The antioxidant effects of some progressively purified fractions from Helleborus purpurascens

Romanian Biotechnological Letters

Volumn 16, Issue 6, 2011, Pages 6673-6682

  Apetrei, N S ^a   Lupu, A R ^a   Calugaru, A ^a   Kerek, F ^b   Szegli, G ^a   Cremer, L ^a  

^a NATIONAL INSTITUTE FOR RESEARCH AND DEVELOPMENT IN MICROTECHNOLOGIES   (Romania)

^b Donatur GmbH   (Germany)

Author keywords

Antioxidant; PMNs; Purified vegetal fractions; ROS; Scavenger

Indexed keywords

HELLEBORUS PURPURASCENS; VERATRUM;

EID: 84858309786     PISSN: 12245984     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. K. Apel, H. Hirt, Reactive oxygen species: Metabolism, Oxidative Stress, and Signal Transduction, Annu Rev Plant Biol.; 55:373-399 (2004).
2. C.M. Bergamini, S. Gambetti, A. Dondi, C. Cervellati, Oxygen, reactive oxygen species and tissue damage, Curr Pharm Des.; 10:1611-26 (2004).
3. E. Kopp, R. Medzhitov, Recognition of microbial infection by Toll - like receptors, Curr. Opin. Immunol; 15: 396 - 401 (2003).
4. Akira, H. Hemmi, Recognition of pathogen - associated molecular patterns by TLR family, Immunol. Lett.; 85: 85 - 95 (2003).
5. J.A. Knight, Diseases related to oxygen-derived free radicals, Ann Clin Lab Sci.; 25: 111-121 (1995).
6. I. Fridovich, Superoxide radical and superoxide dismutases, Annu Rev Biochem.; 64:97-112 (1995).
7. B. Halliwell, Antioxidants and human diseases: A general introduction, Nutr Rev.; 55: S44-S52 (1997).
8. B. Halliwell, J.M. Gutteridge, Free Radicals in Biology and Medicine, Oxford University Press; pp: 139-189 (1985).
9. G. Lenaz, The mitochondrial production of reactive oxygen species: mechanisms and implications in human pathology, IUBMB Life; 52:159-164 (2001).
10. W. Gulam, A. Haseeb, Reactive oxygen species: role in the development of cancer and various chronic conditions, Journal of Carcinogenesis; 5:14 (2006).
11. V.J. Thannickal, B.L. Fanburg, Reactive oxygen species in cell signaling, Am J Physiol Lung Cell Mol Physiol.; 279: L1005-L1028 (2000).
12. W. Droge, Free radicals in the physiological control of cell function, Physiol Rev.; 82:47-95 (2000).
13. G.E. Conner, M. Salathe, R. Forteza, Lactoperoxidase and Hydrogen Peroxide Metabolism in the Airway, Am J Respir Crit Care Med.; 166 (12): S57 (2002).
14. I.A. Jaiyesimi, A.U. Buzdar, G. Hotrobagyi, Inflammatory breast cancer: a review, J Clin Oncol.; 10:1014-24 (1992).
15. B. Gaston, J.M. Drazen, J. Loscalzo, J.S. Stamler, The biology of nitrogen oxides in the airways, Am J Respir Crit Care Med; 149:538-551 (1994).
16. X. Shi, M. Ding, F. Chen, Reactive oxygen species and molecular mechanism of silica-induced lung injury, J Environ Pathol Toxicol Oncol; 20:Suppl. 1, 85-93 (2001).
17. B.N. Ames, L.S. Gold, W.C. Willet, The causes and prevention of cancer, Proc Natl Acad Sci.; 92:5258-5265 (1995).
18. U.R. Kuppusamy, M. Indran, B.R.S. Balraj, Antioxidant effects of local fruits and vegetable extracts, J Trop Med Plants; 3: 47-53 (2002).
19. S. Hasani-Ranibar, B. Larijani, M. Abdollahi, A systematic review of the potential herbal sources of future drugs effective in oxidant-related diseases. Inflamm Allergy Drug Targets; 8(1):2-10 (2009).
20. T. Iannitti, B. Palmieri, Antioxidant therapy effectiveness: an up to date, Eur Rev Med Pharmacol Sci. 13(4):245-278 (2009).
21. M. Bergman, L. Varshavsky, H.E. Gottlieb, S. Nad GROSSMAN, The antioxidant activity of aqueous spinach extract: chemical identification of active fractions, Phytochemistry; 58: 143-152 (2001).
22. M. Badulescu, A-R. Lupu, L. Cremer, A. Calugaru, N. Apetrei, M. Moscovici, G. Mocanu, The modulation of reactive oxygen species production from human polymorphnuclear cells by Curdlan derivatives as Dectin-1 agonists/antagonists, Rom.Arch.Microbiol.Immunol.; 68(2): 63-68 (2009).
23. L. Cremer, A-R. Lupu, M. Badulescu, G. Mocanu, D. Mihai, A. Calugaru, N. Apetrei, M. Moscovici, G. Szegli, Assessment of two synthesized curdlan derivatives as possible antioxidants and/or modulators of human PMN cells respiratory burst, Rom.Biotechnol.Lett., 15(6): 5718-5728 (2010).
24. A.G. Milbrandt, F. Kerek, L. Moroder, C. Renner, Structural characterization of hellethionins from Helleborus purpurascens, Biochemistry. 42(8):2404-11 (2003).
25. L. Littermann, S. Rosner, F. Kerek, A. Steinkasserer, E. Zinser, Modulation of murine bone marrow derived dendritic cells and B-cells by MCS-18 a natural product isolated from Helleborus purpurascens, Immunobiology; 213(9-10):871-8 (2008).
26. B. Horstmann, E. Zinser, N. Turza, F. Kerek, A. Steinkasserer, MCS-18, a novel natural product isolated from Helleborus purpurascens, inhibits dendritic cell activation and prevents autoimmunity as shown in vivo using the EAE model, Immunobiology; 212(9-10):839-53 (2007).
27. F. Kerek, G. Szegli, L. Cremer, A-R. Lupu, S. Durbaca, A. Calugaru, A. Herold, D.L. Radu, The novel arthritis drug substance MCS-18 attenuates the antibody production in vivo, Acta Microbiologica et Immunologica Hungarica; 55(1), 15-31 (2008).
28. A-R. Lupu, L. Cremer, S. Durbaca, A. Calugaru, A. Herold, F. Kerek, G. Szegli, D.L. Radu, COX-2 inhibitors can down-regulate in vivo antibody response against T-dependent antigens, Roum.Arch.Microbiol.Immunol.; 65(1-2), 59-65 (2006).
29. C. Neacsu, C. Ciobanu, I. Barbu, O. Toader, G. Szegli, F. Kerek, A. Babes, Substance MCS-18 isolated from Helleborus purpurascens is a potent antagonist od the Capsaicin Receptor, TRPV1, in rat cultured sensory neurons, Physiol.Res.,59(2):289-298 (2010).
30. FL)) of plasma and other biological and food samples, J Agric Food Chem. 51: 3273-3279 (2003).
31. P. Prieto, M. Pineda, M. Aguilar, Spectrophotometric quantitation of antioxidant capacity through the formation of a phosphomolybdenum complex: specific application to the determination of vitamin E, Anal.Biochem. 269(2):337-41 (1999).
32. D. Roos, M. De Boer, Purification and cryopreservation of phagocytes from human blood, Meth Enzymol. 132, 225 (1986).
33. R.C. Allen, Phagocytic leukocyte oxygenation activities and chemiluminescence: a kinetic approach to analysis, Methods Enzymol. 133, 449 (1986).
34. T. Mosmann, Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays, Journal of immunological methods. 65(1-2): 55-63 (1983).