Comparison of protein phosphatase inhibitory activity and apparent toxicity of microcystins and related compounds

Toxicon

Volumn 40, Issue 7, 2002, Pages 1017-1025

  Ito, Emiko ^a   Takai, Akira ^b   Kondo, Fumio ^c   Masui, Hiroaki ^d   Imanishi, Susumu ^d   Harada, Ken ichi ^d  

^a CHIBA UNIVERSITY   (Japan)

^b NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c AICHI PREFECTURAL INSTITUTE OF PUBLIC HEALTH   (Japan)

^d MEIJO UNIVERSITY   (Japan)

Author keywords

Accumulation and metabolism; In vivo; MCLR cysteine conjugate; MCLR glutathione conjugate; Microcystin LR; Microcystin RR; Protein phosphatases 1 and 2A

Indexed keywords

ADENOSINE TRIPHOSPHATE; CYANOGINOSIN; CYANOGINOSIN CYSTEINE CONJUGATE; CYANOGINOSIN GLUTATHIONE CONJUGATE; CYANOGINOSIN LR; CYANOGINOSIN RR; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHOPROTEIN PHOSPHATASE 1; PHOSPHOPROTEIN PHOSPHATASE 2A; UNCLASSIFIED DRUG; CYCLOPEPTIDE; CYSTEINE; ENZYME INHIBITOR; GLUTATHIONE; IMMUNOTOXIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLEEDING; CONTROLLED STUDY; ENZYME INHIBITION; GLUTATHIONE METABOLISM; IMMUNOHISTOCHEMISTRY; INTESTINE; KIDNEY; LD 50; LETHAL DOSE; LIVER; MOUSE; NONHUMAN; ORGAN DISTRIBUTION; PRIORITY JOURNAL; ANIMAL; BIOTRANSFORMATION; CHEMISTRY; COMPARATIVE STUDY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; ENDOTRACHEAL INTUBATION; LIVER CELL; METABOLISM; PATHOLOGY; RABBIT;

ANIMAL; BIOTRANSFORMATION; COMPARATIVE STUDY; CYSTEINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; GLUTATHIONE; HEPATOCYTES; IMMUNOHISTOCHEMISTRY; IMMUNOTOXINS; INTESTINES; INTUBATION, INTRATRACHEAL; KIDNEY; LETHAL DOSE 50; LIVER; MICE; PEPTIDES, CYCLIC; PHOSPHOPROTEIN PHOSPHATASE; RABBITS; SUPPORT, NON-U.S. GOV'T; ANIMALS; MICROCYSTINS;

EID: 0035998334     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0041-0101(02)00099-5     Document Type: Article

References (37)

1. Inhibitor-2 functions like a chaperone to fold three expressed isoforms of mammalian protein phosphatase-1 into a conformation with the specificity and regulatory properties of the native enzyme
2. Use of a colorimetric protein phosphatase inhibition assay and enzyme linked immunosorbent assay for the study of microcystins and nodularins
3. Inhibitory effect of a marine-sponge toxin, okadaic acid, on protein phosphatases
4. Human fatalities from cyanobacteria: Chemical and biological evidence for cyanotoxins
5. Two isoforms of protein phosphatase 1 may be produced from the same gene
6. The toxicology of microcystins
7. Microcystis cyanobacteria extract induces cytoskeletal disruption and intracellular glutathione alteration in hepatocytes
8. Protein phosphatase 1 activity in Drosophila mutants with abnormalities in mitosis and chromosome condensation
9. Drosophila contains three genes that encode distinct isoforms of protein phosphatase 1
10. Chemistry and detection of microcystins
11. Selective purification of the 20,000-Da light chains of smooth muscle myosin
12. Evaluation of potential chemoprotectants against microcystin-LR hepatotoxicity in mice
13. Hepatic necrosis in aged mice by oral administration of microcystin-LR
14. First report on the distribution of orally administered microcystin-LR in mouse tissue using an immunostaining method
15. Intratracheal administration of microcystin-LR, and its distribution
16. Liver failure and death after exposure to microcystins at a hemodialysis center in Brazil
17. Formation, characterization, and toxicity of the glutathione and cystein conjugates of toxic hepatopeptide microcystins
18. Detection and identification of metabolites of microcystins formed in vivo in mouse and rat livers
19. Cyanobacterial toxins
20. Isolation of the native form of chicken gizzard myosin light-chain kinase
21. Fatal microcystin intoxication in haemodialysis unit in Caruaru, Brazil
22. Injury to hepatocytes induced by a peptide toxin from the cyanobacterium Microcystis aeruginosa
23. Cyanobacterial toxins
24. 7-prostaglandin A1 and prostaglandin A1 methyl esters with thiols
25. Freshwater hepatotoxins: Ecobiology and classification
26. Inhibitory effect of okadaic acid on the p-nitrophenyl phosphate phosphatase activity of protein phosphatases
27. Inhibitory effect of okadaic acid derivatives on protein phosphatases: A study on structure-affinity relationship
28. Estimation of the rate constants associated with the inhibitory effect of okadaic acid on type 2A protein phosphatase by time-course analysis
29. Inhibition of specific binding of okadaic acid to protein phosphatase 2A by microcystin-LR, calyculin-A and tautomycin: Method of analysis of interactions of tight-binding ligands with target protein
30. Effects of modification of the hydrophobic C1-C16 segment of tautomycin on its affinity to type 1 and type 2A protein phosphatases
31. Effects of L-cystein and reduced glutathione on the toxicities of microcystin LR: The effect for acute liver failure and inhibition of protein phosphatase 2A activity
32. Protein phosphatases maintain the organization and structural interaction of hepatic keratin intermediate filaments
33. The catalytic subunits of protein phosphatase-1 and protein phosphatase-2A are distinct gene products
34. Acute oral toxicity of microcystin-LR, a cyanobacterial hepatotoxin, in mice
35. Inhibition of protein phosphatase by microcystin and nodularin associated with hepatotoxicity