Functional 'glial' GLYT1 glycine transporters expressed in neurons

Journal of Neurochemistry

Volumn 114, Issue 3, 2010, Pages 647-653

  Raiteri, Luca ^a   Raiteri, Maurizio ^a  

^a UNIVERSITY OF GENOA   (Italy)

Author keywords

conditional knockout mice; glycine transporters; glycine glutamate interactions; neuronal glycine transporter 1; NMDA receptors; schizophrenia

Indexed keywords

GLUTAMIC ACID; GLYCINE TRANSPORTER 1; GLYCINE TRANSPORTER 2; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; GLYCINE; GLYCINE TRANSPORTER; SLC6A9 PROTEIN, MOUSE;

ANIMAL TISSUE; ASTROCYTE; CELLULAR DISTRIBUTION; COGNITION; CONFOCAL MICROSCOPY; GLIA CELL; IMMUNOHISTOCHEMISTRY; KNOCKOUT MOUSE; MOLECULAR INTERACTION; MOUSE; NERVE ENDING; NEUROMODULATION; NEUROTRANSMITTER RELEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; SCHIZOPHRENIA; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; CENTRAL NERVOUS SYSTEM; CYTOLOGY; GENETICS; GLIA; HUMAN; METABOLISM; NERVE CELL; PHYSIOLOGY;

ANIMALIA; MUS;

ANIMALS; CENTRAL NERVOUS SYSTEM; GLYCINE; GLYCINE PLASMA MEMBRANE TRANSPORT PROTEINS; HUMANS; MICE; MICE, KNOCKOUT; NEUROGLIA; NEURONS;

EID: 77954342341     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2010.06802.x     Document Type: Review

References (57)

1. Aragón C. López-Corcuera B. (2005) Glycine transporters: crucial roles of pharmacological interest revealed by gene deletion. Trends Pharmacol. Sci. 26, 283 286.
2. Attwell D. Bouvier M. (1992) Cloners quick on the uptake. Curr. Biol. 2, 541 543.
3. Aubrey K. R., Vandenberg R. J. Clements J. D. (2005) Dynamics of forward and reverse transport by the glial glycine transporter, Glyt1b. Biophys. J. 89, 1657 1668.
4. Aubrey K. R., Rossi F. M., Ruivo R., Alboni S., Bellenchi G. C., Le Goff A., Gasnier B. Supplisson S. (2007) The transporters GlyT2 and VIAAT cooperate to determine the vesicular glycinergic phenotype. J. Neurosci. 27, 6273 6281.
5. Berger A. J., Dieudonné S. Ascher P. (1998) Glycine uptake governs site occupancy at NMDA receptors of excitatory synapses. J. Neurophysiol. 80, 3336 3340.
6. Bergeron R., Meyer T. M., Coyle J. T. Greene R. W. (1998) Modulation of N-methyl-d-aspartate receptor function by glycine transport. Proc. Natl Acad. Sci. USA 95, 15730 15734.
7. Betz H. Laube B. (2006) Glycine receptors: recent insights into their structural organization and functional diversity. J. Neurochem. 97, 1600 1610.
8. Boulay D., Pichat P., Dargazanli G. et al. (2008) Characterization of SSR103800, a selective inhibitor of the glycine transporter-1 in models predictive of therapeutic activity in schizophrenia. Pharmacol. Biochem. Behav. 91, 47 58.
9. Boulland J. L., Jenstad M., Boekel A. J., Wouterlood F. G., Edwards R. H., Storm-Mathisen J. Chaudhry F. A. (2009) Vesicular glutamate and GABA transporters sort to distinct sets of vesicles in a population of presynaptic terminals. Cereb. Cortex 19, 241 248.
10. Chaudry F. A., Reimer R. J., Bellocchio E. E., Danbolt N. C., Osen K. K., Edwards R. H. Storm-Mathisen J. (1998) The vesicular GABA transporter VGAT, localizes to synaptic vesicles in sets of glycinergic as well as GABAergic neurons. J. Neurosci. 18, 9733 9750.
11. Coyle J. T. (2006) Glutamate and schizophrenia: beyond the dopamine hypothesis. Cell. Mol. Neurobiol. 26, 365 384.
12. Cubelos B., Giménez C. Zafra F. (2005a) Localization of the GLYT1 glycine transporter at glutamatergic synapses in the rat brain. Cereb. Cortex 15, 448 459. (Pubitemid 40388245)
13. Cubelos B., González-González I. M., Giménez C. Zafra F. (2005b) The scaffolding protein PSD-95 interacts with the glycine transporter GLYT1 and impairs its internalization. J. Neurochem. 95, 1047 1058.
14. Depoortère R., Dargazanli G., Estenne-Bouhtou G. et al. (2005) Neurochemical, electrophysiological and pharmacological profiles of the selective inhibitor of the glycine transporter-1 SSR504734, a potential new type of antipsychotic. Neuropsychopharmacology 30, 1963 1985.
15. Eulenburg V., Armsen W., Betz H. Gomeza J. (2005) Glycine transporters: essential regulators of neurotransmission. Trends Biochem. Sci. 30, 325 333.
16. Fattorini G., Verderio C., Melone M., Giovedì S., Benfenati F., Matteoli M. Conti F. (2009) VGLUT1 and VGAT are sorted to the same population of synaptic vesicles in subsets of cortical axon terminals. J. Neurochem. 110, 1538 1546.
17. Gabernet L., Pauly-Evers M., Schwerdel C., Lentz M., Bluethmann H., Vogt K., Alberati D., Mohler H. Boison D. (2005) Enhancement of the NMDA receptor function by reduction of glycine transporter-1 expression. Neurosci. Lett. 373, 79 84.
18. Geerlings A., Núñez E., López-Corcuera B. Aragón C. (2001) Calcium- and syntaxin 1-mediated trafficking of the neuronal glycine transporter GLYT2. J. Biol. Chem. 276, 17584 17590.
19. Gomeza J., Hülsmann S., Ohno K., Eulenburg V., Szöke K., Richter D. Betz H. (2003a) Inactivation of the glycine transporter 1 gene discloses vital role of glial glycine uptake in glycinergic inhibition. Neuron 40, 785 796.
20. Gomeza J., Ohno K., Hülsmann S., Armsen W., Eulenburg V., Richter D. W., Laube B. Betz H. (2003b) Deletion of the mouse glycine transporter 2 results in a hyperekplexia phenotype and postnatal lethality. Neuron 40, 797 806.
21. Henneberger C., Papouin T., Oliet S. H. R. Rusakov D. A. (2010) Long-term potentiation depends on release of d-serine from astrocytes. Nature 463, 232 236.
22. Huang H., Barakat L., Wang D. Bordey A. (2004) Bergmann glial GlyT1 mediates glycine uptake and release in mouse cerebellar slices. J. Physiol. 560, 721 736.
23. Javitt D. C. (2009) Glycine transport inhibitors for the treatment of schizophrenia: symptom and disease modification. Curr. Opin. Drug Discov. Devel. 12, 468 478.
24. Jonas P., Bischofberger J. Sandkühler J. (1998) Corelease of two fast neurotransmitters at a central synapse. Science 281, 419 424.
25. Keck T. White J. A. (2009) Glycinergic inhibition in the hippocampus. Rev. Neurosci. 20, 13 22.
26. Kinney G. G., Sur C., Burno M., Mallorga P. J., Williams J. B., Figueroa D. J., Wittmann M., Lemaire W. Conn P. J. (2003) The glycine transporter type 1 inhibitor N-[3-(4′-fluorophenyl)-3-(4′-phenylphenoxy)propyl] sarcosine potentiates NMDA receptor-mediated responses in vivo and produces an antipsychotic profile in rodent behavior. J. Neurosci. 23, 7586 7591.
27. Klausberger T. Somogyi P. (2008) Neuronal diversity and temporal dynamics: the unity of hippocampal circuit operations. Science 321, 53 57.
28. Laube B., Maksay G., Schemm R. Betz H. (2002) Modulation of glycine receptor function: a novel approach for therapeutic intervention at inhibitory synapses? Trends Pharmacol. Sci. 23, 519 527.
29. Legendre P. (2001) The glycinergic inhibitory synapse. Cell. Mol. Life Sci. 58, 760 793.
30. Luccini E., Musante V., Neri E., Raiteri M. Pittaluga A. (2007) N-methyl-d-aspartate autoreceptors respond to low and high agonist concentrations by facilitating, respectively, exocytosis and carrier-mediated release of glutamate in rat hippocampus. J. Neurosci. Res. 85, 3657 3665.
31. Luccini E., Romei C. Raiteri L. (2008) Glycinergic nerve endings in hippocampus and spinal cord release glycine by different mechanisms in response to identical depolarizing stimuli. J. Neurochem. 105, 2179 2189.
32. Martina M., B-Turcotte M. E., Halman S., Tsai G., Tiberi M., Coyle J. T. Bergeron R. (2005) Reduced glycine transporter type 1 expression leads to major changes in glutamatergic neurotransmission of CA1 hippocampal neurones in mice. J. Physiol. 563, 777 793.
33. McIntire S. L., Reimer R. J., Schuske K., Edwards R. H. Jorgensen E. M. (1997) Identification and characterization of the vesicular GABA transporter. Nature 389, 870 876.
34. Moghaddam B. (2003) Bringing order to the glutamate chaos in schizophrenia. Neuron 40, 881 884.
35. A receptors and glycine transporter 1. Pharmacol. Biochem. Behav. 90, 58 64.
36. Mothet J. P., Parent A. T., Wolosker H., Brady R. O. Jr., Linden D. J., Ferris C. D., Rogawski M. A. Snyder S. H. (2000) d-serine is an endogenous ligand for the glycine site of the N-methyl-d-aspartate receptor. Proc. Natl Acad. Sci. USA 97, 4926 4931.
37. Nong Y., Huang Y. Q., Ju W., Kalia L. V., Ahmadian G., Wang Y. T. Salter M. W. (2003) Glycine binding primes NMDA receptor internalization. Nature 422, 302 307.
38. Olivares L., Aragón C., Giménez C. Zafra F. (1997) Analysis of the transmembrane topology of the glycine transporter GLYT1. J. Biol. Chem. 272, 1211 1217. (Pubitemid 27034619)
39. Poyatos I., Ponce J., Aragón C., Giménez C. Zafra F. (1997) The glycine transporter GLYT2 is a reliable marker for glycine-immunoreactive neurons. Mol. Brain Res. 49, 63 70.
40. Raiteri L., Raiteri M. Bonanno G. (2002) Coexistence and function of different neurotransmitter transporters in the plasma membrane of CNS neurons. Prog. Neurobiol. 68, 287 309.
41. Raiteri L., Stigliani S., Siri A., Passalacqua M., Melloni E., Raiteri M. Bonanno G. (2005) Glycine taken up through GLYT1 and GLYT2 heterotransporters into glutamatergic axon terminals of mouse spinal cord elicits release of glutamate by homotransporter reversal and through anion channels. Biochem. Pharmacol. 69, 159 168. (Pubitemid 39592882)
42. Raiteri L., Stigliani S., Usai C., Diaspro A., Paluzzi S., Raiteri M. Bonanno G. (2008) Functional expression of release-regulating glycine transporters GLYT1 on GABAergic neurons and GLYT2 on astrocytes in mouse spinal cord. Neurochem. Int. 52, 103 112.
43. Rosenberg D., Kartvelishvily E., Shleper M., Klinker C. M., Bowser M. T. Wolosker H. (2010) Neuronal release of D-serine: a physiological pathway controlling extracellular D-serine concentration. FASEB J. doi:.
44. Rousseau F., Aubrey K. R. Supplisson S. (2008) The glycine transporter GlyT2 controls the dynamics of synaptic vesicle refilling in inhibitory spinal cord neurons. J. Neurosci. 28, 9755 9768.
45. Roux M. J. Supplisson S. (2000) Neuronal and glial glycine transporters have different stoichiometries. Neuron 25, 373 383.
46. Singer P., Boison D., Möhler H., Feldon J. Yee B. K. (2007) Enhanced recognition memory following glycine transporter 1 deletion in forebrain neurons. Behav. Neurosci. 121, 815 825.
47. Singer P., Yee B. K., Feldon J. et al. (2009) Altered mnemonic functions and resistance to N-methyl-d-Aspartate receptor antagonism by forebrain conditional knockout of glycine transporter 1. Neuroscience 161, 635 654.
48. Smith K. E., Borden L. A., Hartig P. R., Branchek T. Weinshank R. L. (1992) Cloning and expression of a glycine transporter reveal colocalization with NMDA receptors. Neuron 8, 927 935.
49. Stevens E. R., Gustafson E. C. Miller R. F. (2010) Glycine transport accounts for the differential role of glycine vs. d-serine at NMDA receptor coagonist sites in the salamander retina. Eur. J. Neurosci. 31, 808 816.
50. Sur C. Kinney G. G. (2007) Glycine transporter 1 inhibitors and modulation of NMDA receptor-mediated excitatory neurotransmission. Curr. Drug Targets 8, 643 649.
51. Tsai G., Ralph-Williams R. J., Martina M., Bergeron R., Berger-Sweeney J., Dunham K. S., Jiang Z., Caine S. B. Coyle J. T. (2004) Gene knockout of glycine transporter 1: characterization of the behavioral phenotype. Proc. Natl Acad. Sci. USA 101, 8485 8490.
52. Tsen G., Williams B., Allaire P., Zhou Y. D., Ikonomov O., Kondova I. Jacob M. H. (2000) Receptors with opposing functions are in postsynaptic microdomains under one presynaptic terminal. Nat. Neurosci. 3, 126 132.
53. Wojcik S. M., Katsurabayashi S., Guillemin I., Friauf E., Rosenmund C., Brose N. Rhee J. S. (2006) A shared vesicular carrier allows synaptic corelease of GABA and glycine. Neuron 50, 575 587.
54. Yang J., Chamberlain S. E., Woodhall G. L. Jones R. S. (2008) Mobility of NMDA autoreceptors but not postsynaptic receptors at glutamate synapses in the rat entorhinal cortex. J. Physiol. 586, 4905 4924.
55. Yee B. K., Balic E., Singer P. et al. (2006) Disruption of glycine transporter 1 restricted to forebrain neurons is associated with a procognitive and antipsychotic phenotypic profile. J. Neurosci. 26, 3169 3181.
56. Zafra F., Aragón C., Olivares L., Danbolt N. C., Giménez C. Storm-Mathisen J. (1995a) Glycine transporters are differentially expressed among CNS cells. J. Neurosci. 15, 3952 3969.
57. Zafra F., Gomeza J., Olivares L., Aragón C. Giménez C. (1995b) Regional distribution and developmental variation of the glycine transporters GLYT1 and GLYT2 in the rat CNS. Eur. J. Neurosci. 7, 1342 1352.