A mutation in the E(Z) methyltransferase that increases trimethylation of histone H3 lysine 27 and causes inappropriate silencing of active Polycomb target genes

Developmental Biology

Volumn 364, Issue 2, 2012, Pages 249-258

  Stepanik, Vincent A ^a   Harte, Peter J ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

E(z); Gain of function; Histone methyltransferase; Polycomb; Silencing

Indexed keywords

HISTONE H3; HISTONE H3 LYSINE 27; HISTONE LYSINE METHYLTRANSFERASE; METHYLTRANSFERASE; POLYCOMB GROUP PROTEIN; UNCLASSIFIED DRUG;

ABD B GENE; ACETYLATION; ARTICLE; BIOACCUMULATION; CONTROLLED STUDY; DEVELOPMENTAL GENE; DNA METHYLATION; EMBRYO DEVELOPMENT; GENE; GENE ACTIVATION; GENE EXPRESSION; GENE FUNCTION; GENE IDENTIFICATION; GENE LOCATION; GENE MUTATION; GENE SILENCING; HOMOZYGOSITY; NONHUMAN; POLYCOMB TARGET GENE; PRIORITY JOURNAL; PROTEIN MODIFICATION; TRANSCRIPTION INITIATION; WILD TYPE;

EID: 84858078701     PISSN: 00121606     EISSN: 1095564X     Source Type: Journal    
DOI: 10.1016/j.ydbio.2011.12.007     Document Type: Article

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