Mesenchymal stem cells with rhBMP-2 inhibits the growth of canine osteosarcoma cells

BMC Veterinary Research

Volumn 8, Issue , 2012, Pages

  Grassi Rici, Rose E ^a   Alcântara, Dayane ^a   Fratini, Paula ^a   Wenceslau, Cristiane V ^b   Ambrósio, Carlos E ^a   Miglino, Maria A ^a   Maria, Durvanei A ^c  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b University Center of the Octavio Bastos Educational Foundation   (Brazil)

^c INSTITUTO BUTANTAN   (Brazil)

Author keywords

Canine; Mesenchymal stem cell; Osteosarcoma; rhBMP 2

Indexed keywords

CD59 ANTIGEN; COMPLEMENT; DECAY ACCELERATING FACTOR; GLYCOPROTEIN; IMMEDIATE EARLY PROTEIN; MEMBRANE COFACTOR PROTEIN; MEMBRANE PROTEIN; RNA BINDING PROTEIN; US11 PROTEIN, HERPESVIRUS; US2 PROTEIN, VARICELLOVIRUS; US3 PROTEIN, CYTOMEGALOVIRUS; US6 PROTEIN, HUMAN CYTOMEGALOVIRUS; VIRUS ENVELOPE PROTEIN; VIRUS PROTEIN; BMP2 PROTEIN, HUMAN; BONE MORPHOGENETIC PROTEIN 2; RECOMBINANT PROTEIN;

ARTICLE; CELL CULTURE; CELL ENGINEERING; CYTOLOGY; CYTOMEGALOVIRUS; GENE VECTOR; GENETIC TRANSDUCTION; GENETICS; HUMAN; IMMUNOLOGY; MESENCHYMAL STROMA CELL; METABOLISM; METHODOLOGY; ANIMAL; BONE MARROW CELL; CELL PROLIFERATION; COCULTURE; DOG; GENE EXPRESSION REGULATION; MESENCHYMAL STEM CELL; OSTEOSARCOMA; PHYSIOLOGY; TUMOR CELL LINE;

ANTIGENS, CD46; ANTIGENS, CD55; ANTIGENS, CD59; CELL ENGINEERING; CELLS, CULTURED; COMPLEMENT SYSTEM PROTEINS; CYTOMEGALOVIRUS; GENETIC VECTORS; GLYCOPROTEINS; HUMANS; IMMEDIATE-EARLY PROTEINS; MEMBRANE PROTEINS; MESENCHYMAL STROMAL CELLS; RNA-BINDING PROTEINS; TRANSDUCTION, GENETIC; VIRAL ENVELOPE PROTEINS; VIRAL PROTEINS; ANIMALS; BONE MARROW CELLS; BONE MORPHOGENETIC PROTEIN 2; CELL LINE, TUMOR; CELL PROLIFERATION; COCULTURE TECHNIQUES; DOGS; GENE EXPRESSION REGULATION, NEOPLASTIC; MESENCHYMAL STEM CELLS; OSTEOSARCOMA; RECOMBINANT PROTEINS;

ANIMALIA;

EID: 84858442887     PISSN: None     EISSN: 17466148     Source Type: Journal    
DOI: 10.1186/1746-6148-8-17     Document Type: Article

References (34)

1. Heckler MCT, Fruet CL, Freitas GC, Montoya MAM. Osteossarcoma canino relato de caso. Anclivepa Anais do XXV Congresso de Clínicos Veterinárias de pequenos Animais 2004, 66. Gramado.
2. Fossum TW, Hedlund CS, Hulse DA, Johnson AL, Seim HB, Willard MD, Carroll GL. Outras doenças ósseas e articulares. Cirurgia de Pequenos Animais 2001, 1115-1137. São Paulo: Roca, Fossum TW.
3. Johnson KA, Watson ADJ. Doenças esqueléticas. Tratado de Medicina Interna Veterinária: Doenças Do Cão E Do Gato 2004, 2:1988-2019. Rio de Janeiro: Guanabara Koogan, Ettinger SJ, Feldman EC, 5.
4. Kleiner JA, Silva EG. Tumores ósseos em pequenos animais. Rev Científica de Med Veterinária Pequenos Animais e Animais de Estimação 2003, 1:193-200.
5. Pool RR. Tumors of bone and cartilage. Tumors of domestic animals 1990, 157-230. Berkeley: University of California Press, Moulton JE, 3.
6. Daleck CR, Fonseca CS, Canola JL. Osteossarcoma canino - revisão. Rev de Educação Contínua 2002, 5:233-242.
7. Oya N, Kokubo M, Mizowaki T, Shibamoto Y, Nagata Y, Sasai K, Nishimura Y, Tsuboyama T, Toguchida J, Nakamura T, Hiraoka M. Definitive intraoperative very high-dose radiotherapy for localized osteosarcoma in the extremities. Int J Radiat Oncol Biol Phys 2001, 51:87-93.
8. Withrow SJ, Powers BE, Straw RC, Wilkins RM. Comparative aspects of osteosarcoma: dog versus man. Clin Orthop Relat Res 1991, 270:159-168.
9. Silveira PR, Daleck CR, Eurides D, Silva LAF, Repetti CSF, Nardi AB. Estudo retrospectivo de osteossarcoma apendicular em cães. Ciência Animal Bras 2008, 9:487-495. 3281110, 22359665.
10. Eichhorn ME, Kleespies A, Angele MK, Jauch KW, Bruns CJ. Angiogenesis in cancer: molecular mechanisms, clinical impact. Langenbeck's Arch Surgery 2007, 392:371-379. 10.1007/s00423-007-0150-0, 22349237.
11. Urist MR. Bone: formation by autoinduction. Science 1965, 150:893-899. 10.1126/science.150.3698.893, 5319761.
12. Wang EA. Bone morphogenetic proteins (BMPs): therapeutic potential in healing bony defects. Trends Biotechnol 1993, 11:379-383. 10.1016/0167-7799(93)90096-R, 7764084.
13. Wozney JM. The bone morphogenetic protein family and osteogenesis. Mol Reprod Dev 1992, 32:160-167. 10.1002/mrd.1080320212, 1637554.
14. Reddi AH. Bone and cartilage differentiation. Curr Opin Genet Dev 1994, 4:737-744. 10.1016/0959-437X(94)90141-O, 7849513.
15. Vukicevic S, Luyten FP, Reddi AH. Stimulation of the expression of osteogenic and chondrogenic phenotypes in vitr by osteogenin. Proc Natl Acad Sci USA 1989, 86:8793-8797. 10.1073/pnas.86.22.8793, 298376, 2554330.
16. Beck SE, Jung BH, Fiorino A, Gomez J, Rosario ED, Cabrera BL. Bone morphogenetic protein signaling and growth suppression in colon cancer. Am J Physiol Gastrointest Liver Physiol 2006, 291:135-145.
17. Kawamura C, Kizaki M, Yamato K, Uchida H, Fukuchi Y, Hattori Y. Bone morphogenetic protein- 2 induces apoptosis in human myeloma cells with modulation of STAT3. Blood 2000, 96:2005-2011.
18. Wen X-Z, Miyake S, Akiyama Y, Yuasa Y. BMP-2 modulates the proliferation and differentiation of normal and cancerous gastric cells. BBRC 2004, 316:100-106.
19. Piccirillo SG, Reynolds BA, Zanetti N, Lamorte G, Binda E, Broggi G. Bone morphogenetic proteins inhibit the tumorigenic potential of human brain tumour-initiating cells. Nature 2006, 444:761-765. 10.1038/nature05349, 17151667.
20. Murakami N, Saito N, Horiuchi H, Okada T, Nozaki K, Takaoka K. Repair of segmental defects in rabbit humeri with titanium fiber mesh cylinders containing recombinant human bone morphogenetic protein-2 (rhBMP-2) and a synthetic polymer. J Biomed Mater Res 2002, 62:169-174. 10.1002/jbm.10236, 12209936.
21. Chang SC, Chuang HL, Chen YR, Chen JK, Chung HY, Lu YL, Lin HY, Tai CL, Lou J. Ex vivo gene therapy in autologous bone marrow stromal stem cells for tissueengineered maxillofacial bone regeneration?. Gene Ther 2003, 10:2013-2019. 10.1038/sj.gt.3302106, 14566360.
22. Sandhu HS. Bone morphogenic proteins and spine surgery. Spine 2003, 28(15S):S64-S73. 10.1097/00007632-200308011-00012, 12897477.
23. Wang L, Park P, Zhang H, La Marca F, Claeson A, Valdivia J, Lin CY. rhBMP-2 inhibits the tumorigenicity of cancer stem cells in human osteosarcoma OS99-1 cell line. Cancer Biol Therapy 2011, 11:457-463.
24. Hardwick JC, Van Den Brink GR, Bleuming SA, Ballester I, Van Den Brande JM, Keller JJ, Offerhaus GJ, Van Deventer SJ, Peppelenbosch MP. Bone morphogenetic protein 2 is expressed by, and acts upon, mature epithelial cells in the colon. Gastroenterology 2004, 126:111-121. 10.1053/j.gastro.2003.10.067, 14699493.
25. Brubaker KD, Corey E, Brown LG, Vessella RL. Bone morphogenetic protein signaling in prostate cancer cell lines. J Cell Biochem 2004, 91:151-160. 10.1002/jcb.10679, 14689587.
26. Eliseev RA, Dong Y-F, Sampson E, Zuscik MJ, Schwarz EM, O'Keefe RJ, Rosier RN, Drissi MH. Runx2-mediated activation of the Bax gene increases osteosarcoma cell sensitivity to apoptosis. Oncogene 2008, 27:3605-3614. 10.1038/sj.onc.1211020, 18223689.
27. Hsu MY, Rovinsky S, Penmatcha S, Herlyn M, Muirhead D. Bone morphogenetic protein in melanoma: angel or devil?. Cancer Metastasis Rev 2005, 24:251-263. 10.1007/s10555-005-1575-y, 15986135.
28. Ben-Porath I, Thomson MW, Carey VJ, Ge R, Bell GW, Regev A, Weinberg RA. An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors. Nat Genet 2008, 40:499-507. 10.1038/ng.127, 2912221, 18443585.
29. Santagata S, Ligon KL, Hornick JL. Embryonic stem cell transcription factor signatures in the diagnosis ofvprimary and metastatic germ cell tumors. Am J Surg Pathol 2007, 31:836-845. 10.1097/PAS.0b013e31802e708a, 17527070.
30. Kuznetsov S. Gehron Robey P: Species differences in growth requirements for bone marrow stromal fibroblast colony formation in vitr. Calcif Tissue Int 1996, 59:265-270. 10.1007/s002239900121, 8781050.
31. Abe E, Yamamoto M, Taguchi Y, Lecka-Czernik B, O'Brien CA, Economides AN, Stahl N, Jilka RL, Manolagas SC. Essential requirement of BMPs-2/4 for both osteoblast and osteoclast formation in murine bone marrow cultures from adult mice: antagonism by noggin. J Bone Miner Re 2000, 15:663-673.
32. Gronthos S, Graves SE, Ohta S, Simmons PJ. The STRO- 1 fraction of adult human bone marrow contains the osteogenic precursors. Blood 1994, 84:4164-4173.
33. Mitchell JB, McIntosh K, Zvonic S, et al. Immunophenotype of human adipose-derived ells: Temporal changes in stromal-associated and stem cell-associated markers. Stem Cells 2006, 24:376-385. 10.1634/stemcells.2005-0234, 16322640.
34. Langenfeld EM, Bojnowski J, Perone J, Langenfeld J. Expression of bone morphogenetic proteins in human lung carcinomas. Ann Thorac Surg 2005, 80:1028-1032. 10.1016/j.athoracsur.2005.03.094, 16122479.