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Volumn 34, Issue 4, 2012, Pages 311-319

Genes at work in random bouts: Stochastically discontinuous gene activity makes cell cycle duration and cell fate decisions variable, thus providing for stem cells plasticity

Author keywords

Cell cycle; Cell differentiation; Embryogenesis; Gene expression; Stochasticity

Indexed keywords

CONNECTIVE TISSUE GROWTH FACTOR; CYCLIN D1; ENHANCED GREEN FLUORESCENT PROTEIN; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; MESSENGER RNA; RNA POLYMERASE II; TRANSCRIPTION FACTOR E2F1; TRANSCRIPTION FACTOR E2F2;

EID: 84858293805     PISSN: 02659247     EISSN: 15211878     Source Type: Journal    
DOI: 10.1002/bies.201100119     Document Type: Article
Times cited : (9)

References (79)
  • 1
    • 79957929161 scopus 로고    scopus 로고
    • Simulation of cellular biochemical system kinetics
    • Beard DA. 2011. Simulation of cellular biochemical system kinetics. WIREs Syst Biol Med 3: 136-46.
    • (2011) WIREs Syst Biol Med , vol.3 , pp. 136-146
    • Beard, D.A.1
  • 2
    • 33644524741 scopus 로고    scopus 로고
    • Cell-signalling dynamics in time and space
    • Kholodenko BN. 2006. Cell-signalling dynamics in time and space. Nat Rev Mol Cell Biol 7: 165-76.
    • (2006) Nat Rev Mol Cell Biol , vol.7 , pp. 165-176
    • Kholodenko, B.N.1
  • 3
    • 70349559776 scopus 로고    scopus 로고
    • Why are cellular switches Boolean? General conditions for multistable genetic circuits
    • Macia J, Widder S, Sole R. 2009. Why are cellular switches Boolean? General conditions for multistable genetic circuits. J Theor Biol 261: 126-35.
    • (2009) J Theor Biol , vol.261 , pp. 126-135
    • Macia, J.1    Widder, S.2    Sole, R.3
  • 4
    • 57149091743 scopus 로고    scopus 로고
    • Multistable decision switches for flexible control of epigenetic differentiation
    • Guantes Ri, Poyatos JF. 2008. Multistable decision switches for flexible control of epigenetic differentiation. PLoS Comput Biol 4: e1000235.
    • (2008) PLoS Comput Biol , vol.4
    • Guantes, R.1    Poyatos, J.F.2
  • 5
    • 77951681944 scopus 로고    scopus 로고
    • Functional motifs in biochemical reaction networks
    • Tyson JJ, Novak B. 2010. Functional motifs in biochemical reaction networks. Annu Rev Phys Chem 61: 219-40.
    • (2010) Annu Rev Phys Chem , vol.61 , pp. 219-240
    • Tyson, J.J.1    Novak, B.2
  • 6
    • 79951929145 scopus 로고    scopus 로고
    • A multi-functional synthetic gene network: a frequency multiplier, oscillator and switch
    • Purcell O, di Bernardo M, Grierson CS, Savery NJ. 2011. A multi-functional synthetic gene network: a frequency multiplier, oscillator and switch. PLoS One 6: e16140.
    • (2011) PLoS One , vol.6
    • Purcell, O.1    di Bernardo, M.2    Grierson, C.S.3    Savery, N.J.4
  • 7
    • 74549136804 scopus 로고    scopus 로고
    • Restriction point control of the mammalian cell cycle via the cyclin E/Cdk2:p27 complex
    • Conradie R, Bruggeman FJ, Ciliberto A, Csikasz-Nagy A, et al. 2010. Restriction point control of the mammalian cell cycle via the cyclin E/Cdk2:p27 complex. FEBS J 277: 357-67.
    • (2010) FEBS J , vol.277 , pp. 357-367
    • Conradie, R.1    Bruggeman, F.J.2    Ciliberto, A.3    Csikasz-Nagy, A.4
  • 8
    • 33744792286 scopus 로고    scopus 로고
    • Analysis of a generic model of eukaryotic cell-cycle regulation
    • Csikasz-Nagy A, Battogtokh D, Chen KC, Novak B, et al. 2006. Analysis of a generic model of eukaryotic cell-cycle regulation. Biophys J 90: 4361-79.
    • (2006) Biophys J , vol.90 , pp. 4361-4379
    • Csikasz-Nagy, A.1    Battogtokh, D.2    Chen, K.C.3    Novak, B.4
  • 9
    • 78650876743 scopus 로고    scopus 로고
    • A general framework for modeling growth and division of mammalian cells
    • Gauthier J, Pohl P. 2011. A general framework for modeling growth and division of mammalian cells. BMC Syst Biol 5: 3.
    • (2011) BMC Syst Biol , vol.5 , pp. 3
    • Gauthier, J.1    Pohl, P.2
  • 10
    • 0030177132 scopus 로고    scopus 로고
    • Accidental necessity, initiation of transcription, cell differentiation, and necessary accidents
    • Golubev AG. 1996. Accidental necessity, initiation of transcription, cell differentiation, and necessary accidents. Biochemistry (Moscow) 61: 1303-19.
    • (1996) Biochemistry (Moscow) , vol.61 , pp. 1303-1319
    • Golubev, A.G.1
  • 11
    • 0029853061 scopus 로고    scopus 로고
    • A chance-selection model for cell differentiation
    • Kupiec JJ. 1996. A chance-selection model for cell differentiation. Cell Death Differ 3: 385-90.
    • (1996) Cell Death Differ , vol.3 , pp. 385-390
    • Kupiec, J.J.1
  • 12
    • 0034307684 scopus 로고    scopus 로고
    • Probability in transcriptional regulation and its implications for leukocyte differentiation and inducible gene expression
    • Hume DA. 2000. Probability in transcriptional regulation and its implications for leukocyte differentiation and inducible gene expression. Blood 96: 2323-8.
    • (2000) Blood , vol.96 , pp. 2323-2328
    • Hume, D.A.1
  • 13
    • 70450162700 scopus 로고    scopus 로고
    • Non-genetic heterogeneity of cells in development: more than just noise
    • Huang S. 2009. Non-genetic heterogeneity of cells in development: more than just noise. Development 136: 3853-62.
    • (2009) Development , vol.136 , pp. 3853-3862
    • Huang, S.1
  • 14
    • 77952474987 scopus 로고    scopus 로고
    • Cellular heterogeneity: do differences make a difference
    • Altschuler SJ, Wu LF. 2010. Cellular heterogeneity: do differences make a difference? Cell 141: 559-63.
    • (2010) Cell , vol.141 , pp. 559-563
    • Altschuler, S.J.1    Wu, L.F.2
  • 15
    • 70450263340 scopus 로고    scopus 로고
    • Exponentially modified Gaussian (EMG) relevance to distributions related to cell proliferation and differentiation
    • Golubev A. 2010. Exponentially modified Gaussian (EMG) relevance to distributions related to cell proliferation and differentiation. J Theor Biol 262: 257-66.
    • (2010) J Theor Biol , vol.262 , pp. 257-266
    • Golubev, A.1
  • 16
    • 0035681083 scopus 로고    scopus 로고
    • Myc/Max/Mad regulate the frequency but not the duration of productive cell cycles
    • Holzel M, Kohlhuber F, Schlosser I, Holzel D, et al. 2001. Myc/Max/Mad regulate the frequency but not the duration of productive cell cycles. EMBO Rep 2: 1125-32.
    • (2001) EMBO Rep , vol.2 , pp. 1125-1132
    • Holzel, M.1    Kohlhuber, F.2    Schlosser, I.3    Holzel, D.4
  • 17
    • 3042788717 scopus 로고
    • Variations in the generation times of a strain of rat sarcoma cells in culture
    • Dawson KB, Madoc-Jones H, Field EO. 1965. Variations in the generation times of a strain of rat sarcoma cells in culture. Exp Cell Res 38: 75-84.
    • (1965) Exp Cell Res , vol.38 , pp. 75-84
    • Dawson, K.B.1    Madoc-Jones, H.2    Field, E.O.3
  • 18
    • 33744455697 scopus 로고    scopus 로고
    • High-resolution video monitoring of hematopoietic stem cells cultured in single-cell arrays identifies new features of self-renewal
    • Dykstra B, Ramunas J, Kent D, McCaffrey L, et al. 2006. High-resolution video monitoring of hematopoietic stem cells cultured in single-cell arrays identifies new features of self-renewal. Proc Natl Acad Sci USA 103: 8185-90.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 8185-8190
    • Dykstra, B.1    Ramunas, J.2    Kent, D.3    McCaffrey, L.4
  • 19
    • 77952942458 scopus 로고    scopus 로고
    • Variability in the control of cell division underlies sepal epidermal patterning in Arabidopsis thaliana
    • Roeder AHK, Chickarmane V, Cunha A, Obara B, et al. 2010. Variability in the control of cell division underlies sepal epidermal patterning in Arabidopsis thaliana. PLoS Biol 8: e1000367.
    • (2010) PLoS Biol , vol.8
    • Roeder, A.H.K.1    Chickarmane, V.2    Cunha, A.3    Obara, B.4
  • 21
    • 78651158197 scopus 로고
    • Stochastic model of stem cell proliferation based on growth of spleen colony-forming cells
    • Till JE, Siminovitch L, McCulloch EA. 1964. Stochastic model of stem cell proliferation based on growth of spleen colony-forming cells. Proc Natl Acad Sci USA 51: 29-36.
    • (1964) Proc Natl Acad Sci USA , vol.51 , pp. 29-36
    • Till, J.E.1    Siminovitch, L.2    McCulloch, E.A.3
  • 22
    • 16844385540 scopus 로고    scopus 로고
    • Modeling embryogenesis and cancer: an approach based on an equilibrium between the autostabilization of stochastic gene expression and the interdependence of cells for proliferation
    • Laforge B, Guez D, Martinez M, Kupiec JJ. 2005. Modeling embryogenesis and cancer: an approach based on an equilibrium between the autostabilization of stochastic gene expression and the interdependence of cells for proliferation. Prog Biophys Mol Biol 89: 93-120.
    • (2005) Prog Biophys Mol Biol , vol.89 , pp. 93-120
    • Laforge, B.1    Guez, D.2    Martinez, M.3    Kupiec, J.J.4
  • 23
    • 79958268849 scopus 로고    scopus 로고
    • Universal patterns of stem cell fate in cycling adult tissues
    • Klein AM, Simons BD. 2011. Universal patterns of stem cell fate in cycling adult tissues. Development 138: 3103-11.
    • (2011) Development , vol.138 , pp. 3103-3111
    • Klein, A.M.1    Simons, B.D.2
  • 24
    • 77956668964 scopus 로고    scopus 로고
    • Random discrete competing events vs. dynamic bistable switches in cell proliferation in differentiation
    • Golubev A. 2010. Random discrete competing events vs. dynamic bistable switches in cell proliferation in differentiation. J Theor Biol 267: 341-54.
    • (2010) J Theor Biol , vol.267 , pp. 341-354
    • Golubev, A.1
  • 25
    • 0142217926 scopus 로고    scopus 로고
    • An in silico investigation into the causes of telomere length heterogeneity and its implications for the Hayflick limit
    • Golubev A, Khrustalev S, Butov A. 2003. An in silico investigation into the causes of telomere length heterogeneity and its implications for the Hayflick limit. J Theor Biol 225: 153-70.
    • (2003) J Theor Biol , vol.225 , pp. 153-170
    • Golubev, A.1    Khrustalev, S.2    Butov, A.3
  • 26
    • 77955174763 scopus 로고    scopus 로고
    • Single-allele analysis of transcription kinetics in living mammalian cells
    • Yunger S, Rosenfeld L, Garini Y, Shav-Tal Y. 2010. Single-allele analysis of transcription kinetics in living mammalian cells. Nat Methods 7: 631-3.
    • (2010) Nat Methods , vol.7 , pp. 631-633
    • Yunger, S.1    Rosenfeld, L.2    Garini, Y.3    Shav-Tal, Y.4
  • 28
    • 79955381895 scopus 로고    scopus 로고
    • Mammalian genes are transcribed with widely different bursting kinetics
    • Suter DM, Molina N, Gatfield D, Schneider K, et al. 2011. Mammalian genes are transcribed with widely different bursting kinetics. Science 332: 472-4.
    • (2011) Science , vol.332 , pp. 472-474
    • Suter, D.M.1    Molina, N.2    Gatfield, D.3    Schneider, K.4
  • 29
    • 34247167103 scopus 로고    scopus 로고
    • Variations in cyclin D1 levels through the cell cycle determine the proliferative fate of a cell
    • Yang K, Hitomi M, Stacey D. 2006. Variations in cyclin D1 levels through the cell cycle determine the proliferative fate of a cell. Cell Div 1: 32.
    • (2006) Cell Div , vol.1 , pp. 32
    • Yang, K.1    Hitomi, M.2    Stacey, D.3
  • 30
    • 0003418645 scopus 로고
    • Restriction point for control of normal animal-cell proliferation
    • Pardee AB. 1974. Restriction point for control of normal animal-cell proliferation. Proc Natl Acad Sci USA 71: 1286-90.
    • (1974) Proc Natl Acad Sci USA , vol.71 , pp. 1286-1290
    • Pardee, A.B.1
  • 31
    • 69249155033 scopus 로고    scopus 로고
    • Cyclin D1 degradation is sufficient to induce G1 cell cycle arrest despite constitutive expression of cyclin E2 in ovarian cancer cells
    • Masamha CP, Benbrook DM. 2009. Cyclin D1 degradation is sufficient to induce G1 cell cycle arrest despite constitutive expression of cyclin E2 in ovarian cancer cells. Cancer Res 69: 6565-72.
    • (2009) Cancer Res , vol.69 , pp. 6565-6572
    • Masamha, C.P.1    Benbrook, D.M.2
  • 32
    • 33748679908 scopus 로고    scopus 로고
    • A cell-type-specific transcriptional network required for estrogen regulation of cyclin D1 and cell cycle progression in breast cancer
    • Eeckhoute J, Carroll JS, Geistlinger TR, Torres-Arzayus MI, et al. 2006. A cell-type-specific transcriptional network required for estrogen regulation of cyclin D1 and cell cycle progression in breast cancer. Gene Dev 20: 2513-26.
    • (2006) Gene Dev , vol.20 , pp. 2513-2526
    • Eeckhoute, J.1    Carroll, J.S.2    Geistlinger, T.R.3    Torres-Arzayus, M.I.4
  • 33
    • 59349108429 scopus 로고    scopus 로고
    • Transcriptional regulation of the cyclin D1 gene at a glance
    • Klein EA, Assoian RK. 2008. Transcriptional regulation of the cyclin D1 gene at a glance. J Cell Sci 121: 3853-7.
    • (2008) J Cell Sci , vol.121 , pp. 3853-3857
    • Klein, E.A.1    Assoian, R.K.2
  • 34
    • 80051978060 scopus 로고    scopus 로고
    • Reverse transcriptase-coupled quantitative real time PCR analysis of cell-free transcription on the chromatin-assembled p21 promoter
    • Park JH, Magan N. 2011. Reverse transcriptase-coupled quantitative real time PCR analysis of cell-free transcription on the chromatin-assembled p21 promoter. PLoS One 6: e23617.
    • (2011) PLoS One , vol.6
    • Park, J.H.1    Magan, N.2
  • 36
    • 70249104647 scopus 로고    scopus 로고
    • Defining mechanisms that regulate RNA polymerase II transcription in vivo
    • Fuda NJ, Ardehali MB, Lis JT. 2009. Defining mechanisms that regulate RNA polymerase II transcription in vivo. Nature 461: 186-92.
    • (2009) Nature , vol.461 , pp. 186-192
    • Fuda, N.J.1    Ardehali, M.B.2    Lis, J.T.3
  • 37
    • 79952660821 scopus 로고    scopus 로고
    • Control of the embryonic stem cell state
    • Young RA. 2011. Control of the embryonic stem cell state. Cell 144: 940-54.
    • (2011) Cell , vol.144 , pp. 940-954
    • Young, R.A.1
  • 38
    • 66049096618 scopus 로고    scopus 로고
    • The basal initiation machinery: beyond the general transcription factors
    • Sikorski TW, Buratowski S. 2009. The basal initiation machinery: beyond the general transcription factors. Curr Opin Cell Biol 21: 344-51.
    • (2009) Curr Opin Cell Biol , vol.21 , pp. 344-351
    • Sikorski, T.W.1    Buratowski, S.2
  • 39
    • 78650242291 scopus 로고    scopus 로고
    • The three Rs of transcription: recruit, retain, and recycle
    • Motta-Mena LB, Partch CL, Gardner KH. 2010. The three Rs of transcription: recruit, retain, and recycle. Mol Cell 40: 855-8.
    • (2010) Mol Cell , vol.40 , pp. 855-858
    • Motta-Mena, L.B.1    Partch, C.L.2    Gardner, K.H.3
  • 41
    • 77957145277 scopus 로고    scopus 로고
    • Gene expression: the coherent mediator
    • Ohlsson R. 2010. Gene expression: the coherent mediator. Nature 467: 406-7.
    • (2010) Nature , vol.467 , pp. 406-407
    • Ohlsson, R.1
  • 42
    • 79953163378 scopus 로고    scopus 로고
    • Chromatin higher-order structures and gene regulation
    • Li G, Reinberg D. 2011. Chromatin higher-order structures and gene regulation. Curr Opin Genet Dev 21: 175-86.
    • (2011) Curr Opin Genet Dev , vol.21 , pp. 175-186
    • Li, G.1    Reinberg, D.2
  • 43
    • 77958184700 scopus 로고    scopus 로고
    • Transcription, one allele at a time
    • Lionnet T, Singer RH. 2010. Transcription, one allele at a time. Genome Biol 11: 129.
    • (2010) Genome Biol , vol.11 , pp. 129
    • Lionnet, T.1    Singer, R.H.2
  • 47
    • 70350518308 scopus 로고    scopus 로고
    • Differentiation driven changes in the dynamic organization of basal transcription initiation
    • Giglia-Mari G, Theil AF, Mari PO, Mourgues S, et al. 2009. Differentiation driven changes in the dynamic organization of basal transcription initiation. PLoS Biol 7: e1000220.
    • (2009) PLoS Biol , vol.7
    • Giglia-Mari, G.1    Theil, A.F.2    Mari, P.O.3    Mourgues, S.4
  • 48
    • 77949523739 scopus 로고    scopus 로고
    • On the spontaneous stochastic dynamics of a single gene: complexity of the molecular interplay at the promoter
    • Coulon A, Gandrillon O, Beslon G. 2010. On the spontaneous stochastic dynamics of a single gene: complexity of the molecular interplay at the promoter. BMC Syst Biol 4: 2.
    • (2010) BMC Syst Biol , vol.4 , pp. 2
    • Coulon, A.1    Gandrillon, O.2    Beslon, G.3
  • 49
    • 79952280117 scopus 로고    scopus 로고
    • Dynamic as well as stable protein interactions contribute to genome function and maintenance
    • Hemmerich P, Schmiedeberg L, Diekmann S. 2011. Dynamic as well as stable protein interactions contribute to genome function and maintenance. Chromosome Res 19: 131-51.
    • (2011) Chromosome Res , vol.19 , pp. 131-151
    • Hemmerich, P.1    Schmiedeberg, L.2    Diekmann, S.3
  • 50
    • 75149141847 scopus 로고    scopus 로고
    • Mechanisms of transcription factor selectivity
    • Pan Y, Tsai CJ, Ma B, Nussinov R. 2010. Mechanisms of transcription factor selectivity. Trends Genet 26: 75-83.
    • (2010) Trends Genet , vol.26 , pp. 75-83
    • Pan, Y.1    Tsai, C.J.2    Ma, B.3    Nussinov, R.4
  • 51
    • 67349180635 scopus 로고    scopus 로고
    • Fine tuning gene expression through short DNA-protein binding cycles
    • Michel D. 2009. Fine tuning gene expression through short DNA-protein binding cycles. Biochimie 91: 933-41.
    • (2009) Biochimie , vol.91 , pp. 933-941
    • Michel, D.1
  • 52
    • 79955407832 scopus 로고    scopus 로고
    • Real-time observation of transcription initiation and elongation on an endogenous yeast gene
    • Larson DR, Zenklusen D, Wu B, Chao JA, et al. 2011. Real-time observation of transcription initiation and elongation on an endogenous yeast gene. Science 332: 475-8.
    • (2011) Science , vol.332 , pp. 475-478
    • Larson, D.R.1    Zenklusen, D.2    Wu, B.3    Chao, J.A.4
  • 53
    • 43149108161 scopus 로고    scopus 로고
    • A bistable Rb-E2F switch underlies the restriction point
    • Yao G, Lee TJ, Mori S, Nevins JR, et al. 2008. A bistable Rb-E2F switch underlies the restriction point. Nat Cell Biol 10: 476-82.
    • (2008) Nat Cell Biol , vol.10 , pp. 476-482
    • Yao, G.1    Lee, T.J.2    Mori, S.3    Nevins, J.R.4
  • 54
    • 79955553550 scopus 로고    scopus 로고
    • Origin of bistability underlying mammalian cell cycle entry
    • Yao G, Tan C, West M, Nevins JR, et al. 2011. Origin of bistability underlying mammalian cell cycle entry. Mol Syst Biol 7: 485.
    • (2011) Mol Syst Biol , vol.7 , pp. 485
    • Yao, G.1    Tan, C.2    West, M.3    Nevins, J.R.4
  • 55
    • 77954076709 scopus 로고    scopus 로고
    • Intraclonal protein expression heterogeneity in recombinant CHO cells
    • Pilbrough W, Munro TP, Gray P. 2009. Intraclonal protein expression heterogeneity in recombinant CHO cells. PLoS One 4: e8432.
    • (2009) PLoS One , vol.4
    • Pilbrough, W.1    Munro, T.P.2    Gray, P.3
  • 58
    • 78249250559 scopus 로고    scopus 로고
    • Phenotypic heterogeneity among tumorigenic melanoma cells from patients that is reversible and not hierarchically organized
    • Quintana E, Shackleton M, Foster HR, Fullen DR, et al. 2010. Phenotypic heterogeneity among tumorigenic melanoma cells from patients that is reversible and not hierarchically organized. Cancer Cell 18: 510-23.
    • (2010) Cancer Cell , vol.18 , pp. 510-523
    • Quintana, E.1    Shackleton, M.2    Foster, H.R.3    Fullen, D.R.4
  • 59
    • 78049237405 scopus 로고    scopus 로고
    • Cancer stem cells versus phenotype-switching in melanoma
    • Hoek KS, Goding CR. 2010. Cancer stem cells versus phenotype-switching in melanoma. Pigment Cell Melanoma Res 23: 746-59.
    • (2010) Pigment Cell Melanoma Res , vol.23 , pp. 746-759
    • Hoek, K.S.1    Goding, C.R.2
  • 60
    • 77950809059 scopus 로고    scopus 로고
    • A Chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations
    • Sharma SV, Lee DY, Li B, Quinlan MP, et al. 2010. A Chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations. Cell 141: 69-80.
    • (2010) Cell , vol.141 , pp. 69-80
    • Sharma, S.V.1    Lee, D.Y.2    Li, B.3    Quinlan, M.P.4
  • 61
    • 70549093092 scopus 로고    scopus 로고
    • Non-genetic cell-to-cell variability and the consequences for pharmacology
    • Niepel M, Spencer SL, Sorger PK. 2009. Non-genetic cell-to-cell variability and the consequences for pharmacology. Curr Opin Chem Biol 13: 556-61.
    • (2009) Curr Opin Chem Biol , vol.13 , pp. 556-561
    • Niepel, M.1    Spencer, S.L.2    Sorger, P.K.3
  • 62
    • 77952502408 scopus 로고    scopus 로고
    • A temporarily distinct subpopulation of slow-cycling melanoma cells is required for continuous tumor growth
    • Roesch A, Fukunaga-Kalabis M, Schmidt EC, Zabierowski SE, et al. 2010. A temporarily distinct subpopulation of slow-cycling melanoma cells is required for continuous tumor growth. Cell 141: 583-94.
    • (2010) Cell , vol.141 , pp. 583-594
    • Roesch, A.1    Fukunaga-Kalabis, M.2    Schmidt, E.C.3    Zabierowski, S.E.4
  • 63
    • 44349162752 scopus 로고    scopus 로고
    • Transcriptome-wide noise controls lineage choice in mammalian progenitor cells
    • Chang HH, Hemberg M, Barahona M, Ingber DE, et al. 2008. Transcriptome-wide noise controls lineage choice in mammalian progenitor cells. Nature 453: 544-7.
    • (2008) Nature , vol.453 , pp. 544-547
    • Chang, H.H.1    Hemberg, M.2    Barahona, M.3    Ingber, D.E.4
  • 64
    • 69249215528 scopus 로고    scopus 로고
    • The cyclic gene Hes1 contributes to diverse differentiation responses of embryonic stem cells
    • Kobayashi T, Mizuno H, Imayoshi I, Furusawa C, et al. 2009. The cyclic gene Hes1 contributes to diverse differentiation responses of embryonic stem cells. Gene Dev 23: 1870-5.
    • (2009) Gene Dev , vol.23 , pp. 1870-1875
    • Kobayashi, T.1    Mizuno, H.2    Imayoshi, I.3    Furusawa, C.4
  • 65
    • 79953728762 scopus 로고    scopus 로고
    • Hes1 oscillations contribute to heterogeneous differentiation responses in embryonic stem cells
    • Kobayashi T, Kageyama R. 2011. Hes1 oscillations contribute to heterogeneous differentiation responses in embryonic stem cells. Genes 2: 219-28.
    • (2011) Genes , vol.2 , pp. 219-228
    • Kobayashi, T.1    Kageyama, R.2
  • 66
    • 79952219919 scopus 로고    scopus 로고
    • Single cell transcriptional profiling reveals heterogeneity of human induced pluripotent stem cells
    • Narsinh KH, Sun N, Sanchez-Freire V, Lee AS, et al. 2011. Single cell transcriptional profiling reveals heterogeneity of human induced pluripotent stem cells. J Clin Invest 121: 1217-21.
    • (2011) J Clin Invest , vol.121 , pp. 1217-1221
    • Narsinh, K.H.1    Sun, N.2    Sanchez-Freire, V.3    Lee, A.S.4
  • 67
    • 77956643643 scopus 로고    scopus 로고
    • Multiple, interconvertible states of human pluripotent stem cells
    • Kerr CL, Cheng L. 2010. Multiple, interconvertible states of human pluripotent stem cells. Cell Stem Cell 6: 497-9.
    • (2010) Cell Stem Cell , vol.6 , pp. 497-499
    • Kerr, C.L.1    Cheng, L.2
  • 68
    • 68049139696 scopus 로고    scopus 로고
    • Regulated fluctuations in Nanog expression mediate cell fate decisions in embryonic stem cells
    • Kalmar T, Lim C, Hayward P, Munoz-Descalzo S, et al. 2009. Regulated fluctuations in Nanog expression mediate cell fate decisions in embryonic stem cells. PLoS Biol 7: e1000149.
    • (2009) PLoS Biol , vol.7
    • Kalmar, T.1    Lim, C.2    Hayward, P.3    Munoz-Descalzo, S.4
  • 69
    • 79953847687 scopus 로고    scopus 로고
    • A precarious balance: pluripotency factors as lineage specifiers
    • Loh KM, Lim B. 2011. A precarious balance: pluripotency factors as lineage specifiers. Cell Stem Cell 8: 363-9.
    • (2011) Cell Stem Cell , vol.8 , pp. 363-369
    • Loh, K.M.1    Lim, B.2
  • 70
    • 77956906135 scopus 로고    scopus 로고
    • Stochastic variation: from single cells to superorganisms
    • Kilfoil ML, Lasko P, Abouheif E. 2009. Stochastic variation: from single cells to superorganisms. HFSP J 3: 379-85.
    • (2009) HFSP J , vol.3 , pp. 379-385
    • Kilfoil, M.L.1    Lasko, P.2    Abouheif, E.3
  • 71
    • 78650813064 scopus 로고    scopus 로고
    • Bistable cell fate specification as a result of stochastic fluctuations and collective spatial cell behaviour
    • Stockholm D, Edom-Vovard F, Coutant S, Sanatine P, et al. 2010. Bistable cell fate specification as a result of stochastic fluctuations and collective spatial cell behaviour. PLoS One 5: e14441.
    • (2010) PLoS One , vol.5
    • Stockholm, D.1    Edom-Vovard, F.2    Coutant, S.3    Sanatine, P.4
  • 72
    • 30444446493 scopus 로고    scopus 로고
    • Stochastic gene expression, disruption of tissue averaging effects and cancer as a disease of development
    • Capp JP. 2005. Stochastic gene expression, disruption of tissue averaging effects and cancer as a disease of development. BioEssays 27: 1277-85.
    • (2005) BioEssays , vol.27 , pp. 1277-1285
    • Capp, J.P.1
  • 73
    • 79956132200 scopus 로고    scopus 로고
    • Characterization of stem cells and cancer cells on the basis of gene expression profile stability, plasticity, and robustness
    • Kaneko K. 2011. Characterization of stem cells and cancer cells on the basis of gene expression profile stability, plasticity, and robustness. BioEssays 33: 403-13.
    • (2011) BioEssays , vol.33 , pp. 403-413
    • Kaneko, K.1
  • 74
    • 66449090934 scopus 로고    scopus 로고
    • Reprogramming cell fates: reconciling rarity with robustness
    • Huang S. 2009. Reprogramming cell fates: reconciling rarity with robustness. BioEssays 31: 546-60.
    • (2009) BioEssays , vol.31 , pp. 546-560
    • Huang, S.1
  • 75
    • 0031029852 scopus 로고    scopus 로고
    • Stochastic mechanisms in gene expression
    • McAdams HH, Arkin A. 1997. Stochastic mechanisms in gene expression. Proc Natl Acad Sci USA 94: 814-9.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 814-819
    • McAdams, H.H.1    Arkin, A.2
  • 76
    • 79958078747 scopus 로고    scopus 로고
    • Transcriptional regulation: effects of promoter proximal pausing on speed, synchrony and reliability
    • Boettiger AN, Ralph PL, Evans SN. 2011. Transcriptional regulation: effects of promoter proximal pausing on speed, synchrony and reliability. PLoS Comput Biol 7: e1001136.
    • (2011) PLoS Comput Biol , vol.7
    • Boettiger, A.N.1    Ralph, P.L.2    Evans, S.N.3
  • 77
    • 34447098370 scopus 로고    scopus 로고
    • A chromatin landmark and transcription initiation at most promoters in human cells
    • Guenther MG, Levine SS, Boyer LA, Jaenisch R, et al. 2007. A chromatin landmark and transcription initiation at most promoters in human cells. Cell 130: 77-88.
    • (2007) Cell , vol.130 , pp. 77-88
    • Guenther, M.G.1    Levine, S.S.2    Boyer, L.A.3    Jaenisch, R.4
  • 78
    • 83455164706 scopus 로고    scopus 로고
    • Temporal competition between differentiation programs determines cell fate choice
    • Kuchina A, Espinar L, Cagatay T, Balbin AO, et al. 2011. Temporal competition between differentiation programs determines cell fate choice. Mol Syst Biol 7: 557.
    • (2011) Mol Syst Biol , vol.7 , pp. 557
    • Kuchina, A.1    Espinar, L.2    Cagatay, T.3    Balbin, A.O.4
  • 79
    • 84856072934 scopus 로고    scopus 로고
    • Activation-induced B cell fates are selected by intracellular stochastic competition
    • Duffy KR, Wellard CJ, Markham JF, Zhou JHS, et al. 2012. Activation-induced B cell fates are selected by intracellular stochastic competition. Science 335: 338-41.
    • (2012) Science , vol.335 , pp. 338-341
    • Duffy, K.R.1    Wellard, C.J.2    Markham, J.F.3    Zhou, J.H.S.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.