Efficacy and safety of vitamin D3 intake exceeding the lowest observed adverse effect level

American Journal of Clinical Nutrition

Volumn 73, Issue 2, 2001, Pages 288-294

  Vieth, Reinhold ^a   Chan, Pak Cheung R ^b   MacFarlane, Gordon D ^b  

^a MOUNT SINAI HOSPITAL   (Canada)

^b NONE

Author keywords

Calcidiol; Cholecalciferol; Efficacy; Hypercalciuria; LOAEL; Lowest observed adverse effect level; Toxicity; Vitamin D3

Indexed keywords

CALCIUM; COLECALCIFEROL DERIVATIVE; CREATININE;

ADULT; ARTICLE; CALCIUM BLOOD LEVEL; CALCIUM URINE LEVEL; CREATININE URINE LEVEL; DOSE RESPONSE; DRUG EFFECT; DRUG EFFICACY; DRUG SAFETY; FEMALE; HUMAN; HYPERCALCEMIA; HYPERCALCIURIA; LONG TERM CARE; MALE; NORMAL HUMAN; VITAMIN BLOOD LEVEL; VITAMIN INTAKE;

EID: 0035145947     PISSN: 00029165     EISSN: None     Source Type: Journal    
DOI: 10.1093/ajcn/73.2.288     Document Type: Article

References (47)

1. Role of vitamin D in pulmonary tuberculosis
2. Gains in bone mineral density with resolution of vitamin D intoxication
3. Vitamin D supplementation: A word of caution
4. Process and development of dietary reference intakes: Basis, need, and application of recommended dietary allowances
5. Calciotropic hormones and bone markers in the elderly
6. Seasonal changes in plasma 25-hydroxyvitamin D concentrations of young American black and white women
7. Prevalence of vitamin D insufficiency in an adult normal population
8. Seasonal prevalence of vitamin D deficiency in institutionalized older adults
9. Hypovitaminosis D in medical inpatients
10. The effect of aging on bone mineral metabolism and bone mass in Native American women
11. Effects of calcium and vitamin D insufficiency on the skeleton
12. Secondary hyperparathyroidism in the elderly: Means to defining hypovitaminosis D
13. Vitamin D: How much do we need, and how much is too much?
14. Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety
15. Effect of low-dose calcitriol and calcium therapy on bone histomorphometry and urinary calcium excretion in osteopenic women
16. 3 in normal premenopausal women
17. Vitamin D and its major metabolites: Serum levels after graded oral dosing in healthy men
18. 2
19. Use of random urine samples to estimate total urinary calcium and phosphate excretion
20. Robust locally weighted regression and smoothing scatterplots
21. Regression and correlation
22. Environmental factors that influence the cutaneous production of vitamin D
23. Oral calcium load test: Diagnostic and physiologic implications in hyperparathyroidism
24. Effects on calcium and phosphate metabolism and on parathyroid function of acute administration of tricalcium phosphate
25. Estimation of 24 hour protein excretion from single random urine specimen
26. Spot urine samples for the metabolic evaluation of urolithiasis patients
27. Comparative study of 24-hour calciuria and urinary calcium/creatinine ratio in children over 4 years of age
28. Significance of the calcium to creatinine concentration ratio of a single-voided urine specimen in patients with hypercalciuric urolithiasis
29. Urinary calcium excretion. Normal values for urinary calcium/creatinine ratio in Hungary. Multicenter study
30. Urinary calcium to creatinine ratio for predicting preeclampsia
31. Questionable significance of the chemical analysis of a single 24-hour urine sample in recurrent calcium oxalate nephrolithiasis
32. A simple test for the diagnosis of absorptive, resorptive and renal hypercalciurias
33. Predictive value of lithogenic risk in hypercalciuria: Should 24-hour urine calcium be measured?
34. Bone density and vitamin D intoxication
35. Bone density and vitamin D intoxication
36. Vitamin D. The antirachitic or calcifying vitamin
37. A comparison of the hypervitaminosis induced by irradiated ergosterol and fish liver oil concentrates
38. Dangerous effects of vitamin D overdosage on dental and paradental structures
39. 3
40. 3 in human milk
41. Binding of vitamin D to its human carrier plasma protein
42. 2 detectable in human serum
43. Lessons for nutritional science from vitamin D
44. Is the recommended daily allowance for vitamin D too low for the homebound elderly?
45. Hypovitaminosis D and response to supplementation in older patients with cystic fibrosis