The 1α,25-dihydroxy-vitamin D3 reduces dengue virus infection in human myelomonocyte (U937) and hepatic (Huh-7) cell lines and cytokine production in the infected monocytes

Antiviral Research

Volumn 94, Issue 1, 2012, Pages 57-61

  Puerta Guardo, Henry ^a   De la Cruz Hernández, Sergio Isaac ^a,c   Rosales, Victor H ^b   Ludert, Juan E ^a   del Angel, Rosa María ^a  

^a Departamento de Infectómica y Patogénesis Molecular   (Mexico)

^b DEPARTAMENTO DE FÍSICA   (Mexico)

^c Instituto Nacional de Diagnostico y Referencia Epidemiologicos   (Mexico)

Author keywords

Antivirals; Cytokines; Dengue; Dengue virus; Vitamin D

Indexed keywords

CALCITRIOL; INTERLEUKIN 12P70; INTERLEUKIN 1BETA; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA;

ANTIINFLAMMATORY ACTIVITY; ANTIVIRAL ACTIVITY; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENGUE; DENGUE VIRUS; DRUG CYTOTOXICITY; DRUG EXPOSURE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOMODULATION; INFECTION PREVENTION; LIVER CELL; MONOCYTE; PRIORITY JOURNAL; VIRUS REPLICATION;

CELL LINE; CYTOKINES; DENGUE; DENGUE VIRUS; DOWN-REGULATION; HUMANS; MONOCYTES; U937 CELLS; VIRUS REPLICATION; VITAMIN D;

DENGUE VIRUS;

EID: 84857986406     PISSN: 01663542     EISSN: 18729096     Source Type: Journal    
DOI: 10.1016/j.antiviral.2012.02.006     Document Type: Article

References (40)

1. Agarwal R., Kapoor S., Nagar R., Misra A., Tandon R., Mathur A., Misra A.K., Srivastava K.L., Chaturvedi U.C. A clinical study of the patients with dengue hemorrhagic fever during the epidemic of 1996 at Lucknow, India. Southeast Asian J. Trop. Med. Publ. Health 1999, 30:735-740.
2. Almerighi C., Sinistro A., Cavazza A., Ciaprini C., Rocchi G., Bergamini A. 1Alpha,25-dihydroxyvitamin D3 inhibits CD40L-induced pro-inflammatory and immunomodulatory activity in human monocytes. Cytokine 2009, 45:190-197.
3. Baeke F., Takiishi T., Koft H., Gysemans C., Mathieu C. Vitamin D: modulator of the immune system. Curr. Opin. Pharmacol. 2010, 10:482-496.
4. Bang U.C., Shakar S.A., Hitz M.F., Jespersen M.S., Andersen O., Nielsen S.D., Jensen J.E. Deficiency of 25-hydroxyvitamin D in male HIV-positive patients: a descriptive cross-sectional study. Scand. J. Infect. Dis. 2010, 42:306-310.
5. Beard J.A., Bearden A., Striker R. Vitamin D and the anti-viral state. J. Clin. Virol. 2011, 50:194-200.
6. Bozza F.A., Cruz O.G., Zagne S.M., Azeredo E.L., Nogueira R.M., Assis E.F., Bozza P.T., Kubelka C.F. Multiplex cytokine profile from dengue patients: MIP-1beta and IFN-gamma as predictive factors for severity. BMC Infect. Dis. 2008, 8:86.
7. Bruce D., Ooi J.H., Yu S., Cantorna M.T. Vitamin D and host resistance to infection? Putting the cart in front of the horse. Exp. Biol. Med. 2010, 235:921-927.
8. Callahan J.D., Wu S.J., Dion-Schultz A., Mangold B.E., Peruski L.F., Watts D.M., Porter K.R., Murphy G.R., Suharyono W., King C.C., Hayes C.G., Temenak J.J. Development and evaluation of serotype- and group-specific fluorogenic reverse transcriptase PCR (TaqMan) assay for dengue virus. J. Clin. Microbiol. 2001, 39:4119-4124.
9. Cannell J.J., Zasloff M., Garland C.F., Scragg R., Giovannucci E. On the epidemiology of influenza. Virol. J. 2008, 5:29.
10. Cardier J., Mariño E., Romano E., Taylor P., Liprandi F., Bosch N., Rothman A. Proinflammatory factors present in sera from patients with acute dengue infection induce activation and apoptosis of human microvascular endothelial cells: possible role of TNF-α in endothelial cell damage in dengue. Cytokine 2005, 30:359-365.
11. Carr J.M., Hocking H., Bunting K., Wright P.J., Davidson A., Gamble J., Burrell C.J., Li P. Supernatants from dengue virus type-2 infected macrophages induce permeability changes in endothelial cell monolayers. J. Med. Virol. 2003, 69:521-528.
12. Ceballos-Olvera I., Chávez-Salinas S., Medina F., Ludert J.E., del Angel R.M. JNK phosphorylation, induced during dengue virus infection, is important for viral infection and requires the presence of cholesterol. Virology 2010, 396:30-36.
13. Chaturvedi U.C., Elbishbishi E.A., Agarwal R., Raghupathy R., Nagar R., Tandon R., Pacsa A.S., Younis O.I., Azizieh F. Sequential production of cytokines by dengue virus-infected human peripheral blood leukocyte cultures. J. Med. Virol. 1999, 59:335-340.
14. Chaturvedi U.C., Agarwal R., Elbishbishi E.A., Mustafa A.S. Cytokine cascade in dengue hemorrhagic fever: implications for pathogenesis. FEMS Immunol. Med. Microbiol. 2000, 28:183-188.
15. Cohen-Lahav M., Shany S., Tobvin D., Chaimovitz C., Douvdevani A. Vitamin D decreases NFkappaB activity by increasing IkappaBalpha levels. Nephrol. Dial. Transplant. 2006, 21:889-897.
16. D'Ambrosio D., Cippitelli M., Cocciolo M.G., Mazzeo D., Di Lucia P., Lang R., Sinigaglia F., Panina-Bordignon P. Inhibition of IL-12 production by 1,25-dihydroxyvitamin D3. Involvement of NF-kappaB downregulation in transcriptional repression of the p40 gene. J. Clin. Invest. 1998, 101:252-262.
17. Gagnon S.J., Mori M., Kurane I., Green S., Vaughn D.W., Kalayanarooj S., Suntayakorn S., Ennis F.A., Rothman A.L. Cytokine gene expression and protein production in peripheral blood mononuclear cells of children with acute dengue virus infections. J. Med. Virol. 2002, 67:41-46.
18. Gal-Tanamy M., Bachmetov L., Ravid A., Koren R., Erman A., Tur-Kaspa R., Zemel R. Vitamin D: an innate antiviral agent suppressing hepatitis C virus in human hepatocytes. Hepatology 2011, 54:1570-1579.
19. Green S., Vaughn D.W., Kalayanarooj S., Nimmannitya S., Suntayakorn S., Nisalak A., Lew R., Innis B.L., Kurane I., Rothman A.L., Ennis F.A. Early immune activation in acute dengue illness is related to development of plasma leakage and disease severity. J. Infect. Dis. 1999, 179:755-762.
20. Green S., Rothman A. Immunopathological mechanisms in dengue and dengue hemorrhagic fever. Curr. Opin. Infect. Dis. 2006, 19:429-436.
21. Gubler D.J. Dengue/dengue haemorrhagic fever: history and current status. Novartis Found. Symp. 2006, 277:3-16.
22. Johnson B.W., Russell B.J., Lanciotti R.S. Serotype-specific detection of dengue viruses in a fourplex real-time reverse transcriptase PCR assay. J. Clin. Microbiol. 2005, 43:4977-4983.
23. Juffrie M., Meer G.M., Hack C.E., Haasnoot K., Sutaryo, Veerman A.J., Thijs L.G. Inflammatory mediators in dengue virus infection in children: interleukin-6 and its relation to C-reactive protein and secretory phospholipase A2. Am. J. Trop. Med. Hyg. 2001, 65:70-75.
24. Lemire J.M., Archer D.C., Beck L., Spiegelberg H.L. Immunosuppressive actions of 1,25-dihydroxyvitaminD3: preferential inhibition of Th1 functions. J. Nutr. 1995, 125:1704S-1708S.
25. Li Q., Verma I.M. NF-κB regulation in the immune system. Nat. Rev. Immunol. 2002, 2:725-734.
26. Lin Y.W., Wang K.J., Lei H.Y., Lin Y.S., Yeh T.M., Liu H.S., Liu C.C., Chen S.H. Virus replication and cytokine production in dengue virus-infected human B lymphocytes. J. Virol. 2002, 76:12242-12249.
27. Liu P.T., Stenger S., Li H., Wenzel L., Tan B.H., Krutzik S.R., Ochoa M.T., Schauber J., Wu K., Meinken C., Kamen D.L., Wagner M., Bals R., Steinmeyer A., Zügel U., Gallo R.L., Eisenberg D., Hewison M., Hollis B.W., Adams J.S., Bloom B.R., Modlin R.L. Toll-like receptor triggering of a vitamin D-mediated antimicrobial response. Science 2006, 311:1770-1773.
28. Loke H., Bethell D., Phuong C.X., Day N., White N., Farrar J., Hill A. Susceptibility to dengue hemorrhagic fever in Vietnam: evidence of an association with variation in the vitamin D receptor and Fc gamma receptor IIa genes. Am. J. Trop. Med. Hyg. 2002, 67:102-106.
29. Mosso C., Galván-Mendoza I., Ludert J.E., del Angel R.M. Endocytic pathway followed by dengue virus to infect the mosquito cell line C6/36 HT. Virology 2008, 378:193-199.
30. Noble C.G., Chen Y.L., Dong H., Gu F., Lim S.P., Schul W., Wang Q.Y., Shi P.Y. Strategies for development of dengue virus inhibitors. Antiviral Res. 2010, 85:450-462.
31. O'Neill L.A. Signal transduction pathways activated by the IL-1 receptor/toll-like receptor superfamily. Curr. Top Microbiol. Immunol. 2002, 270:47-61.
32. Puerta-Guardo H., Mosso C., Medina F., Liprandi F., Ludert J.E., del Angel R.M. Antibody-dependent enhancement of dengue virus infection in U937 cells requires cholesterol-rich membrane microdomains. J. Gen. Virol. 2010, 91:394-403.
33. Raghupathy R., Chaturvedi U.C., Al-Sayer H., Elbishbishi E.A., Agarwal R., Nagar R., Kapoor S., Misra A., Mathur A., Nusrat H., Azizieh F., Khan M.A., Mustafa A.S. Elevated levels of IL-8 in dengue hemorrhagic fever. J. Med. Virol. 1998, 56:280-285.
34. Sadeghi K., Wessner B., Laggner U., Ploder M., Tamandl D., Friedl J., Zügel U., Steinmeyer A., Pollak A., Roth E., Boltz-Nitulescu G., Spittler A. Vitamin D3 down-regulates monocyte TLR expression and triggers hyporesponsiveness to pathogen-associated molecular patterns. Eur. J. Immunol. 2006, 36:361-370.
35. Sanchez-Valdez E., Delgado-Aradillas M., Torres-Martínez J.A., Torres-Benítez J.M. Clinical response in patients with dengue fever to oral calcium plus vitamin D administration: study of 5 cases. Proc. West. Pharmacol. Soc. 2009, 52:14-17.
36. Shum D., Smith J.L., Hirsch A.J., Bhinder B., Radu C., Stein D.A., Nelson J.A., Früh K., Djaballah H. High-content assay to identify inhibitors of dengue virus infection. Assay Drug Dev. Technol. 2010, 8:553-570.
37. Silveira G.F., Meyer F., Delfraro A., Mosimann A.L., Coluchi N., Vasquez C., Probst C.M., Báfica A., Bordignon J., Dos Santos C.N. Dengue virus type 3 isolated from a fatal case with visceral complications induces enhanced proinflammatory responses and apoptosis of human dendritic cells. J. Virol. 2011, 85:5374-5383.
38. Ubol S., Masrinoul P., Chaijaruwanich J., Kalayanarooj S., Charoensirisuthikul S., Kasisith J. Differences in global gene expression in peripheral blood mononuclear cells indicate a significant role of the innate responses in progression of dengue fever but not dengue hemorrhagic fever. J. Infect. Dis. 2008, 197:1459-1467.
39. Watford W.T., Moriguchi M., Morinobu A., ÓShea J.J. The biology of IL-12: coordinating innate and adaptive immune response. Cytokine Growth Factor Rev. 2003, 14:361-368.
40. Zasloff M. Fighting infections with vitamin D. Nat. Med. 2006, 12:388-390.