The DHEA metabolite 7β-hydroxy-epiandrosterone exerts anti-estrogenic effects on breast cancer cell lines

Steroids

Volumn 77, Issue 5, 2012, Pages 542-551

  Sandra, Niro ^a   Ester, Pereira ^a   Marie Agnès, Pélissier ^a   Robert, Morfin ^a   Olivier, Hennebert ^a,b  

^a Bioinformatique et Chimie Moléculaire   (France)

^b HÔPITAL ROBERT DEBRÉ   (France)

Author keywords

7 Hydroxy epiandrosterone; Breast cancer cell lines; Estrogen receptors; Proliferation; Transactivation

Indexed keywords

7BETA HYDROXYEPIANDROSTERONE; DRUG METABOLITE; ESTROGEN; ESTROGEN RECEPTOR; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; G PROTEIN COUPLED RECEPTOR 30; MEMBRANE RECEPTOR; PRASTERONE; PROSTAGLANDIN E2; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CANCER SURVIVAL; CELL CYCLE ARREST; CELL LINEAGE; CELL PROLIFERATION; CELL STRAIN MCF 7; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; INFLAMMATION; NUCLEOTIDE SEQUENCE; PROSTAGLANDIN SYNTHESIS; RECEPTOR BINDING; TRANSACTIVATION;

ANDROSTERONE; APOPTOSIS; BREAST NEOPLASMS; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLOOXYGENASE 2; DEHYDROEPIANDROSTERONE; DOSE-RESPONSE RELATIONSHIP, DRUG; ESTROGEN ANTAGONISTS; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INTRAMOLECULAR OXIDOREDUCTASES; LIPOCALINS; METABOLIC NETWORKS AND PATHWAYS; MOLECULAR STRUCTURE; PPAR GAMMA; RECEPTORS, ESTROGEN; RECEPTORS, G-PROTEIN-COUPLED; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TIME FACTORS;

EID: 84858341350     PISSN: 0039128X     EISSN: 18785867     Source Type: Journal    
DOI: 10.1016/j.steroids.2012.01.019     Document Type: Article

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