Deconstruction of activity-dependent covalent modification of heme in human neutrophil myeloperoxidase by multistage mass spectrometry (MS 4)

Biochemistry

Volumn 51, Issue 10, 2012, Pages 2065-2077

  Geoghegan, Kieran F ^a   Varghese, Alison H ^a   Feng, Xidong ^a   Bessire, Andrew J ^a   Conboy, James J ^a   Ruggeri, Roger B ^a   Ahn, Kay ^a   Spath, Samantha N ^a   Filippov, Sergey V ^a   Conrad, Steven J ^a   Carpino, Philip A ^a   Guimarães, Cristiano R W ^a   Vajdos, Felix F ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACCURATE MASS; ACTIVITY-DEPENDENT; COLLISION ENERGIES; COLLISION-INDUCED DISSOCIATION; COVALENT LINK; COVALENT MODIFICATIONS; CRYSTALLOGRAPHIC ANALYSIS; D-RINGS; HEME ENZYME; HEME GROUP; HUMAN NEUTROPHIL; HYDROGEN ATOMS; ION TRAPS; IRON ISOTOPES; MASS INCREASE; MULTI-STAGE MASS SPECTROMETRY; MYELOPEROXIDASE; ONE-ELECTRON OXIDATION; OXIDATIVE COUPLINGS; PEPTIDE MAPPING; POLYPEPTIDE CHAIN; STRUCTURAL ASSIGNMENTS; SULFUR ATOMS;

ENZYMES; HYDROGEN PEROXIDE; ISOTOPES; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PEPTIDES; SULFUR;

PORPHYRINS;

HEME; HYDROGEN; HYDROGEN PEROXIDE; IRON; MYELOPEROXIDASE;

ARTICLE; CHEMICAL STRUCTURE; COVALENT BOND; CRYSTALLOGRAPHY; ENZYME MODIFICATION; ENZYME STRUCTURE; HUMAN; HUMAN CELL; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NEUTROPHIL; OXIDATIVE COUPLING; PEPTIDE MAPPING; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; CATALYTIC DOMAIN; CHROMATOGRAPHY, LIQUID; CRYSTALLOGRAPHY, X-RAY; HEME; HUMANS; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MOLECULAR WEIGHT; NEUTROPHILS; OXIDATION-REDUCTION; PEPTIDE FRAGMENTS; PEPTIDE MAPPING; PEROXIDASE; TANDEM MASS SPECTROMETRY;

EID: 84858245878     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi201872j     Document Type: Article

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