The importance of bystander effects in radiation therapy in melanoma skin-cancer cells and umbilical-cord stromal stem cells

Radiotherapy and Oncology

Volumn 102, Issue 3, 2012, Pages 450-458

  Gómez Millán, Jaime ^b   Katz, Iana Suly Santos ^c   Farias, Virgínea De Araujo ^a   Linares Fernández, Jose Luis ^a   López Peñalver, Jesús ^a   Ortiz Ferrón, Gustavo ^a   Ruiz Ruiz, Carmen ^a   Oliver, Francisco Javier ^d   Ruiz De Almodóvar, José Mariano ^a,e  

^a UNIVERSITY OF GRANADA   (Spain)

^b HOSPITAL UNIVERSITARIO VIRGEN DE LA VICTORIA   (Spain)

^c INSTITUTO BUTANTAN   (Brazil)

^d INSTITUTO DE PARASITOLOGÍA Y BIOMEDICINA LÓPEZ NEYRA   (Spain)

^e HOSPITAL UNIVERSITARIO SAN CECILIO   (Spain)

Author keywords

Fractionation in the bystander effect; Melanoma cancer cells; Radiation induced bystander cell death; Radiosensitivity; Umbilical cord stromal stem cells

Indexed keywords

APOPTOSIS; ARTICLE; BYSTANDER EFFECT; CANCER CELL; CANCER RADIOTHERAPY; CELL COMMUNICATION; CELL DEATH; CELL SURVIVAL; COMET ASSAY; CONTROLLED STUDY; CULTURE MEDIUM; DNA STRAND BREAKAGE; HUMAN; HUMAN CELL; IN VITRO STUDY; IONIZING RADIATION; LIGAND BINDING; MEASUREMENT; MELANOMA CELL; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RADIATION DOSE; RADIATION DOSE FRACTIONATION; RADIOSENSITIVITY; SKIN CANCER; STEM CELL; STROMA CELL; UMBILICAL CORD;

APOPTOSIS; BYSTANDER EFFECT; CELL LINE; CELL SURVIVAL; DNA BREAKS; DOSE FRACTIONATION; DOSE-RESPONSE RELATIONSHIP, RADIATION; HUMANS; MELANOMA; MESENCHYMAL STEM CELLS; RADIATION TOLERANCE; SKIN NEOPLASMS; UMBILICAL CORD;

EID: 84857913277     PISSN: 01678140     EISSN: 18790887     Source Type: Journal    
DOI: 10.1016/j.radonc.2011.11.002     Document Type: Article

References (62)

1. I. Turesson The progression rate of late radiation effects in normal tissue and its impact on dose-response relationships Radiother Oncol 15 1989 217 226 (Pubitemid 19193913)
2. H. Jung, H.P. Beck-Bornholdt, V. Svoboda, W. Alberti, and T. Herrmann Quantification of late complications after radiation therapy Radiother Oncol 61 2001 233 246 (Pubitemid 33127228)
3. B. Pinar, P.C. Lara, and M. Lloret Radiation-induced DNA damage as a predictor of long-term toxicity in locally advanced breast cancer patients treated with high-dose hyperfractionated radical radiotherapy Radiat Res 168 2007 415 422 (Pubitemid 351303169)
4. J. Yarnold, A. Ashton, and J. Bliss Fractionation sensitivity and dose response of late adverse effects in the breast after radiotherapy for early breast cancer: long-term results of a randomised trial Radiother Oncol 75 2005 9 17 (Pubitemid 40616788)
5. D. Guirado, and J.M. Ruiz de Almodovar Prediction of normal tissue response and individualization of doses in radiotherapy Phys Med Biol 48 2003 3213 3223 (Pubitemid 37258364)
6. E. Lopez, R. Guerrero, and M.I. Nunez Early and late skin reactions to radiotherapy for breast cancer and their correlation with radiation-induced DNA damage in lymphocytes Breast Cancer Res 7 2005 R690 R698
7. J.M. Ruiz de Almodovar, M.I. Nunez, and T.J. McMillan Initial radiation-induced DNA damage in human tumour cell lines: a correlation with intrinsic cellular radiosensitivity Br J Cancer 69 1994 457 462 (Pubitemid 24076461)
8. E. Siles, M. Villalobos, and M.T. Valenzuela Relationship between p53 status and radiosensitivity in human tumour cell lines Br J Cancer 73 1996 581 588 (Pubitemid 26068860)
9. M.T. Valenzuela, R. Guerrero, and M.I. Nunez PARP-1 modifies the effectiveness of p53-mediated DNA damage response Oncogene 21 2002 1108 1116 (Pubitemid 34174523)
10. D. Averbeck Non-targeted effects as a paradigm breaking evidence Mutat Res 687 2010 7 12
11. H. Nagasawa, and J.B. Little Induction of sister chromatid exchanges by extremely low doses of alpha-particles Cancer Res 52 1992 6394 6396
12. E.I. Azzam, S.M. de Toledo, and J.B. Little Oxidative metabolism, gap junctions and the ionizing radiation-induced bystander effect Oncogene 22 2003 7050 7057 (Pubitemid 37386674)
13. J.F. Ward The radiation-induced lesions which trigger the bystander effect Mutat Res 499 2002 151 154 (Pubitemid 34119391)
14. O.V. Belyakov, M. Folkard, C. Mothersill, K.M. Prise, and B.D. Michael A proliferation-dependent bystander effect in primary porcine and human urothelial explants in response to targeted irradiation Br J Cancer 88 2003 767 774 (Pubitemid 36411458)
15. K.M. Prise, O.V. Belyakov, and H.C. Newman Non-targeted effects of radiation: bystander responses in cell and tissue models Radiat Prot Dosimetry 99 2002 223 226
16. P. Dent, A. Yacoub, P.B. Fisher, M.P. Hagan, and S. Grant MAPK pathways in radiation responses Oncogene 22 2003 5885 5896 (Pubitemid 37176709)
17. K.M. Prise, and J.M. O'Sullivan Radiation-induced bystander signalling in cancer therapy Nat Rev Cancer 9 2009 351 360
18. S.C. Formenti, and S. Demaria Systemic effects of local radiotherapy Lancet Oncol 10 2009 718 726
19. D.T. Goodhead New radiobiological, radiation risk and radiation protection paradigms Mutat Res 687 2010 13 16
20. J.F. Fowler 21 Years of biologically effective dose Br J Radiol 83 2010 554 568
21. W.M. Mendenhall, C.E. Riggs, M. Vaysberg, R.J. Amdur, and J.W. Werning Altered fractionation and adjuvant chemotherapy for head and neck squamous cell carcinoma Head Neck 32 2010 939 945
22. C. Mothersill, and C. Seymour Medium from irradiated human epithelial cells but not human fibroblasts reduces the clonogenic survival of unirradiated cells Int J Radiat Biol 71 1997 421 427 (Pubitemid 27187398)
23. R. Sarugaser, D. Lickorish, D. Baksh, M.M. Hosseini, and J.E. Davies Human umbilical cord perivascular (HUCPV) cells: a source of mesenchymal progenitors Stem Cells 23 2005 220 229 (Pubitemid 40239517)
24. Farias VA, Linares-Fernandez JL, Penalver JL, et al. Human umbilical cord stromal stem cells express CD10 and exert contractile properties. Placenta.
25. J.L. Peñalver, J.-L. Linares-Fernández, and Vd.A. Farías Activated carbon cloth as support for mesenchymal stem cell growth and differentiation to osteocytes Carbon 47 2009 3574 3577
26. C. Munoz-Pinedo, F.J. Oliver, and A. Lopez-Rivas Apoptosis of haematopoietic cells upon thymidylate synthase inhibition is independent of p53 accumulation and CD95-CD95 ligand interaction Biochem J 353 2001 101 108 (Pubitemid 32094604)
27. O. Garcia, I. Romero, J.E. Gonzalez, and T. Mandina Measurements of DNA damage on silver stained comets using free Internet software Mutat Res 627 2007 186 190 (Pubitemid 46099080)
28. M.M. Shareef, N. Cui, and R. Burikhanov Role of tumor necrosis factor-alpha and TRAIL in high-dose radiation-induced bystander signaling in lung adenocarcinoma Cancer Res 67 2007 11811 11820
29. J.H. Peacock, M.R. de Almodovar, T.J. McMillan, and G.G. Steel The nature of the initial slope of radiation cell survival curves BJR Suppl 24 1992 57 60
30. S.B. Curtis Lethal and potentially lethal lesions induced by radiation - a unified repair model Radiat Res 106 1986 252 270 (Pubitemid 16073231)
31. B. Marples, and M.C. Joiner The response of Chinese hamster V79 cells to low radiation doses: evidence of enhanced sensitivity of the whole cell population Radiat Res 133 1993 41 51 (Pubitemid 23070024)
32. L. Apetoh, F. Ghiringhelli, and A. Tesniere Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy Nat Med 13 2007 1050 1059 (Pubitemid 47517504)
33. M.I. Nunez, M. Villalobos, and N. Olea Radiation-induced DNA double-strand break rejoining in human tumour cells Br J Cancer 71 1995 311 316
34. O. Momcilovic, S. Choi, S. Varum, C. Bakkenist, G. Schatten, and C. Navara Ionizing radiation induces ataxia telangiectasia mutated-dependent checkpoint signaling and G(2) but not G(1) cell cycle arrest in pluripotent human embryonic stem cells Stem Cells 27 2009 1822 1835
35. M.B. Sowa, W. Goetz, and J.E. Baulch Lack of evidence for low-LET radiation induced bystander response in normal human fibroblasts and colon carcinoma cells Int J Radiat Biol 86 2010 102 113
36. N. Cogan, D.M. Baird, and R. Phillips DNA damaging bystander signalling from stem cells, cancer cells and fibroblasts after Cr(VI) exposure and its dependence on telomerase Mutat Res 683 2010 1 8
37. E. Szegezdi, A. O'Reilly, and Y. Davy Stem cells are resistant to TRAIL receptor-mediated apoptosis J Cell Mol Med 13 2009 4409 4414
38. Grisendi G, Bussolari R, Cafarelli L, et al. Adipose-derived mesenchymal stem cells as stable source of tumor necrosis factor-related apoptosis-inducing ligand delivery for cancer therapy. Cancer Res;70:3718-29.
39. B. Thayaparasingham, A. Kunz, N. Peters, and D. Kulms Sensitization of melanoma cells to TRAIL by UVB-induced and NF-kappaB-mediated downregulation of xIAP Oncogene 28 2009 345 362
40. T. Haapajarvi, K. Pitkanen, and M. Laiho Human melanoma cell line UV responses show independency of p53 function Cell Growth Differ 10 1999 163 171 (Pubitemid 29138523)
41. J. Rzeszowska-Wolny, R. Herok, M. Widel, and R. Hancock X-irradiation and bystander effects induce similar changes of transcript profiles in most functional pathways in human melanoma cells DNA Repair (Amst) 8 2009 732 738
42. C.E. Mothersill, M.J. Moriarty, and C.B. Seymour Radiotherapy and the potential exploitation of bystander effects Int J Radiat Oncol Biol Phys 58 2004 575 579 (Pubitemid 38142486)
43. S. Burdak-Rothkamm, S.C. Short, M. Folkard, K. Rothkamm, and K.M. Prise ATR-dependent radiation-induced gamma H2AX foci in bystander primary human astrocytes and glioma cells Oncogene 26 2007 993 1002
44. P. Lambin, B. Marples, B. Fertil, E.P. Malaise, and M.C. Joiner Hypersensitivity of a human tumour cell line to very low radiation doses Int J Radiat Biol 63 1993 639 650 (Pubitemid 23162770)
45. P. Lambin, E.P. Malaise, and M.C. Joiner The effect of very low radiation doses on the human bladder carcinoma cell line RT112 Radiother Oncol 32 1994 63 72 (Pubitemid 24246765)
46. S.C. Gamble, M.J. Dunn, C.H. Wheeler, M.C. Joiner, A. Adu-Poku, and J.E. Arrand Expression of proteins coincident with inducible radioprotection in human lung epithelial cells Cancer Res 60 2000 2146 2151 (Pubitemid 30225176)
47. J.S. Dickey, B.J. Baird, C.E. Redon, M.V. Sokolov, O.A. Sedelnikova, and W.M. Bonner Intercellular communication of cellular stress monitored by gamma-H2AX induction Carcinogenesis 30 2009 1686 1695
48. L.S. Sasportas, R. Kasmieh, and H. Wakimoto Assessment of therapeutic efficacy and fate of engineered human mesenchymal stem cells for cancer therapy Proc Natl Acad Sci USA 106 2009 4822 4827
49. A. Ashkenazi, and V.M. Dixit Apoptosis control by death and decoy receptors Curr Opin Cell Biol 11 1999 255 260 (Pubitemid 29164042)
50. M.H. Barcellos-Hoff, and A.L. Brooks Extracellular signaling through the microenvironment: a hypothesis relating carcinogenesis, bystander effects, and genomic instability Radiat Res 156 2001 618 627 (Pubitemid 33027539)
51. S. Burdak-Rothkamm, K. Rothkamm, and K.M. Prise ATM acts downstream of ATR in the DNA damage response signaling of bystander cells Cancer Res 68 2008 7059 7065
52. V.N. Ivanov, H. Zhou, and S.A. Ghandhi Radiation-induced bystander signaling pathways in human fibroblasts: a role for interleukin-33 in the signal transmission Cell Signal 22 2010 1076 1087
53. C. Mothersill, and C.B. Seymour Radiation-induced bystander effects - implications for cancer Nat Rev Cancer 4 2004 158 164 (Pubitemid 38198744)
54. H. Zhou, V.N. Ivanov, Y.C. Lien, M. Davidson, and T.K. Hei Mitochondrial function and nuclear factor-kappaB-mediated signaling in radiation-induced bystander effects Cancer Res 68 2008 2233 2240 (Pubitemid 351521796)
55. S.A. Ghandhi, B. Yaghoubian, and S.A. Amundson Global gene expression analyses of bystander, alpha particle irradiated normal human lung fibroblasts: synchronous, differential responses BMC Med Genomics 1 2008 63
56. T.K. Hei, H. Zhou, and V.N. Ivanov Mechanism of radiation-induced bystander effects: a unifying model J Pharm Pharmacol 60 2008 943 950
57. A. Luce, A. Courtin, and C. Levalois Death receptor pathways mediate targeted and non-targeted effects of ionizing radiations in breast cancer cells Carcinogenesis 30 2009 432 439
58. J.H. Maduro, E.G. de Vries, G.J. Meersma, B.M. Hougardy, A.G. Van der Zee, and S. de Jong Targeting pro-apoptotic trail receptors sensitizes HeLa cervical cancer cells to irradiation-induced apoptosis Int J Radiat Oncol Biol Phys 72 2008 543 552
59. H. Miletic, Y. Fischer, and S. Litwak Bystander killing of malignant glioma by bone marrow-derived tumor-infiltrating progenitor cells expressing a suicide gene Mol Ther 15 2007 1373 1381 (Pubitemid 46965333)
60. K. Nakamura, Y. Ito, and Y. Kawano Antitumor effect of genetically engineered mesenchymal stem cells in a rat glioma model Gene Ther 11 2004 1155 1164 (Pubitemid 39117311)
61. B. Marples, B.G. Wouters, and M.C. Joiner An association between the radiation-induced arrest of G2-phase cells and low-dose hyper-radiosensitivity: a plausible underlying mechanism? Radiat Res 160 2003 38 45 (Pubitemid 36828611)
62. M.A. Ebert, N. Suchowerska, M.A. Jackson, and D.R. McKenzie A mathematical framework for separating the direct and bystander components of cellular radiation response Acta Oncol 49 2010 1334 1343