메뉴 건너뛰기




Volumn 13, Issue 5, 2012, Pages 699-715

Pharmacotherapy of the third-generation AEDs: Lacosamide, retigabine and eslicarbazepine acetate

Author keywords

Adverse effect profiles; Drugdrug interactions; Efficacy profiles; Eslicarbazepine acetate; Lacosamide; Novel mechanisms of action; Pharmacokinetics; Retigabine; Therapeutic drug monitoring; Third generation antiepileptic drugs

Indexed keywords

CARBAMAZEPINE; CLOBAZAM; CLONAZEPAM; DIGOXIN; ESLICARBAZEPINE ACETATE; ETHINYLESTRADIOL; ETHOSUXIMIDE; ETIRACETAM; GABAPENTIN; HARKOSERIDE; LAMOTRIGINE; METFORMIN; OMEPRAZOLE; OXCARBAZEPINE; PHENOBARBITAL; PHENYTOIN; PLACEBO; PREGABALIN; PRIMIDONE; RETIGABINE; STEDESA; TIAGABINE; TOPIRAMATE; UNCLASSIFIED DRUG; VALPROIC ACID; VIGABATRIN; ZONISAMIDE;

EID: 84858641737     PISSN: 14656566     EISSN: 17447666     Source Type: Journal    
DOI: 10.1517/14656566.2012.667803     Document Type: Review
Times cited : (38)

References (129)
  • 1
    • 3242756518 scopus 로고    scopus 로고
    • Medical risks in epilepsy: A review with focus on physical injuries, mortality, traffic accidents and their prevention
    • DOI 10.1016/j.eplepsyres.2004.05.004, PII S0920121104000944
    • Tomson T, Beghi E, Sundqvist A, Johannessen SI. Medical risks in epilepsy: A review with focus on physical injuries, mortality, traffic accidents and their prevention. Epilepsy Res 2004;60:1-16 (Pubitemid 38981756)
    • (2004) Epilepsy Research , vol.60 , Issue.1 , pp. 1-16
    • Tomson, T.1    Beghi, E.2    Sundqvist, A.3    Johannessen, S.I.4
  • 2
    • 0031721247 scopus 로고    scopus 로고
    • Pharmacoresistance in epilepsy: How should it be defined
    • DOI 10.2165/00023210-199810030-00002
    • Perucca E. Pharmacoresistance in epilepsy. How should it be defined? CNS Drugs 1998;10:171-9 (Pubitemid 28449011)
    • (1998) CNS Drugs , vol.10 , Issue.3 , pp. 171-179
    • Perucca, E.1
  • 3
    • 79954622504 scopus 로고    scopus 로고
    • The pharmacological treatment of epilepsy in adults
    • Perucca E, Tomson T. The pharmacological treatment of epilepsy in adults. Lancet Neurol 2011;10:446-56
    • (2011) Lancet Neurol. , vol.10 , pp. 446-456
    • Perucca, E.1    Tomson, T.2
  • 4
    • 0034598762 scopus 로고    scopus 로고
    • Early identification of refractory epilepsy
    • DOI 10.1056/NEJM200002033420503
    • Kwan P, Brodie MJ. Early identification of refractory epilepsy. N Engl J Med 2000;342:314-19 (Pubitemid 30075244)
    • (2000) New England Journal of Medicine , vol.342 , Issue.5 , pp. 314-319
    • Kwan, P.1    Brodie, M.J.2
  • 5
    • 37849053121 scopus 로고    scopus 로고
    • Quantifying the response to antiepileptic drugs: Effect of past treatment history
    • Schiller Y, Najjar Y. Quantifying the response to antiepileptic drugs: Effect of past treatment history. Neurology 2008;70:54-65
    • (2008) Neurology , vol.70 , pp. 54-65
    • Schiller, Y.1    Najjar, Y.2
  • 6
    • 77954625557 scopus 로고    scopus 로고
    • Definition of drug resistant epilepsy: Consensus proposal by the ad hoc task force of the ilae commission on therapeutic strategies
    • Kwan P, Arzimanoglou A, Berg AT, et al. Definition of drug resistant epilepsy: Consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies. Epilepsia 2010;51:1069-77
    • (2010) Epilepsia , vol.51 , pp. 1069-1077
    • Kwan, P.1    Arzimanoglou, A.2    Berg, A.T.3
  • 7
    • 67249111268 scopus 로고    scopus 로고
    • Remission of epilepsy after two drug failures in children: A prospective study
    • Berg AT, Levy SR, Testa FM, et al. Remission of epilepsy after two drug failures in children: A prospective study. Ann Neurol 2009;65:510-19
    • (2009) Ann. Neurol. , vol.65 , pp. 510-519
    • Berg, A.T.1    Levy, S.R.2    Testa, F.M.3
  • 8
    • 79952575320 scopus 로고    scopus 로고
    • Remission and relapse in a drug-resistant epilepsy population followed prospectively
    • Callaghan B, Schlesinger M, Rodemer W, et al. Remission and relapse in a drug-resistant epilepsy population followed prospectively. Epilepsia 2011;52:619-26
    • (2011) Epilepsia , vol.52 , pp. 619-626
    • Callaghan, B.1    Schlesinger, M.2    Rodemer, W.3
  • 9
    • 0038196961 scopus 로고    scopus 로고
    • Clinically important drug interactions in epilepsy: General features and interactions between antiepileptic drugs
    • DOI 10.1016/S1474-4422(03)00409-5, PII S1474442203004095
    • Patsalos PN, Perucca E. Clinically important drug interactions in epilepsy: General features and interactions between antiepileptic drugs. Lancet Neurol 2003;2:347-56 (Pubitemid 38352562)
    • (2003) Lancet Neurology , vol.2 , Issue.6 , pp. 347-356
    • Patsalos, P.N.1    Perucca, E.2
  • 10
    • 0038714895 scopus 로고    scopus 로고
    • Clinically important drug interactions in epilepsy: Interactions between antiepileptic drugs and other drugs
    • DOI 10.1016/S1474-4422(03)00483-6
    • Patsalos PN, Perucca E. Clinically important drug interactions in epilepsy: Interactions between antiepileptic drugs and other drugs. Lancet Neurol 2003;2:473-81 (Pubitemid 36876104)
    • (2003) Lancet Neurology , vol.2 , Issue.8 , pp. 473-481
    • Patsalos, P.N.1    Perucca, E.2
  • 11
    • 74949138710 scopus 로고    scopus 로고
    • Drug interactions involving the new second- and third-generation antiepileptic drugs
    • Johannessen Landmark C, Patsalos PN. Drug interactions involving the new second- and third-generation antiepileptic drugs. Expert Rev Neurother 2010;10(1):119-40
    • (2010) Expert Rev. Neurother , vol.10 , Issue.1 , pp. 119-140
    • Johannessen Landmark, C.1    Patsalos, P.N.2
  • 12
    • 77953397673 scopus 로고    scopus 로고
    • New treatment option for partial-onset seizures: Efficacy and safety of lacosamide
    • Chung SS. New treatment option for partial-onset seizures: Efficacy and safety of lacosamide. Ther Adv Neurol Disord 2010;3:77-83
    • (2010) Ther. Adv. Neurol. Disord. , vol.3 , pp. 77-83
    • Chung, S.S.1
  • 13
    • 84858697195 scopus 로고    scopus 로고
    • Available from: http://www.medicines.org.uk/emc/medicines/ 21158
    • Vimpat, SPC, UCB Pharma, Slough, Berkshire, UK. Available from: http:// www.medicines.org.uk/emc/medicines/ 21158
    • UCB Pharma. Slough Berkshire UK
    • Vimpat, S.P.C.1
  • 14
    • 57849141134 scopus 로고    scopus 로고
    • Progress report on new antiepileptic drugs: A summary of the ninth eilat conference (EILAT IX)
    • Bialer M, Johannessen SI, Levy RH, et al. Progress report on new antiepileptic drugs: A summary of the Ninth Eilat Conference (EILAT IX). Epilepsy Res 2009;83:1-43
    • (2009) Epilepsy Res. , vol.83 , pp. 1-43
    • Bialer, M.1    Johannessen, S.I.2    Levy, R.H.3
  • 15
    • 34247550257 scopus 로고    scopus 로고
    • Lacosamide, a novel anti-convulsant drug, shows efficacy with a wide safety margin in rodent models for epilepsy
    • DOI 10.1016/j.eplepsyres.2007.03.004, PII S092012110700085X
    • Stohr T, Kupferberg HJ, Stables JP, et al. Lacosamide, a novel anti-convulsant drug, shows efficacy with a wide safety margin in rodent models for epilepsy. Epilepsy Res 2007;74:147-54 (Pubitemid 46654745)
    • (2007) Epilepsy Research , vol.74 , Issue.2-3 , pp. 147-154
    • Stohr, T.1    Kupferberg, H.J.2    Stables, J.P.3    Choi, D.4    Harris, R.H.5    Kohn, H.6    Walton, N.7    White, H.S.8
  • 16
    • 37349071555 scopus 로고    scopus 로고
    • The investigational anticonvulsant lacosamide selectively enhances slow inactivation of voltage-gated sodium channels
    • DOI 10.1124/mol.107.039867
    • Errington AC, Stohr T, Heers C, et al. The investigational anticonvulsant lacosamide selectively enhances slow inactivation of voltage-gated sodium channels. Mol Pharmacol 2008;73:157-69 (Pubitemid 350294207)
    • (2008) Molecular Pharmacology , vol.73 , Issue.1 , pp. 157-169
    • Errington, A.C.1    Stohr, T.2    Heers, C.3    Lees, G.4
  • 17
    • 67649388104 scopus 로고    scopus 로고
    • Lacosamide: A new approach to target voltage-gated sodium currents in epileptic disorders
    • Curia G, Biagini G, Perucca E, et al. Lacosamide: A new approach to target voltage-gated sodium currents in epileptic disorders. CNS Drugs 2009;23:555-68
    • (2009) CNS Drugs , vol.23 , pp. 555-568
    • Curia, G.1    Biagini, G.2    Perucca, E.3
  • 18
    • 33846193132 scopus 로고    scopus 로고
    • Bioequivalence of short-time infusions compared to oral administration of SPM 927
    • Kropeit D, Schiltmeyer B, Cawello W, et al. Bioequivalence of short-time infusions compared to oral administration of SPM 927. Epilepsia 2004;45(Suppl 7):123-4
    • (2004) Epilepsia , vol.45 , Issue.SUPPL7 , pp. 123-124
    • Kropeit, D.1    Schiltmeyer, B.2    Cawello, W.3
  • 19
    • 55849095223 scopus 로고    scopus 로고
    • Pharmacokinetics and safety of lacosamide administered as a replacement for adjunctive oral Lacosamide in patients with partial onset seizures
    • Rosenfeld W, Biton V, Mameniskiene R, et al. Pharmacokinetics and safety of lacosamide administered as a replacement for adjunctive oral Lacosamide in patients with partial onset seizures. Epilepsia 2005;46(Suppl 8):184
    • (2005) Epilepsia , vol.46 , Issue.SUPPL8 , pp. 184
    • Rosenfeld, W.1    Biton, V.2    Mameniskiene, R.3
  • 20
    • 39749167069 scopus 로고    scopus 로고
    • Intravenous lacosamide in patients with partial onset seizures
    • Biton V, Rosenfeld WE, Whitesides J, et al. Intravenous lacosamide in patients with partial onset seizures. Epilepsia 2008;49:418-24
    • (2008) Epilepsia , vol.49 , pp. 418-424
    • Biton, V.1    Rosenfeld, W.E.2    Whitesides, J.3
  • 21
    • 33846242456 scopus 로고    scopus 로고
    • Food does not affect the pharmacokinetics of SPM 927
    • Cawello W, Kropeit D, Schiltmeyer B, et al. Food does not affect the pharmacokinetics of SPM 927. Epilepsia 2004;45(Suppl 7):307
    • (2004) Epilepsia , vol.45 , Issue.SUPPL7 , pp. 307
    • Cawello, W.1    Kropeit, D.2    Schiltmeyer, B.3
  • 22
    • 33846234734 scopus 로고    scopus 로고
    • Lacosamide
    • DOI 10.1016/j.nurt.2006.10.002, PII S1933721306001759, New Antiepileptic Drugs: Discovery, Development, and Update
    • Doty P, Rudd GD, Stohr T, et al. Lacosamide. Neurotherapeutics 2007;4:145-8 (Pubitemid 46107317)
    • (2007) Neurotherapeutics , vol.4 , Issue.1 , pp. 145-148
    • Doty, P.1    Rudd, G.D.2    Stoehr, T.3    Thomas, D.4
  • 23
    • 79960353827 scopus 로고    scopus 로고
    • Fluctuation of Lacosamide serum concentrations during the day and occurrence of adverse drug reactions - First clinical experience
    • Sattler A, Schaefer M, May TW, et al. Fluctuation of Lacosamide serum concentrations during the day and occurrence of adverse drug reactions - first clinical experience. Epilepsy Res 2011;95(3):207-12
    • (2011) Epilepsy Res. , vol.95 , Issue.3 , pp. 207-212
    • Sattler, A.1    Schaefer, M.2    May, T.W.3
  • 24
    • 11144232600 scopus 로고    scopus 로고
    • Basic clinical pharmacological investigations of the new antiepileptic drug SPM 927
    • Horstmann R, Bonn R, Cawello W, et al. Basic clinical pharmacological investigations of the new antiepileptic drug SPM 927. Epilepsia 2002;43(Suppl 7):188
    • (2002) Epilepsia , vol.43 , Issue.SUPPL7 , pp. 188
    • Horstmann, R.1    Bonn, R.2    Cawello, W.3
  • 25
    • 79958269328 scopus 로고    scopus 로고
    • Lacosamide for the prevention of partial onset seizures in epileptic adults
    • Kelemen A, Halasz P. Lacosamide for the prevention of partial onset seizures in epileptic adults. Neuropsychol Dis Treat 2010;6:465-71
    • (2010) Neuropsychol. Dis. Treat , vol.6 , pp. 465-471
    • Kelemen, A.1    Halasz, P.2
  • 26
    • 79951659549 scopus 로고    scopus 로고
    • Saliva and serum lacosamide concentrations in patients with epilepsy
    • Greenaway C, Ratnaraj N, Sander JW, Patsalos PN. Saliva and serum lacosamide concentrations in patients with epilepsy. Epilepsia 2011;52:258-63
    • (2011) Epilepsia , vol.52 , pp. 258-263
    • Greenaway, C.1    Ratnaraj, N.2    Sander, J.W.3    Patsalos, P.N.4
  • 27
    • 33846244930 scopus 로고    scopus 로고
    • Pharmacokinetics of the new antiepileptic drug SPM 927 in human subjects with different age and gender
    • Schiltmeyer B, Cawello W, Kropeit D, et al. Pharmacokinetics of the new antiepileptic drug SPM 927 in human subjects with different age and gender. Epilepsia 2004;45(Suppl 7):313
    • (2004) Epilepsia , vol.45 , Issue.SUPPL7 , pp. 313
    • Schiltmeyer, B.1    Cawello, W.2    Kropeit, D.3
  • 29
    • 77954907520 scopus 로고    scopus 로고
    • No pharmacokinetic interaction between lacosamide and carbamazepine in healthy volunteers
    • Cawello W, Nickel B, Eggert-Formella A. No pharmacokinetic interaction between lacosamide and carbamazepine in healthy volunteers. J Clin Pharmacol 2010;50:459-71
    • (2010) J. Clin. Pharmacol. , vol.50 , pp. 459-471
    • Cawello, W.1    Nickel, B.2    Eggert-Formella, A.3
  • 30
    • 61849088333 scopus 로고    scopus 로고
    • Adjunctive lacosamide for partial-onset seizures: Efficacy and safety results from a randomized controlled trial
    • Halasz P, Kalviainen R, Mazurkiewicz-Beldzinska M, et al. Adjunctive lacosamide for partial-onset seizures: Efficacy and safety results from a randomized controlled trial. Epilepsia 2009;50(3):443-53
    • (2009) Epilepsia , vol.50 , Issue.3 , pp. 443-453
    • Halasz, P.1    Kalviainen, R.2    Mazurkiewicz-Beldzinska, M.3
  • 31
    • 34447344551 scopus 로고    scopus 로고
    • Efficacy and safety of oral lacosamide as adjunctive therapy in adults with partial-onset seizures
    • DOI 10.1111/j.1528-1167.2007.01188.x
    • Ben-Menachem E, Biton V, Jatuzis D, et al. Efficacy and safety of oral lacosamide as adjunctive therapy in adults with partial-onset seizures. Epilepsia 2007;48:1308-17 (Pubitemid 47063096)
    • (2007) Epilepsia , vol.48 , Issue.7 , pp. 1308-1317
    • Ben-Menachem, E.1    Biton, V.2    Jatuzis, D.3    Abou-Khalil, B.4    Doty, P.5    Rudd, G.D.6
  • 32
    • 33846258011 scopus 로고    scopus 로고
    • Evaluation of the effect of oral lacosamide on concomitant AED plasma concentrations in patients with partial seizures
    • Jatuzis D, Biton V, Ben-Menachem E, et al. Evaluation of the effect of oral lacosamide on concomitant AED plasma concentrations in patients with partial seizures. Epilepsia 2005;46(Suppl 8):170
    • (2005) Epilepsia , vol.46 , Issue.SUPPL8 , pp. 170
    • Jatuzis, D.1    Biton, V.2    Ben-Menachem, E.3
  • 33
    • 77953033494 scopus 로고    scopus 로고
    • Lacosamide as adjunctive therapy for partial-onset seizures: A randomized controlled trial
    • Chung S, Sperling MR, Biton V, et al. Lacosamide as adjunctive therapy for partial-onset seizures: A randomized controlled trial. Epilepsia 2010;51:958-67
    • (2010) Epilepsia , vol.51 , pp. 958-967
    • Chung, S.1    Sperling, M.R.2    Biton, V.3
  • 34
    • 78649339546 scopus 로고    scopus 로고
    • Examining the clinical utility of lacosamide: Pooled analyses of three phase 2/3 clinical trials
    • Chung S, Ben-Menachem E, Sperling MR, et al. Examining the clinical utility of lacosamide: Pooled analyses of three phase 2/3 clinical trials. CNS Drugs 2010;24:1041-54
    • (2010) CNS Drugs , vol.24 , pp. 1041-1054
    • Chung, S.1    Ben-Menachem, E.2    Sperling, M.R.3
  • 35
    • 78649357007 scopus 로고    scopus 로고
    • A pooled analysis of lacosamide clinical trial data grouped by mechanism of action of concomitant antiepileptic drugs
    • Sake JK, Hebert D, Isojarvi J, et al. A pooled analysis of lacosamide clinical trial data grouped by mechanism of action of concomitant antiepileptic drugs. CNS Drugs 2010;24:1955-68
    • (2010) CNS Drugs , vol.24 , pp. 1955-1968
    • Sake, J.K.1    Hebert, D.2    Isojarvi, J.3
  • 36
    • 78651251889 scopus 로고    scopus 로고
    • Lacosamide neurotoxicity associated with concomitant use of sodium channel-blocking antiepileptic drugs: A pharmacodynamic interaction
    • Novy J, Patsalos PN, Sander JW, et al. Lacosamide neurotoxicity associated with concomitant use of sodium channel-blocking antiepileptic drugs: A pharmacodynamic interaction? Epilepsy Behav 2011;20:20-23
    • (2011) Epilepsy Behav. , vol.20 , pp. 20-23
    • Novy, J.1    Patsalos, P.N.2    Sander, J.W.3
  • 37
    • 78649964704 scopus 로고    scopus 로고
    • Does lacosamide aggravate lennox-Gastaut syndrome? Report on three consecutive cases
    • Cuzzola A, Ferlazzo E, Italiano D, et al. Does lacosamide aggravate Lennox-Gastaut syndrome? Report on three consecutive cases. Epilepsy Behav 2010;19:650-1
    • (2010) Epilepsy Behav. , vol.19 , pp. 650-651
    • Cuzzola, A.1    Ferlazzo, E.2    Italiano, D.3
  • 38
    • 79954606109 scopus 로고    scopus 로고
    • Efficacy and tolerability of oral lacosamide as adjunctive therapy in pediatric patients with pharmacoresistant focal epilepsy
    • Gavatha M, Ioannou I, Papavasiliou AS. Efficacy and tolerability of oral lacosamide as adjunctive therapy in pediatric patients with pharmacoresistant focal epilepsy. Epilepsy Behav 2011;20:691-3
    • (2011) Epilepsy Behav. , vol.20 , pp. 691-693
    • Gavatha, M.1    Ioannou, I.2    Papavasiliou, A.S.3
  • 39
    • 79955833087 scopus 로고    scopus 로고
    • Experience with lacosamide in a series of children with drug resistant focal seizures
    • Guilhoto LM, Loddenkemper T, Gooty VD, et al. Experience with lacosamide in a series of children with drug resistant focal seizures. Pediatr Neurol 2011;44:414-19
    • (2011) Pediatr. Neurol. , vol.44 , pp. 414-419
    • Guilhoto, L.M.1    Loddenkemper, T.2    Gooty, V.D.3
  • 40
    • 78650789188 scopus 로고    scopus 로고
    • Intravenous lacosamide for treatment of status epilepticus
    • Kellinghaus C, Berning S, Immisch I, et al. Intravenous lacosamide for treatment of status epilepticus. Acta Neurol Scand 2011;123:137-41
    • (2011) Acta. Neurol. Scand. , vol.123 , pp. 137-141
    • Kellinghaus, C.1    Berning, S.2    Immisch, I.3
  • 41
    • 79955685095 scopus 로고    scopus 로고
    • Intravenous lacosamide-an effective add-on treatment of refractory status epilepticus
    • Albers JM, Moddel G, Dittrich R, et al. Intravenous lacosamide-an effective add-on treatment of refractory status epilepticus. Seizure 2011;21:428-30
    • (2011) Seizure , vol.21 , pp. 428-430
    • Albers, J.M.1    Moddel, G.2    Dittrich, R.3
  • 42
    • 79960897395 scopus 로고    scopus 로고
    • Efficacy of intravenous lacosamide in refractory nonconvulsive status epilepticus and simple partial status epilepticus
    • Rantsch K, Walter U, Wittsrock M, et al. Efficacy of intravenous lacosamide in refractory nonconvulsive status epilepticus and simple partial status epilepticus. Seizure 2011;20(7):529-32
    • (2011) Seizure , vol.20 , Issue.7 , pp. 529-532
    • Rantsch, K.1    Walter, U.2    Wittsrock, M.3
  • 43
    • 79960926642 scopus 로고    scopus 로고
    • Successful treatment of childhood prolonged status epilepticus with lacosamide
    • Shiloh-Malawsky Y, Fan Z, Greenwood R, et al. Successful treatment of childhood prolonged status epilepticus with lacosamide. Seizure 2011;20(7):586-8
    • (2011) Seizure , vol.20 , Issue.7 , pp. 586-588
    • Shiloh-Malawsky, Y.1    Fan, Z.2    Greenwood, R.3
  • 44
    • 78650783166 scopus 로고    scopus 로고
    • Efficacy and safety of intravenous lacosamide in refractory nonconvulsive status epilepticus
    • Koubeissi MZ, Mayor CL, Estephan B, et al. Efficacy and safety of intravenous lacosamide in refractory nonconvulsive status epilepticus. Acta Neurol Scand 2011;123:142-6
    • (2011) Acta. Neurol. Scand. , vol.123 , pp. 142-146
    • Koubeissi, M.Z.1    Mayor, C.L.2    Estephan, B.3
  • 45
    • 79952449282 scopus 로고    scopus 로고
    • Successful treatment of refractory simple motor status epilepticus with lacosamide and levetiracetam
    • Chen LL, Haneef Z, Dorsch A, et al. Successful treatment of refractory simple motor status epilepticus with lacosamide and levetiracetam. Seizure 2011;20:263-5
    • (2011) Seizure , vol.20 , pp. 263-265
    • Chen, L.L.1    Haneef, Z.2    Dorsch, A.3
  • 46
    • 78651225263 scopus 로고    scopus 로고
    • Lacosamide in the treatment of acute recurrent seizures and periodic epileptiform patterns in critically ill patients
    • Parkerson KA, Reinsberger C, Chou SH, et al. Lacosamide in the treatment of acute recurrent seizures and periodic epileptiform patterns in critically ill patients. Epilepsy Behav 2011;20:48-51
    • (2011) Epilepsy Behav. , vol.20 , pp. 48-51
    • Parkerson, K.A.1    Reinsberger, C.2    Chou, S.H.3
  • 47
    • 79955827689 scopus 로고    scopus 로고
    • The use of lacosamide in refractory status epilepticus
    • Goodwin H, Hinson HE, Shermock KM, et al. The use of lacosamide in refractory status epilepticus. Neurocrit Care 2011;14:348-53
    • (2011) Neurocrit Care , vol.14 , pp. 348-353
    • Goodwin, H.1    Hinson, H.E.2    Shermock, K.M.3
  • 48
  • 49
    • 77952781301 scopus 로고    scopus 로고
    • Intravenous lacosamide as short-term replacement for oral lacosamide in partial-onset seizures
    • Krauss G, Ben-Menachem E, Mameniskiene R, et al. Intravenous lacosamide as short-term replacement for oral lacosamide in partial-onset seizures. Epilepsia 2010;51:951-7
    • (2010) Epilepsia , vol.51 , pp. 951-957
    • Krauss, G.1    Ben-Menachem, E.2    Mameniskiene, R.3
  • 50
    • 77954382660 scopus 로고    scopus 로고
    • Atrial flutter/atrial fibrillation associated with lacosamide for partial seizures
    • Degiorgio CM. Atrial flutter/atrial fibrillation associated with lacosamide for partial seizures. Epilepsy Behav 2010;18:322-4
    • (2010) Epilepsy Behav. , vol.18 , pp. 322-324
    • Degiorgio, C.M.1
  • 51
    • 79953031818 scopus 로고    scopus 로고
    • New and forthcoming antiepileptic drugs
    • Prunetti P, Perucca E. New and forthcoming antiepileptic drugs. Curr Opin Neurol 2011;24:159-64
    • (2011) Curr. Opin. Neurol. , vol.24 , pp. 159-164
    • Prunetti, P.1    Perucca, E.2
  • 53
    • 77952238102 scopus 로고    scopus 로고
    • Lacosamide intoxication in attempted suicide
    • Bauer S, Rudd D, Mylius V, et al. Lacosamide intoxication in attempted suicide. Epilepsy Behav 2010;17:549-51
    • (2010) Epilepsy Behav. , vol.17 , pp. 549-551
    • Bauer, S.1    Rudd, D.2    Mylius, V.3
  • 54
    • 84964230572 scopus 로고    scopus 로고
    • Analysis for lacosamide in human serum by LC/MS/ MS and a summary of 8,000 patient values
    • McMullin M, Dalrymple R. Analysis for lacosamide in human serum by LC/MS/ MS and a summary of 8,000 patient values. Ther Drug Monit 2011;33(4):520-1
    • (2011) Ther. Drug Monit. , vol.33 , Issue.4 , pp. 520-521
    • McMullin, M.1    Dalrymple, R.2
  • 55
    • 45749150011 scopus 로고    scopus 로고
    • Antiepileptic drugs - Best practice guidelines for therapeutic drug monitoring: A position paper by the subcommission on therapeutic drug monitoring, ILAE Commission on Therapeutic Strategies
    • DOI 10.1111/j.1528-1167.2008.01561.x
    • Patsalos PN, Berry DJ, Bourgeois BFD, et al. Antiepileptic drugs - best practice guidelines for therapeutic drug monitoring: A position paper by the subcommission on therapeutic drug monitoring, ILAE Commission on Therapeutic Strategies. Epilepsia 2008;49:1239-76 (Pubitemid 351991390)
    • (2008) Epilepsia , vol.49 , Issue.7 , pp. 1239-1276
    • Patsalos, P.N.1    Berry, D.J.2    Bourgeois, B.F.D.3    Cloyd, J.C.4    Glauser, T.A.5    Johannessen, S.I.6    Leppik, I.E.7    Tomson, T.8    Perucca, E.9
  • 56
    • 77953317302 scopus 로고    scopus 로고
    • Retigabine: The newer potential antiepileptic drug
    • Czuczwar P, Wojtak A, Cioczek-Czuczwar A, et al. Retigabine: The newer potential antiepileptic drug. Pharmacol Rep 2010;62(2):211-19
    • (2010) Pharmacol. Rep. , vol.62 , Issue.2 , pp. 211-219
    • Czuczwar, P.1    Wojtak, A.2    Cioczek-Czuczwar, A.3
  • 58
    • 0001208372 scopus 로고
    • The phenyl carbamic acid ester D-23129 is highly effective in epilepsy models for generalized and focal seizures at nontoxic doses
    • Tober C, Rundfeldt C, Rostock A, et al. The phenyl carbamic acid ester D-23129 is highly effective in epilepsy models for generalized and focal seizures at nontoxic doses. Abstr Soc Neurosci 1994;20:1641
    • (1994) Abstr. Soc. Neurosci. , vol.20 , pp. 1641
    • Tober, C.1    Rundfeldt, C.2    Rostock, A.3
  • 59
    • 0029086889 scopus 로고
    • Anticonvulsant properties of D-20443 in genetically epilepsy-prone rats: Prediction of clinical response
    • Dailey JW, Cheong JH, Kh K, et al. Anticonvulsant properties of D-20443 in genetically epilepsy-prone rats: Prediction of clinical response. Neurosci Lett 1995;195:77-80
    • (1995) Neurosci. Lett. , vol.195 , pp. 77-80
    • Dailey, J.W.1    Cheong, J.H.2    Kh, K.3
  • 61
    • 0034677733 scopus 로고    scopus 로고
    • The novel anticonvulsant retigabine activates M-currents in Chinese hamster ovary-cells tranfected with human KCNQ2/3 subunits
    • DOI 10.1016/S0304-3940(00)00866-1, PII S0304394000008661
    • Rundfeldt C, Netzer R. The novel anticonvulsant retigabine activates M-currents in Chinese hamster ovary-cells transfected with human KCNQ2/3 subunits. Neurosci Lett 2000;282:73-6 (Pubitemid 30129172)
    • (2000) Neuroscience Letters , vol.282 , Issue.1-2 , pp. 73-76
    • Rundfeldt, C.1    Netzer, R.2
  • 64
    • 78650178478 scopus 로고    scopus 로고
    • Progress report on new antiepileptic drugs: A summary of the tenth eilat conference (EILAT X)
    • Bialer M, Johannessen SI, Levy RH, et al. Progress report on new antiepileptic drugs: A summary of the Tenth Eilat Conference (EILAT X). Epilepsy Res 2010;92:89-124
    • (2010) Epilepsy Res. , vol.92 , pp. 89-124
    • Bialer, M.1    Johannessen, S.I.2    Levy, R.H.3
  • 66
    • 15744400656 scopus 로고    scopus 로고
    • v7.2 (KCNQ2) channel by binding to its activation gate
    • DOI 10.1124/mol.104.010793
    • Wuttke TV, Seebohm G, Bail S, et al. The new anticonvulsant retigabine favors voltage-dependent opening of the Kv7.2 (KCNQ2) channel by binding to its activation gate. Mol Pharmacol 2005;67:1009-17 (Pubitemid 40410403)
    • (2005) Molecular Pharmacology , vol.67 , Issue.4 , pp. 1009-1017
    • Wuttke, T.V.1    Seebohm, G.2    Bail, S.3    Maljevic, S.4    Lerche, H.5
  • 68
    • 0033862433 scopus 로고    scopus 로고
    • Retigabine, a novel anticonvulsant, enhances activation of KCNQ2/Q3 potassium channels
    • Wickenden AD, Yu W, Zou A, et al. Retigabine, a novel anticonvulsant, enhances activation of KCNQ2/Q3 potassium channels. Mol Pharmacol 2000;58:591-600
    • (2000) Mol. Pharmacol. , vol.58 , pp. 591-600
    • Wickenden, A.D.1    Yu, W.2    Zou, A.3
  • 69
    • 0038187795 scopus 로고    scopus 로고
    • Effect of the KCNQ potassium channel opener retigabine on single KCNQ2/3 channels expressed in CHO cells
    • DOI 10.1113/jphysiol.2003.039842
    • Tatulian L, Brown DA. Effects of the KCNQ potassium channel opener retigabine on single KCNQ2/3 channels expressed in CHO cells. J Physiol 2003;549(Pt 1):57-63 (Pubitemid 36626397)
    • (2003) Journal of Physiology , vol.549 , Issue.1 , pp. 57-63
    • Tatulian, L.1    Brown, D.A.2
  • 72
    • 84858650912 scopus 로고    scopus 로고
    • Summary of product characteristics, eslicarbazepine acetate, zebinix, EISAI
    • Summary of Product Characteristics, Eslicarbazepine acetate, Zebinix, EISAI. Hatfield, Hertfordshire, UK 2011
    • (2011) Hatfield, Hertfordshire, UK
  • 76
    • 33744543460 scopus 로고    scopus 로고
    • The role of Gilbert's syndrome and frequent NAT2 slow acetylation polymorphisms in the pharmacokinetics of retigabine
    • DOI 10.1038/sj.tpj.6500359, PII 6500359
    • Hermann R, Borlak J, Munzel U, et al. The role of Gilbert's syndrome and frequent NAT2 slow acetylation polymorphisms in the pharmacokinetics of retigabine. Pharmacogenomics J 2006;6:211-19 (Pubitemid 43811572)
    • (2006) Pharmacogenomics Journal , vol.6 , Issue.3 , pp. 211-219
    • Hermann, R.1    Borlak, J.2    Munzel, U.3    Niebch, G.4    Fuhr, U.5    Maus, J.6    Erb, K.7
  • 77
    • 80155204701 scopus 로고    scopus 로고
    • Retigabine. In: A Shorvon S., Perucca E., Engle J editors. 3rd edition. Blackwell Publishing; Chichester
    • Mansbach H, Baulac M. Retigabine. In: Shorvon S, Perucca E, Engle J, editors. The Treatment of Epilepsy. 3rd edition. Blackwell Publishing; Chichester: 2009. p. 637-46
    • (2009) Treatment of Epilepsy , pp. 637-646
    • Mansbach, H.1    Baulac, M.2
  • 78
    • 0037660846 scopus 로고    scopus 로고
    • Lack of pharmacokinetic interaction between retigabine and phenobarbitone at steady-state in healthy subjects
    • DOI 10.1046/j.1365-2125.2003.01825.x
    • Ferron GM, Patat A, Parks V, et al. Lack of pharmacokinetic interaction between retigabine and phenobarbitone at steady-state in healthy subjects. Br J Clin Pharmacol 2003;56:39-45 (Pubitemid 36886487)
    • (2003) British Journal of Clinical Pharmacology , vol.56 , Issue.1 , pp. 39-45
    • Ferron, G.M.1    Patat, A.2    Parks, V.3    Rolan, P.4    Troy, S.M.5
  • 79
    • 0038084973 scopus 로고    scopus 로고
    • Pharmacokinetic interaction between valproic acid, topiramate, phenytoin or carbamazepine and retigabine in epileptic patients
    • Ferron GM, Sachdeo R, Pardot A, et al. Pharmacokinetic interaction between valproic acid, topiramate, phenytoin or carbamazepine and retigabine in epileptic patients. Clin Pharm Ther 2001;69:18
    • (2001) Clin. Pharm. Ther. , vol.69 , pp. 18
    • Ferron, G.M.1    Sachdeo, R.2    Pardot, A.3
  • 80
    • 33646533005 scopus 로고    scopus 로고
    • Retigabine does not alter the pharmacokinetics of a low-dose oral contraceptive in women
    • Paul J, Ferron GM, Richards L, et al. Retigabine does not alter the pharmacokinetics of a low-dose oral contraceptive in women. Neurology 2001;56(Suppl 3):A335-6
    • (2001) Neurology , vol.56 , Issue.SUPPL3
    • Paul, J.1    Ferron, G.M.2    Richards, L.3
  • 81
    • 34247252905 scopus 로고    scopus 로고
    • Randomized, multicenter, dose-ranging trial of retigabine for partial-onset seizures
    • DOI 10.1212/01.wnl.0000259034.45049.00, PII 0000611420070410000009
    • Porter RJ, Partiot A, Sachdeo R, et al. Randomised multicenter, dose-ranging trial of retigabine for partial-onset seizures. Neurology 2007;68:1197-204 (Pubitemid 46608467)
    • (2007) Neurology , vol.68 , Issue.15 , pp. 1197-1204
    • Porter, R.J.1    Partiot, A.2    Sachdeo, R.3    Nohria, V.4    Alves, W.M.5
  • 82
    • 78649984382 scopus 로고    scopus 로고
    • Efficacy and safety of adjunctive ezogabine (retigabine) in refractory partial epilepsy
    • Brodie MJ, Lerche H, Gil-Nagel A, et al. Efficacy and safety of adjunctive ezogabine (retigabine) in refractory partial epilepsy. Neurology 2010;75:1817-24
    • (2010) Neurology , vol.75 , pp. 1817-1824
    • Brodie, M.J.1    Lerche, H.2    Gil-Nagel, A.3
  • 83
    • 79955592696 scopus 로고    scopus 로고
    • Randomised, double-blind, placebo-controlled trial of ezogabine (retigabine) in partial epilepsy
    • French JA, Abou-Khalil BW, Leroy RF, et al. Randomised, double-blind, placebo-controlled trial of ezogabine (retigabine) in partial epilepsy. Neurology 2011;76:1555-63
    • (2011) Neurology , vol.76 , pp. 1555-1563
    • French, J.A.1    Abou-Khalil, B.W.2    Leroy, R.F.3
  • 84
    • 5444225675 scopus 로고    scopus 로고
    • Urodynamic effects of the K+ channel (KCNQ) opener retigabine in freely moving, conscious rats
    • DOI 10.1097/01.ju.0000138155.33749.f4
    • + channel (KCNQ) opener retigabine in freely moving, conscious rats. J Urol 2004;172(5 Pt):2054-8 (Pubitemid 39363127)
    • (2004) Journal of Urology , vol.172 , Issue.5 , pp. 2054-2058
    • Streng, T.1    Christoph, T.2    Andersson, K.-E.3
  • 85
    • 77953536118 scopus 로고    scopus 로고
    • Functional effects of the KCNQ modulators retigabine and XE991 in the rat urinary bladder
    • Rode F, Svalo J, Sheykhzade M, et al. Functional effects of the KCNQ modulators retigabine and XE991 in the rat urinary bladder. Eur J Pharmacol 2010;638:121-7
    • (2010) Eur. J. Pharmacol. , vol.638 , pp. 121-127
    • Rode, F.1    Svalo, J.2    Sheykhzade, M.3
  • 86
    • 80155158768 scopus 로고    scopus 로고
    • Update on treatment of partial onset epilepsy: Role of eslicarbazepine
    • Rauchenzauner M, Luef G. Update on treatment of partial onset epilepsy: Role of eslicarbazepine. Neuropsychiatry Dis Treat 2010;6:723-30
    • (2010) Neuropsychiatry Dis. Treat , vol.6 , pp. 723-730
    • Rauchenzauner, M.1    Luef, G.2
  • 87
    • 77950838484 scopus 로고    scopus 로고
    • Role of eslicarbazepine in the treatment of epilepsy in adult patients with partial-onset seizures
    • Brown ME, El-Mallakh RS. Role of eslicarbazepine in the treatment of epilepsy in adult patients with partial-onset seizures. Ther Clin Risk Manag 2010;6:103-9
    • (2010) Ther. Clin. Risk Manag. , vol.6 , pp. 103-109
    • Brown, M.E.1    El-Mallakh, R.S.2
  • 89
    • 0036127241 scopus 로고    scopus 로고
    • Mechanism of action of carbamazepine. Oxcarbazepine BIA-2-093 and BIA-2-024
    • Ambrosio AF, Soares-da-Silva P, Carvalho CM, et al. Mechanism of action of carbamazepine. Oxcarbazepine, BIA-2-093, and BIA-2-024. Neurochem Res 2002;27:121-30
    • (2002) Neurochem. Res. , vol.27 , pp. 121-130
    • Ambrosio, A.F.1    Soares-da-Silva, P.2    Carvalho, C.M.3
  • 91
    • 0034644868 scopus 로고    scopus 로고
    • Neurotoxic/neuroprotective profile of carbamazepine, oxcarbazepine and two new putative antiepileptic drugs, BIA 2-093 and BIA 2-024
    • Ambrosio AF, Silva AP, Araujo I, et al. Neurotoxic/neuroprotective profile of carbamazepine, oxcarbazepine and two new putative antiepileptic drugs, BIA 2-093 and BIA 2-024. Eur J Pharmacol 2000;46:191-201
    • (2000) Eur. J. Pharmacol. , vol.46 , pp. 191-201
    • Ambrosio, A.F.1    Silva, A.P.2    Araujo, I.3
  • 92
    • 0035873841 scopus 로고    scopus 로고
    • Inhibition of glutamate release by BIA 2-093 and BIA 2-024, two novel derivatives of carbamazepine, due to blockade of sodium but not calcium channels
    • DOI 10.1016/S0006-2952(01)00584-6, PII S0006295201005846
    • Ambrosio AF, Silva AP, Malva JO, et al. Inhibition of glutamate release by BIA 2-093 and BIA 2-024, two novel derivatives of carbamazepine, due to blockade of sodium but not calcium channels. Biochem Pharmacol 2001;61:1271-5 (Pubitemid 32375119)
    • (2001) Biochemical Pharmacology , vol.61 , Issue.10 , pp. 1271-1275
    • Ambrosio, A.F.1    Silva, A.P.2    Malva, J.O.3    Soares-da-Silva, P.4    Carvalho, A.P.5    Carvalho, C.M.6
  • 93
    • 33846184701 scopus 로고    scopus 로고
    • Eslicarbazepine Acetate (BIA 2-093)
    • DOI 10.1016/j.nurt.2006.10.005, PII S1933721306001735, New Antiepileptic Drugs: Discovery, Development, and Update
    • Almeida L, Soares-da-Silva P. Eslicarbazepine acetate (BIA 2-093). Neurotherapeutics 2007;4:88-96 (Pubitemid 46107316)
    • (2007) Neurotherapeutics , vol.4 , Issue.1 , pp. 88-96
    • Almeida, L.1    Soares-da-Silva, P.2
  • 94
    • 0036161923 scopus 로고    scopus 로고
    • The novel anticonvulsant BIA 2-093 inhibits transmitter release during opening of voltage-gated sodium channels: A comparison with carbamazepine and oxcarbazepine
    • DOI 10.1016/S0197-0186(01)00101-2, PII S0197018601001012
    • Parada A, Soares-da-Silva P. The novel anticonvulsant BIA 2-093 inhibits transmitter release during opening of voltage-gated sodium channels: A comparison with carbamazepine and oxcarbazepine. Neurochem Int 2002;40:435-40 (Pubitemid 34121989)
    • (2002) Neurochemistry International , vol.40 , Issue.5 , pp. 435-440
    • Parada, A.1    Soares-Da-Silva, P.2
  • 95
    • 0141504128 scopus 로고    scopus 로고
    • Safety, tolerability and pharmacokinetic profile of BIA 2-093, a novel putative antiepileptic agent, during first administration to humans
    • DOI 10.2165/00126839-200304050-00001
    • Almeida L, Soares-da-Silva P. Safety, tolerability, and pharmacokinetics profile of BIA 2-093, a novel putative antiepileptic agent, during first administration to humans. Drugs 2003;4:269-84 (Pubitemid 37184388)
    • (2003) Drugs in R and D , vol.4 , Issue.5 , pp. 269-284
    • Almeida, L.1    Soares-da-Silva, P.2
  • 96
    • 3242768230 scopus 로고    scopus 로고
    • Safety, tolerability, and pharmacokinetic profile of BIA 2-093, a novel putative antiepileptic, in a rising multiple-dose study in young healthy humans
    • DOI 10.1177/0091270004267591
    • Almeida L, Soares-da-Silva P. Safety, tolerability, and pharmacokinetics profile of BIA 2-093, a novel putative antiepileptic, in a rising multiple-dose study in young healthy humans. J Clin Pharmacol 2004;44:906-18 (Pubitemid 38971573)
    • (2004) Journal of Clinical Pharmacology , vol.44 , Issue.8 , pp. 906-918
    • Almeida, L.1    Soares-Da-Silva, P.2
  • 97
    • 23944448566 scopus 로고    scopus 로고
    • Single-dose and steady-state pharmacokinetics of eslicarbazepine acetate (BIA 2-093) in healthy elderly and young subjects
    • DOI 10.1177/0091270005279364
    • Almeida L, Falcao A, Maia J, et al. Single-dose and steady-state pharmacokinetics of eslicarbazepine acetate (BIA 2-093) in healthy elderly and young subjects. J Clin Pharmacol 2005; 45:1062-6 (Pubitemid 41192366)
    • (2005) Journal of Clinical Pharmacology , vol.45 , Issue.9 , pp. 1062-1066
    • Almeida, L.1    Falcao, A.2    Maia, J.3    Mazur, D.4    Gellert, M.5    Soares-Da-Silva, P.6
  • 98
    • 4644301804 scopus 로고    scopus 로고
    • Progress report on new antiepileptic drugs: A summary of the Seventh Eilat Conference (EILAT VII)
    • DOI 10.1016/j.eplepsyres.2004.07.010, PII S0920121104001457
    • Bialer M, Johannessen SI, Kupferberg HJ, et al. Progress report on new antiepileptic drugs: A summary of the Seventh Eilat Conference (EILAT VII). Epilepsy Res 2004;61:1-48 (Pubitemid 39296697)
    • (2004) Epilepsy Research , vol.61 , Issue.1-3 , pp. 1-48
    • Bialer, M.1    Johannessen, S.I.2    Kupferberg, H.J.3    Levy, R.H.4    Perucca, E.5    Tomson, T.6
  • 100
    • 55749106790 scopus 로고    scopus 로고
    • Dosage form proportionality and food effect of the final tablet formulation of eslicarbazepine acetate: Randomized, ope-label, crossover, single-centre study in healthy volunteers
    • Fontes-Ribeiro C, Macedo T, Nunes T, et al. Dosage form proportionality and food effect of the final tablet formulation of eslicarbazepine acetate: Randomized, ope-label, crossover, single-centre study in healthy volunteers. Drugs R D 2008;9:447-54
    • (2008) Drugs R D , vol.9 , pp. 447-454
    • Fontes-Ribeiro, C.1    Macedo, T.2    Nunes, T.3
  • 101
    • 33644815864 scopus 로고    scopus 로고
    • Eslicarbazepine acetate (BIA 2- 093): Relative bioavailability and bioequivalence of 50 mg/ml oral suspension and 200 mg and 800 mg tablet formulations
    • Fontes-Ribeiro C, Macedo T, Falcao A, et al. Eslicarbazepine acetate (BIA 2- 093): Relative bioavailability and bioequivalence of 50 mg/ml oral suspension and 200 mg and 800 mg tablet formulations. Drugs R D 2005;6:253-60
    • (2005) Drugs R D , vol.6 , pp. 253-260
    • Fontes-Ribeiro, C.1    Macedo, T.2    Falcao, A.3
  • 102
    • 80051986999 scopus 로고    scopus 로고
    • Hepatic UDP-glucuronosyltransferase responsible for esclicarbazepine glucuronidation
    • Epub ahead of print]
    • Loureiro AI, Fernandes-Lopes C, Bonifacio MJ, et al. Hepatic UDP-glucuronosyltransferase responsible for esclicarbazepine glucuronidation. Drug Metab Dispos 2011; [Epub ahead of print]
    • (2011) Drug Metab. Dispos.
    • Loureiro, A.I.1    Fernandes-Lopes, C.2    Bonifacio, M.J.3
  • 103
    • 80052837786 scopus 로고    scopus 로고
    • Pharmacokinetics of eslicarbazepine acetate at steady-state in adults with partial-onset seizures
    • Perucca E, Elger C, Halasz P, et al. Pharmacokinetics of eslicarbazepine acetate at steady-state in adults with partial-onset seizures. Epilepsy Res 2011;96:132-9
    • (2011) Epilepsy Res. , vol.96 , pp. 132-139
    • Perucca, E.1    Elger, C.2    Halasz, P.3
  • 104
  • 105
    • 0025952283 scopus 로고
    • The influence of age on the pharmacokinetics of the antiepileptic agent oxcarbazepine
    • Van Heininggen PNM, Eve MD, Oosterhuis B, et al. The influence of age on the pharmacokinetics of the antiepileptic agent oxcarbazepine. Clin Pharmacol Ther 1991; 50:410-19
    • (1991) Clin. Pharmacol. Ther. , vol.50 , pp. 410-419
    • Van Heininggen, P.N.M.1    Eve, M.D.2    Oosterhuis, B.3
  • 106
    • 0028786903 scopus 로고
    • Clinical pharmacokinetics of antiepileptic drugs in pediatric patients. Part II. Phenytoin, carbamazepine, sulthiame, lamotrigine, vigabatrin, oxcarbazepine and felbamate
    • Battino D, Estienne M, AVanzini G. Clinical pharmacokinetics of antiepileptic drugs in pediatric patients. Part II. Phenytoin, carbamazepine, sulthiame, lamotrigine, vigabatrin, oxcarbazepine and felbamate. Clin Pharmacokinet 1995; 29:341-69
    • (1995) Clin. Pharmacokinet , vol.29 , pp. 341-369
    • Battino, D.1    Estienne, M.2    Avanzini, G.3
  • 109
    • 43049177758 scopus 로고    scopus 로고
    • Pharmacokinetics of eslicarbazepine acetate in patients with moderate hepatic impairment
    • Almeida L, Potgieter JH, Maia J, et al. Pharmacokinetics of eslicarbazepine acetate in patients with moderate hepatic impairment. Eur J Clin Pharmacol 2008; 64:267-73
    • (2008) Eur. J. Clin. Pharmacol. , vol.64 , pp. 267-273
    • Almeida, L.1    Potgieter, J.H.2    Maia, J.3
  • 110
    • 77955704455 scopus 로고    scopus 로고
    • Binding of licarbazepine enantiomers to mouse and human plasma proteins
    • Fortuna A, Alves G, Falcao A, et al. Binding of licarbazepine enantiomers to mouse and human plasma proteins. Biopharm Drug Dispos 2010; 31:362-6
    • (2010) Biopharm. Drug Dispos , vol.31 , pp. 362-366
    • Fortuna, A.1    Alves, G.2    Falcao, A.3
  • 111
    • 0025133374 scopus 로고
    • Protein binding of oxcarbazepine and its primary active metabolite, 10-hydroxycarbazepine, in patients with trigeminal neuralgia
    • Patsalos PN, Elyas AA, Zakrewska JM. Protein binding of oxcarbazepine and its primary active metabolite, 10-hydroxycarbamazepine, in patients with trigeminal neuralgia. Eur J Clin Pharmacol 1990; 39:413-15 (Pubitemid 20362358)
    • (1990) European Journal of Clinical Pharmacology , vol.39 , Issue.4 , pp. 413-415
    • Patsalos, P.N.1    Elyas, A.A.2    Zakrzewska, J.M.3
  • 112
    • 80053566885 scopus 로고    scopus 로고
    • In vitro transport profile of carbamazepine, oxcarbazepine, Eslicarbazepine acetate, and their active metabolites by human P-glycoprotein
    • Zhang C, Zuo Z, Kwan P, et al. In vitro transport profile of carbamazepine, oxcarbazepine, Eslicarbazepine acetate, and their active metabolites by human P-glycoprotein. Epilepsia 2011;52(10):1894-904
    • (2011) Epilepsia , vol.52 , Issue.10 , pp. 1894-904
    • Zhang, C.1    Zuo, Z.2    Kwan, P.3
  • 113
    • 76349100077 scopus 로고    scopus 로고
    • Population pharmacokinetics of eslicarbazepine acetate in adult patients with refractory partial seizures
    • Fuseau E, Fabre MA, Falcao A, et al. Population pharmacokinetics of eslicarbazepine acetate in adult patients with refractory partial seizures. Epilepsia 2008;49:432
    • (2008) Epilepsia , vol.49 , pp. 432
    • Fuseau, E.1    Fabre, M.A.2    Falcao, A.3
  • 115
    • 77749279921 scopus 로고    scopus 로고
    • Pharmacokinetic interaction study between eslicarbazepine acetate and lamotrigine in healthy subjects
    • Almeida L, Nunes T, Sicard E, et al. Pharmacokinetic interaction study between eslicarbazepine acetate and lamotrigine in healthy subjects. Acta Neurol Scand 2010; 121:257-64
    • (2010) Acta. Neurol. Scand. , vol.121 , pp. 257-264
    • Almeida, L.1    Nunes, T.2    Sicard, E.3
  • 116
    • 77952477242 scopus 로고    scopus 로고
    • Pharmacokinetic interaction study between eslicarbazepine acetate and topiramate in healthy subjects
    • Nunes T, Sicard E, Almeida L, et al. Pharmacokinetic interaction study between eslicarbazepine acetate and topiramate in healthy subjects. Curr Med Res Opin 2010; 26:1355-62
    • (2010) Curr. Med. Res. Opin. , vol.26 , pp. 1355-1362
    • Nunes, T.1    Sicard, E.2    Almeida, L.3
  • 117
    • 65549151370 scopus 로고    scopus 로고
    • Effect of eslicarbazepine acetate on the pharmacokinetics of metformin in healthy subjects
    • Rocha JF, Vaz-da-Silva M, Almeida L, et al. Effect of eslicarbazepine acetate on the pharmacokinetics of metformin in healthy subjects. Int J Clin Pharmacol Ther 2009;47:255-61
    • (2009) Int. J. Clin. Pharmacol. Ther. , vol.47 , pp. 255-261
    • Rocha, J.F.1    Vaz-Da-Silva, M.2    Almeida, L.3
  • 118
    • 68749086397 scopus 로고    scopus 로고
    • Effect of eslicarbazepine acetate on the pharmacokinetics of digoxin in healthy subjects
    • Vaz-da-Silva M, Costa R, Soares E, et al.Effect of eslicarbazepine acetate on the pharmacokinetics of digoxin in healthy subjects. Fundam Clin Pharmacol 2009;23:509-14
    • (2009) Fundam Clin. Pharmacol. , vol.23 , pp. 509-514
    • Vaz-Da-Silva, M.1    Costa, R.2    Soares, E.3
  • 119
    • 77952294567 scopus 로고    scopus 로고
    • Effect of eslicarbazepine acetate on the steady-state pharmacokinetics and pharmacodynamics of warfarin in healthy subjects during a three-stage open-label, multiple-dose, single-period study
    • Vaz-da-Silva M, Almeida L, Falcao A, et al. Effect of eslicarbazepine acetate on the steady-state pharmacokinetics and pharmacodynamics of warfarin in healthy subjects during a three-stage open-label, multiple-dose, single-period study. Clin Ther 2010;32:179-92
    • (2010) Clin. Ther. , vol.32 , pp. 179-192
    • Vaz-da-Silva, M.1    Almeida, L.2    Falcao, A.3
  • 120
    • 61849168486 scopus 로고    scopus 로고
    • Efficacy and safety of eslicarbazepine acetate as adjunctive treatment in adults with refractory partial-onset seizures: A randomized double-blind, placebo-controlled, parallel-group phase III study
    • Elger C, Halasz P, Maia J, et al. Efficacy and safety of eslicarbazepine acetate as adjunctive treatment in adults with refractory partial-onset seizures: A randomized double-blind, placebo-controlled, parallel-group phase III study. Epilepsia 2009;50:454-63
    • (2009) Epilepsia , vol.50 , pp. 454-463
    • Elger, C.1    Halasz, P.2    Maia, J.3
  • 121
    • 70349972675 scopus 로고    scopus 로고
    • Efficacy and safety of 800 and 1200 mg eslicarbazepine acetate as adjunctive treatment in adults with refractory partial-onset seizures
    • Gil-Nagel A, Lopes-Lima J, Almeida L, et al. Efficacy and safety of 800 and 1200 mg eslicarbazepine acetate as adjunctive treatment in adults with refractory partial-onset seizures. Acta Neurol Scand 2009;120:281-7
    • (2009) Acta. Neurol. Scand. , vol.120 , pp. 281-287
    • Gil-Nagel, A.1    Lopes-Lima, J.2    Almeida, L.3
  • 122
    • 77951297857 scopus 로고    scopus 로고
    • Eslicarbazepine acetate as adjunctive therapy in adult patients with partial epilepsy
    • Ben-Menachem E, Gabbai AA, Huffnagel A, et al. Eslicarbazepine acetate as adjunctive therapy in adult patients with partial epilepsy. Epilepsy Res 2010;89:278-85
    • (2010) Epilepsy Res. , vol.89 , pp. 278-285
    • Ben-Menachem, E.1    Gabbai, A.A.2    Huffnagel, A.3
  • 123
    • 33847611166 scopus 로고    scopus 로고
    • Eslicarbazepine acetate: A double-blind, add-on, placebo-controlled exploratory trial in adult patients with partial-onset seizures
    • DOI 10.1111/j.1528-1167.2007.00984.x
    • Elger C, Bialer M, Cramer JA, et al. Eslicarbazepine acetate: A double-blind, add-on, placebo-controlled exploratory trial in adult patients with partial-onset seizures. Epilepsia 2007;48:497-504 (Pubitemid 46365199)
    • (2007) Epilepsia , vol.48 , Issue.3 , pp. 497-504
    • Elger, C.1    Bialer, M.2    Cramer, J.A.3    Maia, J.4    Almeida, L.5    Soares-Da-Silva, P.6
  • 125
    • 84858669121 scopus 로고    scopus 로고
    • Evaluation of eslicarbazepine acetate on cardiac repolarisation in a thorough QT/QTc study
    • Epub ahead of print]
    • Vaz-da-Silva M, Nunes T, Almeida L, et al. Evaluation of eslicarbazepine acetate on cardiac repolarisation in a thorough QT/QTc study. J Clin Pharmacol 2011; [Epub ahead of print]
    • (2011) J. Clin. Pharmacol.
    • Vaz-da-Silva, M.1    Nunes, T.2    Almeida, L.3
  • 126
    • 84858647837 scopus 로고    scopus 로고
    • Physicians' Desk Reference. 5th edition Montvale NJ:
    • Physicians' Desk Reference. 5th edition. Medical Economics Co.; Montvale, NJ: 2001
    • (2001) Medical Economics Co.
  • 129
    • 80155168901 scopus 로고    scopus 로고
    • Novel medications for epilepsy
    • Fattore C, Perucca E. Novel medications for epilepsy. Drugs 2011;71:2151-78
    • (2011) Drugs , vol.71 , pp. 2151-2178
    • Fattore, C.1    Perucca, E.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.