The high fermentative metabolism of Kluyveromyces marxianus UFV-3 relies on the increased expression of key lactose metabolic enzymes

Antonie van Leeuwenhoek, International Journal of General and Molecular Microbiology

Volumn 101, Issue 3, 2012, Pages 541-550

  Diniz, Raphael H S ^a   Silveira, Wendel B ^a   Fietto, Luciano G ^a   Passos, Flávia M L ^a  

^a FEDERAL UNIVERSITY OF VIÇOSA   (Brazil)

Author keywords

Ethanol; Kluyveromyces marxianus; Lactose; Metabolism

Indexed keywords

ALCOHOL; BETA GALACTOSIDASE; EPIMERASE; GALACTOSE 1 PHOSPHATE URIDYLYLTRANSFERASE; LACTOSE; PYRUVATE DECARBOXYLASE;

ARTICLE; CHEESE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENZYME ACTIVITY; FERMENTATION; GENE EXPRESSION; KLUYVEROMYCES LACTIS; KLUYVEROMYCES MARXIANUS; NONHUMAN; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; WHEY; YEAST;

AEROBIOSIS; ANAEROBIOSIS; BETA-GALACTOSIDASE; BIOMASS; CULTURE MEDIA; DAIRY PRODUCTS; ENZYME INDUCTION; ETHANOL; FERMENTATION; FUNGAL PROTEINS; GENE EXPRESSION REGULATION, FUNGAL; INDUSTRIAL MICROBIOLOGY; KLUYVEROMYCES; LACTOSE; MYCOLOGY; PYRUVATE DECARBOXYLASE; REAL-TIME POLYMERASE CHAIN REACTION; RNA, FUNGAL; SPECIES SPECIFICITY; UDPGLUCOSE 4-EPIMERASE; UDPGLUCOSE-HEXOSE-1-PHOSPHATE URIDYLYLTRANSFERASE;

KLUYVEROMYCES LACTIS; KLUYVEROMYCES MARXIANUS;

EID: 84857910677     PISSN: 00036072     EISSN: 15729699     Source Type: Journal    
DOI: 10.1007/s10482-011-9668-9     Document Type: Article

References (33)

1. Aktas N, Boyaci IH, Mutlu M, Tanyolac A (2005) Optimization of lactose utilization in deproteinated whey by Kluyveromyces marxianus using response surface methodology (RSM). Bioresour Technol 97:2252-2259. doi:10.1016/j. biortech.2005.10.039 (Pubitemid 44093251)
2. Barnett JA (1992) Some controls on oligosacharide utilization by yeasts: the physiologycal basis of the Kluyver effect. FEMS Microbiol Lett 79:371-378. doi:10.1016/0378-1097(92)90234-F
3. Bellaver LH, Carvalho NMB, Abrahão-Neto J, Gombert AK (2004) Ethanol formation and enzyme activities around glucose-6-phosphate in Kluyveromyces marxianus CBS 6556 exposed to glucose or lactose excess. FEMS Yeast Res 4:691-698. doi:10.1016/j.femsyr.2004.01.004
4. Bianchi MM, Tizzani L, Destruelle M, Frontali L, Wésolowski ML (1996) The petite negative yeast Kluyveromyces lactis has a single gene expressing pyruvate decarboxylase activity. Mol Microbiol 19:27-36. doi:10.1046/j.1365-2958.1996.346875.x (Pubitemid 26025868)
5. Bradford MM (1976) A rapid and sensitive method for quantitation of microgram quantities of protein utilizing the principle of protein-dye-binding. Anal Biochem 72:248-254. doi:10.1016/0003-2697(76)90527-3
6. Breunig KD, Kuger P (1987) Functional homology between the yeast regulatory proteins GAL4 and LAC9: LAC9-mediated transcriptional activation in Kluyveromyces lactis involves protein binding to a regulatory sequence homologous to the GAL4 protein-binding site. Mol Cell Biol 7: 4400-4406
7. Brink J, Daran-Lapujade P, Pronk JT, de Winde JH (2008) New insights into the Saccharomyces cerevisiae fermentation switch: dynamic transcriptional response to anaerobicity and glucose-excess. BMC Genomics 9:100. doi:10.1186/1471-2164-9-100
8. Cortes G, Trujillo-Roldan MA, Ramirez OT, Galindo E (2005) Production of b-galactosidase by Kluyveromyces marxianus under oscillating dissolved oxygen tension. Process Biochem 40:773-778. doi:10.1016/j.procbio.2004.02.001 (Pubitemid 39437881)
9. Domingues L, Guimaräes PMR, Oliveira C (2010) Metabolic engineering of Saccharomyces cerevisiae for lactose/whey fermentation. Bioeng Bugs 1(3):164-171. doi:10.4161/bbug.1.3.10619
10. Flores CL, Rodríguez C, Petit T, Gancedo C (2000) Carbohydrate and energy-metabolism in non-conventional yeasts. FEMS Microbiol Rev 24:507-529. doi:10.1111/j.1574-6976.2000.tb00553.x
11. Fonseca GG, Gombert AK, Heinzle E, Wittmann C (2007) Physiology of the yeast Kluyveromyces marxianus during batch and chemostat cultures with glucose as the sole carbon source. FEMS Yeast Res 7:422-435. doi:10.1111/j.1567-1364. 2006.00192.x (Pubitemid 46555512)
12. Fonseca GG, Heinzle E, Wittmann C, Gombert AK (2008) The yeast Kluyveromyces marxianus and its biotechnological potential. Appl Microbiol Biot 79:339-354. doi:10.1007/s00253-008-1458-6
13. Frishman D, Albermann K, Hani J, Heumann K, Metanomski A, Zollner A, Mewes HW (2001) Functional and structural genomics using PEDANT. Bioinformatics 17:44-57. doi: 10.1093/bioinformatics/17.1.44 (Pubitemid 32178012)
14. Fukuhara H (2006) Kluyveromyces lactis - a retrospective. FEMS Yeast Res 6:323-324. doi:10.1111/j.1567-1364. 2005.00012.x
15. Ghaly AE, Singh RK (1989) Pollution potential reduction of cheese whey through yeast fermentation. Appl Biochem Biotechnol 22:181-203. doi:10.1007/BF02921744 (Pubitemid 19268220)
16. Gödecke A, Zachariae W, Arvanitidis A, Breunig KD (1991) Coregulation of the Kluyveromyces lactis lactose permease and beta-galactosidase genes is achieved by interaction of multiple LAC9 binding sites in a 2.6 kbp divergent promoter. Nucleic Acids Res 19:5351-5358. doi:10.1093/nar/19.19.5351 (Pubitemid 21912933)
17. González-Siso MI, Ramil, Cerdán ME, Freire-Picos MA (1996) Respiro-fermentative metabolism in Kluyveromyces lactis: ethanol production and Crabtree effect. Enzyme Microb Tech 18:585-591. doi:10.1016/S0141-0229(00)00161- 7
18. Hoek P, van Dijken JP, Pronk JT (2000) Regulation of fermentative capacity and levels of glycolytic enzymes in chemostat cultures of Saccharomyces cerevisiae. Enzyme Microb Tech 26:724-736. doi:10.1016/S0141-0229(00)00164-2 (Pubitemid 30345539)
19. Ishida N, Suzuki T, Tokuhiro K, Nagamori E, Onishi T, Saitoh S, Kitamoto K, Takahashi H (2006) D-Lactic acid production by metabolically engineered Saccharomyces cerevisiae. J Biosci Bioeng 101:172-177. doi:10.1263/jbb.101.172 (Pubitemid 44355022)
20. Lane MM, Morrissey JP (2010) Kluyveromyces marxianus: a yeast emerging from its sister's shadow. Fungal Biol Rev 24:17-26. doi:10.1016/j.fbr.2010.01. 001
21. Lane MM, Burke N, Karreman R, Wolfe KH, O'Byrne CP, Morrissey JP (2011) Physiological and metabolic diversity in the yeast Kluyveromyces marxianus. Antonie van Leeuwenhoek. doi:10.1007/s10482-011-9606-x
22. Liu Y (2007) Overview of some theoretical approaches for derivation of the Monod equation. Appl Microbiol Biotechnol 73:1241-1250. doi:10.1007/s00253- 006-0717-7
23. Lodi T, Donnini C (2005) Lactose-induced cell death of b-galactosidase mutants in Kluyveromyces lactis. FEMS Yeast Res 5(8):727-734. doi:10.1016/j.femsyr.2005.01.005 (Pubitemid 40558920)
24. Mahoney RR, Nickerson TA, Whitaker JR (1975) Selection of strain, growth conditions, and extraction procedures for optimum production of lactase from Kluyveromyces fragilis. J Dairy Sci 58:1620-1629. doi:10.3168/jds.S0022-0302(75) 84760-6
25. Mawson AJ (1994) Bioconversions for whey utilization and waste abatement. Bioresour Technol 47:195-203. doi: 10.1016/0960-8524(94)90180-5
26. Monod J (1949) The growth of bacterial cultures. Annu Rev Microbiol 3:371-394. doi:10.1146/annurev.mi.03.100149.002103
27. Ostergaard S, Olsson L, Johnston M, Nielsen J (2000) Increasing galactose consumption by Saccharomyces cerevisiae through metabolic engineering of the GAL gene regulatory network. Nat Biotechnol 18:1283-1286. doi:10.1038/82400
28. Pang Z, Liang J, Qin X, Wang J, Feng J, Huang R (2010) Multiple induced mutagenesis for improvement of ethanol production by Kluyveromyces marxianus. Biotechnol Lett 32:1847-1851. doi:10.1007/s10529-010-0384-8
29. Ralser M, Goehler H, Wanker EE, Lehrach H, Krobitsch S (2005) Generation of a yeast two-hybrid strain suitable for competitive protein binding analysis. Biotechniques 39: 165-168
30. Rubio-Texeira M (2005) A comparative analysis of the GAL genetic switch between not-so distant cousins - Saccharomyces cerevisiae versus Kluyveromyces lactis. FEMS Yeast Res 5:1115-1128. doi:10.1016/j.femsyr.2005.05.003
31. Schmitt ME, Brown TA, Trumpower BL (1990) A rapid and simple method for preparation of RNA from Saccharomyces cerevisiae. Nucleic Acids Res 18:3091-3092. doi: 10.1093/nar/18.10.3091 (Pubitemid 20178191)
32. Sherman DJ, Martin T, Nikolski M, Cayla C, Souciet JL, Durrens P, Génolevures Consortium (2009) Génolevures: protein families and synteny among complete hemiascomycetous yeast proteomes and genomes. Nucleic Acids Res 37:550-554. doi:10.1093/nar/gkn859
33. Silveira WB, Passos FJV, Mantovani HC, Passos FML (2005) Ethanol production from cheese whey permeate by Kluyveromyces marxianus UFV-3: a flux analysis of oxidoreductive metabolism as a function of lactose concentration and oxygen levels. Enzyme Microb Tech 36:930-936. doi: 10.1016/j.enzmictec.2005.01. 018 (Pubitemid 40591712)