Molecular mechanisms underlying renal accumulation of aminoglycoside antibiotics and mechanism-based approach for developing nonnephrotoxic aminoglycoside therapy

Yakugaku Zasshi

Volumn 126, Issue 5, 2006, Pages 327-335

  Nagai, Junya ^a  

^a HIROSHIMA UNIVERSITY   (Japan)

Author keywords

Aminoglycoside antibiotics; Basic peptides; Megalin; Nephrotoxicity; Receptor mediated endocytosis

Indexed keywords

AMIKACIN; AMINOGLYCOSIDE ANTIBIOTIC AGENT; GENTAMICIN; MEGALIN; PHOSPHOLIPID DERIVATIVE;

BACTERIAL INFECTION; BINDING SITE; CELL MEMBRANE; DRUG MECHANISM; DRUG URINE LEVEL; HUMAN; KIDNEY CORTEX; KIDNEY INJURY; KIDNEY PROXIMAL TUBULE; NEPHROTOXICITY; OTOTOXICITY; REVIEW;

AMINOGLYCOSIDES; ANIMALS; ANTI-BACTERIAL AGENTS; KIDNEY; LDL-RECEPTOR RELATED PROTEIN 2;

EID: 33646472405     PISSN: 00316903     EISSN: 13475231     Source Type: Journal    
DOI: 10.1248/yakushi.126.327     Document Type: Review

References (14)

1. Saito A., Pietromonaco S., Loo A. K., Farquhar M. G., Proc. Natl. Acad. Sci. U.S.A., 91, 9725-9729 (1994).
2. Christensen E. I., Birn H., Nat. Rev. Mol. Cell Biol., 3, 256-266 (2002).
3. Moestrup S. K., Cui S., Vorum H., Bregengård C., Bjørn S. E., Norris K., Gliemann J., Christensen E. I., J. Clin. Invest., 96, 1404-1413 (1995).
4. Nagai J., Takano M., Drug Metab. Pharmacokinet., 19, 159-170 (2004).
5. Nagai J., Tanaka H., Nakanishi N., Murakami T., Takano M., Am. J. Physiol. Renal Physiol., 281, F337-F344 (2001).
6. Nagai J., Katsube T., Murakami T., Takano M., J. Pharm. Pharmacol., 54, 1491-1496 (2002).
7. Bergeron M., Mayers P., Brown D., Am. J. Physiol. Renal Physiol., 271, F908-F916 (1996).
8. Nykjaer A., Dragun D., Walther D., Vorum H., Jacobsen C., Herz J., Melsen F., Christensen E. I., Willnow T. E., Cell, 96, 507-515 (1999).
9. Schmitz C., Hilpert J., Jacobsen C., Boensch C., Christensen E. I., Luft F. C., Willnow T. E., J. Biol. Chem., 277, 618-622 (2002).
10. Watanabe A., Nagai J., Adachi Y., Katsube T., Kitahara Y., Murakami T., Takano M., J. Control. Release, 95, 423-433 (2004).
11. Takano M., Nakanishi N., Kitahara Y., Sasaki Y., Murakami T., Nagai J., Kidney Int., 62, 1707-1717 (2002).
12. Nagai J., Saito M., Adachi Y., Yumoto R., Takano M., J. Control. Release, (2006) (in press).
13. Prehoda K. E., Scott J. A., Mullins R. D., Lim W. A., Science, 290, 801-806 (2000).
14. Mahley R. W., Science, 240, 622-630 (1988).