Nutrient deprivation and brain function: Iron

Nutrition

Volumn 16, Issue 7-8, 2000, Pages 504-508

  Youdim, Moussa B H ^a  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

IRON; NEUROTRANSMITTER; NEUROTRANSMITTER RECEPTOR;

BRAIN FUNCTION; CONFERENCE PAPER; FETUS; FOOD DEPRIVATION; IRON DEFICIENCY; LEARNING; NEWBORN; NONHUMAN; NUTRITION; PRIORITY JOURNAL; RAT;

ANIMALS; BEHAVIOR; BRAIN; DOPAMINE; HUMANS; IRON; NUTRITION DISORDERS; OPIOID PEPTIDES;

EID: 0034234727     PISSN: 08999007     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0899-9007(00)00251-3     Document Type: Conference Paper

References (52)

1. Dobbing J. Brain Behavior and Iron in the Infant Diet. 1990;Springer-Verlag, Berlin.
2. Youdim M.B.H. Neuropharmacological and neurochemical aspects of iron deficiency. Dobbing J. Brain Behavior and Iron in the Infant Diet. 1990;83 Springer-Verlag, Berlin.
3. Youdim M.B.H., Riederer P. Iron in the brain, normal and pathological. Adelman G., Smith B.H. Encyclopedia of Neuroscience. 1999;983 Elsevier, Amsterdam.
4. Youdim M.B.H., Riederer P. Understanding Parkinson's disease. Sci Am. 257:1997;59.
5. Pollit E., Haas J., Levitsky D.A. International conference of iron deficiency and behavioural development. Am J Clin Nutr. 50:1989;565.
6. Hallgren B., Sourander P. The effect of age on the non-haem iron in the human brain. J Neurochem. 3:1958;41.
7. Hill J.M. The distribution of iron in the brain. Youdim M.B.H. Brain Iron Neurochemistry and Behavioural Aspects . 1988;1 Taylor and Francis, London.
8. Riederer P., Sofic E., Rouch W.D., Youdim M.B.H. Transition metal, ferritin, glutathime and ascorbic acid in Parkinsonian brains. J Neurochem. 52:1989;515.
9. Dwork A.J., Schon E.A., Herbert J. Non-identical distribution of transferin and ferric iron in human brain. Neuroscience. 27:1988;333.
10. Connor J.R., Pillips T.M., Lakshman M.R., et al. Regional variation in the levels of transferrin in the CNS of normal and myelin-deficient rats. J Neurochem. 49:1987;1523.
11. Dwork A.J., Lawler G., Zybert P.A., et al. An autoradiographic study of the uptake and distribution of iron by the brain of the young rat. Brain Res. 4:1990;31.
12. Ben-Shachar D., Ashkenazi R., Youdim M.B.H. Long term consequences of early iron-deficiency on dopaminergic neurotransmission. Int J Dev Neurosci. 4:1986;81.
13. Pollitt E., Leibel R.L. Iron-Deficiency, Brain Biochemistry and Behavior. 1982;Raven Press, New York.
14. Dobbing J. Vunerable periods in developing brain In: Dobbing J, ed. Brain Behavior and Iron in the Infant Diet. New York: Springer-Verlag, 1990:1.
15. Spatz H. Uber des eisennachewis in gehrin besonders in zentren des extra-pyramidal motorrischen systems. Neural Psychiat. 77:1992;261.
16. Werkman S., Shifman L., Shelly T. Psychosocial correlates of iron deficiency in early childhood. Psychosom Med. 26:1964;125.
17. Webb T.F., Oski F.A. Iron deficiency anemia and scholastic achievements behavioral stability and perceptual sensitivity to adolescents . J Pediatr. 82:1973;827.
18. Dallman P.R., Siimes M.A., Manies E.C. Brain iron persistent deficiency following short-term iron deprivation in the young rat . Br J Haematol. 31:1975;209.
19. Dallman P.R., Spirito R.A. Brain iron in the rat extremely slow turnover in normal rats may explain the long-lasting effects of early iron deficiency . J Nutr. 107:1977;1075.
20. Youdim M.B.H., Green A.R. Biogenic monamine metabolism and functional activity in iron-deficient rats behavioural correlates . Ciba Found Symp. 51:1977;201.
21. Youdim M.B.H., Ben-Shachar D., Yehuda S. Putative biological mechanisms of the effect of iron-deficiency on brain biochemistry and behavior. Am J Clin Nutr. 50:1989;607.
22. Ben-Shachar D., Yehuda S., Finberg J.P.M., Spanier I., Youdim M.B.H. Selective alteration in blood brain barrier and insulin transport in iron-deficient rat. J Neurochem. 50:1988;1434.
23. Taylor E.M., Crowe A., Morgan E.H. Transferrin and iron uptake by the brain effects of altered iron status . J Neurochem. 57:1991;1584.
24. Eisenstein R.S., Blemings K.P. Iron regulatory proteins, iron responsive elements and iron homeostasis. J Nutr. 128:1998;2295.
25. Haile D.J. Regulation of genes of iron metabolism by the iron-response proteins. Am J Med Sci. 318:1999;230.
26. Erikson K.M., Pinero D.J., Connor J.R., Beard J.L. Regional brain iron, ferritin and transferrin concentrations during iron deficiency and iron repletion in developing rats. J Nutri. 127:1997;2030.
27. Connor J.R., Menzies S.L. Relationship of iron to oligodendrocytes and myelination. Glia. 17:1996;83.
28. Lozoff B. Behavioral alteration in iron deficiency. Adv Pediatr. 6:1988;331.
29. Lozoff B., Brittenham G.M. Behavioral aspects of iron deficiency. Prog Hematol. 14:1986;23.
30. Parks Y.A., Wharton B. Iron-deficiency and the brain. Clinical significance of behavioral changes. Dobbing J. Brain, Behavior and Iron in the Infant Diet. 1990;157 Springer-Verlag, Berlin.
31. Felt B.T., Lozoff B. Brain iron and behavior of rats are not normalized by treatment of iron deficiency anemia during early development. J Nutr. 126:1996;693.
32. Guesry P. The role of nutrition in brain development. Prev Med. 27:1998;189.
33. Rao R., de Ungria M., Sullivan D., et al. Perinatal brain iron deficiency increases the vulnerability of rat hippocampus to hypoxic ischemic insult. J Nutr. 129:1999;199.
34. Georgieff M.K., Petry C.D., Wobken J.D., Oyer C.E. Liver and brain iron deficiency in newborn infants with bilateral renal agenesis (Potter's syndrome). Pediatr Pathol Lab Med. 16:1996;509.
35. Yehuda S., Youdim M.B.H., Mostofsky M. Brain iron deficiency causes reduced learning capacity in rats. Pharmacol Biochem Behav. 25:1986;141.
36. Yehuda S., Youdim M.B.H. Brain iron a lesson from animal models . Am J Clin Nutr. 50:(suppl):1989;618.
37. Yehuda S. Neurochemical bases of behavioral effects on brain iron-deficiency in animals. Dobbing J. Brain, Behavior and Iron in the Infant Diet. 1990;63 Springer-Verlag, Berlin.
38. Chua A.C., Morgan E.H. Effect of iron deficiency and iron overload on manganese uptake and deposition in the brain and other organs of the rat. Biol Trace Element Res. 55:1996;39.
39. Adhami V.M., Husain R., Husain R., Seth P.K. Influence of iron deficiency and lead treatment on behavior and cerebellar and hippocampal polyamine levels in neonatal rats. Neur Res. 21:1996;915.
40. Moos T., Oates P.S., Morgan E.H. Expression of the neuronal transferrin receptor is age dependent and susceptible to iron deficiency. J Comp Neurol. 398:1998;420.
41. Youdim M.B.H., Sills M.A., Neydron W.E., Creed G.J., Jacobowitz D.H. Iron deficiency alters discrete proteins in rat caudate nucleus and nucleus accumbens. J Neurochem. 47:1986;794.
42. Pablo Huidobro-Toro J., Leong Way E. Opiates. Grahame-Smith D.G., Cowen P.J. Preclinical Psychopharmacology, part 1. 1983;300 Excerpta Medica, Amsterdam.
43. Pablo Huidobro-Toro J., Leong Way E. Opiates. Grahame-Smith D.G., Cowen P.J. Preclinical Psychopharmacology, part 2. 1985;283 Elsevier, Amsterdam.
44. Yehuda S., Youdim M.B.H. The increased opiate action of β-endorphin in iron-deficient rats the possible involvement of dopamine . Eur J Pharmacol. 105:1984;245.
45. Yehuda S., Youdim M.B.H., Zamir N. Iron-deficiency induces increased brain metenkaphalin and pain threshold in response to opiate peptides. Br J Pharmacol. (suppl):1988;87.
46. Youdim M.B.H., Zamir N., Yehuda S. Antinociception in iron-deficient rats related to subsensitivety of dopamine D2 receptor induced increase of opiate peptides. Nutri Neurosci. 2000;. (in press).
47. Tang F.E., Costa E., Schartz J.P. Increase of proenkephalin mRNA and enkephalin content of rat striatum after daily injection of haloperidol for 2 to 3 weeks. Proc Natl Acad Sci USA. 80:1983;3841.
48. Durham RA, et al. Evidence that D2 receptor-mediated activation of hypothalamic tuberoinfundibular dopaminergic neurons in the male rat occurs via inhibition of tonically active afferent dynorphinergic neurons. Brain Res 1996;2;732:113.
49. Angulo J.A. Involvement of dopamine D1 and D2 receptors in the regulation of proenkephalin mRNA abundance in the striatum and accumbens of the rat brain. J Neurochem. 58:1992;1104.
50. Morris B.J., et al. Dopaminergic regulation of striatal proenkephalin mRNA and prodynorphin mRNA contrasting effects of D1 and D2 antagonists. Neuroscience. 25:1988;525.
51. Li D. Effect of iron deficiency on iron distribution and gamma-aminobutyric acid (GABA) metabolism in young rat brain tissues. Hokkaido J Med Sci. 73:1998;215.
52. Shoham S., Youdim M.B.H. Prevention of reactive microglia proliferation and neurodegeneration, as induced by kainate, in iron deficient rats. Neurosci Lett. (suppl):2000;55.