Ionic mechanisms underlying cardiac toxicity of the organochloride solvent trichloromethane

Toxicology

Volumn 290, Issue 2-3, 2011, Pages 295-304

  Zhou, Yuan ^a   Wu, Hui Jun ^a   Zhang, Yan Hui ^a   Sun, Hai Ying ^a   Wong, Tak Ming ^a   Li, Gui Rong ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Arrhythmogenic effect; Cardiac toxicity; Multiple ion channel blockade; Trichloromethane; Ventricular fibrillation

Indexed keywords

CHLOROFORM; POTASSIUM; SODIUM CHANNEL NAV1.5;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRADYCARDIA; CARDIOTOXICITY; HEART CONDUCTION; HEART ELECTROPHYSIOLOGY; HEART MUSCLE FIBER MEMBRANE POTENTIAL; IC 50; ION TRANSPORT; MALE; NONHUMAN; POTASSIUM CURRENT; PRIORITY JOURNAL; RAT;

RATTUS;

EID: 84858619354     PISSN: 0300483X     EISSN: 18793185     Source Type: Journal    
DOI: 10.1016/j.tox.2011.10.009     Document Type: Article

References (38)

1. Antzelevitch C., Yan G.X., Shimizu W. Transmural dispersion of repolarization and arrhythmogenicity: the Brugada syndrome versus the long QT syndrome. J. Electrocardiol. 1999, 32(Suppl):158-165.
2. Barbuti A., DiFrancesco D. Control of cardiac rate by " funny" channels in health and disease. Ann. N. Y. Acad. Sci. 2008, 1123:213-223.
3. Bezzina C., Veldkamp M.W., van Den Berg M.P., Postma A.V., Rook M.B., Viersma J.W., et al. A single Na(+) channel mutation causing both long-QT and Brugada syndromes. Circ. Res. 1999, 85(12):1206-1213.
4. Brock W.J., Rusch G.M., Trochimowicz H.J. Cardiac sensitization: methodology and interpretation in risk assessment. Regul. Toxicol. Pharmacol. 2003, 38(1):78-90.
5. Cao C.M., Chen M., Wong T.M. The K(Ca) channel as a trigger for the cardioprotection induced by kappa-opioid receptor stimulation - its relationship with protein kinase C. Br. J. Pharmacol. 2005, 145(7):984-991.
6. Gao Z., Lau C.P., Wong T.M., Li G.R. Protein tyrosine kinase-dependent modulation of voltage-dependent potassium channels by genistein in rat cardiac ventricular myocytes. Cell Signal. 2004, 16(3):333-341.
7. Hayashi Y., Sumikawa K., Yamatodani A., Kamibayashi T., Kuro M., Yoshiya I. Myocardial epinephrine sensitization with subanesthetic concentrations of halothane in dogs. Anesthesiology 1991, 74(1):134-137.
8. Himmel H.M. Mechanisms involved in cardiac sensitization by volatile anesthetics: general applicability to halogenated hydrocarbons?. Crit. Rev. Toxicol. 2008, 38(9):773-803.
9. Jiao Z., De Jesus V.R., Iravanian S., Campbell D.P., Xu J., Vitali J.A., et al. A possible mechanism of halocarbon-induced cardiac sensitization arrhythmias. J. Mol. Cell. Cardiol. 2006, 41(4):698-705.
10. Lessard Y., Desbrousses S., Paulet G. [Cardiac arrhythmia in dogs under the action of adrenaline and difluorodichloromethane (FC 12)]. C. R. Seances Soc. Biol. Fil. 1977, 171(6):1270-1282.
11. Levy A.G. Sudden death under light trichloromethane anesthesia. Int. J. Physiol. 1911, 43(3):3-7.
12. Li G.R., Lau C.P., Ducharme A., Tardif J.C., Nattel S. Transmural action potential and ionic current remodeling in ventricles of failing canine hearts. Am. J. Physiol. Heart Circ. Physiol. 2002, 283(3):H1031-H1041.
13. Li G.R., Lau C.P., Leung T.K., Nattel S. Ionic current abnormalities associated with prolonged action potentials in cardiomyocytes from diseased human right ventricles. Heart Rhythm 2004, 1(4):460-468.
14. Li G.R., Lau C.P., Shrier A. Heterogeneity of sodium current in atrial vs epicardial ventricular myocytes of adult guinea pig hearts. J. Mol. Cell. Cardiol. 2002, 34(9):1185-1194.
15. Li G.R., Yang B., Feng J., Bosch R.F., Carrier M., Nattel S. Transmembrane ICa contributes to rate-dependent changes of action potentials in human ventricular myocytes. Am. J. Physiol. 1999, 276(1 Pt 2):H98-H106.
16. Liu H., Sun H.Y., Lau C.P., Li G.R. Regulation of voltage-gated cardiac sodium current by epidermal growth factor receptor kinase in guinea pig ventricular myocytes. J. Mol. Cell. Cardiol. 2007, 42(4):760-768.
17. Liu H., Yang L., Jin M.W., Sun H.Y., Huang Y., Li G.R. The selective estrogen receptor modulator raloxifene inhibits cardiac delayed rectifier potassium currents and voltage-gated sodium current without QTc interval prolongation. Pharmacol. Res. 2010, 62(5):384-390.
18. Meichsner K., Lessig R., Muller K., Wehran H.J. Suicidal trichloromethane poisoning. Arch. Kriminol. 1998, 201(1-2):21-23.
19. Milanesi R., Baruscotti M., Gnecchi-Ruscone T., DiFrancesco D. Familial sinus bradycardia associated with a mutation in the cardiac pacemaker channel. N. Engl. J. Med. 2006, 354(2):151-157.
20. Muller S.P., Wolna P., Wunscher U., Pankow D. Cardiotoxicity of chlorodibromomethane and trichloromethane in rats and isolated rat cardiac myocytes. Arch. Toxicol. 1997, 71(12):766-777.
21. Nadjem H., Logemann E. A case of suicidal trichloromethane poisoning. Arch. Kriminol. 1998, 202(1-2):29-37.
22. Payne J.P. Trichloromethane in clinical anaesthesia. Br. J. Anaesth. 1981, 53(Suppl 1):11S-15S.
23. Risse M., Erdmann F., Schutz H., Weiler G. Multiple homicides as a result of trichloromethane poisoning: case report and experimental study. Forensic Sci. Int. 2001, 124(2-3):209-213.
24. Roden D.M., Balser J.R., George A.L., Anderson M.E. Cardiac ion channels. Annu. Rev. Physiol. 2002, 64:431-475.
25. Scholz E.P., Alter M., Zitron E., Kiesecker C., Kathofer S., Thomas D., et al. In vitro modulation of HERG channels by organochlorine solvent trichlormethane as potential explanation for proarrhythmic effects of trichloromethane. Toxicol. Lett. 2006, 165(2):156-166.
26. Schott J.J., Alshinawi C., Kyndt F., Probst V., Hoorntje T.M., Hulsbeek M., et al. Cardiac conduction defects associate with mutations in SCN5A. Nat. Genet. 1999, 23(1):20-21.
27. Schroeder H.G. Acute and delayed trichloromethane poisoning. A case report. Br. J. Anaesth. 1965, 37(12):972-975.
28. Takahara A., Sugiyama A., Hashimoto K. Reduction of repolarization reserve by halothane anaesthesia sensitizes the guinea-pig heart for drug-induced QT interval prolongation. Br. J. Pharmacol. 2005, 146(4):561-567.
29. Tang Q., Li Z.Q., Li W., Guo J., Sun H.Y., Zhang X.H., et al. The 5-HT2 antagonist ketanserin is an open channel blocker of human cardiac ether-a-go-go-related gene (hERG) potassium channels. Br. J. Pharmacol. 2008, 155(3):365-373.
30. Trochimowicz H.J., Reinhardt C.F., Mullin L.S., Azar A., Karrh B.W. The effect of myocardial infarction on the cardiac sensitization potential of certain halocarbons. J. Occup. Med. 1976, 18(1):26-30.
31. Van de Water A., Verheyen J., Xhonneux R., Reneman R.S. An improved method to correct the QT interval of the electrocardiogram for changes in heart rate. J. Pharmacol. Methods 1989, 22(3):207-217.
32. Vinegar A. Modeling cardiac sensitization potential of humans exposed to Halon 1301 or Halon 1211 aboard aircraft. Aviat. Space Environ. Med. 2001, 72(10):928-936.
33. Wang D.W., Makita N., Kitabatake A., Balser J.R., George A.L. Enhanced Na(+) channel intermediate inactivation in Brugada syndrome. Circ. Res. 2000, 87(8):E37-E43.
34. Wang D.W., Viswanathan P.C., Balser J.R., George A.L., Benson D.W. Clinical, genetic, and biophysical characterization of SCN5A mutations associated with atrioventricular conduction block. Circulation 2002, 105(3):341-346.
35. Weigt H.U., Kwok W.M., Rehmert G.C., Turner L.A., Bosnjak Z.J. Voltage-dependent effects of volatile anesthetics on cardiac sodium current. Anesth. Analg. 1997, 84(2):285-293.
36. Whitaker A.M., Jones C.S. Report of 1500 trichloromethane anesthetics administered with a precision vaporizer. Anesth. Analg. 1965, 44:60-65.
37. Zhang D.Y., Lau C.P., Li G.R. Human Kir2.1 channel carries a transient outward potassium current with inward rectification. Pflugers Arch. 2009, 457(6):1275-1285.
38. Zhang D.Y., Wang Y., Lau C.P., Tse H.F., Li G.R. Both EGFR kinase and Src-related tyrosine kinases regulate human ether-a-go-go-related gene potassium channels. Cell Signal. 2008, 20(10):1815-1821.