-
1
-
-
0025297583
-
The signal peptide
-
doi:10.1007/BF01868635
-
von Heijne, G. 1990 The signal peptide. J. Membr. Biol. 115, 195-201.(doi:10.1007/BF01868635)
-
(1990)
J. Membr. Biol
, vol.115
, pp. 195-201
-
-
von Heijne, G.1
-
2
-
-
0034602846
-
Discrimination between SRP- and SecA/SecBdependent substrates involves selective recognition of nascent chains by SRP and trigger factor
-
doi:10.1093/emboj/19.1.134
-
Beck, K., Wu, L. F., Brunner, J. & Muller, M. 2000 Discrimination between SRP- and SecA/SecBdependent substrates involves selective recognition of nascent chains by SRP and trigger factor. EMBO J. 19, 134-143.(doi:10.1093/emboj/19.1.134)
-
(2000)
EMBO J
, vol.19
, pp. 134-143
-
-
Beck, K.1
Wu, L.F.2
Brunner, J.3
Muller, M.4
-
3
-
-
33744925719
-
Sequence-specific interactions of nascent Escherichia coli polypeptides with trigger factor and signal recognition particle
-
Ullers, R. S., Houben, E. N., Brunner, J., Oudega, B., Harms, N. & Luirink, J. 2006 Sequence-specific interactions of nascent Escherichia coli polypeptides with trigger factor and signal recognition particle. J. Biol. Chem. 281, 13999-14005.
-
(2006)
J. Biol. Chem
, vol.281
, pp. 13999-14005
-
-
Ullers, R.S.1
Houben, E.N.2
Brunner, J.3
Oudega, B.4
Harms, N.5
Luirink, J.6
-
4
-
-
0020357598
-
Protein translocation across the endoplasmic reticulum. I. Detection in the microsomal membrane of a receptor for the signal recognition particle
-
doi:10.1083/jcb.95.2.463
-
Gilmore, R., Blobel, G. & Walter, P. 1982 Protein translocation across the endoplasmic reticulum. I. Detection in the microsomal membrane of a receptor for the signal recognition particle. J. Cell Biol. 95, 463-469.(doi:10.1083/jcb.95.2.463)
-
(1982)
J. Cell Biol
, vol.95
, pp. 463-469
-
-
Gilmore, R.1
Blobel, G.2
Walter, P.3
-
5
-
-
0019822645
-
Translocation of proteins across the endoplasmic reticulum. III. Signal recognition protein (SRP) causes signal sequencedependent and site-specific arrest of chain elongation that is released by microsomal membranes
-
doi:10.1083/jcb.91.2.557
-
Walter, P. & Blobel, G. 1981 Translocation of proteins across the endoplasmic reticulum. III. Signal recognition protein (SRP) causes signal sequencedependent and site-specific arrest of chain elongation that is released by microsomal membranes. J. Cell Biol. 91, 557-561.(doi:10.1083/jcb.91.2.557)
-
(1981)
J. Cell Biol
, vol.91
, pp. 557-561
-
-
Walter, P.1
Blobel, G.2
-
6
-
-
0024449598
-
Three pure chaperone proteins of Escherichia coli-SecB, trigger factor and GroEL-form soluble complexes with precursor proteins in vitro
-
Lecker, S., Lill, R., Ziegelhoffer, T., Georgopoulos, C., Bassford Jr, P. J., Kumamoto, C. A. & Wickner, W. 1989 Three pure chaperone proteins of Escherichia coli-SecB, trigger factor and GroEL-form soluble complexes with precursor proteins in vitro. EMBO J. 8, 2703-2709.
-
(1989)
EMBO J
, vol.8
, pp. 2703-2709
-
-
Lecker, S.1
Lill, R.2
Ziegelhoffer, T.3
Georgopoulos, C.4
Bassford, P.J.5
Kumamoto, C.A.6
Wickner, W.7
-
7
-
-
0031037648
-
Binding of SecB to ribosome-bound polypeptides has the same characteristics as binding to full-length, denatured proteins
-
doi:10.1073/pnas.94.3.802
-
Randall, L. L., Topping, T. B., Hardy, S. J., Pavlov, M. Y., Freistroffer, D. V. & Ehrenberg, M. 1997 Binding of SecB to ribosome-bound polypeptides has the same characteristics as binding to full-length, denatured proteins. Proc. Natl Acad. Sci. USA 94, 802-807.(doi:10.1073/pnas.94.3.802)
-
(1997)
Proc. Natl Acad. Sci. USA
, vol.94
, pp. 802-807
-
-
Randall, L.L.1
Topping, T.B.2
Hardy, S.J.3
Pavlov, M.Y.4
Freistroffer, D.V.5
Ehrenberg, M.6
-
8
-
-
0025087853
-
The purified E. coli integral membrane protein SecY/E is sufficient for reconstitution of SecA-dependent precursor protein translocation
-
doi:10.1016/0092-8674(90)90111-Q
-
Brundage, L., Hendrick, J. P., Schiebel, E., Driessen, A. J. & Wickner, W. 1990 The purified E. coli integral membrane protein SecY/E is sufficient for reconstitution of SecA-dependent precursor protein translocation. Cell 62, 649-657.(doi:10.1016/0092-8674(90)90111-Q)
-
(1990)
Cell
, vol.62
, pp. 649-657
-
-
Brundage, L.1
Hendrick, J.P.2
Schiebel, E.3
Driessen, A.J.4
Wickner, W.5
-
9
-
-
0347192985
-
X-ray structure of a protein-conducting channel
-
doi:10.1038/nature02218
-
van den Berg, B., Clemons Jr, W. M., Collinson, I., Modis, Y., Hartmann, E., Harrison, S. C. & Rapoport, T. A. 2004 X-ray structure of a protein-conducting channel. Nature 427, 36-44.(doi:10.1038/nature02218)
-
(2004)
Nature
, vol.427
, pp. 36-44
-
-
van den Berg, B.1
Clemons, W.M.2
Collinson, I.3
Modis, Y.4
Hartmann, E.5
Harrison, S.C.6
Rapoport, T.A.7
-
10
-
-
0028142465
-
Reconstitution of an efficient protein translocation machinery comprising SecA and the three membrane proteins, SecY, SecE, and SecG (p12)
-
Hanada, M., Nishiyama, K. I., Mizushima, S. & Tokuda, H. 1994 Reconstitution of an efficient protein translocation machinery comprising SecA and the three membrane proteins, SecY, SecE, and SecG (p12). J. Biol. Chem. 269, 23625-23631.
-
(1994)
J. Biol. Chem
, vol.269
, pp. 23625-23631
-
-
Hanada, M.1
Nishiyama, K.I.2
Mizushima, S.3
Tokuda, H.4
-
11
-
-
0028241570
-
Disruption of the gene encoding p12 (SecG) reveals the direct involvement and important function of SecG in the protein translocation of Escherichia coli at low temperature
-
Nishiyama, K., Hanada, M. & Tokuda, H. 1994 Disruption of the gene encoding p12 (SecG) reveals the direct involvement and important function of SecG in the protein translocation of Escherichia coli at low temperature. EMBO J. 13, 3272-3277.
-
(1994)
EMBO J
, vol.13
, pp. 3272-3277
-
-
Nishiyama, K.1
Hanada, M.2
Tokuda, H.3
-
12
-
-
0027217073
-
A novel membrane protein involved in protein translocation across the cytoplasmic membrane of Escherichia coli
-
Nishiyama, K., Mizushima, S. & Tokuda, H. 1993 A novel membrane protein involved in protein translocation across the cytoplasmic membrane of Escherichia coli. EMBO J. 12, 3409-3415.
-
(1993)
EMBO J
, vol.12
, pp. 3409-3415
-
-
Nishiyama, K.1
Mizushima, S.2
Tokuda, H.3
-
13
-
-
0030029447
-
SecG plays a critical role in protein translocation in the absence of the proton motive force as well as at low temperature
-
doi:10.1016/0014-5793(96)00066-X
-
Hanada, M., Nishiyama, K. & Tokuda, H. 1996 SecG plays a critical role in protein translocation in the absence of the proton motive force as well as at low temperature. FEBS Lett. 381, 25-28.(doi:10.1016/0014-5793(96)00066-X)
-
(1996)
FEBS Lett
, vol.381
, pp. 25-28
-
-
Hanada, M.1
Nishiyama, K.2
Tokuda, H.3
-
14
-
-
0035108130
-
SecG function and phospholipid metabolism in Escherichia coli
-
doi:10.1128/JB.183.6.2006-2012.2001
-
Flower, A. M. 2001 SecG function and phospholipid metabolism in Escherichia coli. J. Bacteriol. 183, 2006-2012.(doi:10.1128/JB.183.6.2006-2012.2001)
-
(2001)
J. Bacteriol
, vol.183
, pp. 2006-2012
-
-
Flower, A.M.1
-
15
-
-
0033694344
-
Both transmembrane domains of SecG contribute to signal sequence recognition by the Escherichia coli protein export machinery
-
doi:10.1046/j.1365-2958.2000.02153.x
-
Bost, S., Silva, F., Rudaz, C. & Belin, D. 2000 Both transmembrane domains of SecG contribute to signal sequence recognition by the Escherichia coli protein export machinery. Mol. Microbiol. 38, 575-587.(doi:10.1046/j.1365-2958.2000.02153.x)
-
(2000)
Mol. Microbiol
, vol.38
, pp. 575-587
-
-
Bost, S.1
Silva, F.2
Rudaz, C.3
Belin, D.4
-
16
-
-
0033833862
-
SecG is an auxiliary component of the protein export apparatus of Escherichia coli
-
doi:10.1007/s004380050039
-
Flower, A. M., Hines, L. L. & Pfennig, P. L. 2000 SecG is an auxiliary component of the protein export apparatus of Escherichia coli. Mol. Gen. Genet. 263, 131-136.(doi:10.1007/s004380050039)
-
(2000)
Mol. Gen. Genet
, vol.263
, pp. 131-136
-
-
Flower, A.M.1
Hines, L.L.2
Pfennig, P.L.3
-
17
-
-
0030949334
-
Subunit interactions in the Escherichia coli protein translocase: SecE and SecG associate independently with SecY
-
doi:10.1016/S0014-5793(97)00376-1
-
Homma, T., Yoshihisa, T. & Ito, K. 1997 Subunit interactions in the Escherichia coli protein translocase: SecE and SecG associate independently with SecY. FEBS Lett. 408, 11-15.(doi:10.1016/S0014-5793(97)00376-1)
-
(1997)
FEBS Lett
, vol.408
, pp. 11-15
-
-
Homma, T.1
Yoshihisa, T.2
Ito, K.3
-
18
-
-
2942517660
-
Mutational analysis of transmembrane regions 3 and 4 of SecY, a central component of protein translocase
-
doi:10.1128/JB.186.12.3960-3969.2004
-
Mori, H., Shimokawa, N., Satoh, Y. & Ito, K. 2004 Mutational analysis of transmembrane regions 3 and 4 of SecY, a central component of protein translocase. J. Bacteriol. 186, 3960-3969.(doi:10.1128/JB.186.12.3960-3969.2004)
-
(2004)
J. Bacteriol
, vol.186
, pp. 3960-3969
-
-
Mori, H.1
Shimokawa, N.2
Satoh, Y.3
Ito, K.4
-
19
-
-
0038408667
-
Nearest neighbor analysis of the SecYEG complex. I. Identification of a SecY-SecG interface
-
doi:10.1021/bi034331a
-
Satoh, Y., Matsumoto, G., Mori, H. & Ito, K. 2003 Nearest neighbor analysis of the SecYEG complex. I. Identification of a SecY-SecG interface. Biochemistry 42, 7434-7441.(doi:10.1021/bi034331a)
-
(2003)
Biochemistry
, vol.42
, pp. 7434-7441
-
-
Satoh, Y.1
Matsumoto, G.2
Mori, H.3
Ito, K.4
-
20
-
-
0037063356
-
SecY-SecY and SecY-SecG contacts revealed by sitespecific crosslinking
-
doi:10.1016/S0014-5793(02)03202-7
-
van der Sluis, E. O., Nouwen, N. & Driessen, A. J. 2002 SecY-SecY and SecY-SecG contacts revealed by sitespecific crosslinking. FEBS Lett. 527, 159-165.(doi:10.1016/S0014-5793(02)03202-7)
-
(2002)
FEBS Lett
, vol.527
, pp. 159-165
-
-
van der Sluis, E.O.1
Nouwen, N.2
Driessen, A.J.3
-
21
-
-
0142039007
-
Depletion of SecDF-YajC causes a decrease in the level of SecG: Implication for their functional interaction
-
doi:10.1016/S0014-5793(03)00847-0
-
Kato, Y., Nishiyama, K. & Tokuda, H. 2003 Depletion of SecDF-YajC causes a decrease in the level of SecG: implication for their functional interaction. FEBS Lett. 550, 114-118.(doi:10.1016/S0014-5793(03)00847-0)
-
(2003)
FEBS Lett
, vol.550
, pp. 114-118
-
-
Kato, Y.1
Nishiyama, K.2
Tokuda, H.3
-
22
-
-
0030959069
-
Distinct catalytic roles of the SecYE, SecG and SecDFyajC subunits of preprotein translocase holoenzyme
-
doi:10.1093/emboj/16.10.2756
-
Duong, F. & Wickner, W. 1997 Distinct catalytic roles of the SecYE, SecG and SecDFyajC subunits of preprotein translocase holoenzyme. EMBO J. 16, 2756-2768.(doi:10.1093/emboj/16.10.2756)
-
(1997)
EMBO J
, vol.16
, pp. 2756-2768
-
-
Duong, F.1
Wickner, W.2
-
23
-
-
35748932922
-
Topology inversion of SecG is essential for cytosolic SecA-dependent stimulation of protein translocation
-
doi:10.1074/jbc.m704716200
-
Sugai, R., Takemae, K., Tokuda, H. & Nishiyama, K. 2007 Topology inversion of SecG is essential for cytosolic SecA-dependent stimulation of protein translocation. J. Biol. Chem. 282, 29540-29548.(doi:10.1074/jbc.m704716200)
-
(2007)
J. Biol. Chem
, vol.282
, pp. 29540-29548
-
-
Sugai, R.1
Takemae, K.2
Tokuda, H.3
Nishiyama, K.4
-
24
-
-
0036775559
-
Membrane topology inversion of SecG detected by labeling with a membrane-impermeable sulfhydryl reagent that causes a close association of SecG with SecA
-
Nagamori, S., Nishiyama, K. & Tokuda, H. 2002 Membrane topology inversion of SecG detected by labeling with a membrane-impermeable sulfhydryl reagent that causes a close association of SecG with SecA. J. Biochem. 132, 629-634.
-
(2002)
J. Biochem
, vol.132
, pp. 629-634
-
-
Nagamori, S.1
Nishiyama, K.2
Tokuda, H.3
-
25
-
-
0029997381
-
Inversion of the membrane topology of SecG coupled with SecAdependent preprotein translocation
-
doi:10.1016/S0092-8674(00)81083-1
-
Nishiyama, K., Suzuki, T. & Tokuda, H. 1996 Inversion of the membrane topology of SecG coupled with SecAdependent preprotein translocation. Cell 85, 71-81.(doi:10.1016/S0092-8674(00)81083-1)
-
(1996)
Cell
, vol.85
, pp. 71-81
-
-
Nishiyama, K.1
Suzuki, T.2
Tokuda, H.3
-
26
-
-
0032506216
-
Roles of SecG in ATP- and SecA-dependent protein translocation
-
doi:10. 1073/pnas.95.23.13567
-
Matsumoto, G., Mori, H. & Ito, K. 1998 Roles of SecG in ATP- and SecA-dependent protein translocation. Proc. Natl Acad. Sci. USA 95, 13567-13572.(doi:10. 1073/pnas.95.23.13567)
-
(1998)
Proc. Natl Acad. Sci. USA
, vol.95
, pp. 13567-13572
-
-
Matsumoto, G.1
Mori, H.2
Ito, K.3
-
27
-
-
31344480940
-
Topologically fixed SecG is fully functional
-
doi:10.1128/JB.188.3.1188-1190.2006
-
van der Sluis, E. O., van der Vries, E., Berrelkamp, G., Nouwen, N. & Driessen, A. J. 2006 Topologically fixed SecG is fully functional. J. Bacteriol. 188, 1188-1190.(doi:10.1128/JB.188.3.1188-1190.2006)
-
(2006)
J. Bacteriol
, vol.188
, pp. 1188-1190
-
-
van der Sluis, E.O.1
van der Vries, E.2
Berrelkamp, G.3
Nouwen, N.4
Driessen, A.J.5
-
28
-
-
0031820398
-
Amino-terminal region of SecA is involved in the function of SecG for protein translocation into Escherichia coli membrane vesicles
-
Mori, H., Sugiyama, H., Yamanaka, M., Sato, K., Tagaya, M. & Mizushima, S. 1998 Amino-terminal region of SecA is involved in the function of SecG for protein translocation into Escherichia coli membrane vesicles. J. Biochem. 124, 122-129.
-
(1998)
J. Biochem
, vol.124
, pp. 122-129
-
-
Mori, H.1
Sugiyama, H.2
Yamanaka, M.3
Sato, K.4
Tagaya, M.5
Mizushima, S.6
-
29
-
-
0031596299
-
Coupled structure changes of SecA and SecG revealed by the synthetic lethality of the secAcsR11 and delta secG: Kan double mutant
-
doi:10.1046/j.1365-2958.1998.00937.x
-
Suzuki, H., Nishiyama, K. & Tokuda, H. 1998 Coupled structure changes of SecA and SecG revealed by the synthetic lethality of the secAcsR11 and delta secG: kan double mutant. Mol. Microbiol. 29, 331-341.(doi:10. 1046/j.1365-2958.1998.00937.x)
-
(1998)
Mol. Microbiol
, vol.29
, pp. 331-341
-
-
Suzuki, H.1
Nishiyama, K.2
Tokuda, H.3
-
30
-
-
54049111011
-
Structure of a complex of the ATPase SecA and the protein-translocation channel
-
doi:10.1038/nature07335
-
Zimmer, J., Nam, Y. & Rapoport, T. A. 2008 Structure of a complex of the ATPase SecA and the protein-translocation channel. Nature 455, 936-943.(doi:10.1038/nature07335)
-
(2008)
Nature
, vol.455
, pp. 936-943
-
-
Zimmer, J.1
Nam, Y.2
Rapoport, T.A.3
-
31
-
-
79953302604
-
Mapping of the SecA.SecY and SecA.SecG interfaces by site-directed in vivo photocross- linking
-
Das, S. & Oliver, D. B. 2011 Mapping of the SecA.SecY and SecA.SecG interfaces by site-directed in vivo photocross- linking. J. Biol. Chem. 286, 12371-12380.
-
(2011)
J. Biol. Chem
, vol.286
, pp. 12371-12380
-
-
Das, S.1
Oliver, D.B.2
-
32
-
-
33845999952
-
The long alpha-helix of SecA is important for the ATPase coupling of translocation
-
Mori, H. & Ito, K. 2006 The long alpha-helix of SecA is important for the ATPase coupling of translocation. J. Biol. Chem. 281, 36249-36256.
-
(2006)
J. Biol. Chem
, vol.281
, pp. 36249-36256
-
-
Mori, H.1
Ito, K.2
-
33
-
-
0026073130
-
Purification of SecE and reconstitution of SecE-dependent protein translocation activity
-
doi:10.1016/0014-5793(91)80156-W
-
Tokuda, H., Akimaru, J., Matsuyama, S., Nishiyama, K. & Mizushima, S. 1991 Purification of SecE and reconstitution of SecE-dependent protein translocation activity. FEBS Lett. 279, 233-236.(doi:10.1016/0014-5793(91)80156-W)
-
(1991)
FEBS Lett
, vol.279
, pp. 233-236
-
-
Tokuda, H.1
Akimaru, J.2
Matsuyama, S.3
Nishiyama, K.4
Mizushima, S.5
-
34
-
-
0026688434
-
The carboxyl-terminal region of SecE interacts with SecY and is functional in the reconstitution of protein translocation activity in Escherichia coli
-
Nishiyama, K., Mizushima, S. & Tokuda, H. 1992 The carboxyl-terminal region of SecE interacts with SecY and is functional in the reconstitution of protein translocation activity in Escherichia coli. J. Biol. Chem. 267, 7170-7176.
-
(1992)
J. Biol. Chem
, vol.267
, pp. 7170-7176
-
-
Nishiyama, K.1
Mizushima, S.2
Tokuda, H.3
-
35
-
-
0025732834
-
One of three transmembrane stretches is sufficient for the functioning of the SecE protein, a membrane component of the E. Coli Secretion Machinery
-
Schatz, P. J., Bieker, K. L., Ottemann, K. M., Silhavy, T. J. & Beckwith, J. 1991 One of three transmembrane stretches is sufficient for the functioning of the SecE protein, a membrane component of the E. coli secretion machinery. EMBO J. 10, 1749-1757.
-
(1991)
EMBO J
, vol.10
, pp. 1749-1757
-
-
Schatz, P.J.1
Bieker, K.L.2
Ottemann, K.M.3
Silhavy, T.J.4
Beckwith, J.5
-
36
-
-
0037427963
-
The general protein secretory pathway: Phylogenetic analyses leading to evolutionary conclusions
-
doi:10.1016/S0005-2736(02)00662-4
-
Cao, T. B. & Saier Jr, M. H. 2003 The general protein secretory pathway: phylogenetic analyses leading to evolutionary conclusions. Biochim. Biophys. Acta 1609, 115-125.(doi:10.1016/S0005-2736(02)00662-4)
-
(2003)
Biochim. Biophys. Acta
, vol.1609
, pp. 115-125
-
-
Cao, T.B.1
Saier, M.H.2
-
37
-
-
0028334912
-
Residues essential for the function of SecE, a membrane component of the Escherichia coli secretion apparatus, are located in a conserved cytoplasmic region
-
doi:10.1073/pnas.91.7.2557
-
Murphy, C. K. & Beckwith, J. 1994 Residues essential for the function of SecE, a membrane component of the Escherichia coli secretion apparatus, are located in a conserved cytoplasmic region. Proc. Natl Acad. Sci. USA 91, 2557-2561.(doi:10.1073/pnas.91.7.2557)
-
(1994)
Proc. Natl Acad. Sci. USA
, vol.91
, pp. 2557-2561
-
-
Murphy, C.K.1
Beckwith, J.2
-
38
-
-
0029810616
-
In vivo analyses of interactions between SecE and SecY, core components of the Escherichia coli protein translocation machinery
-
Pohlschroder, M., Murphy, C. & Beckwith, J. 1996 In vivo analyses of interactions between SecE and SecY, core components of the Escherichia coli protein translocation machinery. J. Biol. Chem. 271, 19908-19914.
-
(1996)
J. Biol. Chem
, vol.271
, pp. 19908-19914
-
-
Pohlschroder, M.1
Murphy, C.2
Beckwith, J.3
-
39
-
-
0029017127
-
FtsH is required for proteolytic elimination of uncomplexed forms of SecY, an essential protein translocase subunit
-
doi:10.1073/pnas.92.10.4532
-
Kihara, A., Akiyama, Y. & Ito, K. 1995 FtsH is required for proteolytic elimination of uncomplexed forms of SecY, an essential protein translocase subunit. Proc. Natl Acad. Sci. USA 92, 4532-4536.(doi:10.1073/pnas.92.10.4532)
-
(1995)
Proc. Natl Acad. Sci. USA
, vol.92
, pp. 4532-4536
-
-
Kihara, A.1
Akiyama, Y.2
Ito, K.3
-
40
-
-
59649110315
-
The roles of pore ring and plug in the SecY protein-conducting channel
-
doi:10.1085/jgp.200810062
-
Gumbart, J. & Schulten, K. 2008 The roles of pore ring and plug in the SecY protein-conducting channel. J. Gen. Physiol. 132, 709-719.(doi:10.1085/jgp.200810062)
-
(2008)
J. Gen. Physiol
, vol.132
, pp. 709-719
-
-
Gumbart, J.1
Schulten, K.2
-
41
-
-
34248563028
-
Determining the conductance of the SecY protein translocation channel for small molecules
-
doi:10.1016/j.molcel.2007.03.022
-
Saparov, S. M., Erlandson, K., Cannon, K., Schaletzky, J., Schulman, S., Rapoport, T. A. & Pohl, P. 2007 Determining the conductance of the SecY protein translocation channel for small molecules. Mol. Cell 26, 501-509.(doi:10.1016/j.molcel.2007.03.022)
-
(2007)
Mol. Cell
, vol.26
, pp. 501-509
-
-
Saparov, S.M.1
Erlandson, K.2
Cannon, K.3
Schaletzky, J.4
Schulman, S.5
Rapoport, T.A.6
Pohl, P.7
-
42
-
-
79955901001
-
Preserving the membrane barrier for small molecules during bacterial protein translocation
-
doi:10. 1038/nature10014
-
Park, E. & Rapoport, T. A. 2011 Preserving the membrane barrier for small molecules during bacterial protein translocation. Nature 473, 239-242.(doi:10. 1038/nature10014)
-
(2011)
Nature
, vol.473
, pp. 239-242
-
-
Park, E.1
Rapoport, T.A.2
-
43
-
-
0032544614
-
Signal sequence recognition in posttranslational protein transport across the yeast ER membrane
-
doi:10.1016/S0092-8674(00)81738-9
-
Plath, K., Mothes, W., Wilkinson, B. M., Stirling, C. J. & Rapoport, T. A. 1998 Signal sequence recognition in posttranslational protein transport across the yeast ER membrane. Cell 94, 795-807.(doi:10.1016/S0092-8674(00)81738-9)
-
(1998)
Cell
, vol.94
, pp. 795-807
-
-
Plath, K.1
Mothes, W.2
Wilkinson, B.M.3
Stirling, C.J.4
Rapoport, T.A.5
-
44
-
-
0346099350
-
Interactions between Sec complex and prepro-alpha-factor during posttranslational protein transport into the endoplasmic reticulum
-
doi:10.1091/mbc.E03-06-0390
-
Plath, K., Wilkinson, B. M., Stirling, C. J. & Rapoport, T. A. 2004 Interactions between Sec complex and prepro-alpha-factor during posttranslational protein transport into the endoplasmic reticulum. Mol. Biol. Cell 15, 1-10.(doi:10.1091/mbc.E03-06-0390)
-
(2004)
Mol. Biol. Cell
, vol.15
, pp. 1-10
-
-
Plath, K.1
Wilkinson, B.M.2
Stirling, C.J.3
Rapoport, T.A.4
-
45
-
-
85027919032
-
Cryo-EM structure of the ribosome-SecYE complex in the membrane environment
-
doi:10. 1038/nsmb.2026
-
Frauenfeld, J. et al. 2011 Cryo-EM structure of the ribosome-SecYE complex in the membrane environment. Nat. Struct. Mol. Biol. 18, 614-621.(doi:10. 1038/nsmb.2026)
-
(2011)
Nat. Struct. Mol. Biol
, vol.18
, pp. 614-621
-
-
Frauenfeld, J.1
-
46
-
-
37349107850
-
Ribosome binding of a single copy of the SecY complex: Implications for protein translocation
-
doi:10.1016/j.molcel.2007.10.034
-
Menetret, J. F. et al. 2007 Ribosome binding of a single copy of the SecY complex: implications for protein translocation. Mol. Cell 28, 1083-1092.(doi:10.1016/j.molcel.2007.10.034)
-
(2007)
Mol. Cell
, vol.28
, pp. 1083-1092
-
-
Menetret, J.F.1
-
47
-
-
54049151196
-
Conformational transition of Sec machinery inferred from bacterial SecYE structures
-
doi:10.1038/nature07421
-
Tsukazaki, T. et al. 2008 Conformational transition of Sec machinery inferred from bacterial SecYE structures. Nature 455, 988-991.(doi:10.1038/nature07421)
-
(2008)
Nature
, vol.455
, pp. 988-991
-
-
Tsukazaki, T.1
-
48
-
-
33750844195
-
Different modes of SecY-SecA interactions revealed by site-directed in vivo photocross-linking
-
doi:10.1073/pnas.0606390103
-
Mori, H. & Ito, K. 2006 Different modes of SecY-SecA interactions revealed by site-directed in vivo photocross-linking. Proc. Natl Acad. Sci. USA 103, 16159-16164.(doi:10.1073/pnas.0606390103)
-
(2006)
Proc. Natl Acad. Sci. USA
, vol.103
, pp. 16159-16164
-
-
Mori, H.1
Ito, K.2
-
49
-
-
33746905934
-
Identification of two interaction sites in SecY that are important for the functional interaction with SecA
-
doi:10.1016/j.jmb.2006.07.017
-
van der Sluis, E. O., Nouwen, N., Koch, J., de Keyzer, J., van der Does, C., Tampe, R. & Driessen, A. J. 2006 Identification of two interaction sites in SecY that are important for the functional interaction with SecA. J. Mol. Biol. 361, 839-849.(doi:10.1016/j.jmb.2006.07.017)
-
(2006)
J. Mol. Biol
, vol.361
, pp. 839-849
-
-
van der Sluis, E.O.1
Nouwen, N.2
Koch, J.3
de Keyzer, J.4
van der Does, C.5
Tampe, R.6
Driessen, A.J.7
-
50
-
-
78049253482
-
Lateral opening of a translocon upon entry of protein suggests the mechanism of insertion into membranes
-
doi:10.1073/pnas.1012556107
-
Egea, P. F. & Stroud, R. M. 2010 Lateral opening of a translocon upon entry of protein suggests the mechanism of insertion into membranes. Proc. Natl Acad. Sci. USA 107, 17182-17187.(doi:10.1073/pnas.1012556107)
-
(2010)
Proc. Natl Acad. Sci. USA
, vol.107
, pp. 17182-17187
-
-
Egea, P.F.1
Stroud, R.M.2
-
51
-
-
34848895197
-
Structural determinants of lateral gate opening in the protein translocon
-
doi:10.1021/bi700835d
-
Gumbart, J. & Schulten, K. 2007 Structural determinants of lateral gate opening in the protein translocon. Biochemistry 46, 11147-11157.(doi:10.1021/bi700835d)
-
(2007)
Biochemistry
, vol.46
, pp. 11147-11157
-
-
Gumbart, J.1
Schulten, K.2
-
52
-
-
67650173024
-
The lateral gate of SecYEG opens during protein translocation
-
doi:10.1074/jbc.M901855200
-
du Plessis, D. J., Berrelkamp, G., Nouwen, N. & Driessen, A. J. 2009 The lateral gate of SecYEG opens during protein translocation. J. Biol. Chem. 284, 15805-15814.(doi:10.1074/jbc.M901855200)
-
(2009)
J. Biol. Chem
, vol.284
, pp. 15805-15814
-
-
du Plessis, D.J.1
Berrelkamp, G.2
Nouwen, N.3
Driessen, A.J.4
-
53
-
-
77957347075
-
Light-induced control of protein translocation by the SecYEG complex
-
doi:10.1002/anie.201002243
-
Bonardi, F., London, G., Nouwen, N., Feringa, B. L. & Driessen, A. J. 2010 Light-induced control of protein translocation by the SecYEG complex. Angew. Chem. Int. Ed Engl. 49, 7234-7238.(doi:10.1002/anie.201002243)
-
(2010)
Angew. Chem. Int. Ed Engl
, vol.49
, pp. 7234-7238
-
-
Bonardi, F.1
London, G.2
Nouwen, N.3
Feringa, B.L.4
Driessen, A.J.5
-
54
-
-
33748300566
-
The plug domain of yeast Sec61p is important for efficient protein translocation, but is not essential for cell viability
-
doi:10.1091/mbc.E06-03-0200
-
Junne, T., Schwede, T., Goder, V. & Spiess, M. 2006 The plug domain of yeast Sec61p is important for efficient protein translocation, but is not essential for cell viability. Mol. Biol. Cell 17, 4063-4068.(doi:10.1091/mbc.E06-03-0200)
-
(2006)
Mol. Biol. Cell
, vol.17
, pp. 4063-4068
-
-
Junne, T.1
Schwede, T.2
Goder, V.3
Spiess, M.4
-
55
-
-
34248523155
-
The plug domain of the SecY protein stabilizes the closed state of the translocation channel and maintains a membrane seal
-
doi:10.1016/j.molcel.2007.05.002
-
Li, W., Schulman, S., Boyd, D., Erlandson, K., Beckwith, J. & Rapoport, T. A. 2007 The plug domain of the SecY protein stabilizes the closed state of the translocation channel and maintains a membrane seal. Mol. Cell 26, 511-521.(doi:10.1016/j.molcel.2007.05.002)
-
(2007)
Mol. Cell
, vol.26
, pp. 511-521
-
-
Li, W.1
Schulman, S.2
Boyd, D.3
Erlandson, K.4
Beckwith, J.5
Rapoport, T.A.6
-
56
-
-
33847698213
-
Deregulation of the SecYEG translocation channel upon removal of the plug domain
-
doi:10.1074/jbc.M610060200
-
Maillard, A. P., Lalani, S., Silva, F., Belin, D. & Duong, F. 2007 Deregulation of the SecYEG translocation channel upon removal of the plug domain. J. Biol. Chem. 282, 1281-1287.(doi:10.1074/jbc.M610060200)
-
(2007)
J. Biol. Chem
, vol.282
, pp. 1281-1287
-
-
Maillard, A.P.1
Lalani, S.2
Silva, F.3
Belin, D.4
Duong, F.5
-
57
-
-
0033032483
-
Mapping an interface of SecY (PrlA) and SecE (PrlG) by using synthetic phenotypes and in vivo cross-linking
-
Harris, C. R. & Silhavy, T. J. 1999 Mapping an interface of SecY (PrlA) and SecE (PrlG) by using synthetic phenotypes and in vivo cross-linking. J. Bacteriol. 181, 3438-3444.
-
(1999)
J. Bacteriol
, vol.181
, pp. 3438-3444
-
-
Harris, C.R.1
Silhavy, T.J.2
-
58
-
-
27144525002
-
Investigating the SecY plug movement at the SecYEG translocation channel
-
doi:10.1038/sj.emboj.7600804
-
Tam, P. C., Maillard, A. P., Chan, K. K. & Duong, F. 2005 Investigating the SecY plug movement at the SecYEG translocation channel. EMBO J. 24, 3380-3388.(doi:10.1038/sj.emboj.7600804)
-
(2005)
EMBO J
, vol.24
, pp. 3380-3388
-
-
Tam, P.C.1
Maillard, A.P.2
Chan, K.K.3
Duong, F.4
-
59
-
-
77954912142
-
Immobilization of the plug domain inside the SecY channel allows unrestricted protein translocation
-
doi:10.1074/jbc.M110.124636
-
Lycklama a Nijeholt, J. A., Bulacu, M., Marrink, S. J. & Driessen, A. J. 2010 Immobilization of the plug domain inside the SecY channel allows unrestricted protein translocation. J. Biol. Chem. 285, 23747-23754.(doi:10.1074/jbc.M110.124636)
-
(2010)
J. Biol. Chem
, vol.285
, pp. 23747-23754
-
-
Lycklamaa, N.J.A.1
Bulacu, M.2
Marrink, S.J.3
Driessen, A.J.4
-
60
-
-
77950448361
-
Hydrophobically stabilized open state for the lateral gate of the Sec translocon
-
doi:10.1073/pnas.0914752107
-
Zhang, B. & Miller III, T. F. 2010 Hydrophobically stabilized open state for the lateral gate of the Sec translocon. Proc. Natl Acad. Sci. USA 107, 5399-5404.(doi:10.1073/pnas.0914752107)
-
(2010)
Proc. Natl Acad. Sci. USA
, vol.107
, pp. 5399-5404
-
-
Zhang, B.1
Miller, T.F.2
-
61
-
-
83755168976
-
Conformational dynamics of the plug domain of the SecYEG protein-conducting channel
-
doi:10.1074/jbc.M111.297507
-
Lycklama a Nijeholt, J. A., Wu, Z. C. & Driessen, A. J. 2011 Conformational dynamics of the plug domain of the SecYEG protein-conducting channel. J. Biol. Chem. 286, 43881-43890.(doi:10.1074/jbc.M111.297507)
-
(2011)
J. Biol. Chem
, vol.286
, pp. 43881-43890
-
-
Lycklamaa, N.J.A.1
Wu, Z.C.2
Driessen, A.J.3
-
62
-
-
0020390269
-
Mechanism of incorporation of cell envelope proteins in Escherichia coli
-
doi:10.1146/annurev.mi.36.100182.002251
-
Michaelis, S. & Beckwith, J. 1982 Mechanism of incorporation of cell envelope proteins in Escherichia coli. Annu. Rev. Microbiol. 36, 435-465.(doi:10.1146/annurev.mi.36.100182.002251)
-
(1982)
Annu. Rev. Microbiol
, vol.36
, pp. 435-465
-
-
Michaelis, S.1
Beckwith, J.2
-
63
-
-
0021401874
-
A defined mutation in the protein export gene within the spc ribosomal protein operon of Escherichia coli: Isolation and characterization of a new temperaturesensitive secY mutant
-
Shiba, K., Ito, K., Yura, T. & Cerretti, D. P. 1984 A defined mutation in the protein export gene within the spc ribosomal protein operon of Escherichia coli: isolation and characterization of a new temperaturesensitive secY mutant. EMBO J. 3, 631-635.
-
(1984)
EMBO J
, vol.3
, pp. 631-635
-
-
Shiba, K.1
Ito, K.2
Yura, T.3
Cerretti, D.P.4
-
64
-
-
0029111417
-
A new genetic selection identifies essential residues in SecG, a component of the Escherichia coli protein export machinery
-
Bost, S. & Belin, D. 1995 A new genetic selection identifies essential residues in SecG, a component of the Escherichia coli protein export machinery. EMBO J. 14, 4412-4421.
-
(1995)
EMBO J
, vol.14
, pp. 4412-4421
-
-
Bost, S.1
Belin, D.2
-
65
-
-
0027457077
-
A signal sequence is not required for protein export in prlA mutants of Escherichia coli
-
Derman, A. I., Puziss, J. W., Bassford Jr, P. J. & Beckwith, J. 1993 A signal sequence is not required for protein export in prlA mutants of Escherichia coli. EMBO J. 12, 879-888.
-
(1993)
EMBO J
, vol.12
, pp. 879-888
-
-
Derman, A.I.1
Puziss, J.W.2
Bassford, P.J.3
Beckwith, J.4
-
66
-
-
0019381724
-
Suppressor mutations that restore export of a protein with a defective signal sequence
-
doi:10.1016/0092-8674(81)90272-5
-
Emr, S. D., Hanley-Way, S. & Silhavy, T. J. 1981 Suppressor mutations that restore export of a protein with a defective signal sequence. Cell 23, 79-88.(doi:10.1016/0092-8674(81)90272-5)
-
(1981)
Cell
, vol.23
, pp. 79-88
-
-
Emr, S.D.1
Hanley-Way, S.2
Silhavy, T.J.3
-
67
-
-
0028102530
-
PrlA and PrlG suppressors reduce the requirement for signal sequence recognition
-
Flower, A. M., Doebele, R. C. & Silhavy, T. J. 1994 PrlA and PrlG suppressors reduce the requirement for signal sequence recognition. J. Bacteriol. 176, 5607-5614.
-
(1994)
J. Bacteriol
, vol.176
, pp. 5607-5614
-
-
Flower, A.M.1
Doebele, R.C.2
Silhavy, T.J.3
-
68
-
-
24944465005
-
Modeling the effects of prl mutations on the Escherichia coli SecY complex
-
doi:10.1128/JB.187.18.6454-6465.2005
-
Smith, M. A., Clemons Jr, W. M., DeMars, C. J. & Flower, A. M. 2005 Modeling the effects of prl mutations on the Escherichia coli SecY complex. J. Bacteriol. 187, 6454-6465.(doi:10.1128/JB.187.18.6454-6465.2005)
-
(2005)
J. Bacteriol
, vol.187
, pp. 6454-6465
-
-
Smith, M.A.1
Clemons, W.M.2
Demars, C.J.3
Flower, A.M.4
-
69
-
-
0028925920
-
The allele-specific synthetic lethality of prlA-prlG double mutants predicts interactive domains of SecY and SecE
-
Flower, A. M., Osborne, R. S. & Silhavy, T. J. 1995 The allele-specific synthetic lethality of prlA-prlG double mutants predicts interactive domains of SecY and SecE. EMBO J. 14, 884-893.
-
(1995)
EMBO J
, vol.14
, pp. 884-893
-
-
Flower, A.M.1
Osborne, R.S.2
Silhavy, T.J.3
-
70
-
-
0027219902
-
PrlA suppressor mutations cluster in regions corresponding to three distinct topological domains
-
Osborne, R. S. & Silhavy, T. J. 1993 PrlA suppressor mutations cluster in regions corresponding to three distinct topological domains. EMBO J. 12, 3391-3398.
-
(1993)
EMBO J
, vol.12
, pp. 3391-3398
-
-
Osborne, R.S.1
Silhavy, T.J.2
-
71
-
-
0032125782
-
PrlA4 prevents the rejection of signal sequence defective preproteins by stabilizing the SecA-SecY interaction during the initiation of translocation
-
doi:10.1093/emboj/17.13.3631
-
van der Wolk, J. P., Fekkes, P., Boorsma, A., Huie, J. L., Silhavy, T. J. & Driessen, A. J. 1998 PrlA4 prevents the rejection of signal sequence defective preproteins by stabilizing the SecA-SecY interaction during the initiation of translocation. EMBO J. 17, 3631-3639.(doi:10.1093/emboj/17.13.3631)
-
(1998)
EMBO J
, vol.17
, pp. 3631-3639
-
-
van der Wolk, J.P.1
Fekkes, P.2
Boorsma, A.3
Huie, J.L.4
Silhavy, T.J.5
Driessen, A.J.6
-
72
-
-
77954635029
-
Dynamics of SecY translocons with translocation-defective mutations
-
doi:10.1016/j.str.2010.04.010
-
Bondar, A. N., del Val, C., Freites, J. A., Tobias, D. J. & White, S. H. 2010 Dynamics of SecY translocons with translocation-defective mutations. Structure 18, 847-857.(doi:10.1016/j.str.2010.04.010)
-
(2010)
Structure
, vol.18
, pp. 847-857
-
-
Bondar, A.N.1
del Val, C.2
Freites, J.A.3
Tobias, D.J.4
White, S.H.5
-
73
-
-
0030013237
-
PrlA suppressors in Escherichia coli relieve the proton electrochemical gradient dependency of translocation of wild-type precursors
-
doi:10.1073/pnas.93.12.5953
-
Nouwen, N., de Kruijff, B. & Tommassen, J. 1996 PrlA suppressors in Escherichia coli relieve the proton electrochemical gradient dependency of translocation of wild-type precursors. Proc. Natl Acad. Sci. USA 93, 5953-5957.(doi:10.1073/pnas.93.12.5953)
-
(1996)
Proc. Natl Acad. Sci. USA
, vol.93
, pp. 5953-5957
-
-
Nouwen, N.1
de Kruijff, B.2
Tommassen, J.3
-
74
-
-
79956359999
-
Probing the SecYEG translocation pore size with preproteins conjugated with sizable rigid spherical molecules
-
doi:10.1073/pnas.1101705108
-
Bonardi, F., Halza, E., Walko, M., Du Plessis, F., Nouwen, N., Feringa, B. L. & Driessen, A. J. 2011 Probing the SecYEG translocation pore size with preproteins conjugated with sizable rigid spherical molecules. Proc. Natl Acad. Sci. USA 108, 7775-7780.(doi:10.1073/pnas.1101705108)
-
(2011)
Proc. Natl Acad. Sci. USA
, vol.108
, pp. 7775-7780
-
-
Bonardi, F.1
Halza, E.2
Walko, M.3
du Plessis, F.4
Nouwen, N.5
Feringa, B.L.6
Driessen, A.J.7
-
75
-
-
70450171353
-
Signal peptides are allosteric activators of the protein translocase
-
doi:10.1038/nature08559
-
Gouridis, G., Karamanou, S., Gelis, I., Kalodimos, C. G. & Economou, A. 2009 Signal peptides are allosteric activators of the protein translocase. Nature 462, 363-367.(doi:10.1038/nature08559)
-
(2009)
Nature
, vol.462
, pp. 363-367
-
-
Gouridis, G.1
Karamanou, S.2
Gelis, I.3
Kalodimos, C.G.4
Economou, A.5
-
76
-
-
0025036708
-
The binding cascade of SecB to SecA to SecY/E mediates preprotein targeting to the E. coli plasma membrane
-
doi:10.1016/0092-8674(90)90160-G
-
Hartl, F. U., Lecker, S., Schiebel, E., Hendrick, J. P. & Wickner, W. 1990 The binding cascade of SecB to SecA to SecY/E mediates preprotein targeting to the E. coli plasma membrane. Cell 63, 269-279.(doi:10.1016/0092-8674(90)90160-G)
-
(1990)
Cell
, vol.63
, pp. 269-279
-
-
Hartl, F.U.1
Lecker, S.2
Schiebel, E.3
Hendrick, J.P.4
Wickner, W.5
-
77
-
-
0025019705
-
The ATPase activity of SecA is regulated by acidic phospholipids, SecY, and the leader and mature domains of precursor proteins
-
doi:10.1016/0092-8674(90)90742-W
-
Lill, R., Dowhan, W. & Wickner, W. 1990 The ATPase activity of SecA is regulated by acidic phospholipids, SecY, and the leader and mature domains of precursor proteins. Cell 60, 271-280.(doi:10.1016/0092-8674(90)90742-W)
-
(1990)
Cell
, vol.60
, pp. 271-280
-
-
Lill, R.1
Dowhan, W.2
Wickner, W.3
-
78
-
-
0026344236
-
SecA protein needs both acidic phospholipids and SecY/E protein for functional high-affinity binding to the Escherichia coli plasma membrane
-
Hendrick, J. P. & Wickner, W. 1991 SecA protein needs both acidic phospholipids and SecY/E protein for functional high-affinity binding to the Escherichia coli plasma membrane. J. Biol. Chem. 266, 24596-24600.
-
(1991)
J. Biol. Chem
, vol.266
, pp. 24596-24600
-
-
Hendrick, J.P.1
Wickner, W.2
-
79
-
-
36048929458
-
A large conformational change couples the ATP binding site of SecA to the SecY protein channel
-
doi:10.1016/j.jmb.2007.09.086
-
Robson, A., Booth, A. E., Gold, V. A., Clarke, A. R. & Collinson, I. 2007 A large conformational change couples the ATP binding site of SecA to the SecY protein channel. J. Mol. Biol. 374, 965-976.(doi:10.1016/j.jmb.2007.09.086)
-
(2007)
J. Mol. Biol
, vol.374
, pp. 965-976
-
-
Robson, A.1
Booth, A.E.2
Gold, V.A.3
Clarke, A.R.4
Collinson, I.5
-
80
-
-
3343011973
-
A large conformational change of the translocation ATPase SecA
-
doi:10.1073/pnas.0401742101
-
Osborne, A. R., Clemons Jr, W. M. & Rapoport, T. A. 2004 A large conformational change of the translocation ATPase SecA. Proc. Natl Acad. Sci. USA 101, 10937-10942.(doi:10.1073/pnas.0401742101)
-
(2004)
Proc. Natl Acad. Sci. USA
, vol.101
, pp. 10937-10942
-
-
Osborne, A.R.1
Clemons, W.M.2
Rapoport, T.A.3
-
81
-
-
70449534599
-
Conformational flexibility and peptide interaction of the translocation ATPase SecA
-
doi:10.1016/j.jmb.2009.10.024
-
Zimmer, J. & Rapoport, T. A. 2009 Conformational flexibility and peptide interaction of the translocation ATPase SecA. J. Mol. Biol. 394, 606-612.(doi:10.1016/j.jmb.2009.10.024)
-
(2009)
J. Mol. Biol
, vol.394
, pp. 606-612
-
-
Zimmer, J.1
Rapoport, T.A.2
-
82
-
-
36049046667
-
Structural basis for signalsequence recognition by the translocase motor SecA as determined by NMR
-
doi:10.1016/j.cell.2007.09.039
-
Gelis, I., Bonvin, A. M., Keramisanou, D., Koukaki, M., Gouridis, G., Karamanou, S., Economou, A. & Kalodimos, C. G. 2007 Structural basis for signalsequence recognition by the translocase motor SecA as determined by NMR. Cell 131, 756-769.(doi:10.1016/j.cell.2007.09.039)
-
(2007)
Cell
, vol.131
, pp. 756-769
-
-
Gelis, I.1
Bonvin, A.M.2
Keramisanou, D.3
Koukaki, M.4
Gouridis, G.5
Karamanou, S.6
Economou, A.7
Kalodimos, C.G.8
-
83
-
-
33845667561
-
Selective photoaffinity labeling identifies the signal peptide binding domain on SecA
-
doi:10.1016/j.jmb.2006.10.027
-
Musial-Siwek, M., Rusch, S. L. & Kendall, D. A. 2007 Selective photoaffinity labeling identifies the signal peptide binding domain on SecA. J. Mol. Biol. 365, 637-648.(doi:10.1016/j.jmb.2006.10.027)
-
(2007)
J. Mol. Biol
, vol.365
, pp. 637-648
-
-
Musial-Siwek, M.1
Rusch, S.L.2
Kendall, D.A.3
-
84
-
-
30044431592
-
Identification of the preprotein binding domain of SecA
-
doi:10.1074/jbc.M509990200
-
Papanikou, E., Karamanou, S., Baud, C., Frank, M., Sianidis, G., Keramisanou, D., Kalodimos, C. G., Kuhn, A. & Economou, A. 2005 Identification of the preprotein binding domain of SecA. J. Biol. Chem. 280, 43209-43217.(doi:10.1074/jbc.M509990200)
-
(2005)
J. Biol. Chem
, vol.280
, pp. 43209-43217
-
-
Papanikou, E.1
Karamanou, S.2
Baud, C.3
Frank, M.4
Sianidis, G.5
Keramisanou, D.6
Kalodimos, C.G.7
Kuhn, A.8
Economou, A.9
-
85
-
-
0030703175
-
The molecular chaperone SecB is released from the carboxyterminus of SecA during initiation of precursor protein translocation
-
doi:10.1093/emboj/16.20.6105
-
Fekkes, P., van der Does, C. & Driessen, A. J. 1997 The molecular chaperone SecB is released from the carboxyterminus of SecA during initiation of precursor protein translocation. EMBO J. 16, 6105-6113.(doi:10.1093/emboj/16.20.6105)
-
(1997)
EMBO J
, vol.16
, pp. 6105-6113
-
-
Fekkes, P.1
van der Does, C.2
Driessen, A.J.3
-
86
-
-
0033586722
-
Zinc stabilizes the SecB binding site of SecA
-
doi:10.1021/bi982818r
-
Fekkes, P., de Wit, J. G., Boorsma, A., Friesen, R. H. & Driessen, A. J. 1999 Zinc stabilizes the SecB binding site of SecA. Biochemistry 38, 5111-5116.(doi:10.1021/bi982818r)
-
(1999)
Biochemistry
, vol.38
, pp. 5111-5116
-
-
Fekkes, P.1
de Wit, J.G.2
Boorsma, A.3
Friesen, R.H.4
Driessen, A.J.5
-
87
-
-
0242407175
-
Structural determinants of SecB recognition by SecA in bacterial protein translocation
-
doi:10.1038/nsb980
-
Zhou, J. & Xu, Z. 2003 Structural determinants of SecB recognition by SecA in bacterial protein translocation. Nat. Struct. Biol. 10, 942-947.(doi:10.1038/nsb980)
-
(2003)
Nat. Struct. Biol
, vol.10
, pp. 942-947
-
-
Zhou, J.1
Xu, Z.2
-
88
-
-
0028940082
-
The C terminus of SecA is involved in both lipid binding and SecB binding
-
doi:10.1074/jbc.270.14.7902
-
Breukink, E., Nouwen, N., van Raalte, A., Mizushima, S., Tommassen, J. & de Kruijff, B. 1995 The C terminus of SecA is involved in both lipid binding and SecB binding. J. Biol. Chem. 270, 7902-7907.(doi:10.1074/jbc.270.14.7902)
-
(1995)
J. Biol. Chem
, vol.270
, pp. 7902-7907
-
-
Breukink, E.1
Nouwen, N.2
van Raalte, A.3
Mizushima, S.4
Tommassen, J.5
de Kruijff, B.6
-
89
-
-
0033428711
-
A molecular switch in SecA protein couples ATP hydrolysis to protein translocation
-
doi:10.1046/j.1365-2958.1999.01686.x
-
Karamanou, S., Vrontou, E., Sianidis, G., Baud, C., Roos, T., Kuhn, A., Politou, A. S. & Economou, A. 1999 A molecular switch in SecA protein couples ATP hydrolysis to protein translocation. Mol. Microbiol. 34, 1133-1145.(doi:10.1046/j.1365-2958.1999.01686.x)
-
(1999)
Mol. Microbiol
, vol.34
, pp. 1133-1145
-
-
Karamanou, S.1
Vrontou, E.2
Sianidis, G.3
Baud, C.4
Roos, T.5
Kuhn, A.6
Politou, A.S.7
Economou, A.8
-
90
-
-
2942588637
-
Nucleotide exchange from the high-affinity ATPbinding site in SecA is the rate-limiting step in the ATPase cycle of the soluble enzyme and occurs through a specialized conformational state
-
doi:10.1021/bi0357208
-
Fak, J. J., Itkin, A., Ciobanu, D. D., Lin, E. C., Song, X. J., Chou, Y. T., Gierasch, L. M. & Hunt, J. F. 2004 Nucleotide exchange from the high-affinity ATPbinding site in SecA is the rate-limiting step in the ATPase cycle of the soluble enzyme and occurs through a specialized conformational state. Biochemistry 43, 7307-7327.(doi:10.1021/bi0357208)
-
(2004)
Biochemistry
, vol.43
, pp. 7307-7327
-
-
Fak, J.J.1
Itkin, A.2
Ciobanu, D.D.3
Lin, E.C.4
Song, X.J.5
Chou, Y.T.6
Gierasch, L.M.7
Hunt, J.F.8
-
91
-
-
0035282958
-
Cross-talk between catalytic and regulatory elements in a DEAD motor domain is essential for SecA function
-
doi:10.1093/emboj/20.5.961
-
Sianidis, G., Karamanou, S., Vrontou, E., Boulias, K., Repanas, K., Kyrpides, N., Politou, A. S. & Economou, A. 2001 Cross-talk between catalytic and regulatory elements in a DEAD motor domain is essential for SecA function. EMBO J. 20, 961-970.(doi:10.1093/emboj/20.5.961)
-
(2001)
EMBO J
, vol.20
, pp. 961-970
-
-
Sianidis, G.1
Karamanou, S.2
Vrontou, E.3
Boulias, K.4
Repanas, K.5
Kyrpides, N.6
Politou, A.S.7
Economou, A.8
-
92
-
-
0025959111
-
SecA, an essential component of the secretory machinery of Escherichia coli, exists as homodimer
-
doi:10.1016/0006-291X(91)90507-4
-
Akita, M., Shinkai, A., Matsuyama, S. & Mizushima, S. 1991 SecA, an essential component of the secretory machinery of Escherichia coli, exists as homodimer. Biochem. Biophys. Res. Commun. 174, 211-216.(doi:10.1016/0006-291X(91)90507-4)
-
(1991)
Biochem. Biophys. Res. Commun
, vol.174
, pp. 211-216
-
-
Akita, M.1
Shinkai, A.2
Matsuyama, S.3
Mizushima, S.4
-
93
-
-
79952470913
-
Quaternary structure of SecA in solution and bound to SecYEG probed at the single molecule level
-
doi:10.1016/j.str.2010.12.016
-
Kusters, I., van den Bogaart, G., Kedrov, A., Krasnikov, V., Fulyani, F., Poolman, B. & Driessen, A. J. 2011 Quaternary structure of SecA in solution and bound to SecYEG probed at the single molecule level. Structure 19, 430-439.(doi:10.1016/j.str.2010.12.016)
-
(2011)
Structure
, vol.19
, pp. 430-439
-
-
Kusters, I.1
van den Bogaart, G.2
Kedrov, A.3
Krasnikov, V.4
Fulyani, F.5
Poolman, B.6
Driessen, A.J.7
-
94
-
-
0042736538
-
Nucleotide binding induces changes in the oligomeric state and conformation of Sec A in a lipid environment: A small-angle neutron-scattering study
-
doi:10.1016/S0022-2836(03)00840-4
-
Bu, Z., Wang, L. & Kendall, D. A. 2003 Nucleotide binding induces changes in the oligomeric state and conformation of Sec A in a lipid environment: a small-angle neutron-scattering study. J. Mol. Biol. 332, 23-30.(doi:10.1016/S0022-2836(03)00840-4)
-
(2003)
J. Mol. Biol
, vol.332
, pp. 23-30
-
-
Bu, Z.1
Wang, L.2
Kendall, D.A.3
-
95
-
-
0037423278
-
Phospholipid-induced monomerization and signal-peptide-induced oligomerization of SecA
-
doi:10.1074/jbc.M205992200
-
Benach, J. et al. 2003 Phospholipid-induced monomerization and signal-peptide-induced oligomerization of SecA. J. Biol. Chem. 278, 3628-3638.(doi:10.1074/jbc.M205992200)
-
(2003)
J. Biol. Chem
, vol.278
, pp. 3628-3638
-
-
Benach, J.1
-
96
-
-
0027769773
-
SecA, the peripheral subunit of the Escherichia coli precursor protein translocase, is functional as a dimer
-
Driessen, A. J. 1993 SecA, the peripheral subunit of the Escherichia coli precursor protein translocase, is functional as a dimer. Biochemistry 32, 13190-13197.
-
(1993)
Biochemistry
, vol.32
, pp. 13190-13197
-
-
Driessen, A.J.1
-
97
-
-
0037144467
-
Nucleotide control of interdomain interactions in the conformational reaction cycle of SecA
-
doi:10.1126/science.1074424
-
Hunt, J. F., Weinkauf, S., Henry, L., Fak, J. J., McNicholas, P., Oliver, D. B. & Deisenhofer, J. 2002 Nucleotide control of interdomain interactions in the conformational reaction cycle of SecA. Science 297, 2018-2026.(doi:10.1126/science.1074424)
-
(2002)
Science
, vol.297
, pp. 2018-2026
-
-
Hunt, J.F.1
Weinkauf, S.2
Henry, L.3
Fak, J.J.4
McNicholas, P.5
Oliver, D.B.6
Deisenhofer, J.7
-
98
-
-
33846909238
-
Structure of dimeric SecA, the Escherichia coli preprotein translocase motor
-
doi:10.1016/j.jmb.2006.12.049
-
Papanikolau, Y., Papadovasilaki, M., Ravelli, R. B., McCarthy, A. A., Cusack, S., Economou, A. & Petratos, K. 2007 Structure of dimeric SecA, the Escherichia coli preprotein translocase motor. J. Mol. Biol. 366, 1545-1557.(doi:10.1016/j.jmb.2006.12.049)
-
(2007)
J. Mol. Biol
, vol.366
, pp. 1545-1557
-
-
Papanikolau, Y.1
Papadovasilaki, M.2
Ravelli, R.B.3
McCarthy, A.A.4
Cusack, S.5
Economou, A.6
Petratos, K.7
-
99
-
-
0345184333
-
Crystal structure of Mycobacterium tuberculosis SecA, a preprotein translocating ATPase
-
doi:10.1073/pnas.0538077100
-
Sharma, V., Arockiasamy, A., Ronning, D. R., Savva, C.G., Holzenburg, A., Braunstein, M., Jacobs Jr, W. R. & Sacchettini, J. C. 2003 Crystal structure of Mycobacterium tuberculosis SecA, a preprotein translocating ATPase. Proc. Natl Acad. Sci. USA 100, 2243-2248.(doi:10.1073/pnas.0538077100)
-
(2003)
Proc. Natl Acad. Sci. USA
, vol.100
, pp. 2243-2248
-
-
Sharma, V.1
Arockiasamy, A.2
Ronning, D.R.3
Savva, C.G.4
Holzenburg, A.5
Braunstein, M.6
Jacobs, W.R.7
Sacchettini, J.C.8
-
100
-
-
33750846046
-
Crystal structure of the translocation ATPase SecA from Thermus thermophilus reveals a parallel, head-to-head dimer
-
doi:10.1016/j.jmb.2006.09.061
-
Vassylyev, D. G., Mori, H., Vassylyeva, M. N., Tsukazaki, T., Kimura, Y., Tahirov, T. H. & Ito, K. 2006 Crystal structure of the translocation ATPase SecA from Thermus thermophilus reveals a parallel, head-to-head dimer. J. Mol. Biol. 364, 248-258.(doi:10.1016/j.jmb.2006.09.061)
-
(2006)
J. Mol. Biol
, vol.364
, pp. 248-258
-
-
Vassylyev, D.G.1
Mori, H.2
Vassylyeva, M.N.3
Tsukazaki, T.4
Kimura, Y.5
Tahirov, T.H.6
Ito, K.7
-
101
-
-
33750821188
-
A novel dimer interface and conformational changes revealed by an X-ray structure of B. subtilis SecA
-
doi:10.1016/j.jmb.2006.08.044
-
Zimmer, J., Li, W. & Rapoport, T. A. 2006 A novel dimer interface and conformational changes revealed by an X-ray structure of B. subtilis SecA. J. Mol. Biol. 364, 259-265.(doi:10.1016/j.jmb.2006.08.044)
-
(2006)
J. Mol. Biol
, vol.364
, pp. 259-265
-
-
Zimmer, J.1
Li, W.2
Rapoport, T.A.3
-
102
-
-
0036129188
-
Complex behavior in solution of homodimeric SecA
-
doi:10.1110/ps.4090102
-
Woodbury, R. L., Hardy, S. J. & Randall, L. L. 2002 Complex behavior in solution of homodimeric SecA. Protein Sci. 11, 875-882.(doi:10.1110/ps.4090102)
-
(2002)
Protein Sci
, vol.11
, pp. 875-882
-
-
Woodbury, R.L.1
Hardy, S.J.2
Randall, L.L.3
-
103
-
-
27444439568
-
Covalently dimerized SecA is functional in protein translocation
-
doi:10.1074/jbc.M506157200
-
de Keyzer, J., van der Sluis, E. O., Spelbrink, R. E., Nijstad, N., de Kruijff, B., Nouwen, N., van der Does, C. & Driessen, A. J. 2005 Covalently dimerized SecA is functional in protein translocation. J. Biol. Chem. 280, 35255-35260.(doi:10.1074/jbc.M506157200)
-
(2005)
J. Biol. Chem
, vol.280
, pp. 35255-35260
-
-
de Keyzer, J.1
van der Sluis, E.O.2
Spelbrink, R.E.3
Nijstad, N.4
de Kruijff, B.5
Nouwen, N.6
van der Does, C.7
Driessen, A.J.8
-
104
-
-
0042347712
-
Bacillus subtilis SecA ATPase exists as an antiparallel dimer in solution
-
doi:10.1021/bi0342057
-
Ding, H., Hunt, J. F., Mukerji, I. & Oliver, D. 2003 Bacillus subtilis SecA ATPase exists as an antiparallel dimer in solution. Biochemistry 42, 8729-8738.(doi:10.1021/bi0342057)
-
(2003)
Biochemistry
, vol.42
, pp. 8729-8738
-
-
Ding, H.1
Hunt, J.F.2
Mukerji, I.3
Oliver, D.4
-
105
-
-
34247214427
-
Nanodiscs unravel the interaction between the SecYEG channel and its cytosolic partner SecA
-
doi:10.1038/sj.emboj.7601661
-
Alami, M., Dalal, K., Lelj-Garolla, B., Sligar, S. G. & Duong, F. 2007 Nanodiscs unravel the interaction between the SecYEG channel and its cytosolic partner SecA. EMBO J. 26, 1995-2004.(doi:10.1038/sj.emboj.7601661)
-
(2007)
EMBO J
, vol.26
, pp. 1995-2004
-
-
Alami, M.1
Dalal, K.2
Lelj-Garolla, B.3
Sligar, S.G.4
Duong, F.5
-
106
-
-
0037009514
-
Dissociation of the dimeric SecA ATPase during protein translocation across the bacterial membrane
-
doi:10.1093/emboj/cdf471
-
Or, E., Navon, A. & Rapoport, T. 2002 Dissociation of the dimeric SecA ATPase during protein translocation across the bacterial membrane. EMBO J. 21, 4470-4479.(doi:10.1093/emboj/cdf471)
-
(2002)
EMBO J
, vol.21
, pp. 4470-4479
-
-
Or, E.1
Navon, A.2
Rapoport, T.3
-
107
-
-
0041736710
-
Binding, activation and dissociation of the dimeric SecA ATPase at the dimeric SecYEG translocase
-
doi:10.1093/emboj/cdg418
-
Duong, F. 2003 Binding, activation and dissociation of the dimeric SecA ATPase at the dimeric SecYEG translocase. EMBO J. 22, 4375-4384.(doi:10.1093/emboj/cdg418)
-
(2003)
EMBO J
, vol.22
, pp. 4375-4384
-
-
Duong, F.1
-
108
-
-
33644904085
-
SecA dimer crosslinked at its subunit interface is functional for protein translocation
-
doi:10.1128/JB.188.1.335-338.2006
-
Jilaveanu, L. B. & Oliver, D. 2006 SecA dimer crosslinked at its subunit interface is functional for protein translocation. J. Bacteriol. 188, 335-338.(doi:10.1128/JB.188.1.335-338.2006)
-
(2006)
J. Bacteriol
, vol.188
, pp. 335-338
-
-
Jilaveanu, L.B.1
Oliver, D.2
-
109
-
-
38949141646
-
Additional in vitro and in vivo evidence for SecA functioning as dimers in the membrane: Dissociation into monomers is not essential for protein translocation in Escherichia coli
-
doi:10.1128/JB.01633-07
-
Wang, H., Na, B., Yang, H. & Tai, P. C. 2008 Additional in vitro and in vivo evidence for SecA functioning as dimers in the membrane: dissociation into monomers is not essential for protein translocation in Escherichia coli. J. Bacteriol. 190, 1413-1418.(doi:10.1128/JB.01633-07)
-
(2008)
J. Bacteriol
, vol.190
, pp. 1413-1418
-
-
Wang, H.1
Na, B.2
Yang, H.3
Tai, P.C.4
-
110
-
-
0023142279
-
SecD, a new gene involved in protein export in Escherichia coli
-
Gardel, C., Benson, S., Hunt, J., Michaelis, S. & Beckwith, J. 1987 SecD, a new gene involved in protein export in Escherichia coli. J. Bacteriol. 169, 1286-1290.
-
(1987)
J. Bacteriol
, vol.169
, pp. 1286-1290
-
-
Gardel, C.1
Benson, S.2
Hunt, J.3
Michaelis, S.4
Beckwith, J.5
-
111
-
-
0025045470
-
The secD locus of E. Coli Codes For Two Membrane Proteins Required For Protein Export
-
Gardel, C., Johnson, K., Jacq, A. & Beckwith, J. 1990 The secD locus of E. coli codes for two membrane proteins required for protein export. EMBO J. 9, 3209-3216.
-
(1990)
EMBO J
, vol.9
, pp. 3209-3216
-
-
Gardel, C.1
Johnson, K.2
Jacq, A.3
Beckwith, J.4
-
112
-
-
0027458691
-
SecD is involved in the release of translocated secretory proteins from the cytoplasmic membrane of Escherichia coli
-
Matsuyama, S., Fujita, Y. & Mizushima, S. 1993 SecD is involved in the release of translocated secretory proteins from the cytoplasmic membrane of Escherichia coli. EMBO J. 12, 265-270.
-
(1993)
EMBO J
, vol.12
, pp. 265-270
-
-
Matsuyama, S.1
Fujita, Y.2
Mizushima, S.3
-
113
-
-
0026769684
-
Overproduction, purification and characterization of SecD and SecF, integral membrane components of the protein translocation machinery of Escherichia coli
-
doi:10.1016/0167-4838(92)90130-6
-
Matsuyama, S., Fujita, Y., Sagara, K. & Mizushima, S. 1992 Overproduction, purification and characterization of SecD and SecF, integral membrane components of the protein translocation machinery of Escherichia coli. Biochim. Biophys. Acta 1122, 77-84.(doi:10.1016/0167-4838(92)90130-6)
-
(1992)
Biochim. Biophys. Acta
, vol.1122
, pp. 77-84
-
-
Matsuyama, S.1
Fujita, Y.2
Sagara, K.3
Mizushima, S.4
-
114
-
-
0028009577
-
SecD and SecF facilitate protein export in Escherichia coli
-
Pogliano, J. A. & Beckwith, J. 1994 SecD and SecF facilitate protein export in Escherichia coli. EMBO J. 13, 554-561.
-
(1994)
EMBO J
, vol.13
, pp. 554-561
-
-
Pogliano, J.A.1
Beckwith, J.2
-
115
-
-
0027956170
-
SecA protein is exposed to the periplasmic surface of the E. coli inner membrane in its active state
-
doi:10.1016/S0092-8674(94)90602-5
-
Kim, Y. J., Rajapandi, T. & Oliver, D. 1994 SecA protein is exposed to the periplasmic surface of the E. coli inner membrane in its active state. Cell 78, 845-853.(doi:10.1016/S0092-8674(94)90602-5)
-
(1994)
Cell
, vol.78
, pp. 845-853
-
-
Kim, Y.J.1
Rajapandi, T.2
Oliver, D.3
-
116
-
-
0029561762
-
SecA membrane cycling at SecYEG is driven by distinct ATP binding and hydrolysis events and is regulated by SecD and SecF
-
doi:10.1016/0092-8674(95)90143-4
-
Economou, A., Pogliano, J. A., Beckwith, J., Oliver, D. B. & Wickner, W. 1995 SecA membrane cycling at SecYEG is driven by distinct ATP binding and hydrolysis events and is regulated by SecD and SecF. Cell 83, 1171-1181.(doi:10.1016/0092-8674(95)90143-4)
-
(1995)
Cell
, vol.83
, pp. 1171-1181
-
-
Economou, A.1
Pogliano, J.A.2
Beckwith, J.3
Oliver, D.B.4
Wickner, W.5
-
117
-
-
0030922143
-
The protease- protected 30 kDa domain of SecA is largely inaccessible to the membrane lipid phase
-
doi:10.1093/emboj/16.9.2188
-
Eichler, J., Brunner, J. & Wickner, W. 1997 The protease- protected 30 kDa domain of SecA is largely inaccessible to the membrane lipid phase. EMBO J. 16, 2188-2196.(doi:10.1093/emboj/16.9.2188)
-
(1997)
EMBO J
, vol.16
, pp. 2188-2196
-
-
Eichler, J.1
Brunner, J.2
Wickner, W.3
-
118
-
-
0030903689
-
Both an N-terminal 65-kDa domain and a C-terminal 30-kDa domain of SecA cycle into the membrane at SecYEG during translocation
-
doi:10.1073/pnas.94.11.5574
-
Eichler, J. & Wickner, W. 1997 Both an N-terminal 65-kDa domain and a C-terminal 30-kDa domain of SecA cycle into the membrane at SecYEG during translocation. Proc. Natl Acad. Sci. USA 94, 5574-5581.(doi:10.1073/pnas.94.11.5574)
-
(1997)
Proc. Natl Acad. Sci. USA
, vol.94
, pp. 5574-5581
-
-
Eichler, J.1
Wickner, W.2
-
119
-
-
0030745847
-
The SecDFyajC domain of preprotein translocase controls preprotein movement by regulating SecA membrane cycling
-
doi:10.1093/emboj/16.16.4871
-
Duong, F. & Wickner, W. 1997 The SecDFyajC domain of preprotein translocase controls preprotein movement by regulating SecA membrane cycling. EMBO J. 16, 4871-4879.(doi:10.1093/emboj/16.16.4871)
-
(1997)
EMBO J
, vol.16
, pp. 4871-4879
-
-
Duong, F.1
Wickner, W.2
-
120
-
-
23644461029
-
The large first periplasmic loop of SecD and SecF plays an important role in SecDF functioning
-
doi:10.1128/JB.187.16.5857-5860.2005
-
Nouwen, N., Piwowarek, M., Berrelkamp, G. & Driessen, A. J. 2005 The large first periplasmic loop of SecD and SecF plays an important role in SecDF functioning. J. Bacteriol. 187, 5857-5860.(doi:10.1128/JB.187.16.5857-5860.2005)
-
(2005)
J. Bacteriol
, vol.187
, pp. 5857-5860
-
-
Nouwen, N.1
Piwowarek, M.2
Berrelkamp, G.3
Driessen, A.J.4
-
121
-
-
79958281760
-
Structure and function of a membrane component SecDF that enhances protein export
-
doi:10.1038/nature09980
-
Tsukazaki, T. et al. 2011 Structure and function of a membrane component SecDF that enhances protein export. Nature 474, 235-238.(doi:10.1038/nature09980)
-
(2011)
Nature
, vol.474
, pp. 235-238
-
-
Tsukazaki, T.1
-
122
-
-
0032516913
-
SecDF of Bacillus subtilis, a molecular Siamese twin required for the efficient secretion of proteins
-
Bolhuis, A., Broekhuizen, C. P., Sorokin, A., van Roosmalen, M. L., Venema, G., Bron, S., Quax, W. J. & van Dijl, J. M. 1998 SecDF of Bacillus subtilis, a molecular Siamese twin required for the efficient secretion of proteins. J. Biol. Chem. 273, 21217-21224.
-
(1998)
J. Biol. Chem
, vol.273
, pp. 21217-21224
-
-
Bolhuis, A.1
Broekhuizen, C.P.2
Sorokin, A.3
van Roosmalen, M.L.4
Venema, G.5
Bron, S.6
Quax, W.J.7
van Dijl, J.M.8
-
123
-
-
33748670458
-
Crystal structures of a multidrug transporter reveal a functionally rotating mechanism
-
doi:10.1038/nature05076
-
Murakami, S., Nakashima, R., Yamashita, E., Matsumoto, T. & Yamaguchi, A. 2006 Crystal structures of a multidrug transporter reveal a functionally rotating mechanism. Nature 443, 173-179.(doi:10.1038/nature05076)
-
(2006)
Nature
, vol.443
, pp. 173-179
-
-
Murakami, S.1
Nakashima, R.2
Yamashita, E.3
Matsumoto, T.4
Yamaguchi, A.5
-
124
-
-
0033170990
-
The RND permease superfamily: An ancient, ubiquitous and diverse family that includes human disease and development proteins
-
Tseng, T. T., Gratwick, K. S., Kollman, J., Park, D., Nies, D. H., Goffeau, A. & Saier Jr, M. H. 1999 The RND permease superfamily: an ancient, ubiquitous and diverse family that includes human disease and development proteins. J. Mol. Microbiol. Biotechnol. 1, 107-125.
-
(1999)
J. Mol. Microbiol. Biotechnol
, vol.1
, pp. 107-125
-
-
Tseng, T.T.1
Gratwick, K.S.2
Kollman, J.3
Park, D.4
Nies, D.H.5
Goffeau, A.6
Saier, M.H.7
-
125
-
-
0026073817
-
Delta mu H{thorn} and ATP function at different steps of the catalytic cycle of preprotein translocase
-
doi:10.1016/0092-8674(91)90317-R
-
Schiebel, E., Driessen, A. J., Hartl, F. U. & Wickner, W. 1991 Delta mu H{thorn} and ATP function at different steps of the catalytic cycle of preprotein translocase. Cell 64, 927-939.(doi:10.1016/0092-8674(91)90317-R)
-
(1991)
Cell
, vol.64
, pp. 927-939
-
-
Schiebel, E.1
Driessen, A.J.2
Hartl, F.U.3
Wickner, W.4
-
126
-
-
0031435335
-
The catalytic cycle of the escherichia coli SecAATPase comprises two distinct preprotein translocation events
-
doi:10.1093/emboj/16.24.7297
-
van der Wolk, J. P., de Wit, J. G. & Driessen, A. J. 1997 The catalytic cycle of the escherichia coli SecAATPase comprises two distinct preprotein translocation events. EMBO J. 16, 7297-7304.(doi:10.1093/emboj/16.24.7297)
-
(1997)
EMBO J
, vol.16
, pp. 7297-7304
-
-
van der Wolk, J.P.1
de Wit, J.G.2
Driessen, A.J.3
-
127
-
-
0025968923
-
Proton transfer is rate-limiting for translocation of precursor proteins by the Escherichia coli translocase
-
doi:10.1073/pnas.88.6.2471
-
Driessen, A. J. & Wickner, W. 1991 Proton transfer is rate-limiting for translocation of precursor proteins by the Escherichia coli translocase. Proc. Natl Acad. Sci. USA 88, 2471-2475.(doi:10.1073/pnas.88.6.2471)
-
(1991)
Proc. Natl Acad. Sci. USA
, vol.88
, pp. 2471-2475
-
-
Driessen, A.J.1
Wickner, W.2
-
128
-
-
0026540532
-
Precursor protein translocation by the Escherichia coli translocase is directed by the protonmotive force
-
Driessen, A. J. 1992 Precursor protein translocation by the Escherichia coli translocase is directed by the protonmotive force. EMBO J. 11, 847-853.
-
(1992)
EMBO J
, vol.11
, pp. 847-853
-
-
Driessen, A.J.1
-
129
-
-
0028318253
-
SecF stabilizes SecD and SecY, components of the protein translocation machinery of the Escherichia coli cytoplasmic membrane
-
Sagara, K., Matsuyama, S. & Mizushima, S. 1994 SecF stabilizes SecD and SecY, components of the protein translocation machinery of the Escherichia coli cytoplasmic membrane. J. Bacteriol. 176, 4111-4116.
-
(1994)
J. Bacteriol
, vol.176
, pp. 4111-4116
-
-
Sagara, K.1
Matsuyama, S.2
Mizushima, S.3
-
130
-
-
0036015653
-
SecDFyajC forms a heterotetrameric complex with YidC
-
doi:10.1046/j.1365-2958.2002.02972.x
-
Nouwen, N. & Driessen, A. J. 2002 SecDFyajC forms a heterotetrameric complex with YidC. Mol. Microbiol. 44, 1397-1405.(doi:10.1046/j.1365-2958.2002.02972.x)
-
(2002)
Mol. Microbiol
, vol.44
, pp. 1397-1405
-
-
Nouwen, N.1
Driessen, A.J.2
-
131
-
-
36749071555
-
Crystal structure of AcrB in complex with a single transmembrane subunit reveals another twist
-
doi:10.1016/j.str.2007.09.023
-
Tornroth-Horsefield, S., Gourdon, P., Horsefield, R., Brive, L., Yamamoto, N., Mori, H., Snijder, A. & Neutze, R. 2007 Crystal structure of AcrB in complex with a single transmembrane subunit reveals another twist. Structure 15, 1663-1673.(doi:10.1016/j.str.2007.09.023)
-
(2007)
Structure
, vol.15
, pp. 1663-1673
-
-
Tornroth-Horsefield, S.1
Gourdon, P.2
Horsefield, R.3
Brive, L.4
Yamamoto, N.5
Mori, H.6
Snijder, A.7
Neutze, R.8
-
132
-
-
79953320631
-
Expression, purification and characterization of the Escherichia coli integral membrane protein YajC
-
Fang, J. & Wei, Y. 2011 Expression, purification and characterization of the Escherichia coli integral membrane protein YajC. Protein Pept. Lett. 18, 601-608.
-
(2011)
Protein Pept. Lett
, vol.18
, pp. 601-608
-
-
Fang, J.1
Wei, Y.2
-
133
-
-
57649119791
-
Mechanisms of YidC-mediated insertion and assembly of multimeric membrane protein complexes
-
Kol, S., Nouwen, N. & Driessen, A. J. 2008 Mechanisms of YidC-mediated insertion and assembly of multimeric membrane protein complexes. J. Biol. Chem. 283, 31 269-31 273.
-
(2008)
J. Biol. Chem. 283
, vol.283
-
-
Kol, S.1
Nouwen, N.2
Driessen, A.J.3
-
134
-
-
0028064967
-
SecA promotes preprotein translocation by undergoing ATP-driven cycles of membrane insertion and deinsertion
-
doi:10.1016/S0092-8674(94)90582-7
-
Economou, A. & Wickner, W. 1994 SecA promotes preprotein translocation by undergoing ATP-driven cycles of membrane insertion and deinsertion. Cell 78, 835-843.(doi:10.1016/S0092-8674(94)90582-7)
-
(1994)
Cell
, vol.78
, pp. 835-843
-
-
Economou, A.1
Wickner, W.2
-
135
-
-
33947512486
-
In vivo membrane topology of Escherichia coli SecA ATPase reveals extensive periplasmic exposure of multiple functionally important domains clustering on one face of SecA
-
doi:10.1074/jbc.M610828200
-
Jilaveanu, L. B. & Oliver, D. B. 2007 In vivo membrane topology of Escherichia coli SecA ATPase reveals extensive periplasmic exposure of multiple functionally important domains clustering on one face of SecA. J. Biol. Chem. 282, 4661-4668.(doi:10.1074/jbc.M610828200)
-
(2007)
J. Biol. Chem
, vol.282
, pp. 4661-4668
-
-
Jilaveanu, L.B.1
Oliver, D.B.2
-
136
-
-
0029566085
-
Stepwise movement of preproteins in the process of translocation across the cytoplasmic membrane of Escherichia coli
-
Uchida, K., Mori, H. & Mizushima, S. 1995 Stepwise movement of preproteins in the process of translocation across the cytoplasmic membrane of Escherichia coli. J. Biol. Chem. 270, 30862-30868.
-
(1995)
J. Biol. Chem
, vol.270
, pp. 30862-30868
-
-
Uchida, K.1
Mori, H.2
Mizushima, S.3
-
137
-
-
54049142467
-
A role for the two-helix finger of the SecA ATPase in protein translocation
-
doi:10.1038/nature07439
-
Erlandson, K. J., Miller, S. B., Nam, Y., Osborne, A. R., Zimmer, J. & Rapoport, T. A. 2008 A role for the two-helix finger of the SecA ATPase in protein translocation. Nature 455, 984-987.(doi:10.1038/nature07439)
-
(2008)
Nature
, vol.455
, pp. 984-987
-
-
Erlandson, K.J.1
Miller, S.B.2
Nam, Y.3
Osborne, A.R.4
Zimmer, J.5
Rapoport, T.A.6
-
138
-
-
60149105036
-
Charged amino acids in a preprotein inhibit SecAdependent protein translocation
-
doi:10.1016/j.jmb.2009.01.031
-
Nouwen, N., Berrelkamp, G. & Driessen, A. J. 2009 Charged amino acids in a preprotein inhibit SecAdependent protein translocation. J. Mol. Biol. 386, 1000-1010.(doi:10.1016/j.jmb.2009.01.031)
-
(2009)
J. Mol. Biol
, vol.386
, pp. 1000-1010
-
-
Nouwen, N.1
Berrelkamp, G.2
Driessen, A.J.3
-
139
-
-
0026576592
-
What drives the translocation of proteins
-
doi:10.1073/pnas.89.9.3770
-
Simon, S. M., Peskin, C. S. & Oster, G. F. 1992 What drives the translocation of proteins? Proc. Natl Acad. Sci. USA 89, 3770-3774.(doi:10.1073/pnas.89.9.3770)
-
(1992)
Proc. Natl Acad. Sci. USA
, vol.89
, pp. 3770-3774
-
-
Simon, S.M.1
Peskin, C.S.2
Oster, G.F.3
-
140
-
-
79958272283
-
SecA, a remarkable nanomachine
-
doi:10.1007/s00018-011-0681-y
-
Kusters, I. & Driessen, A. J. 2011 SecA, a remarkable nanomachine. Cell. Mol. Life Sci. 68, 2053-2066.(doi:10.1007/s00018-011-0681-y)
-
(2011)
Cell. Mol. Life Sci
, vol.68
, pp. 2053-2066
-
-
Kusters, I.1
Driessen, A.J.2
-
141
-
-
63449140188
-
Maximal efficiency of coupling between ATP hydrolysis and translocation of polypeptides mediated by SecB requires two protomers of SecA
-
doi:10.1128/JB.01321-08
-
Mao, C., Hardy, S. J. & Randall, L. L. 2009 Maximal efficiency of coupling between ATP hydrolysis and translocation of polypeptides mediated by SecB requires two protomers of SecA. J. Bacteriol. 191, 978-984.(doi:10.1128/JB.01321-08)
-
(2009)
J. Bacteriol
, vol.191
, pp. 978-984
-
-
Mao, C.1
Hardy, S.J.2
Randall, L.L.3
-
142
-
-
1842559293
-
Sites of interaction between SecA and the chaperone SecB, two proteins involved in export
-
doi:10.1110/ps.03410104
-
Randall, L. L., Crane, J. M., Liu, G. & Hardy, S. J. 2004 Sites of interaction between SecA and the chaperone SecB, two proteins involved in export. Protein Sci. 13, 1124-1133.(doi:10.1110/ps.03410104)
-
(2004)
Protein Sci
, vol.13
, pp. 1124-1133
-
-
Randall, L.L.1
Crane, J.M.2
Liu, G.3
Hardy, S.J.4
-
143
-
-
34250792185
-
Preprotein-controlled catalysis in the helicase motor of SecA
-
doi:10.1038/sj.emboj.7601721
-
Karamanou, S., Gouridis, G., Papanikou, E., Sianidis, G., Gelis, I., Keramisanou, D., Vrontou, E., Kalodimos, C. G. & Economou, A. 2007 Preprotein-controlled catalysis in the helicase motor of SecA. EMBO J. 26, 2904-2914.(doi:10.1038/sj.emboj.7601721)
-
(2007)
EMBO J
, vol.26
, pp. 2904-2914
-
-
Karamanou, S.1
Gouridis, G.2
Papanikou, E.3
Sianidis, G.4
Gelis, I.5
Keramisanou, D.6
Vrontou, E.7
Kalodimos, C.G.8
Economou, A.9
-
144
-
-
0019464222
-
The spontaneous insertion of proteins into and across membranes: The helical hairpin hypothesis
-
doi:10.1016/0092-8674(81)90136-7
-
Engelman, D. M. & Steitz, T. A. 1981 The spontaneous insertion of proteins into and across membranes: the helical hairpin hypothesis. Cell 23, 411-422.(doi:10.1016/0092-8674(81)90136-7)
-
(1981)
Cell
, vol.23
, pp. 411-422
-
-
Engelman, D.M.1
Steitz, T.A.2
-
145
-
-
0027393014
-
The SecA and SecY subunits of translocase are the nearest neighbors of a translocating preprotein, shielding it from phospholipids
-
Joly, J. C. & Wickner, W. 1993 The SecA and SecY subunits of translocase are the nearest neighbors of a translocating preprotein, shielding it from phospholipids. EMBO J. 12, 255-263.
-
(1993)
EMBO J
, vol.12
, pp. 255-263
-
-
Joly, J.C.1
Wickner, W.2
-
146
-
-
1842690648
-
Binding of SecA to the SecYEG complex accelerates the rate of nucleotide exchange on SecA
-
Natale, P., Swaving, J., van der Does, C., de Keyzer, J. & Driessen, A. J. 2004 Binding of SecA to the SecYEG complex accelerates the rate of nucleotide exchange on SecA. J. Biol. Chem. 279, 13769-13777.
-
(2004)
J. Biol. Chem
, vol.279
, pp. 13769-13777
-
-
Natale, P.1
Swaving, J.2
van der Does, C.3
de Keyzer, J.4
Driessen, A.J.5
|