Novel selective PDE4 inhibitors. 2. Synthesis and structure-activity relationships of 4-aryl-substituted cis-tetra- and cis-hexahydrophthalazinones

Journal of Medicinal Chemistry

Volumn 44, Issue 16, 2001, Pages 2523-2535

  Van der Mey, M ^a,b   Hatzelmann, A ^c   Van Klink, G P M ^b   Van der Laan, I J ^b   Sterk, G J ^b   Thibaut, U ^c   Ulrich, W R ^c   Timmerman, H ^a  

^a VU UNIVERSITY AMSTERDAM   (Netherlands)

^b Byk Nederland   (Netherlands)

^c ALTANA PHARMA AG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

2 CYCLOHEPTYL 4 [3 [4 (4 IMIDAZOL 1 YLPHENOXY)BUTOXY] 4 METHOXYPHENYL] 4A,5,8,8A TETRAHYDRO 2H PHTHALAZIN 1 ONE; PHOSPHODIESTERASE; PHOSPHODIESTERASE III; PHOSPHODIESTERASE IV; PHOSPHODIESTERASE IV INHIBITOR; PHTHALAZINE DERIVATIVE; ROLIPRAM; UNCLASSIFIED DRUG;

ARTICLE; ASTHMA; BINDING SITE; DRUG SYNTHESIS; ENZYME INHIBITION; INFLAMMATORY DISEASE; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RHEUMATOID ARTHRITIS;

3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE; ENZYME INHIBITORS; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; NEUTROPHILS; PHTHALAZINES; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; REGRESSION ANALYSIS; ROLIPRAM; STEREOISOMERISM;

EID: 0035797365     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm010838c     Document Type: Article

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