Estimation of intradermal disposition kinetics of drugs: II. Factors determining penetration of drugs from viable skin to muscular layer

International Journal of Pharmaceutics

Volumn 239, Issue 1-2, 2002, Pages 129-141

  Higaki, Kazutaka ^a   Asai, Masahide ^a   Suyama, Takayuki ^a   Nakayama, Kazuki ^a   Ogawara, Ken Ichi ^a   Kimura, Toshikiro ^a  

^a OKAYAMA UNIVERSITY   (Japan)

Author keywords

Distribution from systemic circulation; Intradermal disposition; Multiregression analysis; Penetration into muscular layer; Systemic absorption; Unbound fraction

Indexed keywords

DICLOFENAC; FELBINAC; FLURBIPROFEN; KETOPROFEN; NAPROXEN; PHENAZONE; PROPRANOLOL; SALICYLIC ACID; TOLMETIN; ZOMEPIRAC;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; COMPARTMENT MODEL; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG ABSORPTION; DRUG BINDING; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG PENETRATION; LINEAR REGRESSION ANALYSIS; MALE; MOLECULAR WEIGHT; MUSCLE; NONHUMAN; PARTITION COEFFICIENT; PLASMA CLEARANCE; PRIORITY JOURNAL; RAT; SIMULATION; SKIN PENETRATION;

ADMINISTRATION, CUTANEOUS; ALGORITHMS; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTIPYRINE; CHEMISTRY, PHYSICAL; INJECTIONS, INTRADERMAL; KINETICS; MALE; MODELS, BIOLOGICAL; MOLECULAR WEIGHT; MUSCLE, SKELETAL; RATS; RATS, WISTAR; SKIN ABSORPTION;

EID: 0037018957     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(02)00084-4     Document Type: Article

References (23)

1. Is there tissue penetration after application of topical salicylate formulations?
2. The disposition of biphenylacetic acid following topical application
3. Facilitated transport of sodium salicylate across an artificial lipid membrane by Azone
4. Enhanced delivery of mitomycin C prodrugs through the skin
5. Percutaneous penetration as a method of delivery to muscle and other tissues
6. Topical penetration of piroxicam is dependent on the distribution of the local cutaneous vasculature
7. Promoting effect of o-ethylmenthol on the percutaneous absorption of ketoprofen
8. Estimation of intradermal disposition kinetics of drugs: I. Analysis by compartment model with contralateral tissues
9. Pharmacokinetic analysis of drug absorption from muscle based on a physiological diffusion model: Effect of molecular size on absorption
10. In vitro and in vivo evaluation of terpenoid esters of indomethacin as dermal prodrugs
11. Diclofenac concentrations in synovial fluid and plasma after cutaneous application in inflammatory and degenerative joint disease
12. Electrically-assisted transdermal drug delivery
13. A physiological pharmacokinetic model for solute disposition in tissues below a topical application site
14. Dermal and underlying tissue pharmacokinetics of salicylic acid after topical application
15. Dermal and underlying tissue pharmacokinetics of lidocaine after topical application
16. Local deep tissue penetration of compounds after dermal application: Structure-tissue penetration relationships
17. Modelling of plasma levels of drugs following transdermal iontophoresis
18. Analysis of skin disposition of flurbiprofen after topical application in hairless rats
19. Skin absorption enhancers
20. Factors determining drug residence in skin during transdermal absorption: Studies on β-blocking agents
21. A nonlinear least squares program based on differential equations, multi (runge), for microcomputers
22. Application of Akaike's information criterion (AIC) in the evaluation of linear pharmacokinetic equations
23. A new in-situ experimental method to evaluate the cutaneous disposition of flurbiprofen after topical application in hairless rats