Inhibiting glycine transporter-1 facilitates cocaine-cue extinction and attenuates reacquisition of cocaine-seeking behavior

Drug and Alcohol Dependence

Volumn 122, Issue 1-2, 2012, Pages 119-126

  Nic Dhonnchadha, Bríd Á ^a   Pinard, Emmanuel ^c   Alberati, Daniela ^c   Wettstein, Joseph G ^c   Spealman, Roger D ^b   Kantak, Kathleen M ^a  

^a BOSTON UNIVERSITY   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

Cocaine seeking behavior; Cognitive enhancer; Extinction training; Glycine transporter 1 inhibitor; Relapse

Indexed keywords

[1 (4 FLUORO PHENYL) 8 [2 (4 FLUORO PHENYL) 2 HYDROXY CYCLOHEXYL] 1,3,8 TRIAZA SPIRO[4.5]DECAN 4 ONE]; DRUGS USED IN THE TREATMENT OF ADDICTION; GLYCINE TRANSPORTER 1; RO 4543338; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASSOCIATION; COCAINE DEPENDENCE; CONTROLLED STUDY; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG MECHANISM; DRUG SEEKING BEHAVIOR; INTRAVENOUS DRUG ABUSE; LEARNING; MALE; NONHUMAN; OUTCOME ASSESSMENT; PHOTOSTIMULATION; PRIORITY JOURNAL; RAT; REINFORCEMENT; TREATMENT RESPONSE;

ANIMALS; COCAINE; CONDITIONING, OPERANT; CUES; DOPAMINE UPTAKE INHIBITORS; DRUG-SEEKING BEHAVIOR; EXTINCTION, PSYCHOLOGICAL; GLYCINE PLASMA MEMBRANE TRANSPORT PROTEINS; IMIDAZOLIDINES; MALE; RATS; RATS, WISTAR; SELF ADMINISTRATION; SPIRO COMPOUNDS;

RATTUS;

EID: 84858440227     PISSN: 03768716     EISSN: 18790046     Source Type: Journal    
DOI: 10.1016/j.drugalcdep.2011.09.017     Document Type: Article

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