Single sublethal dose of microcystin-LR is responsible for different alterations in biochemical, histological and physiological renal parameters

Toxicon

Volumn 59, Issue 6, 2012, Pages 601-609

  Lowe, J ^a,b   Souza Menezes, J ^a   Freire, D S ^a,b   Mattos, L J ^a   Castiglione, R C ^a   Barbosa, C M L ^a   Santiago, L ^a   Ferrao F M ^a,b   Cardoso, L H D ^a,b   da Silva, R T ^a,b   Vieira Beiral, H J ^a,b   Vieyra, A ^a,b   Morales, M M ^a   Azevedo, S M F O ^a   Soares, R M ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^b The National Institute for Science and Technology in Structural Biology and Bioimage   (Brazil)

Author keywords

Kidney; Microcystin LR; Oxidative stress; Renal physiology; Sodium pump

Indexed keywords

ADENOSINE TRIPHOSPHATASE; ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); CREATININE; MICROCYSTIN LR; REACTIVE OXYGEN METABOLITE; SODIUM ION; WATER;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; COLLAGEN SYNTHESIS; CONTROLLED STUDY; CREATININE BLOOD LEVEL; CREATININE URINE LEVEL; DRUG ELIMINATION; DRUG MECHANISM; ELECTROLYTE DISTURBANCE; EXPOSURE; FLUID INTAKE; FOOD INTAKE; FRACTIONAL EXCRETION OF MICROCYSTIN; GLOMERULUS FILTRATION RATE; HISTOPATHOLOGY; KIDNEY FIBROSIS; KIDNEY FUNCTION; KIDNEY METABOLISM; KIDNEY PARENCHYMA; KIDNEY TUBULE; LD 50; LETHAL DOSE; MALE; NEPHROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEINURIA; RAT; RENAL INDEX; RENAL SYSTEM PARAMETERS; SODIUM ABSORPTION; SODIUM CLEARANCE; URINE FLOW RATE;

ANIMALS; BACTERIAL TOXINS; CYANOBACTERIA; GLUTATHIONE; KIDNEY; MALE; MICROCYSTINS; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; SODIUM-POTASSIUM-EXCHANGING ATPASE;

CYANOBACTERIA; RATTUS; RATTUS NORVEGICUS;

EID: 84857967791     PISSN: 00410101     EISSN: 18793150     Source Type: Journal    
DOI: 10.1016/j.toxicon.2012.02.003     Document Type: Article

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