A dynamic structure for the acyl-enzyme species of the antibiotic aztreonam with the Citrobacter freundii β-lactamase revealed by infrared spectroscopy and molecular dynamics simulations

Biochemistry

Volumn 42, Issue 7, 2003, Pages 1950-1957

  Wilkinson, Alan Shaun ^a   Bryant, Patrick K ^a   Meroueh, Samy O ^b   Page, Malcolm G P ^c   Mobashery, Shahriar ^a   Wharton, Christopher W ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b WAYNE STATE UNIVERSITY   (United States)

^c BASILEA PHARMACEUTICA INTERNATIONAL LTD   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTICS; COMPUTER SIMULATION; CONFORMATIONS; CRYSTAL STRUCTURE; HYDROGEN BONDS; INFRARED SPECTROSCOPY; MOLECULAR DYNAMICS; X RAY CRYSTALLOGRAPHY;

BAND ASSIGNMENT;

ENZYMES;

AZTREONAM; BETA LACTAMASE;

ABSORPTION; ARTICLE; CITROBACTER FREUNDII; DRUG STRUCTURE; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME SPECIFICITY; HYDROGEN BOND; INFRARED SPECTROSCOPY; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN TRANSPORT; STRUCTURE ANALYSIS; TRANSPORT KINETICS; X RAY CRYSTALLOGRAPHY;

ACYLATION; ANTI-BACTERIAL AGENTS; AZTREONAM; BETA-LACTAMASES; BINDING SITES; CITROBACTER FREUNDII; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; ESTERS; HYDROGEN BONDING; HYDROLYSIS; METHICILLIN; MODELS, MOLECULAR; PROTEIN CONFORMATION; SPECTROPHOTOMETRY, INFRARED; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS;

CITROBACTER FREUNDII; NEGIBACTERIA;

EID: 0037465439     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0266941     Document Type: Article

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