메뉴 건너뛰기




Volumn 4, Issue 125, 2012, Pages

Treating human autoimmunity: Current practice and future prospects

Author keywords

[No Author keywords available]

Indexed keywords

ABATACEPT; AMG 557; ANTIDIABETIC AGENT; AZACITIDINE; BG 9588; CD28 ANTIGEN; CD4 ANTIGEN; CYCLOPHOSPHAMIDE; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; DIAPEP277; EFALIZUMAB; FORIGERIMOD; GLUTAMATE DECARBOXYLASE 65; IMMUNOMODULATING AGENT; IMMUNOSUPPRESSIVE AGENT; INSULIN; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR ALPHA; LEUKOCYTE ANTIGEN; METHOTREXATE; PLACEBO; RAPAMYCIN; RECOMBINANT HUMAN INSULIN; RECOMBINANT INTERLEUKIN 2; TGN 1412; TRANSCRIPTION FACTOR FOXP3; UNCLASSIFIED DRUG;

EID: 84858307154     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.3003504     Document Type: Review
Times cited : (165)

References (67)
  • 2
    • 0033851221 scopus 로고    scopus 로고
    • Autoimmune diseases: A leading cause of death among young and middle-aged women in the United States
    • S. J. Walsh, L. M. Rau, Autoimmune diseases: A leading cause of death among young and middle-aged women in the United States. Am. J. Public Health 90, 1463-1466 (2000).
    • (2000) Am. J. Public Health , vol.90 , pp. 1463-1466
    • Walsh, S.J.1    Rau, L.M.2
  • 3
    • 79960835109 scopus 로고    scopus 로고
    • Interrogating the repertoire: Broadening the scope of peptide - MHC multimer analysis
    • M. M. Davis, J. D. Altman, E. W. Newell, Interrogating the repertoire: Broadening the scope of peptide - MHC multimer analysis. Nat. Rev. Immunol. 11, 551-558 (2011).
    • (2011) Nat. Rev. Immunol. , vol.11 , pp. 551-558
    • Davis, M.M.1    Altman, J.D.2    Newell, E.W.3
  • 4
    • 74049160009 scopus 로고    scopus 로고
    • Mechanisms maintaining peripheral tolerance
    • D. L. Mueller, Mechanisms maintaining peripheral tolerance. Nat. Immunol. 11, 21-27 (2010).
    • (2010) Nat. Immunol. , vol.11 , pp. 21-27
    • Mueller, D.L.1
  • 6
    • 76649140079 scopus 로고    scopus 로고
    • Abatacept for rheumatoid arthritis: A Cochrane systematic review
    • L. J. Maxwell, J. A. Singh, Abatacept for rheumatoid arthritis: A Cochrane systematic review. J. Rheumatol. 37, 234-245 (2010).
    • (2010) J. Rheumatol. , vol.37 , pp. 234-245
    • Maxwell, L.J.1    Singh, J.A.2
  • 10
    • 77957682858 scopus 로고    scopus 로고
    • The efficacy and safety of abatacept in patients with non - Life-threatening manifestations of systemic lupus erythematosus: Results of a twelve-month, multicenter, exploratory, phase IIb, randomized, double-blind, placebo-controlled trial
    • J. T. Merrill, R. Burgos-Vargas, R. Westhovens, A. Chalmers, D. D'Cruz, D. J. Wallace, S. C. Bae, L. Sigal, J. C. Becker, S. Kelly, K. Raghupathi, T. Li, Y. Peng, M. Kinaszczuk, P. Nash, The efficacy and safety of abatacept in patients with non - life-threatening manifestations of systemic lupus erythematosus: Results of a twelve-month, multicenter, exploratory, phase IIb, randomized, double-blind, placebo-controlled trial. Arthritis Rheum. 62, 3077-3087 (2010).
    • (2010) Arthritis Rheum. , vol.62 , pp. 3077-3087
    • Merrill, J.T.1    Burgos-Vargas, R.2    Westhovens, R.3    Chalmers, A.4    D'Cruz, D.5    Wallace, D.J.6    Bae, S.C.7    Sigal, L.8    Becker, J.C.9    Kelly, S.10    Raghupathi, K.11    Li, T.12    Peng, Y.13    Kinaszczuk, M.14    Nash, P.15
  • 12
    • 0035059417 scopus 로고    scopus 로고
    • Complexities of CD28/B7: CTLA-4 costimulatory pathways in autoimmunity and transplantation
    • B. Salomon, J. A. Bluestone, Complexities of CD28/B7: CTLA-4 costimulatory pathways in autoimmunity and transplantation. Annu. Rev. Immunol. 19, 225-252 (2001).
    • (2001) Annu. Rev. Immunol. , vol.19 , pp. 225-252
    • Salomon, B.1    Bluestone, J.A.2
  • 14
    • 0347785480 scopus 로고    scopus 로고
    • Control of regulatory T cell development by the transcription factor Foxp3
    • S. Hori, T. Nomura, S. Sakaguchi, Control of regulatory T cell development by the transcription factor Foxp3. Science 299, 1057-1061 (2003).
    • (2003) Science , vol.299 , pp. 1057-1061
    • Hori, S.1    Nomura, T.2    Sakaguchi, S.3
  • 17
    • 33746369415 scopus 로고    scopus 로고
    • Regulatory T-cell physiology and application to treat autoimmunity
    • Q. Tang, J. A. Bluestone, Regulatory T-cell physiology and application to treat autoimmunity. Immunol. Rev. 212, 217-237 (2006).
    • (2006) Immunol. Rev. , vol.212 , pp. 217-237
    • Tang, Q.1    Bluestone, J.A.2
  • 18
    • 33751207432 scopus 로고    scopus 로고
    • Cell-surface IL-7 receptor expression facilitates the purification of FOXP3+ regulatory T cells
    • A. H. Banham, Cell-surface IL-7 receptor expression facilitates the purification of FOXP3+ regulatory T cells. Trends Immunol. 27, 541-544 (2006).
    • (2006) Trends Immunol. , vol.27 , pp. 541-544
    • Banham, A.H.1
  • 24
    • 79251589897 scopus 로고    scopus 로고
    • Retinoic acid and rapamycin differentially affect and synergistically promote the ex vivo expansion of natural human T regulatory cells
    • T. N. Golovina, T. Mikheeva, T. M. Brusko, B. R. Blazar, J. A. Bluestone, J. L. Riley, Retinoic acid and rapamycin differentially affect and synergistically promote the ex vivo expansion of natural human T regulatory cells. PLoS One 6, e15868 (2011).
    • (2011) PLoS One , vol.6
    • Golovina, T.N.1    Mikheeva, T.2    Brusko, T.M.3    Blazar, B.R.4    Bluestone, J.A.5    Riley, J.L.6
  • 30
    • 79956288367 scopus 로고    scopus 로고
    • Human regulatory T cells with alloantigen specificity are more potent inhibitors of alloimmune skin graft damage than polyclonal regulatory T cells
    • P. Sagoo, N. Ali, G. Garg, F. O. Nestle, R. I. Lechler, G. Lombardi, Human regulatory T cells with alloantigen specificity are more potent inhibitors of alloimmune skin graft damage than polyclonal regulatory T cells. Sci. Transl. Med. 3, 83ra42 (2011).
    • (2011) Sci. Transl. Med. , vol.3
    • Sagoo, P.1    Ali, N.2    Garg, G.3    Nestle, F.O.4    Lechler, R.I.5    Lombardi, G.6
  • 34
    • 79955477145 scopus 로고    scopus 로고
    • Immunological mechanisms of allergen-specific immunotherapy
    • M. Jutel, C. A. Akdis, Immunological mechanisms of allergen-specific immunotherapy. Allergy 66, 725-732 (2011).
    • (2011) Allergy , vol.66 , pp. 725-732
    • Jutel, M.1    Akdis, C.A.2
  • 35
    • 58149306013 scopus 로고    scopus 로고
    • In vivo switch to IL-10-secreting T regulatory cells in high dose allergen exposure
    • F. Meiler, J. Zumkehr, S. Klunker, B. Rückert, C. A. Akdis, M. Akdis, In vivo switch to IL-10-secreting T regulatory cells in high dose allergen exposure. J. Exp. Med. 205, 2887-2898 (2008).
    • (2008) J. Exp. Med. , vol.205 , pp. 2887-2898
    • Meiler, F.1    Zumkehr, J.2    Klunker, S.3    Rückert, B.4    Akdis, C.A.5    Akdis, M.6
  • 37
    • 77949901839 scopus 로고    scopus 로고
    • Birch pollen immunotherapy leads to differential induction of regulatory T cells and delayed helper T cell immune deviation
    • C. Möbs, C. Slotosch, H. Löffler, T. Jakob, M. Hertl, W. Pfützner, Birch pollen immunotherapy leads to differential induction of regulatory T cells and delayed helper T cell immune deviation. J. Immunol. 184, 2194-2203 (2010).
    • (2010) J. Immunol. , vol.184 , pp. 2194-2203
    • Möbs, C.1    Slotosch, C.2    Löffler, H.3    Jakob, T.4    Hertl, M.5    Pfützner, W.6
  • 41
    • 57349101501 scopus 로고    scopus 로고
    • Spliceosomal peptide P140 for immunotherapy of systemic lupus erythematosus: Results of an early phase II clinical trial
    • S. Muller, F. Monneaux, N. Schall, R. K. Rashkov, B. A. Oparanov, P. Wiesel, J. M. Geiger, R. Zimmer, Spliceosomal peptide P140 for immunotherapy of systemic lupus erythematosus: Results of an early phase II clinical trial. Arthritis Rheum. 58, 3873-3883 (2008).
    • (2008) Arthritis Rheum. , vol.58 , pp. 3873-3883
    • Muller, S.1    Monneaux, F.2    Schall, N.3    Rashkov, R.K.4    Oparanov, B.A.5    Wiesel, P.6    Geiger, J.M.7    Zimmer, R.8
  • 42
    • 80052908633 scopus 로고    scopus 로고
    • Immune intervention in type 1 diabetes
    • A. W. Michels, G. S. Eisenbarth, Immune intervention in type 1 diabetes. Semin. Immunol. 23, 214-219 (2011).
    • (2011) Semin. Immunol. , vol.23 , pp. 214-219
    • Michels, A.W.1    Eisenbarth, G.S.2
  • 43
    • 0035944844 scopus 로고    scopus 로고
    • β-Cell function in new-onset type 1 diabetes and immunomodulation with a heat-shock protein peptide (DiaPep277): A randomised, double-blind, phase II trial
    • I. Raz, D. Elias, A. Avron, M. Tamir, M. Metzger, I. R. Cohen, β-Cell function in new-onset type 1 diabetes and immunomodulation with a heat-shock protein peptide (DiaPep277): A randomised, double-blind, phase II trial. Lancet 358, 1749-1753 (2001).
    • (2001) Lancet , vol.358 , pp. 1749-1753
    • Raz, I.1    Elias, D.2    Avron, A.3    Tamir, M.4    Metzger, M.5    Cohen, I.R.6
  • 44
    • 80755168854 scopus 로고    scopus 로고
    • C-peptide response and HLA genotypes in subjects with recent-onset type 1 diabetes after immunotherapy with DiaPep277: An exploratory study
    • DiaPep Trialists Group
    • R. Buzzetti, S. Cernea, A. Petrone, M. Capizzi, M. Spoletini, S. Zampetti, C. Guglielmi, C. Venditti, P. Pozzilli; DiaPep Trialists Group, C-peptide response and HLA genotypes in subjects with recent-onset type 1 diabetes after immunotherapy with DiaPep277: An exploratory study. Diabetes 60, 3067-3072 (2011).
    • (2011) Diabetes , vol.60 , pp. 3067-3072
    • Buzzetti, R.1    Cernea, S.2    Petrone, A.3    Capizzi, M.4    Spoletini, M.5    Zampetti, S.6    Guglielmi, C.7    Venditti, C.8    Pozzilli, P.9
  • 45
    • 0023143676 scopus 로고
    • Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo
    • M. K. Jenkins, R. H. Schwartz, Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo. J. Exp. Med. 165, 302-319 (1987).
    • (1987) J. Exp. Med. , vol.165 , pp. 302-319
    • Jenkins, M.K.1    Schwartz, R.H.2
  • 48
    • 33645465526 scopus 로고    scopus 로고
    • Selective stimulation of T cell subsets with antibody-cytokine immune complexes
    • O. Boyman, M. Kovar, M. P. Rubinstein, C. D. Surh, J. Sprent, Selective stimulation of T cell subsets with antibody-cytokine immune complexes. Science 311, 1924-1927 (2006).
    • (2006) Science , vol.311 , pp. 1924-1927
    • Boyman, O.1    Kovar, M.2    Rubinstein, M.P.3    Surh, C.D.4    Sprent, J.5
  • 49
    • 33845339257 scopus 로고    scopus 로고
    • Potential use of IL-2/anti-IL-2 antibody immune complexes for the treatment of cancer and autoimmune disease
    • O. Boyman, C. D. Surh, J. Sprent, Potential use of IL-2/anti-IL-2 antibody immune complexes for the treatment of cancer and autoimmune disease. Expert Opin. Biol. Ther. 6, 1323-1331 (2006).
    • (2006) Expert Opin. Biol. Ther. , vol.6 , pp. 1323-1331
    • Boyman, O.1    Surh, C.D.2    Sprent, J.3
  • 50
    • 79961026869 scopus 로고    scopus 로고
    • In vivo expansion of regulatory T cells with IL-2/IL-2 mAb complexes prevents anti-factor VIII immune responses in hemophilia A mice treated with factor VIII plasmid-mediated gene therapy
    • C. L. Liu, P. Ye, B. C. Yen, C. H. Miao, In vivo expansion of regulatory T cells with IL-2/IL-2 mAb complexes prevents anti-factor VIII immune responses in hemophilia A mice treated with factor VIII plasmid-mediated gene therapy. Mol. Ther. 19, 1511-1520 (2011).
    • (2011) Mol. Ther. , vol.19 , pp. 1511-1520
    • Liu, C.L.1    Ye, P.2    Yen, B.C.3    Miao, C.H.4
  • 51
    • 77953297342 scopus 로고    scopus 로고
    • Expansion of regulatory T cells via IL-2/anti-IL-2 mAb complexes suppresses experimental myasthenia
    • R. Liu, Q. Zhou, A. La Cava, D. I. Campagnolo, L. Van Kaer, F. D. Shi, Expansion of regulatory T cells via IL-2/anti-IL-2 mAb complexes suppresses experimental myasthenia. Eur. J. Immunol. 40, 1577-1589 (2010).
    • (2010) Eur. J. Immunol. , vol.40 , pp. 1577-1589
    • Liu, R.1    Zhou, Q.2    La Cava, A.3    Campagnolo, D.I.4    Van Kaer, L.5    Shi, F.D.6
  • 52
    • 65549091509 scopus 로고    scopus 로고
    • In vivo expansion of T reg cells with IL-2-mAb complexes: Induction of resistance to EAE and long-term acceptance of islet allografts without immunosuppression
    • K. E. Webster, S. Walters, R. E. Kohler, T. Mrkvan, O. Boyman, C. D. Surh, S. T. Grey, J. Sprent, In vivo expansion of T reg cells with IL-2-mAb complexes: Induction of resistance to EAE and long-term acceptance of islet allografts without immunosuppression. J. Exp. Med. 206, 751-760 (2009).
    • (2009) J. Exp. Med. , vol.206 , pp. 751-760
    • Webster, K.E.1    Walters, S.2    Kohler, R.E.3    Mrkvan, T.4    Boyman, O.5    Surh, C.D.6    Grey, S.T.7    Sprent, J.8
  • 57
    • 35349024802 scopus 로고    scopus 로고
    • CXCR3 signaling reduces the severity of experimental autoimmune encephalomyelitis by controlling the parenchymal distribution of effector and regulatory T cells in the central nervous system
    • M. Müller, S. L. Carter, M. J. Hofer, P. Manders, D. R. Getts, M. T. Getts, A. Dreykluft, B. Lu, C. Gerard, N. J. C. King, I. L. Campbell, CXCR3 signaling reduces the severity of experimental autoimmune encephalomyelitis by controlling the parenchymal distribution of effector and regulatory T cells in the central nervous system. J. Immunol. 179, 2774-2786 (2007).
    • (2007) J. Immunol. , vol.179 , pp. 2774-2786
    • Müller, M.1    Carter, S.L.2    Hofer, M.J.3    Manders, P.4    Getts, D.R.5    Getts, M.T.6    Dreykluft, A.7    Lu, B.8    Gerard, C.9    King, N.J.C.10    Campbell, I.L.11
  • 59
    • 33846630040 scopus 로고    scopus 로고
    • Humanized mice in translational biomedical research
    • L. D. Shultz, F. Ishikawa, D. L. Greiner, Humanized mice in translational biomedical research. Nat. Rev. Immunol. 7, 118-130 (2007).
    • (2007) Nat. Rev. Immunol. , vol.7 , pp. 118-130
    • Shultz, L.D.1    Ishikawa, F.2    Greiner, D.L.3
  • 63
    • 81255129068 scopus 로고    scopus 로고
    • Progressive multifocal leukoencephalopathy: An unexpected complication of modern therapeutic monoclonal antibody therapies
    • E. Tavazzi, P. Ferrante, K. Khalili, Progressive multifocal leukoencephalopathy: An unexpected complication of modern therapeutic monoclonal antibody therapies. Clin. Microbiol. Infect. 17, 1776-1780 (2011).
    • (2011) Clin. Microbiol. Infect. , vol.17 , pp. 1776-1780
    • Tavazzi, E.1    Ferrante, P.2    Khalili, K.3
  • 64
    • 0037333857 scopus 로고    scopus 로고
    • A short course of BG9588 (anti-CD40 ligand antibody) improves serologic activity and decreases hematuria in patients with proliferative lupus glomerulonephritis
    • BG9588 Lupus Nephritis Trial Group
    • D. T. Boumpas, R. Furie, S. Manzi, G. G. Illei, D. J. Wallace, J. E. Balow, A. Vaishnaw; BG9588 Lupus Nephritis Trial Group, A short course of BG9588 (anti-CD40 ligand antibody) improves serologic activity and decreases hematuria in patients with proliferative lupus glomerulonephritis. Arthritis Rheum. 48, 719-727 (2003).
    • (2003) Arthritis Rheum , vol.48 , pp. 719-727
    • Boumpas, D.T.1    Furie, R.2    Manzi, S.3    Illei, G.G.4    Wallace, D.J.5    Balow, J.E.6    Vaishnaw, A.7
  • 66
    • 80053597291 scopus 로고    scopus 로고
    • Regulatory T cells in stem cell transplantation: Strategies and first clinical experiences
    • M. Edinger, P. Hoffmann, Regulatory T cells in stem cell transplantation: Strategies and first clinical experiences. Curr. Opin. Immunol. 23, 679-684 (2011).
    • (2011) Curr. Opin. Immunol. , vol.23 , pp. 679-684
    • Edinger, M.1    Hoffmann, P.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.