Novel metabolic aspects related to adenosine deaminase inhibition in a human astrocytoma cell line

Neurochemistry International

Volumn 60, Issue 5, 2012, Pages 523-532

  Garcia Gil, Mercedes ^a   Tozzi, Maria Grazia ^b   Allegrini, Simone ^c   Folcarelli, Serena ^a   Della Sala, Grazia ^d   Voccoli, Vladimir ^d   Colombaioni, Laura ^d   Camici, Marcella ^b  

^a Dipartimento di Biologia   (Italy)

^b Dipartimento di Biologia   (Italy)

^c Dipartimento di Scienze del Farmaco   (Italy)

^d CNR Consiglio Nazionale delle Ricerche   (Italy)

Author keywords

Adenosine deaminase; Apoptosis; Deoxycoformycin; Human astrocytoma cell line; Lactate production; Mitochondrial ROS

Indexed keywords

ADENOSINE DEAMINASE; CASPASE 3; CYTOCHROME C; DEOXYADENOSINE; LACTIC ACID; PENTOSTATIN; PHOSPHATE; PURINE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE;

ARTICLE; ASTROCYTOMA CELL; CELL VIABILITY; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME METABOLISM; ENZYME RELEASE; GLIA CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROGNOSIS;

ADENOSINE DEAMINASE INHIBITORS; ASTROCYTOMA; CASPASE 3; CELL LINE, TUMOR; CYTOCHROMES C; HUMANS; MITOCHONDRIA; NAD; REACTIVE OXYGEN SPECIES; SPECTROMETRY, FLUORESCENCE;

EID: 84857981557     PISSN: 01970186     EISSN: 18729754     Source Type: Journal    
DOI: 10.1016/j.neuint.2012.02.008     Document Type: Article

References (60)

1. R.P. Agarwal, T. Spector, and R.E. Parks Jr. Tight-binding inhibitors IV. Inhibition of adenosine deaminases by various inhibitors Biochem. Pharmacol. 26 1977 359 367
2. M.B. Aldrich, M.R. Blackburn, and R.E. Kellems The importance of adenosine deaminase for lymphocyte development and function Biochem. Biophys. Res. Commun. 272 2000 311 315
3. T.E. Allsopp, J. McLuckie, L.E. Kerr, M. Macleod, J. Sharkey, and J.S. Kelly Caspase 6 activity initiates caspase 3 activation in cerebellar granule cell apoptosis Cell Death Differ. 7 2000 984 993
4. J.R.S. Arch, and E.A. Newsholme Activities and some properties of 5′-nucleotidase, adenosine kinase and adenosine deaminase in tissues from vertebrates and invertebrates in relation to the control of the concentration and the physiological role of adenosine Biochem. J. 174 1978 965 977
5. E. Arpaia, P. Benveniste, A. Di Cristofano, Y. Gu, I. Dalal, S. Kelly, M. Hershfield, P.P. Pandolfi, C.M. Roifman, and A. Cohen Mitochondrial basis for immune deficiency: evidence from purine nuceloside phosphorylase-deficient mice J. Exp. Med. 191 2000 2197 2207
6. F. Balestri, M. Giannecchini, F. Sgarrella, M.C. Carta, M.G. Tozzi, and M. Camici Purine and pyrimidine nucleosides preserve human astrocytoma cell adenylate energy charge under ischemic conditions Neurochem. Int. 50 2007 517 523
7. M.F. Beal Mitochondria take center stage in aging and neurodegeneration Ann. Neurol. 58 2005 495 505
8. P. Benveniste, and A. Cohen P53 expression is required for thymocyte apoptosis induced by adenosine deaminase deficiency Proc. Natl. Acad. Sci. USA 92 1995 8373 8377
9. M.M. Bradford A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding Anal. Biochem. 72 1976 248 254
10. M. Camici, V. Micheli, P.L. Ipata, and M.G. Tozzi Pediatric neurological syndromes and inborn errors of purine metabolism Neurochem. Int. 56 2010 367 378
11. S. Ceruti, E. Beltrami, P. Matarrese, A. Mazzola, F. Cattabeni, W. Malorni, and M.P. Abbracchio A key role for caspase-2 and caspase-3 in the apoptosis induced by 2-chloro-2′-deoxy-adenosine (cladribine) and 2-chloro-adenosine in human astrocytoma cells Mol. Pharmacol. 63 2003 1437 1447
12. S. Ceruti, A. Mazzola, and M.P. Abbracchio Resistance of human astrocytoma cells to apoptosis induced by mitochondria-damaging agents: possible implications for anticancer therapy J. Pharmacol. Exp. Ther. 314 2005 825 837
13. S. Chifflet, A. Torriglia, R. Chiesa, and S. Tolosa A method for the determination of inorganic phosphate in the presence of labile organic phosphate and high concentrations of protein: application to lens ATPases Anal. Biochem. 168 1988 1 4
14. A. Cohen, L.J. Gudas, A.J. Ammann, G.E. Staal, and D.J. Martin Deoxyguanosine triphosphate as a possible toxic metabolite in the immunodeficiency associated with purine nucleoside phosphorylase deficiency J. Clin. Invest. 61 1978 1405 1409
15. L. Colombaioni, L.M. Frago, I. Varela-Nieto, R. Pesi, and M. Garcia-Gil Serum deprivation increases ceramide levels and induces apoptosis in undifferentiated HN9.10e cells Neurochem. Int. 40 2002 327 336
16. T. Decker, and M.-L. Lohmann-Matthes A quick and simple method for the quantitation of lactate dehydrogenase release in measurements of cellular cytotoxicity and tumor necrosis factor (TNF) activity J. Immunol. Methods 15 1988 61 69
17. G. Ferrari, C.Y. Yan, and L.A. Greene N-acetylcysteine (d- and l-stereoisomers) prevents apoptotic death of neuronal cells J. Neurosci. 15 1995 2857 2866
18. C.G. Ferriera, M. Epping, F.E. Kruyt, and G. Giaccone Apoptosis: target of cancer therapy Clin. Cancer Res. 8 2002 2024 2034
19. R. Franco, E.I. Canela, and J. Bozal Catabolismo purinico en cerebro de rata Rev. Esp. Fisiol. 37 1981 255 262
20. F. Giorgelli, M. Giannecchini, V. Bemi, G. Turchi, F. Sgarrella, M.G. Tozzi, and M. Camici Role of the phosphorolysis of deoxyadenosine in the cytotoxic effect of the combination of deoxyadenosine and deoxycoformycin on a human colon carcinoma cell line (LoVo) J. Cell. Biochem. 80 2000 241 247
21. M.S. Hershfield Immunodeficiency caused by adenosine deaminase deficiency Immunol. Allergy Clin. N. Am. 20 2001 161 175
22. R. Hirschhorn, V. Roegner-Maniscalco, L. Kuritsky, and F.S. Rosen Bone marrow transplantation only partially restores purine metabolites to normal in adenosine-deficient patients J. Clin. Invest. 68 1981 1387 1393
23. R. Hirschhorn Overview of biochemical abnormalities and molecular genetics of adenosine deaminase deficiency Pediatr. Res. 33 1993 35 41
24. R.J. Hohman, M.C. Guitton, and M. Veron Inactivation of S-adenosyl-l-homocysteine hydrolase by cAMP results from dissociation of enzyme-bound NAD+ Proc. Natl. Acad. Sci. USA 82 1985 4578 4581
25. M. Hönig, M.H. Albert, A. Schulz, M. Sparber-Sauer, C. Schütz, B. Belohradsky, T. Güngör, M.T. Rojewski, H. Bode, U. Pannicke, D. Lippold, K. Schwarz, K.M. Debatin, M.S. Hershfield, and W. Friedrich Patients with adenosine deaminase deficiency surviving after hematopoietic stem cell transplantation are at high risk of CNS complications Blood 109 2007 3595 3602
26. M. Hoth, C.M. Fanger, and R.S. Lewis Mitochondrial regulation of store-operated calcium signaling in T lymphocytes J. Cell Biol. 137 1997 633 648
27. F.F.H. Igney, and P.H. Krammer Death and anti-death: tumour resistance to apoptosis Nat. Rev. 2 2002 277 288
28. M.J. Jou Pathophysiological and pharmacological implications of mitochondria-targeted reactive oxygen species generation in astrocytes Adv. Drug. Deliv. Rev. 60 2008 1512 1526
29. A. Jurecka Inborn errors of purine and pyrimidine metabolism. 1 J. Inherit. Metab. Dis. 32 2009 247 263
30. G.P. Kaushal, V. Kaushal, C. Herzog, and C. Yang Autophagy delays apoptosis in renal tubular epithelial cells in cisplatin cytotoxicity Autophagy 4 2008 710 712
31. G.F. Kelso, C.M. Porteous, C.V. Coulter, G. Hughes, W.K. Porteous, E.C. Ledgerwood, R.A. Smith, and M.P. Murphy Selective targeting of a redox-active ubiquinone to mitochondria within cells: antioxidant and antiapoptotic properties J. Biol. Chem. 276 2001 4588 4596
32. G.H. Kim, D.K. Song, C.H. Cho, S.K. Yoo, D.K. Kim, G.Y. Park, S.I. Suh, B.C. Jang, and J.G. Lim Muscular cell proliferative and protective effects of N-acetylcysteine by modulating activity of extracellular signal-regulated protein kinase Life Sci. 79 2006 622 628
33. P. Kleihues, F. Soylemezoglu, B. Schäuble, B.W. Scheithauer, and P.C. Burger Histopathology, classification and grading of gliomas Glia 15 1995 211 221
34. T. Kobayashi, and H. Endoh Caspase-like activity in programmed nuclear death during conjugation of Tetrahymena thermophila Cell Death Differ. 10 2003 634 640
35. H.C. Lee, and Y.H. Wei Mitochondrial biogenesis and mitochondrial DNA maintenance of mammalian cells under oxidative stress Int. J. Biochem. Cell Biol. 37 2005 822 834
36. N.J. Maragakis, and J.D. Rothstein Mechanisms of disease: astrocytes in neurodegenerative disease Nat. Clin. Pract. Neurol. 2 2006 679 689
37. R. Mart, E. Varela, R.M. Segura, J. Alegre, J.M. Suriñach, and C. Pascual Determination of d-lactate by enzymatic methods in biological fluids: study of interferences Clin. Chem. 43 1997 1010 1015
38. M.P. Mattson, M. Gleichmann, and A. Cheng Mitochondria in neuroplasticity and neurological disorders Neuron 60 2008 748 766
39. V. Micheli, S. Sestini, M. Rocchigiani, G. Jacomelli, F. Manzoni, L. Peruzzi, B.S. Gathof, E. Zammarchi, and G. Pompucci Hypoxanthine-guanine phosphoribosyltransferase deficiency and erythrocyte synthesis of pyridine coenzymes Life Sci. 64 1999 2479 2487
40. R.W. Miles, P.C. Tyler, R.H. Furneaux, C.K. Bagdassarian, and V.L. Schramm One-third-the-sites transition-state inhibitors for purine nucleoside phosphorylase Biochemistry 37 1998 8615 8621
41. M.P. Murphy, and R.A. Smith Targeting antioxidants to mitochondria by conjugation to lipophilic cations Annu. Rev. Pharmacol. Toxicol. 47 2007 629 656
42. P. Nagley, G.C. Higgins, J.D. Atkin, and P.M. Beart Multifaceted deaths orchestrated by mitochondria in neurones Biochim. Biophys. Acta 1802 2010 167 185
43. C.M. Palmeira, A.P. Rolo, J. Berthiaume, J.A. Bjork, and K.B. Wallace Hyperglycemia decreases mitochondrial function: the regulatory role of mitochondrial biogenesis Toxicol. Appl. Pharmacol. 225 2007 214 220
44. M. Pastor-Anglada, A. Felipe, and F.J. Casado Transport and mode of action of nucleoside derivatives used in chemical and antiviral therapies Trends Pharmacol. Sci. 19 1998 424 430
45. G.L. Peterson Determination of total protein Methods Enzymol. 91 1983 95 119
46. J. Poels, M.R. Spasić, P. Callaerts, and K.K. Norga Expanding roles for AMP-activated protein kinase in neuronal survival and autophagy Bioessays 31 2009 944 952
47. M.H. Rogers, R. Lwin, L. Fairbanks, B. Gerritsen, and H.B. Gaspar Cognitive and behavioural abnormalities in adenosine deaminase deficient severe combined immunodeficiency J. Pediatr. 139 2001 44 50
48. M.E. Saez, R. Ramirez-Lorca, F.J. Moron, and A. Ruiz The therapeutic potential of the calpain family: new aspects Drug Discov. Today 11 2006 917 923
49. F. Sgarrella, F.P.A. Poddie, M.A. Meloni, L. Sciola, P. Pippia, and M.G. Tozzi Channelling of deoxyribose moiety of exogenous DNA into carbohydrate metabolism: role of deoxyriboaldolase Comp. Biochem. Physiol. 117B 1997 253 257
50. M.V. Sofroniew, and H.V. Vinters Astrocytes: biology and pathology Acta Neuropathol. 119 2010 7 35
51. E. Takeda, Y. Kuroda, E. Naito, I. Yokota, T. Saijo, M. Hirose, and M. Miyao Effects of deoxyadenosine on ribonucleotide reductase in adenosine deaminase-deficient lymphocytes J. Inherit. Metab. Dis. 14 1991 87 95
52. U. Theobold, W. Mailinger, M. Baltes, M. Rizzi, and M. Reuss In vivo analysis of metabolic dynamics in Saccharomyces cereevisiae. I. Experimental observations Biotechnol. Bioeng. 55 1997 305 316
53. 2/Omi: an overview Cell Death Differ. 15 2008 453 460
54. A. Verkhratsky, O.A. Krishtal, and G. Burnstock Purinoceptors on neuroglia Mol. Neurobiol. 39 2009 190 208
55. M.F. Vincent, F. Bontemps, and G. Van den Berghe Inhibition of glycolysis by 5-amino-4-imidazolecarboxamide riboside in isolated rat hepatocytes Biochem. J. 281 1992 267 272
56. L. Wang, A. Karlsson, E.S.J. Arnér, and S. Eriksson Substrate specificity of mitochondrial 2′-deoxyguanosine kinase. Efficient phosphorylation of 2-chlorodeoxyadenosine J. Biol. Chem. 268 1993 22847 22852
57. Y. Yamada, H. Goto, and N. Ogasawara Purification and properties of adenosine kinase from rat brain Biochim. Biophys. Acta 616 1980 199 207
58. T. Yu, J.L. Robotham, and Y. Yoon Increased production of reactive oxygen species in hyperglycemic conditions requires dynamic change of mitochondrial morphology Proc. Natl. Acad. Sci. USA 103 2006 2653 2658
59. T. Yu, S.S. Sheu, J.L. Robotham, and Y. Yoon Mitochondrial fission mediates high glucose-induced cell death through elevated production of reactive oxygen species Cardiovasc. Res. 79 2008 341 351
60. L. Yu, and S.J. Yang AMP-activated protein kinase mediates activity-dependent regulation of peroxisome proliferator-activated receptor gamma coactivator-1alpha and nuclear respiratory Neuroscience 169 2010 23 38