Expression of CYP107Z13 in Streptomyces lividans TK54 catalyzes the oxidation of avermectin to 4″-oxo-avermectin

Applied Microbiology and Biotechnology

Volumn 93, Issue 5, 2012, Pages 1957-1963

  Jiang, Xiliang ^a   Liu, Weide ^a   Ji, Ying ^a   Niu, Jing ^a   Li, Mei ^a  

^a INSTITUTE OF PLANT PROTECTION   (China)

Author keywords

Avermectin; CYP107Z13; Expression; Oxidation; Streptomyces lividans TK54

Indexed keywords

AVERMECTINS; BIOCATALYTIC ACTIVITY; CRUDE PROTEINS; CYP107Z13; CYTOCHROME P450 GENES; EXPRESSION; REACTION CONDITIONS; RECOMBINANT STRAINS; REGIO-SELECTIVE; REGIOSPECIFIC OXIDATION; RESTING CELLS; STREPTOMYCES LIVIDANS; WHOLE CELL;

CLONING; GENES; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; OXIDATION; SPECTRUM ANALYSIS;

RECOMBINANT PROTEINS;

4'' OXO AVERMECTIN; AVERMECTIN; CYTOCHROME P450; CYTOCHROME P450107Z13; OXIDOREDUCTASE; UNCLASSIFIED DRUG;

BACTERIUM; CARBON MONOXIDE; CATALYSIS; CELL ORGANELLE; GENE EXPRESSION; OXIDATION; PH; PROTEIN; RECOMBINATION;

ARTICLE; BACTERIAL STRAIN; BIOCATALYSIS; BIOTRANSFORMATION; CONTROLLED STUDY; ENZYME ACTIVITY; MOLECULAR CLONING; NUCLEOTIDE SEQUENCE; OXIDATION; PLASMID; PROMOTER REGION; STREPTOMYCES; STREPTOMYCES AHYGROSCOPICUS; STREPTOMYCES LIVIDANS;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CLONING, MOLECULAR; CULTURE MEDIA; CYTOCHROME P-450 ENZYME SYSTEM; GENE EXPRESSION; IVERMECTIN; METABOLIC ENGINEERING; METABOLOME; OXIDATION-REDUCTION; PROMOTER REGIONS, GENETIC; STREPTOMYCES LIVIDANS;

STREPTOMYCES; STREPTOMYCES LIVIDANS;

EID: 84857911730     PISSN: 01757598     EISSN: 14320614     Source Type: Journal    
DOI: 10.1007/s00253-011-3490-1     Document Type: Article

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