Different doses of supplemental vitamin D maintain interleukin-5 without altering skeletal muscle strength: A randomized, double-blind, placebo-controlled study in vitamin D sufficient adults

Nutrition and Metabolism

Volumn 9, Issue , 2012, Pages

  Barker, Tyler ^a   Martins, Thomas B ^b   Hill, Harry R ^b,c   Kjeldsberg, Carl R ^b,c   Henriksen, Vanessa T ^a   Dixon, Brian M ^d   Schneider, Erik D ^d   Dern, Adam ^d   Weaver, Lindell K ^c,e,f  

^a Orthopedic Specialty Hospital   (United States)

^b ARUP INSTITUTE FOR CLINICAL AND EXPERIMENTAL PATHOLOGY   (United States)

^c UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^d USANA Health Sciences Inc   (United States)

^e INTERMOUNTAIN MEDICAL CENTER   (United States)

^f LDS HOSPITAL   (United States)

Author keywords

Interleukin 5; Skeletal muscle function; Vitamin D

Indexed keywords

25 HYDROXYVITAMIN D; COLECALCIFEROL; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 5; PLACEBO;

ADULT; ARTICLE; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG DOSE COMPARISON; DRUG DOSE REGIMEN; DRUG EFFECT; DRUG MEGADOSE; FEMALE; HUMAN; LEG MUSCLE; LOW DRUG DOSE; MALE; MUSCLE STRENGTH; NORMAL HUMAN; PROTEIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL; VITAMIN BLOOD LEVEL; VITAMIN SUPPLEMENTATION; WINTER;

BACTERIA (MICROORGANISMS);

EID: 84857949993     PISSN: None     EISSN: 17437075     Source Type: Journal    
DOI: 10.1186/1743-7075-9-16     Document Type: Article

References (72)

1. Influence of season and latitude on the cutaneous synthesis of vitamin D3: exposure to winter sunlight in Boston and Edmonton will not promote vitamin D3 synthesis in human skin. Webb AR, Kline L, Holick MF, J Clin Endocrinol Metab 1988 67 373 378 10.1210/jcem-67-2-373 2839537
2. Vitamin D deficiency. Holick MF, N Engl J Med 2007 357 266 281 10.1056/NEJMra070553 17634462 (Pubitemid 47080391)
3. Vitamin D and its major metabolites: serum levels after graded oral dosing in healthy men. Barger-Lux MJ, Heaney RP, Dowell S, Chen TC, Holick MF, Osteoporos Int 1998 8 222 230 10.1007/s001980050058 9797906 (Pubitemid 28427071)
4. Efficacy and safety of vitamin D3 intake exceeding the lowest observed adverse effect level. Vieth R, Chan PC, MacFarlane GD, Am J Clin Nutr 2001 73 288 294 11157326 (Pubitemid 32109858)
5. Human serum 25-hydroxycholecalciferol response to extended oral dosing with cholecalciferol. Heaney RP, Davies KM, Chen TC, Holick MF, Barger-Lux MJ, Am J Clin Nutr 2003 77 204 210 12499343 (Pubitemid 36015393)
6. Difficulties with vitamin D nutrition research: objective targets of adequacy, and assays for 25-hydroxyvitamin D. Vieth R, Carter G, Eur J Clin Nutr 2001 55 221 222 10.1038/sj.ejcn.1601145 11360124 (Pubitemid 32266512)
7. Low vitamin D status has an adverse influence on bone mass, bone turnover, and muscle strength in Chinese adolescent girls. Foo LH, Zhang Q, Zhu K, Ma G, Hu X, Greenfield H, et al. J Nutr 2009 139 1002 1007 10.3945/jn.108.102053 19321588
8. Vitamin D status predicts physical performance and its decline in older persons. Wicherts IS, van Schoor NM, Boeke AJ, Visser M, Deeg DJ, Smit J, et al. J Clin Endocrinol Metab 2007 92 2058 2065 10.1210/jc.2006-1525 17341569 (Pubitemid 46997101)
9. Vitamin D status and muscle function in post-menarchal adolescent girls. Ward KA, Das G, Berry JL, Roberts SA, Rawer R, Adams JE, et al. J Clin Endocrinol Metab 2009 94 559 563 10.1210/jc.2008-1284 19033372
10. Muscle strength and mobility in vitamin D-insufficient female geriatric patients: a randomized controlled trial on vitamin D and calcium supplementation. Janssen HC, Samson MM, Verhaar HJ, Aging Clin Exp Res 2010 22 78 84 20305368
11. Higher 25-hydroxyvitamin D concentrations are associated with better lower-extremity function in both active and inactive persons aged > or = 60 y. Bischoff-Ferrari HA, Dietrich T, Orav EJ, Hu FB, Zhang Y, Karlson EW, et al. Am J Clin Nutr 2004 80 752 758 15321818 (Pubitemid 41115542)
12. Prevalence of sarcopenia and predictors of skeletal muscle mass in healthy, older men and women. Iannuzzi-Sucich M, Prestwood KM, Kenny AM, J Gerontol A Biol Sci Med Sci 2002 57 772 M777 10.1093/gerona/57.12.M772 12456735
13. Association between vitamin D status and physical performance: the InCHIANTI study. Houston DK, Cesari M, Ferrucci L, Cherubini A, Maggio D, Bartali B, et al. J Gerontol A Biol Sci Med Sci 2007 62 440 446 10.1093/gerona/62.4.440 17452740 (Pubitemid 47065713)
14. Muscle strength in the elderly: its relation to vitamin D metabolites. Bischoff HA, Stahelin HB, Urscheler N, Ehrsam R, Vonthein R, Perrig-Chiello P, et al. Arch Phys Med Rehabil 1999 80 54 58 10.1016/S0003-9993(99)90307-6 9915372 (Pubitemid 29035822)
15. Muscle strength, functional mobility and vitamin D in older women. Verhaar HJ, Samson MM, Jansen PA, de Vreede PL, Manten JW, Duursma SA, Aging (Milano) 2000 12 455 460 (Pubitemid 32095602)
16. Low-dose vitamin D prevents muscular atrophy and reduces falls and hip fractures in women after stroke: a randomized controlled trial. Sato Y, Iwamoto J, Kanoko T, Satoh K, Cerebrovasc Dis 2005 20 187 192 10.1159/000087203 16088114 (Pubitemid 41254180)
17. Myopathy in chronic renal failure. Floyd M, Ayyar DR, Barwick DD, Hudgson P, Weightman D, Q J Med 1974 43 509 524 4462721
18. Hypovitaminosis D myopathy without biochemical signs of osteomalacic bone involvement. Glerup H, Mikkelsen K, Poulsen L, Hass E, Overbeck S, Andersen H, et al. Calcif Tissue Int 2000 66 419 424 10.1007/s002230010085 10821877 (Pubitemid 30368371)
19. Low vitamin D impairs strength recovery after anterior cruciate ligament surgery. Barker T, Martins TB, Hill HR, Kjeldsberg CR, Trawick RH, Weaver LK, et al. J Evidence-Based Compl Altern Med 2011 16 201 209
20. Two types of murine helper T cell clone. II. Delayed-type hypersensitivity is mediated by TH1 clones. Cher DJ, Mosmann TR, J Immunol 1987 138 3688 3694 2953788 (Pubitemid 17078235)
21. Antigen-specific activation of effector macrophages by IFN-gamma producing (TH1) T cell clones. Failure of IL-4-producing (TH2) T cell clones to activate effector function in macrophages. Stout RD, Bottomly K, J Immunol 1989 142 760 765 2464024 (Pubitemid 19093903)
22. Dendritic cells produce IL-12 and direct the development of Th1 cells from naive CD4+ T cells. Macatonia SE, Hosken NA, Litton M, Vieira P, Hsieh CS, Culpepper JA, et al. J Immunol 1995 154 5071 5079 7730613
23. 1 Alpha,25-dihydroxyvitamin D3 selectively modulates tolerogenic properties in myeloid but not plasmacytoid dendritic cells. Penna G, Armuchastequi S, Giarratana N, Daniel KC, Vulcano M, Sozzani S, et al. J Immunol 2007 178 145 153 17182549 (Pubitemid 46033595)
24. Regulation of lymphokine production and human T lymphocyte activation by 1,25-dihydroxyvitamin D3. Specific inhibition at the level of messenger RNA. Rigby WF, Denome S, Fanger MW, J Clin Invest 1987 79 1659 1664 10.1172/JCI113004 2884234 (Pubitemid 17117271)
25. 1 alpha,25-Dihydroxyvitamin D3 inhibits gamma-interferon synthesis by normal human peripheral blood lymphocytes. Reichel H, Koeffler HP, Tobler A, Norman AW, Proc Natl Acad Sci USA 1987 84 3385 3389 10.1073/pnas.84.10.3385 3033646 (Pubitemid 17085408)
26. The role of helper T cell products in mouse B cell differentiation and isotype regulation. Coffman RL, Seymour BW, Lebman DA, Hiraki DD, Christiansen JA, Shrader B, et al. Immunol Rev 1988 102 5 28 10.1111/j.1600-065X.1988. tb00739.x 2966762 (Pubitemid 18095718)
27. Heterogeneity of helper/inducer T lymphocytes. II. Effects of interleukin 4- and interleukin 2-producing T cell clones on resting B lymphocytes. Boom WH, Liano D, Abbas AK, J Exp Biol 1988 167 1350 1363
28. Cloned, Ia-restricted T cells that do not produce interleukin 4(IL 4)/B cell stimulatory factor 1(BSF-1) fail to help antigen-specific B cells. Killar L, MacDonald G, West J, Woods A, Bottomly K, J Immunol 1987 138 1674 1679 2950166 (Pubitemid 17040785)
29. Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones. Fiorentino DF, Bond MW, Mosmann TR, J Exp Med 1989 170 2081 2095 10.1084/jem.170.6.2081 2531194 (Pubitemid 20010086)
30. Homology of cytokine synthesis inhibitory factor (IL-10) to the Epstein-Barr virus gene BCRFI. Moore KW, Vieira P, Fiorentino DF, Trounstine ML, Khan TA, Mosmann TR, Science 1990 248 1230 1234 10.1126/science.2161559 2161559
31. Vitamin D has a direct immunomodulatory effect on CD8+ T cells of patients with early multiple sclerosis and healthy control subjects. Lysandropoulos AP, Jaquiery E, Jilek S, Pantaleo G, Schluep M, Du Pasquier RA, J Neuroimmunol 2011 233 240 244 10.1016/j.jneuroim.2010.11.008 21186064
32. In vitro generation of interleukin 10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines. Barrat FJ, Cua DJ, Boonstra A, Richards DF, Crain C, Savelkoul HF, et al. J Exp Med 2002 195 603 616 10.1084/jem.20011629 11877483 (Pubitemid 34461505)
33. 1,25-dihydroxyvitamin D(3) promotes IL-10 production in human B cells. Heine G, Niesner U, Chang HD, Steinmeyer A, Zugel U, Zuberbier T, et al. Eur J Immunol 2008 38 2210 2218 10.1002/eji.200838216 18651709
34. Primary effect of 1alpha,25(OH)D on IL-10 expression in monocytes is short-term down-regulation. Matilainen JM, Husso T, Toropainen S, Seuter S, Turunen MP, Gynther P, et al. Biochim Biophys Acta 2010 1803 1276 1286 10.1016/j.bbamcr.2010.07.009 20691220
35. Regulation of cytokine responses by seasonality of vitamin D status in healthy individuals. Khoo AL, Chai LY, Koenen HJ, Sweep FC, Joosten I, Netea MG, et al. Clin Exp Immunol 2011 164 72 79 10.1111/j.1365-2249.2010.04315.x 21323660
36. Vitamin D supplementation improves cytokine profiles in patients with congestive heart failure: a double-blind, randomized, placebo-controlled trial. Schleithoff SS, Zittermann A, Tenderich G, Berthold HK, Stehle P, Koerfer R, Am J Clin Nutr 2006 83 754 759 16600924 (Pubitemid 44713136)
37. No effect of supplementation with cholecalciferol on cytokines and markers of inflammation in overweight and obese subjects. Jorde R, Sneve M, Torjesen PA, Figenschau Y, Goransson LG, Omdal R, Cytokine 2010 50 175 180 10.1016/j.cyto.2009.12.006 20122848
38. Maintenance of Wintertime Vitamin D Status with Cholecalciferol Supplementation Is Not Associated with Alterations in Serum Cytokine Concentrations among Apparently Healthy Younger or Older Adults. Barnes MS, Horigan G, Cashman KD, Hill TR, Forsythe LK, Lucey AJ, et al. J Nutr 2011 141 476 481 10.3945/jn.110.131516 21270359
39. Institute of Medicine, Dietary reference intakes for calcium and vitamin D Washington, D.C.: The National Academies Press 2010
40. A rapid method of total lipid extraction and purification. Blight EG, Dyer WJ, Can J Biochem Physiol 1959 37 911 917 10.1139/o59-099 13671378
41. Assay of vitamins D2 and D3, and 25-hydroxyvitamins D2 and D3 in human plasma by high-performance liquid chromatography. Jones G, Clin Chem 1978 24 287 298 203413 (Pubitemid 8293929)
42. Determination of cytokine responses using a multiplexed fluorescent microsphere immunoassay. Martins TB, Pasi BM, Pickering JW, Jaskowski TD, Litwin CM, Hill HR, Am J Clin Pathol 2002 118 346 353 10.1309/N0T6-C56B-GXB2-NVFB 12219776 (Pubitemid 37046332)
43. Risk factor analysis of plasma cytokines in patients with coronary artery disease by a multiplexed fluorescent immunoassay. Martins TB, Anderson JL, Muhlestein JB, Horne BD, Carlquist JF, Roberts WL, et al. Am J Clin Pathol 2006 125 906 913 10.1309/Q3E6KF0QD3U3YL6T 16690490 (Pubitemid 43801541)
44. 1,25-dihydroxyvitamin D(3) regulates LPS-induced cytokine production and reduces mortality in rats. Qi XP, Li P, Li G, Sun Z, Li JS, World J Gastroenterol 2008 14 3897 3902 10.3748/wjg.14.3897 18609716
45. Eosinophilia in transgenic mice expressing interleukin 5. Dent LA, Strath M, Mellor AL, Sanderson CJ, J Exp Med 1990 172 1425 1431 10.1084/jem.172.5.1425 2230651 (Pubitemid 20366218)
46. Dual effects of vitamin D-induced alteration of TH1/TH2 cytokine expression: enhancing IgE production and decreasing airway eosinophilia in murine allergic airway disease. Matheu V, Back O, Mondoc E, Issazadeh-Navikas S, J Allergy Clin Immunol 2003 112 585 592 10.1016/S0091-6749(03)01855-4 13679819 (Pubitemid 37108564)
47. The targets of vitamin D depend on the differentiation and activation status of CD4 positive T cells. Mahon BD, Wittke A, Weaver V, Cantorna MT, J Cell Biochem 2003 89 922 932 10.1002/jcb.10580 12874827 (Pubitemid 36927724)
48. Vitamin d and serum cytokines in a randomized clinical trial. Yusupov E, Li-Ng M, Pollack S, Yeh JK, Mikhail M, Aloia JF, Int J Endocrinol 2010 2010 1 7
49. Vitamin D inhibits monocyte/macrophage proinflammatory cytokine production by targeting MAPK phosphatase-1. Zhang Y, Leung DYM, Richers BN, Liu Y, Remigio LK, Riches DW, et al. J Immunol 2012 188 doi:10.4049/jimmunol.1102412
50. Human leukemic (HMC-1) mast cells are responsive to 1alpha, 25-dihydroxyvitamin D(3): selective promotion of ICAM-3 expression and constitutive presence of vitamin D(3) receptor. Babina M, Krautheim M, Grutzkau A, Henz BM, Biochem Biophys Res Commun 2000 273 1104 1110 10.1006/bbrc.2000.3083 10891379 (Pubitemid 30481086)
51. Expression of 1,25-dihydroxyvitamin D(3) receptor in the immune system. Veldman CM, Cantorna MT, DeLuca HF, Arch Biochem Biophys 2000 374 334 338 10.1006/abbi.1999.1605 10666315 (Pubitemid 30120270)
52. Interleukin-5, eosinophils, and disease. Sanderson CJ, Blood 1992 79 3101 3109 1596561
53. IL-9 and its receptor in allergic and nonallergic lung disease: increased expression in asthma. Shimbara A, Christodoulopoulos P, Soussi-Gounni A, Olivenstein R, Nakamura Y, Levitt RC, et al. J Allergy Clin Immunol 2000 105 108 115 10.1016/S0091-6749(00)90185-4 10629460 (Pubitemid 30059110)
54. Regulation of interleukin-2 induced interleukin-5 and interleukin-13 production in human peripheral blood mononuclear cells. Verheyen J, Bonig H, Kim YM, Banning U, Mauz-Korholz C, Kramm C, et al. Scand J Immunol 2000 51 45 53 10.1046/j.1365-3083.2000.00643.x 10632975 (Pubitemid 30074302)
55. Interaction of antigens and antibodies at mucosal surfaces. Lamm ME, Annu Rev Microbiol 1997 51 311 340 10.1146/annurev.micro.51.1.311 9343353 (Pubitemid 27433052)
56. 1alpha,25-Dihydroxyvitamin d3 has a direct effect on naive CD4(+) T cells to enhance the development of Th2 cells. Boonstra A, Barrat FJ, Crain C, Heath VL, Savelkoul HF, O'Garra A, J Immunol 2001 167 4974 4980 11673504 (Pubitemid 33009728)
57. Vitamin D receptor-deficient mice fail to develop experimental allergic asthma. Wittke A, Weaver V, Mahon BD, August A, Cantorna MT, J Immunol 2004 173 3432 3436 15322208 (Pubitemid 39142054)
58. Interleukin-5 is the predominant eosinophilopoietin produced by cloned T lymphocytes in hypereosinophilic syndrome. Schrezenmeier H, Thome SD, Tewald F, Fleischer B, Raghavachar A, Exp Hematol 1993 21 358 365 8425573 (Pubitemid 24216781)
59. Treatment of patients with the hypereosinophilic syndrome with mepolizumab. Rothenberg ME, Klion AD, Roufosse FE, Kahn JE, Weller PF, Simon HU, et al. N Engl J Med 2008 358 1215 1228 10.1056/NEJMoa070812 18344568 (Pubitemid 351439223)
60. Anti-IL-5 treatment reduces deposition of ECM proteins in the bronchial subepithelial basement membrane of mild atopic asthmatics. Flood-Page P, Menzies-Gow A, Phipps S, Ying S, Wangoo A, Ludwig MS, et al. J Clin Invest 2003 112 1029 1036 14523040 (Pubitemid 38056318)
61. Interleukin 5 and interleukin 4 produced by Peyer's patch T cells selectively enhance immunoglobulin A expression. Murray PD, McKenzie DT, Swain SL, Kagnoff MF, J Immunol 1987 139 2669 2674 3498768 (Pubitemid 17153943)
62. The effects of IL-4 and IL-5 on the IgA response by murine Peyer's patch B cell subpopulations. Lebman DA, Coffman RL, J Immunol 1988 141 2050 2056 3262648
63. Vitamin D status relative to diet, lifestyle, injury, and illness in college athletes. Halliday TM, Peterson NJ, Thomas JJ, Kleppinger K, Hollis BW, Larson-Meyer DE, Med Sci Sports Exerc 2011 43 335 343 20543748
64. Immunoglobulin A mediation of murine nasal anti-influenza virus immunity. Renegar KB, Small PA Jr, J Virol 1991 65 2146 2148 2002558
65. A randomized, controlled trial of vitamin D supplementation upon musculosketal health in postmenarchal females. Ward KA, Das G, Roberts SA, Berry JL, Adams JE, Rawer R, et al. J Clin Endocrinol Metab 2010 95 4643 4651 10.1210/jc.2009-2725 20631020
66. Effects of vitamin D supplementation on strength, physical function, and health perception in older, community-dwelling men. Kenny AM, Biskup B, Robbins B, Marcella G, Burleson JA, J Am Geriatr Soc 2003 51 1762 1767 10.1046/j.1532-5415.2003.51561.x 14687355 (Pubitemid 37543363)
67. Effect of vitamin D supplementation on muscle strength: a systematic review and meta-analysis. Stockton KA, Mengersen K, Paratz JD, Kandiah D, Bennell KL, Osteoporos Int 2011 22 859 871 20924748
68. A randomized controlled trial of the effects of vitamin d on muscle strength and mobility in older women with vitamin d insufficiency. Zhu K, Austin N, Devine A, Bruce D, Prince RL, J Am Geriatr Soc 2010 58 2063 2068 10.1111/j.1532-5415.2010.03142.x 21054285
69. Functional improvement with vitamin D replenishment in a cohort of frail, vitamin D-deficient older people. Gloth FM III, Smith CE, Hollis BW, Tobin JD, J Am Geriatr Soc 1995 43 1269 1271 7594162
70. Skeletal muscle calcium metabolism and contractile force in vitamin D-deficient chicks. Pleasure D, Wyszynski B, Sumner A, Schotland D, Feldman B, Nugent N, et al. J Clin Invest 1979 64 1157 1167 10.1172/JCI109569 227925
71. Changes in the kinetics of muscle contraction in vitamin D-depleted rats. Rodman JS, Baker T, Kidney Int 1978 13 189 193 10.1038/ki.1978.28 651119 (Pubitemid 8304324)
72. Serum 25-hydroxyvitamin D concentration and physical function in adult men. Ceglia L, Chiu GR, Harris SS, Araujo AB, Clin Endocrinol (Oxf) 2011 74 370 376 10.1111/j.1365-2265.2010.03926.x