Preparation of a polymethoxyflavone-rich fraction (PRF) of Citrus sunki Hort. ex Tanaka and its antiproliferative effects

Food Chemistry

Volumn 123, Issue 2, 2010, Pages 484-488

  Ko, Hee Chul ^a   Jang, Mi Gyeong ^a   Kang, Chang Hee ^a   Lee, Nam Ho ^a   Kang, Seong Il ^a   Lee, Sun Ryung ^a   Park, Deok Bae ^b   Kim, Se Jae ^a  

^a Jeju National University   (South Korea)

^b Jeju National University School of Medicine   (South Korea)

Author keywords

Antiproliferative activity; Citrus sunki Hort. ex Tanaka; PMF rich fraction (PRF); Polymethoxyflavone

Indexed keywords

FLAVONE; HOT WATER; POLYMETHOXYFLAVONE; UNCLASSIFIED DRUG;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CELL CYCLE G1 PHASE; CELL PROLIFERATION; CELL STRAIN HL 60; CITRUS FRUIT; CITRUS SUNKI; FLOW CYTOMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; PROTON NUCLEAR MAGNETIC RESONANCE;

CITRUS SUNKI;

EID: 77953292240     PISSN: 03088146     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.foodchem.2010.04.028     Document Type: Article

References (24)

1. Akowuah G.A., Zhari I., Norhayati I., Sadikun A., and Khamsah S.M. Sinensetin, eupatorin, 3′-hydroxy-5,6,7,4′-tetramethoxyflavone and rosmarinic acid contents and antioxidative effect of Orthosiphon stamineus from Malaysia. Food Chemistry 87 4 (2004) 559-566
2. Camarda L., Stefano V.D., Bosco S.F.D., and Schillaci D. Antiproliferative activity of citrus juices and HPLC evaluation of their flavonoid composition. Fitoterapia 78 6 (2007) 426-429
3. Carmichael J., DeGraff W.G., Gazdar A.F., Minna J.D., and Mitchell J.B. Evaluation of a tetrazolium-based semiautonated colorimetric assay: Assessment of chemisensitivity testing. Cancer Research 47 4 (1987) 936-942
4. Chen J., Montanari A.M., and Widmer W.W. Two new polymethoxylated flavones, a class of compounds with potential anticancer activity, isolated from cold pressed dancy tangerine peel oil solids. Journal of Agricultural and Food Chemistry 45 2 (1997) 364-368
5. Chen K.H., Weng M.S., and Lin J.K. Tangeretin suppresses IL-1b-induced cyclooxygenase (COX)-2 expression through inhibition of p38 MAPK, JNK, and AKT activation in human lung carcinoma cells. Biochemical Pharmacology 73 2 (2007) 215-227
6. Choi S.Y., Hwang J.H., Ko H.C., Park J.G., and Kim S.J. Nobiletin from citrus peel inhibits the DNA-binding activity of NF-κB and ROS production in LPS-activated RAW 264.7 cells. Journal of Ethnopharmacology 113 1 (2007) 149-155
7. Choi S.Y., Ko H.C., Hwang J.H., Park J.G., Kang S.H., Han S.H., et al. Correlation between flavonoid content and the NO production inhibitory activity of peel extracts from various citrus fruits. Biological and Pharmaceutical Bulletin 30 4 (2007) 772-778
8. Elisa T., Maurizio L.G., Santo G., Danila D.M., and Marco G. Citrus flavonoid: Molecular structure, biological activity and nutritional properties: A review. Food Chemistry 104 2 (2007) 466-479
9. Iwase Y., Takahashi M., Takemura Y., Ju-ichi M., Ito C., Furukawa H., et al. Isolation and identification of two new flavanones and a chalcone from citrus kinokuni. Chemical and Pharmaceutical Bulletin 49 10 (2001) 1356-1358
10. Johann S., Oliveira V.L., Pizzolatti M.G., Schripsema J., Braz-Filho R., Branco A., et al. Antimicrobial activity of wax and hexane extracts from Citrus spp. peels. Memórias do Institudo Oswaldo Cruz 102 6 (2007) 681-685
11. Kummee S., Tewtrakul S., and Subhadhirasakul S. Antimicrobial activity of the ethanol extract and compounds from the rhizomes of kaempferia parviflora. Songklanakarin Journal of Science and Technology 30 4 (2008) 463-466
12. Lai C.S., Li S., Chai C.Y., Lo C.Y., Dushenkov S., Ho C.T., et al. Anti-inflammatory and antitumor promotional effects of a novel urinary metabolite, 3′,4′-didemethylnobiletin, derived from nobiletin. Carcinogenesis 29 12 (2008) 2415-2424
13. Li S., Pan M.H., Lai C.S., Lo C.Y., Dushenkov S., and Ho C.T. Isolation and syntheses of polymethoxyflvones and hydroxylated polymethoxyflavones as inhibitors of HL-60 cell lines. Bioorganic and Medicinal Chemistry 15 10 (2007) 3381-3389
14. Li S., Pan M.H., Lo C.Y., Tan D., Wang Y., Shahidi F., et al. Chemistry and health effect of polymethoxyflavones and hydroxylated polymethoxyflavones. Journal of Functional Foods 1 1 (2009) 2-12
15. Li S., Yu H., and Ho C.T. Nobiletin: Efficient and large quantity isolation from orange peel extract. Biomedical Chromatography 20 11 (2006) 133-138
16. Machida K., and Osawa K. On the flavonoid constituents from the peels of citrus hassaku Hort. Ex Tanaka. Chemical and Pharmaceutical Bulletin 37 4 (1989) 1092-1094
17. Mak N.K., Wong-Leung Y.L., Chan S.C., Wen J., Leung K.N., and Fung M.C. Isolation of anti-leukemia compounds from citrus reticulate. Life Science 58 15 (1996) 1269-1276
18. Miyazawa M., Okuno Y., Fukuyama M., Nakamura S.I., and Kosaka H. Antimutagenic activity of polymethoxyflavonoids from citrus aurantium. Journal of Agricultural and Food Chemistry 47 12 (1999) 5239-5244
19. Nicoletti I., Migliorati G., Pagliacci M.C., Grignani F., and Riccardi C. A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. Journal of Immunological Methods 139 2 (1991) 271-279
20. Nogata Y., Sakamoto K., Shiratsuchi H., Ishii T., Yano M., and Ohta H. Flavonoid composition of fruit tissues of citrus species. Bioscience Biotechnology and Biochemistry 70 1 (2006) 178-192
21. Pan M.H., Chen W.J., Lin-Shiau S.Y., Ho C.T., and Lin J.K. Tangeretin induces cell-cycle G1 arrest through inhibiting cyclin-dependent kinases 2 and 4 activities as well as elevating Cdk inhibitors p21 and p27 in human colorectal carcinoma cells. Carcinogenesis 23 10 (2002) 1677-1684
22. Raman G., Jayaprakasha G.K., Cho M., Brodbelt J., and Patil B.S. Rapid adsorptive separation of citrus polymethoxylated flavones in non-aqueous conditions. Separation and Purification Technology 45 2 (2005) 147-152
23. Wang X., Li F., Zhang H., Geng Y., Yuan J., and Jiang T. Preparative isolation and purification of polymethoxylated flavones from tangerine peel using high-speed counter-current chromatography. Journal of Chromatography A 1090 1-2 (2005) 188-192
24. Yoshimizu N., Otani Y., Saikawa Y., Kubota T., Yoshida M., Furukawa T., et al. Anti-tumour effects of nobiletin, a citrus flavonoid, on gastric cancer include: Antiproliferative effects, induction of apoptosis and cell cycle deregulation. Alimentary Pharmacology and Therapeutics 20 1 (2004) 95-101