In vitro modulation of HERG channels by organochlorine solvent trichlormethane as potential explanation for proarrhythmic effects of chloroform

Toxicology Letters

Volumn 165, Issue 2, 2006, Pages 156-166

  Scholz, Eberhard P ^a   Alter, Markus ^a   Zitron, Edgar ^a   Kiesecker, Claudia ^a   Kathöfer, Sven ^a   Thomas, Dierk ^a   Kreye, Volker A W ^a   Kreuzer, Jörg ^c   Becker, Rüdiger ^a   Katus, Hugo A ^a   Greten, Johannes ^b   Karle, Christoph A ^a  

^a UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^b Deutsche Gesellschaft für Traditionelle Chinesische Medizin ^*  (Germany)

^c Gait Lab Social Pediatric Centre Children's Clinic St Vincenz Hospital   (Germany)

Author keywords

Arrhythmia; Chloroform; HERG channel; Intoxication; Potassium channels; Trichlormethane

Indexed keywords

CHLOROFORM; ORGANOCHLORINE DERIVATIVE; POTASSIUM CHANNEL HERG; SOLVENT;

ANIMAL CELL; ARRHYTHMOGENESIS; ARTICLE; CELL LINE; CONTROLLED STUDY; ELECTROPHYSIOLOGY; EMBRYO; HEART PROARRHYTHMIA; HUMAN; HUMAN CELL; IC 50; INTOXICATION; MEMBRANE CURRENT; MEMBRANE POTENTIAL; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; OOCYTE; PATCH CLAMP; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; STEADY STATE; VOLTAGE CLAMP; XENOPUS;

ANIMALS; CELL LINE; CHLOROFORM; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHER-A-GO-GO POTASSIUM CHANNELS; FEMALE; KIDNEY; MEMBRANE POTENTIALS; OOCYTES; PATCH-CLAMP TECHNIQUES; SOLVENTS; TACHYCARDIA, VENTRICULAR; XENOPUS LAEVIS;

EID: 33745197763     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2006.03.004     Document Type: Article

References (29)

1. Carmeliet E. Mechanisms and control of repolarization. Eur. Heart J. Suppl. H (1993) 3-13
2. Correan A.M. Gating kinetics of shaker K+ channels are differentially modified by general anesthetics. Am. J. Physiol. 275 4 (1998) C1009-C1021
3. Curran M.E., Splawski I., Timothy K.W., Vincent G.M., Green E.D., and Keating M.T. A molecular basis for cardiac arrhythmia: HERG mutations cause long QT-syndrome. Cell 80 (1995) 795-803
4. Fujikawa H., Sato Y., Arakawa H., Mitsuhashi T., Minezaki K., Kuroki S., Sekiguchi H., Nakayama T., Ikeda U., and Shimada K. Induction of torsades de pointes by dobutamine infusion in a patient with idiopathic long QT syndrome. Intern. Med. 37 2 (1998) 149-152
5. Hutchens K.S., and Kung M. "Experimentation" with chloroform. Am. J. Med. 78 4 (1985) 715-718
6. Kiehn J., Lacerda A.E., Wible B., and Brown A.M. Molecular physiology and pharmacology of HERG. Single-channel currents and block by dofetilide. Circulation 94 10 (1996) 2572-2579
7. Kiehn J., Lacerda A.L., and Brown A.M. Pathways of HERG inactivation. Am. J. Physiol. 277 (1999) H199-H210
8. Kim N.Y., Park S.W., and Suh J.K. Two fatal cases of dichloromethane or chloroform poisoning. J. Forensic Sci. 41 3 (1996) 527-529
9. Knight III P.R., and Bacon D.R. An unexplained death: Hannah Greener and chloroform. Anesthesiology 96 5 (2002) 1250-1253
10. Madeja M., Musshoff U., and Speckmann E.J. Follicular tissues reduce drug effects on ion channels in oocytes of Xenopus laevis. Eur. J. Neurosci. 9 (1997) 599-604
11. Meichsner K., Lessig R., Muller K., and Wehran H.J. Suicidal chloroform poisoning. Arch. Kriminol. 201 1-2 (1998) 21-23
12. Muller S.P., Wolna P., Wunscher U., and Pankow D. Cardiotoxicity of chlorodibromomethane and trichloromethane in rats and isolated rat cardiac myocytes. Arch. Toxicol. 71 12 (1997) 766-777
13. Nadjem H., and Logemann E. A case of suicidal chloroform poisoning. Arch. Kriminol. 202 1-2 (1998) 29-37
14. Nashelsky M.B., Dix J.D., and Adelstein E.H. Homicide facilitated by inhalation of chloroform. J. Forensic Sci. 40 1 (1995) 134-138
15. Priori S.G., Napolitano C., Paganini V., Cantu F., and Schwartz P.J. Molecular biology of the long QT syndrome: impact on management. Pacing Clin. Electrophysiol. 20 8 Pt 2 (1997) 2052-2057
16. Redfern W.S., Carlsson L., Davis A.S., Lynch W.G., MacKenzie I., Palethorpe S., Siegl P.K., Strang I., Sullivan A.T., Wallis R., Camm A.J., and Hammond T.G. Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development. Cardiovasc. Res. 58 (2003) 32-45
17. Risse M., Erdmann F., Schutz H., and Weiler G. Multiple homicides as a result of chloroform poisoning: case report and experimental study. Forensic Sci. Int. 124 2-3 (2001) 209-213
18. Roden D.M., Balser J.R., George Jr. A.L., and Anderson M.E. Cardiac ion channels. Annu. Rev. Physiol. 64 (2002) 431-475
19. r potassium channel. Cell 81 (1995) 1-20
20. Sanguinetti M.C., Curran M.E., Spector P.S., and Keating M.T. Spectrum of HERG K+-channel dysfunction in an inherited cardiac arrhythmia. Proc. Natl. Acad. Sci. U.S.A. 93 5 (1996) 2208-2212
21. Scholz E.P., Zitron E., Kiesecker C., Lueck S., Kathofer S., Thomas D., Weretka S., Peth S., Kreye V.A., Schoels W., Katus H.A., Kiehn J., and Karle C.A. Drug binding to aromatic residues in the HERG channel pore cavity as possible explanation for acquired long QT syndrome by antiparkinsonian drug budipine. Naunyn. Schmiedebergs Arch. Pharmacol. 368 (2003) 404-414
22. Stevens R., Rüsch D., Solt K., Raines D.E., and Davies PA. Modulation of human 5-hydroxytryptamine type 3ab receptors by volatile anesthetics and n-alcohols. J. Pharmacol. Exp. Ther. 315 2 (2005) 771-776
23. Storms W.W. Chloroform parties. JAMA 225 2 (1973) 160
24. Trochimowicz H.J., Reinhardt C.F., Mullin L.S., Azar A., and Karrh B.W. The effect of myocardial infarction on the cardiac sensitization potential of certain halocarbons. J. Occup. Med. 18 1 (1976) 26-30
25. Trudeau M.C., Warmke J.W., Ganetzky B., and Robertson G.A. HERG, a human inward rectifier in the voltage-gated potassium channel family. Science 269 5220 (1995) 92-95
26. Vendura K., Strauch H., Pragst F., and Prugel M. Fatal chloroform poisoning with subsequent crime. Arch. Kriminol. 198 3-4 (1996) 83-88
27. Viskin S. Long QT syndromes and torsade de pointes. Lancet 354 9190 (1999) 1625-1633
28. Vos M.A., vanOpstal J.M., Leunissen D.M., and Verduyn S.C. Electrophysiologic parameters and predisposing factors in the generation of drug-induced Torsade de Pointes arrhythmias. Pharm. Ther. 92 (2001) 109-122
29. Wawersik J. History of chloroform anesthesia. Anaesthesiol. Reanim. 22 6 (1997) 144-152