Brain iron levels in attention-deficit/hyperactivity disorder: A pilot MRI study

World Journal of Biological Psychiatry

Volumn 13, Issue 3, 2012, Pages 223-231

  Cortese, Samuele ^a,b,c,d   Azoulay, Robin ^e   Castellanos, F Xavier ^d,f   Chalard, François ^e   Lecendreux, Michel ^a,e   Chechin, David ^g   Delorme, Richard ^a   Sebag, Guy ^e   Sbarbati, Andrea ^h   Mouren, Marie Christine ^a   Bernardina, Bernardo Dalla ^b   Konofal, Eric ^a,e,i  

^a UNIVERSITÉ PARIS DESCARTES   (France)

^b GB Rossi Hospital   (Italy)

^c UNIVERSITÉ DE TOURS   (France)

^d NEW YORK UNIVERSITY CHILD STUDY CENTER   (United States)

^e Pediatric Sleep Disorders Center   (France)

^f NATHAN S KLINE INSTITUTE FOR PSYCHIATRIC RESEARCH   (United States)

^g PHILIPS HEALTHCARE   (United States)

^h UNIVERSITY OF VERONA   (Italy)

ⁱ PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

Author keywords

ADHD; children; iron; magnetic resonance imaging; thalamus

Indexed keywords

FERRITIN; IRON;

ADOLESCENT; ARTICLE; ATTENTION DEFICIT DISORDER; BRAIN LEVEL; CAUDATE NUCLEUS; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; GLOBUS PALLIDUS; HUMAN; IRON BALANCE; IRON BLOOD LEVEL; IRON BRAIN LEVEL; IRON DEFICIENCY; MALE; NEUROIMAGING; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOPHYSIOLOGY; PILOT STUDY; PUTAMEN; SCHOOL CHILD; THALAMUS;

ADOLESCENT; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; BRAIN CHEMISTRY; CASE-CONTROL STUDIES; CAUDATE NUCLEUS; CHILD; FEMALE; FERRITINS; HUMANS; IRON; MAGNETIC RESONANCE IMAGING; MALE; PILOT PROJECTS; PUTAMEN; THALAMUS;

EID: 84858123237     PISSN: 15622975     EISSN: 18141412     Source Type: Journal    
DOI: 10.3109/15622975.2011.570376     Document Type: Article

References (66)

1. Allen RP, Earley CJ. 2007. The role of iron in restless legs syndrome. Mov Disord 22(Suppl 18): S440-448.
2. Allen RP, Barker PB, Wehrl F, Song HK, Earley CJ. 2001. MRI measurement of brain iron in patients with restless legs syndrome. Neurology 56: 263-265. (Pubitemid 32095374)
3. American Psychiatric Association. 2000. Diagnostic and statistical manual of mental disorders, 4th ed. Text Revision. American Psychiatric Association, Washington, DC.
4. Andrews NC. 1999. Disorders of iron metabolism. New Engl J Med 341: 1986-1995. (Pubitemid 30010408)
5. Aquino D, Bizzi A, Grisoli M, Garavaglia B, Bruzzone MG, Nardocci N, et al. 2009. Age-related iron deposition in the basal ganglia: quantitative analysis in healthy subjects. Radiology 252: 165-172.
6. Arcos-Burgos M, Jain M, Acosta MT, Shively S, Stanescu H, Wallis D, et al. 2010. A common variant of the latrophilin 3 gene, LPHN3, confers susceptibility to ADHD and predicts effectiveness of stimulant medication. Mol Psychiatry 47(11): 1053-66.
7. Argyropoulou MI, Metafratzi Z, Kiortsis DN, Bitsis S, Tsatsoulis A, Efremidis S. 2000. T2 relaxation rate as an index of pituitary iron overload in patients with beta-thalassemia major. AJR Am J Roentgenol 175: 1567-1569.
8. Barkley RA. 2002. Major life activity and health outcomes associated with attention-defi cit/hyperactivity disorder. J Clin Psychiatry 63(Suppl 12): 10-15. (Pubitemid 36025582)
9. Bartzokis G, Aravagiri M, Oldendorf WH, Mintz J, Marder SR. 1993. Field dependent transverse relaxation rate increase may be a specifi c measure of tissue iron stores. Magn Reson Med 29: 459-464. (Pubitemid 23112748)
10. Bartzokis G, Tishler TA, Lu PH, Villablanca P, Altshuler LL, Carter M, et al. 2007. Brain ferritin iron may infl uence age-and gender-related risks of neurodegeneration. Neurobiol Aging 28: 414-423. (Pubitemid 46177391)
11. Beard JL, Connor JR, Jones BC. 1993. Iron in the brain. Nutr Rev 51: 157-170. (Pubitemid 23247807)
12. Biederman J, Faraone SV. 2005. Attention-defi cit hyperactivity disorder. Lancet 366: 237-248.
13. Brass SD, Chen NK, Mulkern RV, Bakshi R. 2006. Magnetic resonance imaging of iron deposition in neurological disorders. Top Magn Reson Imaging 17: 31-40. (Pubitemid 46672931)
14. Chavhan GB, Babyn PS, Thomas B, Shroff MM, Haacke EM. 2009. Principles, techniques, and applications of T2 -based MR imaging and its special applications. Radiographics 29: 1433-1449.
15. Christoforidis A, Haritandi A, Perifanis V, Tsatra I, Athanassiou-Metaxa M, Dimitriadis AS. 2007. MRI for the determination of pituitary iron overload in children and young adults with beta-thalassaemia major. Eur J Radiol 62: 138-142. (Pubitemid 46413623)
16. Connor JR, Menzies SL. 1996. Relationship of iron to oligodendrocytes and myelination. Glia 17: 83-93. (Pubitemid 26309437)
17. Cortese S, Lecendreux M, Dalla Bernardina B, Mouren MC, Sbarbati A, Konofal E. 2008. Attention-defi cit/hyperactivity disorder, Tourette's syndrome, and restless legs syndrome: the iron hypothesis. Med Hypotheses 70: 1128-1132.
18. Cortese S, Faraone SV, Konofal E, Lecendreux M. 2009a. Sleep in children with attention-defi cit/hyperactivity disorder: metaanalysis of subjective and objective studies. J Am Acad Child Adolesc Psychiatry 48: 894-908.
19. Cortese S, Konofal E, Dalla Bernardina B, Mouren MC, Lecendreux M. 2009b. Sleep disturbances and serum ferritin levels in children with attention-defi cit/hyperactivity disorder. Eur Child Adolesc Psychiatry 18: 393-399.
20. Dahnke H, Schaeffter T. 2005. Limits of detection of SPIO at 3.0 T using T2 relaxometry. Magn Reson Med 53: 1202-1206. (Pubitemid 40627800)
21. Dickstein SG, Bannon K, Castellanos FX, Milham MP. 2006. The neural correlates of attention defi cit hyperactivity disor der: an ALE meta-analysis. J Child Psychol Psychiatry 47: 1051-1062. (Pubitemid 44642434)
22. Du Paul GJ, Power TJ, Anastopoulos AD, Reid R. 1998. ADHD rating scale-IV: checklists, norms, and interpretation. New York: Guilford Press.
23. Godau J, Klose U, Di Santo A, Schweitzer K, Berg D. 2008. Multiregional brain iron defi ciency in restless legs syndrome. Mov Disord 23: 1184-1187.
24. Golan N, Shahar E, Ravid S, Pillar G. 2004. Sleep disorders and daytime sleepiness in children with attention-defi cit/hyperactive disorder. Sleep 27: 261-266. (Pubitemid 44138835)
25. Haacke EM, Cheng NY, House MJ, Liu Q, Neelavalli J, Ogg RJ, et al. 2005. Imaging iron stores in the brain using magnetic resonance imaging. Magn Reson Imaging 23: 1-25. (Pubitemid 40269946)
26. Haba-Rubio J, Staner L, Petiau C, Erb G, Schunck T, Macher JP. 2005. Restless legs syndrome and low brain iron levels in patients with haemochromatosis. J Neurol Neurosurg Psychiatry 76: 1009-1010. (Pubitemid 40909565)
27. Hallgren B, Sourander P. 1958. The effect of age on the nonhaemin iron in the human brain. J Neurochem 3: 41-51.
28. Ill AM, Mitchell TR, Neely EB, Connor JR. 2006. Metabolic analysis of mouse brains that have compromised iron storage. Metab Brain Dis 21: 77-87.
29. International Committee of Medical Journal Editors. 1989. Statements from the Vancouver Group. Br Med J 299: 1394-1395.
30. Ivanov I, Bansal R, Hao X, Zhu H, Kellendonk C, Miller L, et al. 2010. Morphological abnormalities of the thalamus in youths with attention defi cit hyperactivity disorder. Am J Psychiatry 167: 397-408.
31. Jensen JH, Chandra R, Ramani A, Lu H, Johnson G, Lee SP, et al. 2006. Magnetic field correlation imaging. Magn Reson Med 55: 1350-1361. (Pubitemid 43856773)
32. Juneja M, Jain R, Singh V, Mallika V. 2010. Iron defi ciency in indian children with attention defi cit hyperactivity disorder. Indian Pediatr. 47(11): 955-8
33. Katz MH. 1999. Multivariable analysis: a practical guide for clinicians. Cambridge: Cambridge University Press. p. 55.
34. Kieling C, Goncalves RR, Tannock R, Castellanos FX. 2008. Neurobiology of attention defi cit hyperactivity disorder. Child Adolesc Psychiatr Clin N Am 17: 285-307, viii.
35. Konofal E, Lecendreux M, Arnulf I, Mouren MC. 2004. Iron defi ciency in children with attention-defi cit/hyperactivity disorder. Arch Pediatr Adolesc Med 158: 1113-1115. (Pubitemid 39579170)
36. Konofal E, Lecendreux M, Deron J, Marchand M, Cortese S, Zaim M, et al. 2008. Effects of iron supplementation on attention defi cit hyperactivity disorder in children. Pediatr Neurol 38: 20-26. (Pubitemid 350181289)
37. Lecendreux M, Konofal E, Bouvard M, Falissard B, Mouren-Simeoni MC. 2000. Sleep and alertness in children with ADHD. J Child Psychol Psychiatry 41: 803-812.
38. Lozoff B, Beard J, Connor J, Barbara F, Georgieff M, Schallert T. 2006. Long-lasting neural and behavioral effects of iron defi-ciency in infancy. Nutr Rev 64: S34-S43. (Pubitemid 44606856)
39. Menegassi M, Mello ED, Guimaraes LR, Matte BC, Driemeier F, Pedroso GL, et al. 2010. Food intake and serum levels of iron in children and adolescents with attention-defi cit/hyperactivity disorder. Rev Bras Psiquiatr 32: 132-138.
40. Miano S, Donfrancesco R, Bruni O, Ferri R, Galiffa S, Pagani J, et al. 2006. NREM sleep instability is reduced in children with attention-defi cit/hyperactivity disorder. Sleep 29: 797-803. (Pubitemid 43895048)
41. Mick E, Faraone SV. 2008. Genetics of attention defi cit hyperactivity disorder. Child Adolesc Psychiatr Clin N Am 17: 261-8.
42. Millichap JG. 2008. Etiologic classifi cation of attention-defi cit/hyperactivity disorder. Pediatrics 121: e358-e365.
43. Millichap JG, Yee MM, Davidson SI. 2006. Serum ferritin in children with attention-defi cit hyperactivity disorder. Pediatr Neurol 34: 200-203.
44. Montaron MF, Buser P. 1988. Relationships between nucleus medialis dorsalis, pericruciate cortex, ventral tegmental area and nucleus accumbens in cat: an electrophysiological study. Exp Brain Res 69: 559-566. (Pubitemid 18080289)
45. Morris CM, Candy JM, Oakley AE, Bloxham CA, Edwardson JA. 1992. Histochemical distribution of non-haem iron in the human brain. Acta Anat (Basel) 144: 235-257.
46. Mouren-Sim é oni, Cook S, Flament S, Nedey-Saiag MC, Nollet-Cl é men ç on C, Pailler-Martinot ML. 2002. Kiddie-SADSversion vie enti è re (K-SADS-P/L). Edition revis é e et modifi é e. Paris: Editions INSERM.
47. Novik TS, Hervas A, Ralston SJ, Dalsgaard S, Rodrigues PR, Lorenzo MJ. 2006. Infl uence of gender on attention-defi cit/hyperactivity disorder in Europe-ADORE. Eur Child Adolesc Psychiatry 15(Suppl 1): I15-24.
48. Oldfield RC. 1971. The assessment and analysis of handedness: the Edinburgh inventory. Neuropsychologia 9: 97-113.
49. Oner O, Alkar OY, Oner P. 2008. Relation of ferritin levels with symptom ratings and cognitive performance in children with attention defi cit-hyperactivity disorder. Pediatr Int 50: 40-44. (Pubitemid 351239383)
50. Oner O, Oner P, Bozkurt OH, Odabas E, Keser N, Karadag H, et al. 2010. Effects of zinc and ferritin levels on parent and teacher reported symptom scores in attention defi cit hyperactivity disorder. Child Psychiatry Hum Dev 41: 441-447.
51. Peran P, Cherubini A, Luccichenti G, Hagberg G, Demonet JF, Rascol O, et al. 2009. Volume and iron content in basal ganglia and thalamus. Hum Brain Mapp 30: 2667-2675.
52. Perlov E, Philipsen A, Matthies S, Drieling T, Maier S, Bubl E, et al. 2009. Spectroscopic fi ndings in attention-defi cit/hyperactivity disorder: review and meta-analysis. World J Biol Psychiatry 10: 355-365.
53. Picchietti D. 2007. Is iron defi ciency an underlying cause of pediatric restless legs syndrome and of attention-defi cit/hyperactivity disorder? Sleep Med 8: 693-694. (Pubitemid 47535014)
54. Pliszka S. 2007. Practice parameter for the assessment and treatment of children and adolescents with attention-defi cit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 46: 894-921.
55. Polanczyk G, de Lima MS, Horta BL, Biederman J, Rohde LA. 2007. The worldwide prevalence of ADHD: a systematic review and metaregression analysis. Am J Psychiatry 164: 942-948. (Pubitemid 46972911)
56. Sever Y, Ashkenazi A, Tyano S, Weizman A. 1997. Iron treatment in children with attention defi cit hyperactivity disorder. A preliminary report. Neuropsychobiology 35: 178-180. (Pubitemid 27212154)
57. Stankiewicz J, Panter SS, Neema M, Arora A, Batt CE, Bakshi R. 2007. Iron in chronic brain disorders: imaging and neurotherapeutic implications. Neurotherapeutics 4: 371-386. (Pubitemid 46962416)
58. Wechsler. 1991. Echelle d'intelligence de Wechsler pour enfants; troisi è me edition.
59. Weinberg WA, Brumback RA. 1990. Primary disorder of vigilance: a novel explanation of inattentiveness, daydreaming, boredom, restlessness, and sleepiness. J Pediatr 116: 720-725. (Pubitemid 20162820)
60. Westbrook C, Kaut Roth C, Talbot J. 1993. MRI in practice. Oxford: Blackwell Publishing.
61. Wolraich ML. 1999. Attention Defi cit hyperactivity disorder: the most studied and yet the most controversial diagnosis. Ment Retard Dev Disabil Res Rev 5: 163-168. (Pubitemid 29407200)
62. Xu X, Wang Q, Zhang M. 2008. Age, gender, and hemispheric differences in iron deposition in the human brain: an in vivo MRI study. Neuroimage 40: 35-42.
63. Yip R, Johnson C, Dallman PR. 1984. Age-related changes in laboratory values used in the diagnosis of anemia and iron defi-ciency. Am J Clin Nutr 39: 427-436. (Pubitemid 14154629)
64. Youdim MB. 2000. Nutrient deprivation and brain function: iron. Nutrition 16: 504-508.
65. Youdim MB, Ben-Shachar D, Yehuda S. 1989. Putative biological mechanisms of the effect of iron defi ciency on brain biochemistry and behavior. Am J Clin Nutr 50: 607-615.
66. Zywicke HA, van Gelderen P, Connor JR, Burdo JR, Garrick MD, Dolan KG, et al. 2002. Microscopic R2 mapping of reduced brain iron in the Belgrade rat. Ann Neurol 52: 102-105. (Pubitemid 34693751)