The vital role of polymerase ζ and REV1 in mutagenic, but not correct, DNA synthesis across Benzo[a]pyrene-dG and recruitment of polymerase ζ by REV1 to replication-stalled site

Journal of Biological Chemistry

Volumn 287, Issue 12, 2012, Pages 9613-9622

  Hashimoto, Keiji ^a   Cho, Youngjin ^a   Yang, In Young ^a   Akagi, Jun Ichi ^b,f   Ohashi, Eiji ^c,g   Tateishi, Satoshi ^d   De Wind, Niels ^e   Hanaoka, Fumio ^b   Ohmori, Haruo ^c   Moriya, Masaaki ^a  

^a STONY BROOK UNIVERSITY   (United States)

^b GAKUSHUIN UNIVERSITY   (Japan)

^c KYOTO UNIVERSITY   (Japan)

^d KUMAMOTO UNIVERSITY   (Japan)

^e LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^f NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

^g KYUSHU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BENZO [A] PYRENE; C TERMINUS; CATALYTIC SUBUNITS; COMPLEX PROCESSES; DNA LESIONS; DNA SYNTHESISS; MAMMALIAN CELLS; MISCODING FREQUENCY; MOUSE EMBRYONIC FIBROBLASTS; TRANSLESION SYNTHESIS; WILD TYPES;

CELL CULTURE; DNA; GENES; GENETIC ENGINEERING; MAMMALS; NUCLEOTIDES; POLYMERS;

SEEBECK EFFECT;

BENZO[A]PYRENE; COMPLEMENTARY DNA; DNA DIRECTED DNA POLYMERASE DELTA; DNA POLYMERASE RAD 18; DNA POLYMERASE REV1; DNA POLYMERASE REV1C; DNA POLYMERASE REV3; DNA POLYMERASE REV7; GUANINE; TYROSINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DNA ADDUCT; DNA SYNTHESIS; EMBRYO; ENZYME ACTIVITY; FIBROBLAST; GENE; GENE EXPRESSION REGULATION; HUMAN; MOUSE; MUTAGENIC ACTIVITY; NONHUMAN; PLASMID; POLK POLH POLI GENE; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; REV1 GENE; REV3L GENE; RNA TRANSLATION; VIRUS REPLICATION;

7,8-DIHYDRO-7,8-DIHYDROXYBENZO(A)PYRENE 9,10-OXIDE; AMINO ACID SEQUENCE; ANIMALS; CELL CYCLE PROTEINS; DEOXYGUANOSINE; DNA ADDUCTS; DNA DAMAGE; DNA REPLICATION; DNA-BINDING PROTEINS; DNA-DIRECTED DNA POLYMERASE; HUMANS; MICE; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA; MUTAGENESIS; MUTATION; NUCLEAR PROTEINS; NUCLEOTIDYLTRANSFERASES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEINS; SEQUENCE ALIGNMENT;

MAMMALIA;

EID: 84858608663     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.331728     Document Type: Article

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