Radiation-induced DNA damage as a predictor of long-term toxicity in locally advanced breast cancer patients treated with high-dose hyperfractionated radical radiotherapy

Radiation Research

Volumn 168, Issue 4, 2007, Pages 415-422

  Pinar, Beatriz ^a   Lara, Pedro Carlos ^a   Lloret, Marta ^a   Bordón, Elisa ^a   Núñez, María Isabel ^b   Villalobos, Mercedes ^b   Guerrero, Rosa ^b   Luna, J D ^b   Ruiz De Almodovar J M ^b,c  

^a HOSPITAL UNIVERSITARIO DE GRAN CANARIA DR NEGRÍN   (Spain)

^b UNIVERSITY OF GRANADA   (Spain)

^c UNIVERSITY OF GRANADA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; BREAST CANCER; CANCER RADIOTHERAPY; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; DNA DAMAGE; DNA STRAND BREAKAGE; FEMALE; HUMAN; MULTIVARIATE ANALYSIS; PERIPHERAL LYMPHOCYTE; PREDICTION; PRIORITY JOURNAL; PULSED FIELD GEL ELECTROPHORESIS; RADIATION DOSE; SKIN TOXICITY; AGED; BREAST TUMOR; DOUBLE STRANDED DNA BREAK; MIDDLE AGED; RADIATION DOSE FRACTIONATION; RADIATION EXPOSURE; RADIOTHERAPY; SKIN;

ADULT; AGED; BREAST NEOPLASMS; DNA BREAKS, DOUBLE-STRANDED; DNA DAMAGE; DOSE FRACTIONATION; FEMALE; HUMANS; MIDDLE AGED; RADIATION TOLERANCE; RADIOTHERAPY; SKIN;

EID: 35548995775     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.1667/RR0746.1     Document Type: Article

References (44)

1. T. Shenkier, L. Weir, M. Levine, I. Olivotto, T. Whelan and L. Reyno, Clinical practice guidelines for the care and treatment of breast cancer: 15. Treatment for women with stage III or locally advanced breast cancer. Can. Med. Assoc. J. 170, 983-994 (2004).
2. J. Bedwinek, D. V. Rao, C. Perez, J. Lee and B. Fineberg, Stage III and localized stage IV breast cancer: irradiation alone vs irradiation plus surgery. Int. J. Radiat. Oncol. Biol. Phys. 8, 31-36 (1982).
3. R. Arriagada, H. Mouriesse, D. Sarrazin, R. M. Clark and G. Deboer, Radiotherapy alone in breast cancer. I. Analysis of tumor parameters, tumor dose and local control: the experience of the Gustave-Roussy Institute and the Princess Margaret Hospital. Int. J. Radiat. Oncol. Biol. Phys. 11, 1751-1757 (1985).
4. B. J. Cummings, Benefits of accelerated hyperfractionation for head and neck cancer. Acta Oncol. 38, 131-136 (1999).
5. W. Budach, T. Hehr, V. Budach, C. Belka and K. Dietz, A meta-analysis of hyperfractionated and accelerated radiotherapy and combined chemotherapy and radiotherapy regimens in unresected locally advanced squamous cell carcinoma of the head and neck. BMC Cancer 6, 28 (2006).
6. S. L. Tucker, I. Turesson and H. D. Thames, Evidence for individual differences in the radiosensitivity of human skin. Eur J. Cancer 28A, 1783-1791 (1992).
7. S. Johansson, H. Svensson and J. Denekamp, Dose response and latency for radiation-induced fibrosis, edema, and neuropathy in breast cancer patients. Int. J. Radiat. Oncol. Biol. Phys. 52, 1207-1219 (2002).
8. A. Brahme, Individualizing cancer treatment: biological optimization models in treatment planning and delivery. Int. J. Radiat. Oncol. Biol. Phys. 49, 327-337 (2001).
9. S. Johansson, H. Svensson and J. Denekamp, Timescale of evolution of late radiation injury after postoperative radiotherapy of breast cancer patients. Int. J. Radiat. Oncol. Biol. Phys. 48, 745-750 (2000).
10. H. Jung, H. P. Beck-Bornholdt, V. Svoboda, W. Alberti and T. Herrmann, Quantification of late complications after radiation therapy. Radiother. Oncol. 61, 233-246 (2001).
11. D. Guirado and J. M. Ruiz de Almodovar, Prediction of normal tissue response and individualization of doses in radiotherapy. Phys. Med. Biol. 48, 3213-3223 (2003).
12. I. Turesson, J. Nyman, E. Holmberg and A. Oden, Prognostic factors for acute and late skin reactions in radiotherapy patients. Int. J. Radiat. Oncol. Biol. Phys. 36, 1065-1075 (1996).
13. A. M. Moody, W. P. Mayles, J. M. Bliss, R. P. A'Hern, J. R. Owen, J. Regan, B. Broad and J. R. Yarnold, The influence of breast size on late radiation effects and association with radiotherapy dose inhomogeneity. Radiother. Oncol. 33, 106-112 (1994).
14. E. Lopez, R. Guerrero, M. I. Nunez, R. del Moral, M. Villalobos, J. Martinez-Galan, M. T. Valenzuela, J. A. Munoz-Gamez, F. J. Oliver and J. M. Ruiz de Almodovar, Early and late skin reactions to radiotherapy for breast cancer and their correlation with radiation-induced DNA damage in lymphocytes. Breast Cancer Res. 7, R690-R698 (2005).
15. M. Baumann, T. Holscher and A. C. Begg, Towards genetic prediction of radiation responses: ESTRO's GENEPI project. Radiother. Oncol. 69, 121-125 (2003).
16. R. I. Mackay and J. H. Hendry, The modelled benefits of individualizing radiotherapy patients' dose using cellular radiosensitivity assays with inherent variability. Radiother. Oncol. 50, 67-75 (1999).
17. S. M. Bentzen and S. L. Tucker, Individualization of radiotherapy dose prescriptions by means of an in vitro radiosensitivity assay. Radiother. Oncol. 46, 216-218 (1998).
18. J. Peacock, A. Ashton, J. Bliss, C. Bush, J. Eady, C. Jackson, R. Owen, J. Regan and J. Yarnold, Cellular radiosensitivity and complication risk after curative radiotherapy. Radiother. Oncol. 55, 173-178 (2000).
19. T. J. McMillan, S. Tobi, S. Mateos and C. Lemon, The use of DNA double-strand break quantification in radiotherapy. Int. J. Radiat. Oncol. Biol. Phys. 49, 373-377 (2001).
20. M. I. Nunez, T. J. McMillan, M. T. Valenzuela, J. M. Ruiz de Almodovar and V. Pedraza, Relationship between DNA damage, rejoining and cell killing by radiation in mammalian cells. Radiother. Oncol. 39, 155-165 (1996).
21. R. A. Gatti, The inherited basis of human radiosensitivity. Acta Oncol. 40, 702-711 (2001).
22. M. I. Nunez, M. R. Guerrero, E. Lopez, M. R. del Moral, M. T. Valenzuela, E. Siles, M. Villalobos, V. Pedraza, J. H. Peacock and J. M. Ruiz de Almodovar, DNA damage and prediction of radiation response in lymphocytes and epidermal skin human cells. Int. J. Cancer 76, 354-361 (1998).
23. C. M. West, S. E. Davidson, S. A. Elyan, H. Valentine, S. A. Roberts, R. Swindell and R. D. Hunter, Lymphocyte radiosensitivity is a significant prognostic factor for morbidity in carcinoma of the cervix. Int. J. Radiat. Oncol. Biol. Phys. 51, 10-15 (2001).
24. C. M. West, S. E. Davidson, S. A. Elyan, R. Swindell, S. A. Roberts, C. J. Orton, C. A. Coyle, H. Valentine, D. P. Wilks and J. H. Hendry, The intrinsic radiosensitivity of normal and tumour cells. Int. J. Radiat. Biol. 73, 409-413 (1998).
25. J. B. Barber, C. M. West, A. E. Kiltie, S. A. Roberts and D. Scott, Detection of individual differences in radiation-induced apoptosis of peripheral blood lymphocytes in normal individuals, ataxia telangiectasia homozygotes and heterozygotes, and breast cancer patients after radiotherapy. Radiat. Res. 153, 570-578 (2000).
26. J. M. Ruiz de Almodovar, G. G. Steel, S. J. Whitaker and T. J. McMillan, A comparison of methods for calculating DNA double-strand break induction frequency in mammalian cells by pulsed-field gel electrophoresis. Int. J. Radiat. Biol. 65, 641-649 (1994).
27. P. K. Zhou, A. R. Sproston, B. Marples, C. M. West, G. P. Margison and J. H. Hendry, The radiosensitivity of human fibroblast cell lines correlates with residual levels of DNA double-strand breaks. Radiother. Oncol. 47, 271-276 (1998).
28. A. E. Kiltie, C. J. Orton, A. J. Ryan, S. A. Roberts, B. Marples, S. E. Davidson, R. D. Hunter, G. P. Margison, C. M. West and J. H. Hendry, A correlation between residual DNA double-strand breaks and clonogenic measurements of radiosensitivity in fibroblasts from preradiotherapy cervix cancer patients. Int. J. Radiat. Oncol. Biol. Phys. 39, 1137-1144 (1997).
29. J. Dickson, B. Magee, A. Stewart and C. M. West, Relationship between residual radiation-induced DNA double-strand breaks in cultured fibroblasts and late radiation reactions: a comparison of training and validation cohorts of breast cancer patients. Radiother. Oncol. 62, 321-326 (2002).
30. U. Hoeller, K. Borgmann, M. Bonacker, A. Kuhlmey, A. Bajrovic, H. Jung, W. Alberti and E. Dikomey, Individual radiosensitivity measured with lymphocytes may be used to predict the risk of fibrosis after radiotherapy for breast cancer. Radiother. Oncol. 69, 137-144 (2003).
31. J. Mariano Ruiz de Almodovar, D. Guirado, M. Isabel Nunez, E. Lopez, R. Guerrero, M. Teresa Valenzuela, M. Villalobos and R. del Moral, Individualization of radiotherapy in breast cancer patients: possible usefulness of a DNA damage assay to measure normal cell radiosensitivity. Radiother. Oncol. 62, 327-333 (2002).
32. E. Rached, R. Schindler, K. T. Beer, D. Vetterli and R. H. Greiner, No predictive value of the micronucleus assay for patients with severe acute reaction of normal tissue after radiotherapy. Eur J. Cancer 34, 378-383 (1998).
33. W. U. Muller, T. Bauch, G. Stuben, H. Sack and C. Streffer, Radiation sensitivity of lymphocytes from healthy individuals and cancer patients as measured by the comet assay. Radiat. Environ. Biophys. 40, 83-89 (2001).
34. C. Alapetite, P. Thirion, A. de la Rochefordiere, J. M. Cosset and E. Moustacchi, Analysis by alkaline comet assay of cancer patients with severe reactions to radiotherapy: defective rejoining of radioinduced DNA strand breaks in lymphocytes of breast cancer patients. Int. J. Cancer 83, 83-90 (1999).
35. J. B. Barber, W. Burrill, A. R. Spreadborough, E. Levine, C. Warren, A. E. Kiltie, S. A. Roberts and D. Scott, Relationship between in vitro chromosomal radiosensitivity of peripheral blood lymphocytes and the expression of normal tissue damage following radiotherapy for breast cancer. Radiother. Oncol. 55, 179-186 (2000).
36. S. H. Jung and S. Hui, Sample size calculation for rank tests comparing K survival distributions. Lifetime Data Anal. 8, 361-373 (2002).
37. J. Yarnold, A. Ashton, J. Bliss, J. Homewood, C. Harper, J. Hanson, J. Haviland, S. Bentzen and R. Owen, Fractionation sensitivity and dose response of late adverse effects in the breast after radiotherapy for early breast cancer: long-term results of a randomised trial. Radiother. Oncol. 75, 9-17 (2005).
38. E. Lopez, M. I. Nunez, M. R. Guerrero, R. del Moral, J. de Dios Luna, M. del Mar Rodriguez, M. T. Valenzuela, M. Villalobos and J. M. Ruiz de Almodovar, Breast cancer acute radiotherapy morbidity evaluated by different scoring systems. Breast Cancer Res. Treat. 73, 127-134 (2002).
39. Z. Liao, E. A. Strom, A. U. Buzdar, S. E. Singletary, K. Hunt, P. K. Allen and M. D. McNeese, Locoregional irradiation for inflammatory breast cancer: effectiveness of dose escalation in decreasing recurrence. Int. J. Radiat. Oncol. Biol. Phys. 47, 1191-1200 (2000).
40. C. E. Coles, A. M. Moody, C. B. Wilson and N. G. Burnet, Reduction of radiotherapy-induced late complications in early breast cancer: the role of intensity-modulated radiation therapy and partial breast irradiation. Part II - Radiotherapy strategies to reduce radiation-induced late effects. Clin. Oncol. (R. Col. Radiol.) 17, 98-110 (2005).
41. N. J. Savill, Mathematical models of hierarchically structured cell populations under equilibrium with application to the epidermis. Cell Prolif. 36, 1-26 (2003).
42. H. P. Rodemann and M. Bamberg, Cellular basis of radiation-induced fibrosis. Radiother. Oncol. 35, 83-90 (1995).
43. C. Fournier, M. Scholz, W. K. Weyrather, H. P. Rodemann and G. Kraft, Changes of fibrosis-related parameters after high- and low-LET irradiation of fibroblasts. Int. J. Radiat. Biol. 77, 713-722 (2001).
44. S. A. Lorimore, P. J. Coates, G. E. Scobie, G. Milne and E. G. Wright, Inflammatory-type responses after exposure to ionizing radiation in vivo: a mechanism for radiation-induced bystander effects? Oncogene 20, 7085-7095 (2001).