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Volumn 19, Issue 5, 2012, Pages 395-401

Prevention of free fatty acid-induced lipid accumulation, oxidative stress, and cell death in primary hepatocyte cultures by a Gynostemma pentaphyllum extract

Author keywords

Diabetes mellitus; Free fatty acids; Gynostemma pentaphyllum; Hepatocytes; Lipotoxicity

Indexed keywords

ALCOHOL; CARDIOLIPIN; CHOLESTEROL; FATTY ACID; GLUCOSE; GYNOSTEMMA PENTAPHYLLUM EXTRACT; INSULIN; ISOPROSTANE; LINOLEIC ACID; NITRIC OXIDE; PALMITIC ACID; TRIACYLGLYCEROL;

EID: 84858080264     PISSN: 09447113     EISSN: 1618095X     Source Type: Journal    
DOI: 10.1016/j.phymed.2011.12.002     Document Type: Article
Times cited : (37)

References (49)
  • 2
    • 33845261493 scopus 로고
    • A rapid method of total lipid extraction and purification
    • E.G. Bligh, and W.J. Dyer A rapid method of total lipid extraction and purification Can. J. Biochem. Physiol. 37 1959 911 917
    • (1959) Can. J. Biochem. Physiol. , vol.37 , pp. 911-917
    • Bligh, E.G.1    Dyer, W.J.2
  • 3
  • 5
    • 0033153773 scopus 로고    scopus 로고
    • Cynostemma pentaphyllum: Identification of major sapogenins and differentiation from Panax species
    • DOI 10.1016/S0928-0987(99)00013-5, PII S0928098799000135
    • J. Cui, P. Eneroth, and J.G. Bruhn Gynostemma pentaphyllum: identification of major sapogenins and differentiation from Panax species Eur. J. Pharm. Sci. 8 1999 187 191 (Pubitemid 29324646)
    • (1999) European Journal of Pharmaceutical Sciences , vol.8 , Issue.3 , pp. 187-191
    • Cui, J.-F.1    Eneroth, P.2    Bruhn, J.G.3
  • 6
    • 0023706894 scopus 로고
    • Release of reactive nitrogen intermediates and Reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production
    • A.H. Ding, C.F. Nathan, and D.J. Stuehr Release of reactive nitrogen intermediates and Reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production J. Immunol. 141 1988 2407 2412
    • (1988) J. Immunol. , vol.141 , pp. 2407-2412
    • Ding, A.H.1    Nathan, C.F.2    Stuehr, D.J.3
  • 7
  • 8
    • 17844367159 scopus 로고    scopus 로고
    • A role for iNOS in fasting hyperglycemia and impaired insulin signaling in the liver of obese diabetic mice
    • DOI 10.2337/diabetes.54.5.1340
    • M. Fujimoto, N. Shimizu, K. Kunii, J.A. Martyn, K. Ueki, and M. Kaneki A role for iNOS in fasting hyperglycemia and impaired insulin signaling in the liver of obese diabetic mice Diabetes 54 2005 1340 1348 (Pubitemid 40586662)
    • (2005) Diabetes , vol.54 , Issue.5 , pp. 1340-1348
    • Fujimoto, M.1    Shimizu, N.2    Kunii, K.3    Martyn, J.A.J.4    Ueki, K.5    Kaneki, M.6
  • 10
    • 0032715834 scopus 로고    scopus 로고
    • Nitric oxide and peroxynitrite. The ugly, the uglier and the not so good: A personal view of recent controversies
    • B. Halliwell, K. Zhao, and M. Whiteman Nitric oxide and peroxynitrite. The ugly, the uglier and the not so good: a personal view of recent controversies Free Radic. Res. 31 1999 651 669
    • (1999) Free Radic. Res. , vol.31 , pp. 651-669
    • Halliwell, B.1    Zhao, K.2    Whiteman, M.3
  • 11
    • 33745684789 scopus 로고    scopus 로고
    • Gypenoside XLIX isolated from Gynostemma pentaphyllum inhibits nuclear factor-kappaB activation via a PPAR-alpha-dependent pathway
    • T.H. Huang, Y. Li, V. Razmovski-Naumovski, V.H. Tran, G.Q. Li, C.C. Duke, and B.D. Roufogalis Gypenoside XLIX isolated from Gynostemma pentaphyllum inhibits nuclear factor-kappaB activation via a PPAR-alpha-dependent pathway J. Biomed. Sci. 13 2006 535 548
    • (2006) J. Biomed. Sci. , vol.13 , pp. 535-548
    • Huang, T.H.1    Li, Y.2    Razmovski-Naumovski, V.3    Tran, V.H.4    Li, G.Q.5    Duke, C.C.6    Roufogalis, B.D.7
  • 12
    • 0036784382 scopus 로고    scopus 로고
    • Differential modulation of insulin actions by dexamethasone: Studies in primary cultures of adult rat hepatocytes
    • H.H. Klein, S. Ullmann, M. Drenckhan, T. m Grimmsmann, K. Unthan-Fechner, and I. Probst Differential modulation of insulin actions by dexamethasone: studies in primary cultures of adult rat hepatocytes J. Hepatol. 37 2002 432 440
    • (2002) J. Hepatol. , vol.37 , pp. 432-440
    • Klein, H.H.1    Ullmann, S.2    Drenckhan, M.3    Grimmsmann, T.M.4    Unthan-Fechner, K.5    Probst, I.6
  • 13
    • 0033650715 scopus 로고    scopus 로고
    • Antioxidant and hepatoprotective effects of Anoectochilus formosanus and Gynostemma pentaphyllum
    • C.C. Lin, P.C. Huang, and J.M. Lin Antioxidant and hepatoprotective effects of Anoectochilus formosanus and Gynostemma pentaphyllum Am. J. Chin. Med. 28 2000 87 96
    • (2000) Am. J. Chin. Med. , vol.28 , pp. 87-96
    • Lin, C.C.1    Huang, P.C.2    Lin, J.M.3
  • 14
    • 41549106598 scopus 로고    scopus 로고
    • Method development for gypenosides fingerprint by high performance liquid chromatography with diode-array detection and the addition of internal standard
    • DOI 10.1248/cpb.56.389
    • F. Liu, D. Ren, D.A. Guo, Y. Pan, H. Zhang, and P. Hu Method development for Gypenosides fingerprint by high performance liquid chromatography with diode-array detection and the addition of internal standard Chem. Pharm. Bull. 56 2008 389 393 (Pubitemid 351463257)
    • (2008) Chemical and Pharmaceutical Bulletin , vol.56 , Issue.3 , pp. 389-393
    • Liu, F.1    Ren, D.2    Guo, D.-A.3    Pan, Y.4    Zhang, H.5    Hu, P.6
  • 15
    • 79952196830 scopus 로고    scopus 로고
    • Interrelationships between hepatic fat and insulin resistance in non-alcoholic fatty liver disease
    • K.A. Lockman, and M.J. Nyirenda Interrelationships between hepatic fat and insulin resistance in non-alcoholic fatty liver disease Curr. Diabetes Rev. 6 2010 341 347
    • (2010) Curr. Diabetes Rev. , vol.6 , pp. 341-347
    • Lockman, K.A.1    Nyirenda, M.J.2
  • 17
    • 33744948514 scopus 로고    scopus 로고
    • Free fatty acids induce JNK-dependent hepatocyte lipoapoptosis
    • DOI 10.1074/jbc.M510660200
    • H. Malhi, S.F. Bronk, N.W. Werneburg, and G.J. Gores Free fatty acids induce JNK-dependent hepatocyte lipoapoptosis J. Biol. Chem. 281 2006 12093 12101 (Pubitemid 43855473)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.17 , pp. 12093-12101
    • Malhi, H.1    Bronk, S.F.2    Werneburg, N.W.3    Gores, G.J.4
  • 18
    • 34247519127 scopus 로고    scopus 로고
    • ++-dependent mechanism
    • DOI 10.1007/s11745-006-3004-6
    • C.A. Marra, J. Nella, D. Manti, and M.J.T. de Alaniz Lipid metabolism in rats is modified by nitric oxide availability through a Ca++-dependent mechanism Lipids 42 2007 211 228 (Pubitemid 46651416)
    • (2007) Lipids , vol.42 , Issue.3 , pp. 211-228
    • Marra, C.A.1    Nella, J.2    Manti, D.3    De Alaniz, M.J.T.4
  • 19
    • 33746327466 scopus 로고    scopus 로고
    • Mitochondrial Respiratory Chain Supercomplexes Are Destabilized in Barth Syndrome Patients
    • DOI 10.1016/j.jmb.2006.06.057, PII S0022283606007959
    • M. McKenzie, M. Lazarou, D.R. Thorburn, and M.T. Ryan Mitochondrial respiratory Chain supercomplexes are destabilized in Barth Syndrome patients J. Mol. Biol. 361 2006 462 469 (Pubitemid 44118343)
    • (2006) Journal of Molecular Biology , vol.361 , Issue.3 , pp. 462-469
    • McKenzie, M.1    Lazarou, M.2    Thorburn, D.R.3    Ryan, M.T.4
  • 22
    • 33947523780 scopus 로고    scopus 로고
    • Anti-hyperlipidemic and hypoglycemic effects of Gynostemma pentaphyllum in the Zucker fatty rat
    • S. Megalli, N.M. Davies, and B.D. Roufogalis Anti-hyperlipidemic and hypoglycemic effects of Gynostemma pentaphyllum in the Zucker fatty rat J. Pharm. Pharm. Sci. 9 2006 281 291 (Pubitemid 46614342)
    • (2006) Journal of Pharmacy and Pharmaceutical Sciences , vol.9 , Issue.3 , pp. 281-291
    • Megalli, S.1    Davies, N.M.2    Roufogalis, B.D.3
  • 24
    • 78149248320 scopus 로고    scopus 로고
    • Palmitate protects hepatocytes from oxidative stress and triacylglyceride accumulation by stimulation of nitric oxide synthesis in the presence of high glucose and insulin concentration
    • C. Müller, A. Gardemann, G. Keilhoff, D. Peter, I. Wiswedel, S. Kropf, and L. Schild Palmitate protects hepatocytes from oxidative stress and triacylglyceride accumulation by stimulation of nitric oxide synthesis in the presence of high glucose and insulin concentration Free Radic. Res. 44 2010 1425 1434
    • (2010) Free Radic. Res. , vol.44 , pp. 1425-1434
    • Müller, C.1    Gardemann, A.2    Keilhoff, G.3    Peter, D.4    Wiswedel, I.5    Kropf, S.6    Schild, L.7
  • 25
    • 0025007136 scopus 로고
    • Stimulation of glucose production from glycogen by glucagon, noradrenaline and non-degradable adenosine analogues is counteracted by adenosine and ATP in cultured rat hepatocytes
    • E. Oetjen, C. Schweickhardt, K. Unthan-Fechner, and I. Probst Stimulation of glucose production from glycogen by glucagon, noradrenaline and non-degradable adenosine analogues is counteracted by adenosine and ATP in cultured rat hepatocytes Biochem. J. 271 1990 337 344 (Pubitemid 20344744)
    • (1990) Biochemical Journal , vol.271 , Issue.2 , pp. 337-344
    • Oetjen, E.1    Schweickhardt, C.2    Unthan-Fechner, K.3    Probst, I.4
  • 26
    • 49649091383 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease: An overview of prevalence, diagnosis, pathogenesis and treatment considerations
    • D. Preiss, and N. Sattar Non-alcoholic fatty liver disease: an overview of prevalence, diagnosis, pathogenesis and treatment considerations Clin. Sci. 115 2008 141 150
    • (2008) Clin. Sci. , vol.115 , pp. 141-150
    • Preiss, D.1    Sattar, N.2
  • 28
    • 1142298711 scopus 로고    scopus 로고
    • Inhibition of Hepatocyte Lipogenesis by Nitric Oxide Donor: Could Nitric Oxide Regulate Lipid Synthesis?
    • DOI 10.1080/15216540310001649822
    • W.E. Roediger, R. Hems, D. Wiggins, and G.F. Gibbons Inhibition of hepatocyte lipogenesis by nitric oxide donor: could nitric oxide regulate lipid synthesis? IUBMB Life 56 2004 35 40 (Pubitemid 38209289)
    • (2004) IUBMB Life , vol.56 , Issue.1 , pp. 35-40
    • Roediger, W.E.1    Hems, R.2    Wiggins, D.3    Gibbons, G.F.4
  • 29
    • 0026545285 scopus 로고
    • Serum lipids, hepatic glycerolipid metabolism and peroxisomal fatty acid oxidation in rats fed omega-3 and omega-6 fatty acids
    • A.C. Rustan, E.N. Christiansen, and C.A. Drevon Serum lipids, hepatic glycerolipid metabolism and peroxisomal fatty acid oxidation in rats fed omega-3 and omega-6 fatty acids Biochem. J. 283 Pt 2 1992 333 339
    • (1992) Biochem. J. , vol.283 , Issue.PART 2 , pp. 333-339
    • Rustan, A.C.1    Christiansen, E.N.2    Drevon, C.A.3
  • 30
    • 77952288741 scopus 로고    scopus 로고
    • Selective induction of apoptosis in glioma tumour cells by a Gynostemma pentaphyllum extract
    • L. Schild, B.H. Chen, P. Makarov, K. Kattengell, K. Heinitz, and G. Keilhoff Selective induction of apoptosis in glioma tumour cells by a Gynostemma pentaphyllum extract Phytomedicine 17 2010 589 597
    • (2010) Phytomedicine , vol.17 , pp. 589-597
    • Schild, L.1    Chen, B.H.2    Makarov, P.3    Kattengell, K.4    Heinitz, K.5    Keilhoff, G.6
  • 31
  • 32
    • 30744442160 scopus 로고    scopus 로고
    • Neuronal nitric oxide synthase controls enzyme activity pattern of mitochondria and lipid metabolism
    • DOI 10.1096/fj.05-3898fje
    • L. Schild, I. Jaroscakova, U. Lendeckel, G. Wolf, and G. Keilhoff Neuronal nitric oxide synthase controls enzyme activity pattern of mitochondria and lipid metabolism FASEB J. 20 2006 145 147 (Pubitemid 43100495)
    • (2006) FASEB Journal , vol.20 , Issue.1 , pp. 145-147
    • Schild, L.1    Jaroscakova, I.2    Lendeckel, U.3    Wolf, G.4    Keilhoff, G.5
  • 33
    • 0034193996 scopus 로고    scopus 로고
    • The biosynthesis and functional role of cardiolipin
    • DOI 10.1016/S0163-7827(00)00005-9, PII S0163782700000059
    • M. Schlame, D. Rua, and M.L. Greenberg The biosynthesis and functional role of cardiolipin Prog. Lipid Res. 39 2000 257 288 (Pubitemid 30224706)
    • (2000) Progress in Lipid Research , vol.39 , Issue.3 , pp. 257-288
    • Schlame, M.1    Rua, D.2    Greenberg, M.L.3
  • 34
    • 0015752890 scopus 로고
    • Preparation of rat liver cells. 3. Enzymatic requirements for tissue dispersion
    • P.O. Seglen Preparation of rat liver cells. 3. Enzymatic requirements for tissue dispersion Exp. Cell Res. 82 1973 391 398
    • (1973) Exp. Cell Res. , vol.82 , pp. 391-398
    • Seglen, P.O.1
  • 35
    • 33746210066 scopus 로고    scopus 로고
    • Gypenosides protect primary cultures of rat cortical cells against oxidative neurotoxicity
    • DOI 10.1016/j.brainres.2006.05.035, PII S0006899306013321
    • L. Shang, J. Liu, Q. Zhu, L. Zhao, Y. Feng, X. Wang, W. Cao, and H. Xin Gypenosides protect primary cultures of rat cortical cells against oxidative neurotoxicity Brain Res. 1102 2006 163 174 (Pubitemid 44092666)
    • (2006) Brain Research , vol.1102 , Issue.1 , pp. 163-174
    • Shang, L.1    Liu, J.2    Zhu, Q.3    Zhao, L.4    Feng, Y.5    Wang, X.6    Cao, W.7    Xin, H.8
  • 36
    • 79951795388 scopus 로고    scopus 로고
    • Chinese herbal extracts (SK0506) as a potential candidate for the therapy of the metabolic syndrome
    • Y. Tan, M.A. Kamal, Z.Z. Wang, W. Xiao, J.P. Seale, and X. Qu Chinese herbal extracts (SK0506) as a potential candidate for the therapy of the metabolic syndrome Clin. Sci. 120 2011 297 305
    • (2011) Clin. Sci. , vol.120 , pp. 297-305
    • Tan, Y.1    Kamal, M.A.2    Wang, Z.Z.3    Xiao, W.4    Seale, J.P.5    Qu, X.6
  • 37
    • 0032759472 scopus 로고    scopus 로고
    • The direct release of nitric oxide by gypenosides derived from the herb Gynostemma pentaphyllum
    • DOI 10.1006/niox.1999.0245
    • M.A. Tanner, X. Bu, J.A. Steimle, and P.R. Myers The direct release of nitric oxide by gypenosides derived from the herb Gynostemma pentaphyllum Nitric Oxide 3 1999 359 365 (Pubitemid 29531862)
    • (1999) Nitric Oxide - Biology and Chemistry , vol.3 , Issue.5 , pp. 359-365
    • Tanner, M.A.1    Bu, X.2    Steimle, J.A.3    Myers, P.R.4
  • 38
    • 70349779693 scopus 로고    scopus 로고
    • Voluntary oral feeding of rats not requiring a very high fat diet is a clinically relevant animal model of non-alcoholic fatty liver disease (NAFLD)
    • G.L. Tipoe, C.T. Ho, E.C. Liong, T.M. Leung, T.Y. Lau, M.L. Fung, and A.A. Nanji Voluntary oral feeding of rats not requiring a very high fat diet is a clinically relevant animal model of non-alcoholic fatty liver disease (NAFLD) Histol. Histopathol. 24 2009 1161 1169
    • (2009) Histol. Histopathol. , vol.24 , pp. 1161-1169
    • Tipoe, G.L.1    Ho, C.T.2    Liong, E.C.3    Leung, T.M.4    Lau, T.Y.5    Fung, M.L.6    Nanji, A.A.7
  • 39
    • 0031760336 scopus 로고    scopus 로고
    • A high linoleic acid diet increases oxidative stress in vivo and affects nitric oxide metabolism in humans
    • DOI 10.1016/S0952-3278(98)90067-9
    • A.M. Turpeinen, S. Basu, and M. Mutanen A high linoleic acid diet increases oxidative stress in vivo and affects nitric oxide metabolism in humans Prostaglandins Leukot. Essent. Fatty Acids 59 1998 229 233 (Pubitemid 28505116)
    • (1998) Prostaglandins Leukotrienes and Essential Fatty Acids , vol.59 , Issue.3 , pp. 229-233
    • Turpeinen, A.M.1    Basu, S.2    Mutanen, M.3
  • 40
    • 0033066651 scopus 로고    scopus 로고
    • A high linoleic acid diet increases oxidative stress in vivo and affects nitric oxide metabolism in humans
    • A.M. Turpeinen, S. Basu, and M. Mutanen A high linoleic acid diet increases oxidative stress in vivo and affects nitric oxide metabolism in humans Lipids 34 Suppl. 1999 S291 S292
    • (1999) Lipids , vol.34 , Issue.SUPPL.
    • Turpeinen, A.M.1    Basu, S.2    Mutanen, M.3
  • 41
    • 5344239586 scopus 로고    scopus 로고
    • Oxidative stress and depletion of hepatic long-chain polyunsaturated fatty acids may contribute to nonalcoholic fatty liver disease
    • DOI 10.1016/j.freeradbiomed.2004.06.033, PII S0891584904005271
    • L.A. Videla, R. Rodrigo, J. Araya, and J. Poniachik Oxidative stress and depletion of hepatic long-chain polyunsaturated fatty acids may contribute to nonalcoholic fatty liver disease Free Radic. Biol. Med. 37 2004 1499 1507 (Pubitemid 39349251)
    • (2004) Free Radical Biology and Medicine , vol.37 , Issue.9 , pp. 1499-1507
    • Videla, L.A.1    Rodrigo, R.2    Araya, J.3    Poniachik, J.4
  • 42
    • 33751193496 scopus 로고    scopus 로고
    • Insulin resistance and oxidative stress interdependency in non-alcoholic fatty liver disease
    • DOI 10.1016/j.molmed.2006.10.001, PII S147149140600222X
    • L.A. Videla, R. Rodrigo, J. Araya, and J. Poniachik Insulin resistance and oxidative stress interdependency in non-alcoholic fatty liver disease Trends Mol. Med. 12 2006 555 558 (Pubitemid 44780196)
    • (2006) Trends in Molecular Medicine , vol.12 , Issue.12 , pp. 555-558
    • Videla, L.A.1    Rodrigo, R.2    Araya, J.3    Poniachik, J.4
  • 43
    • 0034150174 scopus 로고    scopus 로고
    • Increased hepatic activity of inducible nitric oxide synthase in rats fed on a high-fat diet
    • G. Wan, S. Ohnomi, and N. Kato Increased hepatic activity of inducible nitric oxide synthase in rats fed on a high-fat diet Biosci. Biotechnol. Biochem. 64 2000 555 561
    • (2000) Biosci. Biotechnol. Biochem. , vol.64 , pp. 555-561
    • Wan, G.1    Ohnomi, S.2    Kato, N.3
  • 44
    • 77954794983 scopus 로고    scopus 로고
    • Neuroprotective effect of gypenosides against oxidative injury in the substantia nigra of a mouse model of Parkinson's disease
    • P. Wang, L. Niu, L. Gao, W.X. Li, D. Jia, X.L. Wang, and G.D. Gao Neuroprotective effect of gypenosides against oxidative injury in the substantia nigra of a mouse model of Parkinson's disease J. Int. Med. Res. 38 2010 1084 1092
    • (2010) J. Int. Med. Res. , vol.38 , pp. 1084-1092
    • Wang, P.1    Niu, L.2    Gao, L.3    Li, W.X.4    Jia, D.5    Wang, X.L.6    Gao, G.D.7
  • 46
    • 74549206782 scopus 로고    scopus 로고
    • Degradation of phospholipids by oxidative stress - Exceptional significance of cardiolipin
    • I. Wiswedel, A. Gardemann, A. Storch, D. Peter, and L. Schild Degradation of phospholipids by oxidative stress - exceptional significance of cardiolipin Free Radic. Res. 44 2010 135 145
    • (2010) Free Radic. Res. , vol.44 , pp. 135-145
    • Wiswedel, I.1    Gardemann, A.2    Storch, A.3    Peter, D.4    Schild, L.5
  • 47
    • 0345803935 scopus 로고    scopus 로고
    • Remodeling of Cardiolipin by Phospholipid Transacylation
    • DOI 10.1074/jbc.M307382200
    • Y. Xu, R.I. Kelley, T.J.J. Blanck, and M. Schlame Remodeling of cardiolipin by phospholipid transacylation J. Biol. Chem. 278 2003 51380 51385 (Pubitemid 38020377)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.51 , pp. 51380-51385
    • Xu, Y.1    Kelley, R.I.2    Blanck, T.J.J.3    Schlame, M.4
  • 48
    • 57349083738 scopus 로고    scopus 로고
    • Potential hypoglycemic effect of an ethanol extract of Gynostemma pentaphyllum in C57BL/KsJ-db/db mice
    • J. Yeo, Y.J. Kang, S.M. Jeon, U.J. Jung, M.K. Lee, H. Song, and M.S. Choi Potential hypoglycemic effect of an ethanol extract of Gynostemma pentaphyllum in C57BL/KsJ-db/db mice J. Med. Food 11 2008 709 716
    • (2008) J. Med. Food , vol.11 , pp. 709-716
    • Yeo, J.1    Kang, Y.J.2    Jeon, S.M.3    Jung, U.J.4    Lee, M.K.5    Song, H.6    Choi, M.S.7
  • 49
    • 58149195347 scopus 로고    scopus 로고
    • Blood F2-Isoprostanes are significantly associated with abnormalities of lipid status in rats with steatosis
    • M. Zhu, L.J. Sun, Y.Q. Liu, Y.L. Feng, H.T. Tong, Y.H. Hu, and Z. Zhao Blood F2-Isoprostanes are significantly associated with abnormalities of lipid status in rats with steatosis World J. Gastroenterol. 14 2008 4677 4683
    • (2008) World J. Gastroenterol. , vol.14 , pp. 4677-4683
    • Zhu, M.1    Sun, L.J.2    Liu, Y.Q.3    Feng, Y.L.4    Tong, H.T.5    Hu, Y.H.6    Zhao, Z.7


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