Convective transport of highly plasma protein bound drugs facilitates direct penetration into deep tissues after topical application

British Journal of Clinical Pharmacology

Volumn 73, Issue 4, 2012, Pages 564-578

  Dancik, Yuri ^a,b,d   Anissimov, Yuri G ^c   Jepps, Owen G ^c   Roberts, Michael S ^a,b  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b UNIVERSITY OF SOUTH AUSTRALIA   (Australia)

^c GRIFFITH UNIVERSITY   (Australia)

^d PROCTER AND GAMBLE COMPANY   (United States)

Author keywords

Blood flow; Dermal absorption; Interstitial convection; Lipophilicity; Lymphatics; Protein binding

Indexed keywords

ALCOHOL; BOVINE SERUM ALBUMIN; DICLOFENAC; FLUCONAZOLE; FLUOROURACIL; IBUPROFEN; KETOPROFEN; LIDOCAINE; NICOTINE; PROPRANOLOL; SALICYLIC ACID; SALICYLIC ACID METHYL ESTER; TRIETHANOLAMINE SALICYLATE;

AREA UNDER THE CURVE; ARTICLE; BINDING AFFINITY; DERMIS; DRUG ABSORPTION; DRUG PENETRATION; DRUG PROTEIN BINDING; DRUG TRANSPORT; FEMALE; HUMAN; IN VITRO STUDY; IN VIVO STUDY; MICRODIALYSIS; NONHUMAN; PRIORITY JOURNAL; RAT; SKIN PENETRATION; STEADY STATE; TOPICAL TREATMENT;

ADMINISTRATION, CUTANEOUS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BIOLOGICAL TRANSPORT; BLOOD PROTEINS; DICLOFENAC; FEMALE; HUMANS; MALE; MODELS, BIOLOGICAL; NICOTINE; NICOTINIC AGONISTS; PROTEIN BINDING; SKIN; SKIN ABSORPTION; TIME FACTORS;

EID: 84858250173     PISSN: 03065251     EISSN: 13652125     Source Type: Journal    
DOI: 10.1111/j.1365-2125.2011.04128.x     Document Type: Article

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