Curcumin implants for continuous systemic delivery: Safety and biocompatibility

Drug Delivery and Translational Research

Volumn 1, Issue 4, 2011, Pages 332-341

  Bansal, Shyam S ^a   Kausar, Hina ^b   Aqil, Farrukh ^b   Jeyabalan, Jeyaprakash ^b   Vadhanam, Manicka V ^b   Gupta, Ramesh C ^a,b   Ravoori, Srivani ^b  

^a University of Louisville School of Medicine   (United States)

^b UNIVERSITY OF LOUISVILLE   (United States)

Author keywords

Bioavailability; Biocompatibility; Chemoprevention; Curcumin; Implants; Toxicity

Indexed keywords

CURCUMIN; MACROGOL 8000; PHOSPHORUS; POLYCAPROLACTONE;

ANIMAL EXPERIMENT; ARTICLE; BIOCOMPATIBILITY; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG EFFECT; DRUG RELEASE; DRUG SAFETY; FEMALE; FOREIGN BODY REACTION; GRANULOMATOUS INFLAMMATION; NONHUMAN; PHOSPHATE BLOOD LEVEL; PRIORITY JOURNAL; RAT;

EID: 84862994005     PISSN: 2190393X     EISSN: 21903948     Source Type: Journal    
DOI: 10.1007/s13346-011-0028-0     Document Type: Article

References (21)

1. Bar-Sela G, Epelbaum R, Schaffer M. Curcumin as an anti-cancer agent: review of the gap between basic and clinical applications. Curr Med Chem. 2010; 17: 190-7.
2. Aggarwal BB, Harikumar KB. Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases. Int J Biochem Cell Biol. 2009; 41: 40-59.
3. Aggarwal BB, Kumar A, Bharti AC. Anticancer potential of curcumin: preclinical and clinical studies. Anticancer Res. 2003; 23: 363-98.
4. Anand P, Thomas SG, Kunnumakkara AB, Sundaram C, Harikumar KB, Sung B, et al. Biological activities of curcumin and its analogues (Congeners) made by man and mother nature. Biochem Pharmacol. 2008; 76: 1590-611.
5. Holder GM, Plummer JL, Ryan AJ. The metabolism and excretion of curcumin (1, 7-bis-(4-hydroxy-3-methoxyphenyl)-1, 6-heptadiene-3, 5-dione) in the rat. Xenobiotica. 1978; 8: 761-8.
6. Ireson CR, Jones DJ, Orr S, Coughtrie MW, Boocock DJ, Williams ML, et al. Metabolism of the cancer chemopreventive agent curcumin in human and rat intestine. Cancer Epidemiol Biomark Prev. 2002; 11: 105-11.
7. Kumar A, Ahuja A, Ali J, Baboota S. Conundrum and therapeutic potential of curcumin in drug delivery. Crit Rev Ther Drug Carrier Syst. 2010; 27: 279-312.
8. Bansal SS, Vadhanam MV, Gupta RC. Development and in vitro-in vivo evaluation of polymeric implants for continuous systemic delivery of curcumin. Pharm Res. 2011; 28: 1121-30.
9. Dandekar P, Dhumal R, Jain R, Tiwari D, Vanage G, Patravale V. Toxicological evaluation of pH-sensitive nanoparticles of curcumin: acute, sub-acute and genotoxicity studies. Food Chem Toxicol. 2010; 48: 2073-89.
10. Woodruff MA, Hutmacher DW. The return of a forgotten polymer-polycaprolactone in the 21st century. Prog Polym Sci. 2010; 35: 1217-56.
11. Sun H, Mei L, Song C, Cui X, Wang P. The in vivo degradation, absorption and excretion of PCL-based implant. Biomaterials. 2006; 27: 1735-40.
12. Ravoori S, Vadhanam MV, Sahoo S, Srinivasan C, Gupta RC. Mammary tumor induction in ACI rats exposed to low levels of 17beta-estradiol. Int J Oncol. 2007; 31: 113-20.
13. Kiso Y, Suzuki Y, Watanabe N, Oshima Y, Hikino H. Antihepatotoxic principles of Curcuma longa rhizomes. Planta Med. 1983; 49: 185-7.
14. Song EK, Cho H, Kim JS, Kim NY, An NH, Kim JA, et al. Diarylheptanoids with free radical scavenging and hepatoprotective activity in vitro from Curcuma longa. Planta Med. 2001; 67: 876-7.
15. Nishiyama T, Mae T, Kishida H, Tsukagawa M, Mimaki Y, Kuroda M, et al. Curcuminoids and sesquiterpenoids in turmeric (Curcuma longa L.) suppress an increase in blood glucose level in type 2 diabetic KK-Ay mice. J Agric Food Chem. 2005; 53: 959-63.
16. Rao DS, Sekhara NC, Satyanarayana MN, Srinivasan M. Effect of curcumin on serum and liver cholesterol levels in the rat. J Nutr. 1970; 100: 1307-15.
17. Laurencin C, Domb A, Morris C, Brown V, Chasin M, McConnell R, et al. Poly(anhydride) administration in high doses in vivo: studies of biocompatibility and toxicology. J Biomed Mater Res. 1990; 24: 1463-81.
18. Laurencin CT, Pierre-Jacques HM, Langer R. Toxicology and biocompatibility considerations in the evaluation of polymeric materials for biomedical applications. Clin Lab Med. 1990; 10: 549-70.
19. White DC, Trepman E, Kolobow T, Shaffer DK, Reddick RL, Bowman RL. The microscopic characterization of multinucleated giant cells formed on polymeric surfaces perfused with blood. Artif Organs. 1979; 3: 86-91.
20. Clark RA, Stone RD, Leung DY, Silver I, Hohn DC, Hunt TK. Role of macrophages in would healing. Surg Forum. 1976; 27: 16-8.
21. Ziats NP, Miller KM, Anderson JM. In vitro and in vivo interactions of cells with biomaterials. Biomaterials. 1988; 9: 5-13.