Proteolytic activation of the epithelial sodium channel and therapeutic application of a serine protease inhibitor for the treatment of salt-sensitive hypertension

Clinical and Experimental Nephrology

Volumn 16, Issue 1, 2012, Pages 44-48

  Kitamura, Kenichiro ^a   Tomita, Kimio ^a  

^a KUMAMOTO UNIVERSITY   (Japan)

Author keywords

Epithelial sodium channel (ENaC); Salt sensitive hypertension; Serine protease; Serine protease inhibitor

Indexed keywords

4 (4 GUANIDINOBENZOLOXY)PHENYLACETATE METHANESULFONIC ACID; 4 (4 GUANIDINOBENZOYLOXY)PHENYLACETIC ACID; ALDOSTERONE; APROTININ; CAMOSTAT MESILATE; EPITHELIAL SODIUM CHANNEL; LEUKOCYTE ELASTASE INHIBITOR; PLASMINOGEN ACTIVATOR INHIBITOR 1; POTASSIUM; PROTEASE NEXIN I; SERINE PROTEINASE INHIBITOR; SODIUM; ULINASTATIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIHYPERTENSIVE ACTIVITY; BLOOD PRESSURE REGULATION; CONTROLLED STUDY; DAHL SALT SENSITIVE RAT; ENZYME ACTIVATION; ENZYME ACTIVITY; HYPERTENSION; NONHUMAN; POTASSIUM URINE LEVEL; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN SECRETION; RAT; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; REVIEW; SALT SENSITIVE HYPERTENSION; SODIUM ABSORPTION; SODIUM URINE LEVEL;

ANIMALS; EPITHELIAL SODIUM CHANNEL; FURIN; GABEXATE; HUMANS; HYPERTENSION; RATS; RATS, INBRED DAHL; SERINE ENDOPEPTIDASES; SERINE PROTEINASE INHIBITORS;

EID: 84858280962     PISSN: 13421751     EISSN: 14377799     Source Type: Journal    
DOI: 10.1007/s10157-011-0506-1     Document Type: Review

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