Double-stranded Let-7 mimics, potential candidates for cancer gene therapy

Journal of Physiology and Biochemistry

Volumn 68, Issue 1, 2012, Pages 107-119

  Wang, Qi Zhao ^a   Lv, Ying Hui ^a   Gong, Yu Hua ^a   Li, Zhao Fa ^a   Xu, William ^a   Diao, Yong ^a   Xu, Ruian ^a  

^a HUAQIAO UNIVERSITY   (China)

Author keywords

Gene therapy; Let 7 mimics; Lung cancer; Oncogene addiction; RNAi

Indexed keywords

ANTINEOPLASTIC AGENT; MESSENGER RNA; PROTEIN LET 7; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER GENE THERAPY; CANCER INHIBITION; CELL CYCLE ARREST; CELL MIGRATION; CELL VIABILITY; CONTROLLED STUDY; GENE EXPRESSION; GENE MUTATION; GENE SEQUENCE; GENE SILENCING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VITRO STUDY; SYNTHESIS;

3' UNTRANSLATED REGIONS; BASE SEQUENCE; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE KNOCKDOWN TECHNIQUES; GENE THERAPY; HUMANS; MICRORNAS; NEOPLASMS; POINT MUTATION; PROTO-ONCOGENE PROTEINS P21(RAS); RNA INTERFERENCE; RNA, DOUBLE-STRANDED; TRANSFECTION;

EID: 84858071139     PISSN: 11387548     EISSN: 18778755     Source Type: Journal    
DOI: 10.1007/s13105-011-0124-0     Document Type: Article

References (59)

1. Akao Y, Nakagawa Y, Naoe T (2006) Let-7 microRNA functions as a potential growth suppressor in human colon cancer cells. Biol Pharm Bull 29:903-906
2. Baek D, Villén J, Shin C, Camargo FD, Gygi SP, Bartel DP (2008) The impact of microRNAs on protein output. Nature 455:64-71
3. Boudreau RL, Martins I, Davidson BL (2008) Artificial microRNAs as siRNA shuttles: improved safety as compared to shRNAs in vitro and in vivo. Mol Ther 17:169-175
4. Castanotto D, Rossi JJ (2009) The promises and pitfalls of RNA-interference-based therapeutics. Nature 457:426-433
5. Castanotto D, Sakurai K, Lingeman R et al (2007) Combinatorial delivery of small interfering RNAs reduces RNAi efficacy by selective incorporation into RISC. Nucleic Acids Res 35:5154-5164 (Pubitemid 47394199)
6. Ding L, Getz G, Wheeler DA et al (2008) Somatic mutations affect key pathways in lung adenocarcinoma. Nature 455:1069-1075
7. Doench JG, Petersen CP, Sharp PA (2003) siRNAs can function as miRNAs. Genes Dev 17:438-442 (Pubitemid 36258757)
8. Esmerina T, Jean-Jacques M, Varsha G, William P, Deepa S, Adrian CG (2007) MiRNAs and their potential for use against cancer and other diseases, miRNA-based gene therapy. Future Oncol 3:521-537
9. Esquela-Kerscher A, Trang P, Wiggins JF et al (2008) The let-7 microRNA reduces tumor growth in mouse models of lung cancer. Cell Cycle 7:759-764 (Pubitemid 351520040)
10. Filipowicz W, Jaskiewicz L, Kolb FA, Pillai RS (2005) Posttranscriptional gene silencing by siRNAs and miRNAs. Curr Opin Struct Biol 15:331-341 (Pubitemid 40826453)
11. Garzon R, Liu S, Fabbri M et al (2009) MicroRNA-29b induces global DNA hypomethylation and tumor suppressor gene reexpression in acute myeloid leukemia by targeting directly DNMT3A and 3B and indirectly DNMT1. Blood 113:6411-6418
12. Gregory RI, Chendrimada TP, Cooch N, Shiekhattar R (2005) Human RISC couples microRNA biogenesis and posttranscriptional gene silencing. Cell 123:631-640 (Pubitemid 41608466)
13. Hüser D, Gogol-Döring A, Lutter T et al (2010) Integration preferences of wildtype AAV-2 for consensus rep-binding sites at numerous loci in the human genome. PLoS Pathog 6:e1000985
14. Inamura K, Togashi Y, Nomura K et al (2007) Let-7 microRNA expression is reduced in bronchioloalveolar carcinoma, a non-invasive carcinoma, and is not correlated with prognosis. Lung Cancer 58:392-396 (Pubitemid 350051514)
15. Ivanovska I, Ball AS, Diaz RL et al (2008) MicroRNAs in the miR-106b family regulate p21/CDKN1A and promote cell cycle progression. Mol Cell Biol 28:2167-2174 (Pubitemid 351429964)
16. Jackson A, Linsley PS (2010) The therapeutic potential of microRNA modulation. Discov Med 9:311-318
17. Johnson CD, Esquela-Kerscher A, Stefani G et al (2007) The let-7 microRNA represses cell proliferation pathways in human cells. Cancer Res 67:7713-7722 (Pubitemid 47281364)
18. Johnson SM, Grosshans H, Shingara J et al (2005) RAS is regulated by the let-7 microRNA family. Cell 120:635-647 (Pubitemid 40343076)
19. Jones S, Zhang X, Parsons DW et al (2008) Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science 321:1801-1806
20. Kaiser PK, Symons RC, Shah SM et al (2010) RNAi-based treatment for neovascular age-related macular degeneration by Sirna-027. Am J Ophthalmol 150:33-39.e2
21. Khvorova A, Reynolds A, Jayasena SD (2003) Functional siRNAs and miRNAs exhibit strand bias. Cell 115:209-216 (Pubitemid 37329584)
22. Koller E, Propp S, Murray H et al (2006) Competition for RISC binding predicts in vitro potency of siRNA. Nucleic Acids Res 34:4467-4476 (Pubitemid 44567046)
23. Kota J, Chivukula RR, O'Donnell KA et al (2009) Therapeutic microRNA delivery suppresses tumorigenesis in a murine liver cancer model. Cell 137:1005-1017
24. Kumar MS, Erkeland SJ, Pester RE, Chen CY, Ebert MS, Sharp PA, Jacks T (2008) Suppression of non-small cell lung tumor development by the let-7 microRNA family. Proc Natl Acad Sci USA 105:3903-3908 (Pubitemid 351723497)
25. Lee I, Ajay SS, Yook JI et al (2009) New class of microRNA targets containing simultaneous 5′-UTR and 3′-UTR interaction sites. Genome Res 19:1175-1183
26. Lee ST, Chu K, Oh HJ et al (2010) Let-7 microRNA inhibits the proliferation of human glioblastoma cells. J Neurooncol (in press)
27. Lee YS, Dutta A (2007) The tumor suppressor microRNA let-7 represses the HMGA2 oncogene. Gene Dev 21:1025-1030
28. Lin T, Dong W, Huang J, Pan Q, Fan X, Zhang C, Huang L (2009) MicroRNA-143 as a tumor suppressor for bladder cancer. J Urol 181:1372-1380
29. Lu J, Qian J, Chen F et al (2005) Differential expression of components of the microRNA machinery during mouse organogenesis. Biochem Biophy Res Co 334:319-323 (Pubitemid 40982372)
30. Luo J, Solinini NL, Elledge SJ (2009) Principles of cancer therapy: oncogene and non-oncogene addiction. Cell 136:823-837
31. Maniataki E, Mourelatos Z (2005) A human, ATP-independent, RISC assembly machine fueled by premiRNA. Genes Dev 19:2979-2990 (Pubitemid 41798114)
32. Manno CS, Pierce GF, Arruda VR et al (2006) Successful transduction of liver in hemophilia by AAV-factor IX and limitations imposed by the host immune response. Nat Med 12:342-34733.
33. Matsubara H, Takeuchi T, Nishikawa E et al (2007) Apoptosis induction by antisense oligonucleotides against miR-17-5p and miR-20a in lung cancers overexpressing miR-17-92. Oncogene 26:6099-6105
34. Metias SM, Lianidou E, Yousef GM (2009) MicroRNAs in clinical oncology: at the crossroads between promises and problems. J Clin Pathol 62:771-776
35. Oberdoerffer P, Kanellopoulou C, Heissmeyer V et al (2005) Efficiency of RNA interference in the mouse hematopoietic system varies between cell types and developmental stages. Mol Cell Biol 25:3896-3905 (Pubitemid 40617641)
36. Parsons DW, Jones S, Zhang X et al (2008) An integrated genomic analysis of human glioblastoma multiforme. Science 321:1807-1812
37. Peng Y, Laser J, Shi G, Mittal K, Melamed J, Lee P, Wei JJ (2008) Antiproliferative effects by Let-7 repression of high-mobility group A2 in uterine leiomyoma. Mol Cancer Res 6:663-673 (Pubitemid 351521848)
38. Petri A, Lindow M, Kauppinen S (2009) MicroRNA silencing in primates: towards development of novel therapeutics. Cancer Res 69:393-395
39. Sampson VB, Rong NH, Han J et al (2007) MicroRNA let-7a down-regulates MYC and reverts MYC-induced growth in Burkitt lymphoma cells. Cancer Res 67:9762-9770 (Pubitemid 47621223)
40. Sasaki T, Shiohama A, Minoshima S, Shimizu N (2003) Identification of eight members of the Argonaute family in the human genome small star, filled. Genomics 82:323-330 (Pubitemid 36957926)
41. Schwarz DS, Hutvágner G, Du T, Xu Z, Aronin N, Zamore PD (2003) Asymmetry in the assembly of the RNAi enzyme complex. Cell 115:199-208 (Pubitemid 37329583)
42. Selbach M, Schwanhäusser B, Thierfelder N, Fang Z, Khanin R, Rajewsky N (2008) Widespread changes in protein synthesis induced by microRNAs. Nature 455:58-63
43. Sharma SV, Settleman J (2007) Oncogene addiction: setting the stage for molecularly targeted cancer therapy. Genes Dev 21:3214-3231 (Pubitemid 350277749)
44. Shell S, Park SM, Radjabi AR (2007) Let-7 expression defines two differentiation stages of cancer. Proc Natl Acad Sci USA 104:11400-11405 (Pubitemid 47175152)
45. Solimini NL, Luo J, Elledge SJ (2007) Non-oncogene addiction and the stress phenotype of cancer cells. Cell 130:986-988 (Pubitemid 47422308)
46. Takamizawa J, Konishi H, Yanagisawa K et al (2004) Reduced expression of the let-7 microRNAs in human lung cancers in association with shortened postoperative survival. Cancer Res 64:3753-3756 (Pubitemid 38697282)
47. Tavazoie SF, Alarcón C, Oskarsson T et al (2008) Endogenous human microRNAs that suppress breast cancer metastasis. Nature 451:147-152
48. Torrisani J, Bournet B, du Rieu MC et al (2009) Let-7 microRNA transfer in pancreatic cancer-derived cells inhibits in vitro cell proliferation but fails to alter tumor progression. Hum Gene Ther 20:831-844
49. Tsuda N, Kawano K, Efferson CL, Ioannides CG (2005) Synthetic microRNA and double-stranded RNA targeting the 3′-untranslated region of HER-2/neu mRNA inhibit HER-2 protein expression in ovarian cancer cells. Int J Oncol 27:1299-1306
50. van Rooij E, Marshall WS, Olson EN (2008) Toward microRNA based therapeutics for heart disease: the sense in antisense. Circ Res 103:919-928
51. Vickers TA, Lima WF, Nichols JG (2007) Reduced levels of Ago2 expression result in increased siRNA competition in mammalian cells. Nucleic Acids Res 35:6598-6610 (Pubitemid 350111625)
52. Wang Q, Diao Y, Lv Y, Li Z, XU R (2009) Mutant K-ras-specific siRNA inhibits proliferation, migration and induces apoptosis of lung cancer A549 cells. Chin J Cancer Biother 16:564-569
53. Wang Q, Lv Y, Diao Y, Xu R (2008) The design of vectors for RNAi delivery system. Curr Pharma Design 14:1327-1340 (Pubitemid 351997826)
54. Wang Q, Xu W, Habib N, Xu R (2009) Potential uses of miRNA in lung cancer diagnosis, prognosis, and therapy. Curr Cancer Drug Targets 9:572-594
55. Weidhaas JB, Babar I, Nallur SM et al (2007) MicroRNAs as potential agents to alter resistance to cytotoxic anticancer therapy. Cancer Res 67:11111-11116 (Pubitemid 350248533)
56. Weinstein IB, Joe A (2008) Oncogene addiction. Cancer Res 68:3077-3080
57. Yanaihara N, Caplen N, Bowman E et al (2006) Unique microRNA molecular profiles in lung cancer diagnosis and prognosis. Cancer Cell 9:189-198 (Pubitemid 43357945)
58. Yu F, Yao H, Zhu P et al (2007) Let-7 regulates self renewal and tumorigenicity of breast cancer cells. Cell 131:1109-1123 (Pubitemid 350235025)
59. Zeng Y, Yi R, Cullen BR (2003) MicroRNAs and small interfering RNAs can inhibit mRNA expression by similar mechanisms. Proc Natl Acad Sci USA 100:9779-9784 (Pubitemid 37087018)