGIC RECEPTOR; FORSKOLIN; ISOPRENALINE; RECEPTOR SUBTYPE;

ANIMAL CELL; ARTICLE; BIOSENSOR; CELL ACTIVATION; CELL MEMBRANE POTENTIAL; CHRONOTROPISM; CONTROLLED STUDY; DRUG DETERMINATION; GENETIC ENGINEERING; HEART MUSCLE CELL; MICROELECTRODE; MOUSE; NEWBORN; NONHUMAN; SIGNAL NOISE RATIO; SIGNAL TRANSDUCTION; SYNCYTIUM; TRANSDUCER; WAVEFORM;

ADRENERGIC BETA-AGONISTS; ANIMALS; BIOSENSING TECHNIQUES; CELLS, CULTURED; EQUIPMENT DESIGN; GENETIC ENGINEERING; ISOPROTERENOL; MICE; MICE, KNOCKOUT; MYOCARDIUM; RECEPTORS, ADRENERGIC, BETA-1; TRANSDUCERS;

EID: 0034861854     PISSN: 09565663     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0956-5663(01)00171-3     Document Type: Article

References (24)

1. Microelectrode arrays for stimulation of neural slice preparations
2. An approach to the classification of unknown biological agents with cell based sensors
3. Whole cell biosensors
4. Targeted disruption of the β2 adrenergic receptor gene
5. Microbial sensor for new-generation cephalosporins based in a protein-engineered β-lactamase
6. A biosensor for the detection of gas toxicity using a recombinant bioluminescent bacterium
7. The use of neuronal networks on multielectrode arrays as biosensors
8. Odor, drug and toxin analysis with neuronal networks in vitro: Extracellular array recording of network responses
9. Development of an automated microbial sensor system
10. Inhibition of the spontaneous rate of contraction of neonatal cardiac myocytes by protein kinase C isozymes. A putative role for the epsilon isozyme
11. A biosensor that monitors cell morphology with electrical fields
12. Conductometric biosensor for ethanol detection based on whole yeast cells
13. Cell-based biosensors for environmental monitoring with special reference to heavy metal analysis
14. 2+ channels in neurons
15. A cell-based immunobiosensor with engineered molecular recognition - Part III: Engineering molecular recognition
16. Development and application of cell-based biosensors
17. Detection of cell-affecting agents with a silicon biosensor
18. Biosensor for lactate determination in biological fluids. I. Construction and properties of the biosensor
19. The electrical properties of metal microelectrodes
20. Targeted disruption of the mouse β1-adrenergic receptor gene: Developmental and cardiovascular effects
21. Bioluminescent bioreporter integrated circuits (BBICs)
22. Development and characterization of a whole-cell bioluminescent sensor for bioavailable middle-chain alkanes in contaminated groundwater samples
23. Microbial cell-based biosensor for sensing glucose, sucrose or lactose
24. Biosensor development