Pharmacological validation of trypanosoma brucei phosphodiesterases as novel drug targets

Journal of Infectious Diseases

Volumn 206, Issue 2, 2012, Pages 229-237

  De Koning, Harry P ^a   Gould, Matthew K ^a   Sterk, Geert Jan ^d   Tenor, Hermann ^b   Kunz, Stefan ^c   Luginbuehl, Edith ^c   Seebeck, Thomas ^c  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b Nycomed GmbH   (Germany)

^c UNIVERSITY OF BERN   (Switzerland)

^d Mercachem BV   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

4 PHENYL 4A,5,6,7,8,8A HEXAHYDROPHTHALAZINONE DERIVATIVE; 4 PHENYL 4A,5,8,8A TETRAHYDROPHTHALAZINONE DERIVATIVE; CYCLIC AMP; CYCLIC NUCLEOTIDE PHOSPHODIESTERASE; DIMINAZENE; DIPYRIDAMOLE; ESTERASE INHIBITOR; NIFURTIMOX; PHOSPHODIESTERASE INHIBITOR; PROTOZOAL PROTEIN; SURAMIN; TETRAHYDROPHTHALAZINONE DERIVATIVE; UNCLASSIFIED DRUG;

AFRICAN TRYPANOSOMIASIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIPROLIFERATIVE ACTIVITY; ANTIPROTOZOAL ACTIVITY; ARTICLE; CELL CYCLE ARREST; CELL DEATH; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; CROSS RESISTANCE; CYTOKINESIS; CYTOLYSIS; DRUG IDENTIFICATION; DRUG MECHANISM; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG TARGETING; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; HIGH THROUGHPUT SCREENING; IC 50; MOUSE; MULTINUCLEAR CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; STRUCTURAL HOMOLOGY; TRYPANOSOMA BRUCEI; UPREGULATION; VALIDATION PROCESS;

ANIMALS; CELL PROLIFERATION; DRUG DELIVERY SYSTEMS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; MICE; MOLECULAR STRUCTURE; PHOSPHODIESTERASE INHIBITORS; PHOSPHORIC DIESTER HYDROLASES; TRYPANOSOMA BRUCEI BRUCEI; TRYPANOSOMIASIS, AFRICAN;

EID: 84858693360     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1093/infdis/jir857     Document Type: Article

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